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Effects of simulated carbon dioxide and helium peumoperitoneum on proliferation and apoptosis of gastric cancer cells

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World Journal of Gastroenterology 2008年第14期14卷 2241-2245页

作者： Ying-Xue Hao Hua zhong Chao Zhang Dong-Zu Zeng yan Shi Bo Tang Pei-wu yu Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery Southwest Hospital Third Military Medical University Chongqing 400038 China Department of Ultrasonography Southwest Hospital Third Military Medical University Chongqing 400038 China

AIM:To investigate the effects of carbon dioxide (CO2) and helium insufflation administered at different pressures on the growth and apoptosis of cultured human gastric cancer cells. METHODS:The gastric cancer cells MKN-45 were exposed to a CO2 and helium environment maintained at different pressures (0, 5, 10 and 15 mmHg). The cells were exposed to simulated pneumoperitoneum environment for 4 h, and pH of the culture media was measured after it was moved to normal conditions for 0, 2, 4, 6 and 8 h. Proliferation viability of MKN-45 was examined by 3-4,5Dimethylthiazol-2-yl,5-diphenyltetrazolium bromide or triazolyl blue (MTT) assay after it was moved to normal conditions. Apoptotic ratio was measured by Annexin V-FITC/PI double labelled staining. RESULTS:The pH of media was acid and recovered to normal after 4 h in the CO2 group while it was basic in the helium group. There was no difference between CO2 groups (under 10 mmHg ) and control group (P > 0.05) in the proliferative viability of the cells. The cultured cells exposed to 15 mmHg CO2 environment grew more slowly than control group from 4 to 7 d (P rence from 1 to 3 d (P > 0.05). The proliferative viability in helium group was not obviously different from the control group (P > 0.05). The apoptotic ratio of the cultured cells was markedly higher than that of the control group (P rent from the control group (P > 0.05). CONCLUSION:There is no obvious effect in the proliferation and apoptosis of MKN-45 cells under 10 mmHg CO2 insufflation pressure and helium in any pressure. Fifteen mmHg CO2 insufflation pressure can inhibit the proliferation of the cells and improve apoptosis.

关键词： Pneumoperitoneum Gastric cancer cells Proliferation Apoptosis

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基于虚拟阻抗的光伏高电压穿越控制策略

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电力电子技术 2024年第7期58卷 73-75,91页

作者：颜湘武杨若嘉贾焦心沈钟毓华北电力大学电气与电子工程学院河北保定071003 国网天津市电力公司建设分公司天津300110

提出了一种增加功率解耦环节的高电压穿越(HVRT)控制策略,对传统双环控制进行改进。通过对电网电压抬升幅度进行检测,超出阈值时对控制策略进行切换使逆变器吸收电网无功。基于光伏并网逆变器数学模型,分析线路阻抗对功率耦合性的影响,... 详细信息

提出了一种增加功率解耦环节的高电压穿越(HVRT)控制策略,对传统双环控制进行改进。通过对电网电压抬升幅度进行检测,超出阈值时对控制策略进行切换使逆变器吸收电网无功。基于光伏并网逆变器数学模型,分析线路阻抗对功率耦合性的影响,采用虚拟阻抗解耦技术实现对有功和无功的分别控制,进而减小控制策略切换时因输出功率耦合造成的功率波动问题。通过实验对比分析采用所提控制策略和传统控制下高电压穿越过程中直流母线电压和有功、无功功率的变化情况,实验表明虚拟阻抗控制策略可以减小功率波动,有效提高高电压穿越控制策略性能。

关键词：光伏高电压穿越并网逆变器

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A highly efficient pathway to recover gold from acid aqueous solution by using an amidoxime-functionalized UHMWPE fiber

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Rare Metals 2019年第11期38卷 1105-1112页

作者： yu-Lin Liang Chan Jin Jiang-Tao Hu Zhen Liu yan Li Jian-Rong Zeng Guo-zhong wu Xiang-Jun Wei Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

A new amidoxime-functionalized ultrahigh molecular weight polyethylene fibrous adsorbent(UHMWPEg-PAO) was used for the recovery of Au(III) from acid aqueous *** maximum experimental absorption capacity of UHMWPE-g-PAO fiber was found to be approximately 220.0 mg·g^-*** adsorption on UHMWPE-g-PAO was characterized by synchrotron radiation-based microcomputed tomography(SR-μ-CT),transmission electron microscopy(TEM),X-ray absorption near-edge structure spectroscopy(XANES) and synchrotron radiation-based Fourier transform infrared microspectroscopy(SR-FTIR).The SR-μ-CT and TEM results showed the distribution features of gold particles on the *** mechanism of Au(III) recovery from aqueous solutions by UHMWPE-g-PAO was based on the adsorbed Au(III) ions,which were reduced to metallic zero-valent gold(Au(0)) by amino groups(-NH2) in the amidoxime(AO)groups during the adsorption process,as confirmed by highresolution TEM(HRTEM) and XANES analyses.X-ray diffraction(XRD) results indicated that the incineration ashes contained metallic zero-valent *** conclusion,this amidoxime-functionalized fibrous adsorbent is a promising material for recovering gold from aqueous solution.

关键词： UHMWPE-g-PAO Adsorption mechanism Gold Reduction

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Efficacy of the herbal pair, Radix Achyranthis Bidentatae and Eucommiae Cortex, in preventing glucocorticoid-induced osteoporosis in the zebrafish model

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Journal of Integrative Medicine 2022年第1期20卷 83-90页

作者： Joon-ho Lee yuan-ji Wei zhong-yan Zhou yu-ming Hou Cheng-long Wang Li-bo Wang Hong-jin wu yu Zhang Wei-wei Dai Central Laboratory of Science and Technology Department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cardiovascular Department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Objective: In traditional Chinese medicine, the herbal pair, Radix Achyranthis Bidentatae(RAB) and Eucommiae Cortex(EC), is widely used to treat osteoporosis. Herein, we determined whether this herbal pair can be used to ameliorate glucocorticoid(GC)-induced osteoporosis(GIOP) and find its optimal dosage in ***: The characteristics of the aqueous extract of RAB and EC were separately characterized using high-performance liquid chromatography. Osteoporosis was induced in 5-day post-fertilization zebrafish larvae by exposing them to 10 lmol/L dexamethasone(Dex) for 96 h. Seven combinations of different ratios of RAB and EC were co-administered. Treatment efficacy was determined by calculating zebrafish vertebral area and sum brightness, via alizarin red staining, and by detecting alkaline phosphatase(ALP)activity. Multiple regression analysis was conducted to test the optimal dosage ***: According to the Chinese Pharmacopoeia(2015), b-ecdysone(b-Ecd) is a major bioactive marker in RAB extract, while pinoresinol diglucoside(PDG) is the major marker in EC extract. Both of b-Ecd and PDG content values aligned with the Chinese Pharmacopoeia standards. Treatment with 10 lmol/L Dex reduced zebrafish vertebral area, sum brightness, and ALP activity, but RAB and EC attenuated these effects. Combining 50 mg/m L RAB and 50 mg/m L EC was optimal for preventing GIOP in *** transcription-quantitative polymerase chain reaction was used to evaluate the m RNA expression of osteogenesis-related genes. A treatment of 10 lmol/L Dex decreased runt-related transcription factor 2(Runx2), osteogenic protein-1(OP-1), bone c-carboxyglutamic acid-containing protein(BGLAP), and bcatenin levels. This effect was counteracted by RAB and EC co-treatment(P < 0.05). Additionally, the effect of using the two herbal extracts together was better than single-herb treatments separately. These results demonstrated that RAB and EC preserve osteoblast function in the pre

关键词： Glucocorticoid Osteoporosis Radix Achyranthis Bidentatae Eucommiae Cortex Zebrafish

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基于白光中子源的^(197)Au中子辐射俘获截面测量及共振参数分析

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物理学报 2024年第7期73卷 104-113页

作者：罗淏天张奇玮栾广源王晓宇邹翀任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉吴鸿毅顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系核探测与核电子学国家重点实验室合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室... 详细信息

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和12块五棱BaF_(2)晶体构成了外径25 cm,内径10 cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了197Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了197Au俘获反应的产额,利用SAMMY程序拟合得到了^(197)Au在1—100 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.

关键词：中子辐射俘获截面共振参数白光中子源伽马全吸收装置

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Determination of Average Wall Thickness of Mesoporous Silica

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Chinese Chemical Letters 2001年第8期12卷 741-744页

作者： Zhi Hong LI yan Jun GONG Dong wu yu Han SUN Jun WANG Yi LIU Bao zhong DONG State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesP.O.Box 165Taiyuan 030001 Laboratory of Synchrotron Radiation Institute of High Energy PhysicsChinese Academy of SciencesP.O.Box 918Beijing 100039

Small Angle X-ray Scattering (SAXS) experiment using Synchrotron Radiation as X-ray source was used to determine the average wall thickness of mesoporous silica prepared by condensation of tetraethylorthosilicate (TEOS) using non-ionic alkylpolyethyleneoxide (AEO(9)) surfactant as templates. The results agreed with that of high-resolution TEM (HRTEM) measurement.

关键词： Small Angle X-ray Scattering(SAXS) mesoporous silica average wall thickness

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Nuclear Effect Study Under K Factor's Nonconstancy

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Communications in Theoretical Physics 2002年第7期38卷 59-64页

作者： HOU Zhao-yu wu Wen-Wang HE Ming-zhong ZHANG Ben-Ai Department of Physics Shijiazhuang Normal College Shijiazhuang 050801 China Graduate School the Chinese Academy of Engineering Physics Beijing 100088 China Department of Mathematics and Physics Shijiazhuang Railway College Shijiazhuang 050043 China Department of Electronics Hebei Normal University Shijiazhuang 050016 China Graduate School the Chinese Academy of Engineering Physics Beijing 100088 China

A consistent approach to estimating nuclear effect functions RA RvA (x2) and RSA(x2) based on numerical iteration technique is presented in the quark-parton model when taking into account the nonconstancy of quantum chromodynamics correction factor K. ARv (x2) and RsA(x2) correspond respectively to the valence quark distributions for one bound nucleon within the nucleus and to the sea quark ones. Related numerical analysis is given for nuclei 6 12C,20 40Ca, and 26 56Fe. As the basis, it adopts both experimental data of the high energy proton-nucleus Drell-yan process and of the high energy lepton-nucleus deep inelastic scattering.

关键词： K-factor, Drell-yan process, deep inelastic scattering, nuclear parton distribution

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聚酰胺-胺树形大分子吸附分离材料的构筑及应用研究进展

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离子交换与吸附 2024年第1期40卷 1-13页

作者：刘同河王柄翔吴开彦汪佳璇牛余忠鲁东大学化学与材料科学学院

聚酰胺-胺(PAMAM)树形大分子具有高度支化的分子结构和丰富的叔胺、酰胺和氨基等功能基团，且各功能基团随树形大分子代数增加呈规律性增加和排布，为吸附位点的集中、层次性分布提供了理想的模板。同时，PAMAM树形大分子具有良好的水... 详细信息

聚酰胺-胺(PAMAM)树形大分子具有高度支化的分子结构和丰富的叔胺、酰胺和氨基等功能基团，且各功能基团随树形大分子代数增加呈规律性增加和排布，为吸附位点的集中、层次性分布提供了理想的模板。同时，PAMAM树形大分子具有良好的水溶性、稳定性和pH响应性，可通过调控树形大分子的代数、中心核、外层端基以及溶液pH等提升其对不同水体环境的适应性及对目标物的选择性吸附分离性能，因此，以PAMAM树形大分子构筑吸附分离材料在金属离子、染料、生物分子和药物分子以及CO2的吸附分离领域具有重要应用。本文对PAMAM树形大分子吸附分离材料的构筑及应用研究进展进行了全面总结，并展望了该类材料未来的应用前景和发展方向。

关键词： PAMAM树形大分子构筑吸附应用

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Clathrin-dependent endocytosis predominantly mediates protein absorption by fat body from the hemolymph in Bombyx mori

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Insect Science 2020年第4期27卷 675-686页

作者： yu-Jie Wang Shu-yan Li Jia-Ye Zhao Kang Li Jing Xu Xian-Ying Xu Wen-Mei wu Rong yang yang Xiao Ming-Qiang Ye Ji-ping Liu yang-Jin zhong yang Cao Hui-yu Yi Ling Tian Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding/Guangdong Provincial Sericulture and Mulberry Engineering Research Center College of Animal ScienceSouth China Agricultural UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina The Sericultural and Agri-Food Research Institute of the Guangdong Academy of Agricultural Sciences GuangzhouChina

During insect larval-pupal metamorphosis,proteins in the hemolymph are absorbed by the fat body for the maintenance of intracellular homeostasis;however,the type of proteins and how these proteins are internalized into the fat body are *** Bombyx mori,the developmental profiles o f total proteins in the hemolymph and fat body showed that hemolymph-decreased protein bands(55-100 kDa)were in accordance with those protein bands that increased in the fat *** o f clathrin-dependent endocytosis predominantly blocked the transportation o f 55-100 kDa proteins from the hemolymph into the fat body,which was further verified by RNA interference treatment o f *** hexamerins were shown to comprise〜90%of the total identified proteins in both the hemolymph and fat body by mass spectrum(MS)*** addition,hemolymphspecific proteins were mainly involved in material transportation,while fat body-specific proteins particularly participated in *** this paper,four hexamerins were found for the first time,and potential proteins absorbed by the fat body from the hemolymph through clathrin-dependent endocytosis were *** study sheds light on the protein absorption mechanism during insect metamorphosis.

关键词： Bombyx mori clathrin-mediated endocytosis fat body hemolymph uptake of proteins

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Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第11期14卷 1033-1040页

作者： Fang LIU Min wu yan-huan FENG Hui zhong Tian-lei CUI You-qun HUANG Ya-ping LIANG Yong-shu DIAO Li ZANG Ling LI Jing ZANG Hong-yu QIU Song-min HUANG ping FU Division of Nephrology West China Hospital of Sichuan University

The aim of this study was to understand the characteristics of blood pressure （BP） variability in subjects with diabetic nephropathy （DN）, and identify the probable predictors affecting BP variability. Fifty-one chronic kidney disease （CKD）-hypertensive patients without diabetes （NDN group） and sixty type 2 diabetic patients with overt DN （DN group） were enrolled in this study. The values of short-term BP variability were obtained from 24 h ambulatory BP monitoring （ABPM）. Variance analysis or nonparametric analysis revealed that 24-h systolic BP variability and night- time systolic BP variability of the DN group were significantly higher than those of the NDN group [（12.23±3.66） vs. （10.74±3.83） mmHg, P〈0.05; （11.23±4.82） vs. （9.48±3.69） mmHg, P〈0.05]. Then the patients of the DN group were divided into two groups according to glycated hemoglobin （HbAlc） level： Group A （HbA1c〈7%） and Group B （HbA1c〉7%）, and the t-test showed that patients in Group B had larger 24-h diastolic, daytime diastolic, and nighttime systolic/diastolic BP variability compared with Group A. In the DN group, partial correlation analysis revealed that HbAlc exhibited a strong association with 24-h diastolic, daytime diastolic, nighttime systolic and diastolic BP vari- ability （P〈0.001, P〈0.001, P〈0.05, and P〈0.001, respectively）. Taken together, larger short-term BP variability was detected in hypertensive type 2 diabetic patients with overt nephropathy and renal insufficiency. It may imply that the optimal BP variability level could benefit from a better glycaemic control.

关键词： Short-term blood pressure variability Diabetic nephropathy Glycated hemoglobin (HbAlc) Hypertension Glycaemic control

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