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Correlation of Oral Microbiota With Different Immune Responses to Antiretroviral Therapy in People Living With HIV

Infectious Microbes & Diseases 2024年第2期6卷 85-92页

作者： Jingying Pan Xiaodi Zhang Danrong Shi Xuebin Tian Lijun Xu Xiangyun Lu Mingqing Dong Peng Yao Zhaoyi Pan nanping wu Hangping Yao State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Infectious Disease Zhejiang Qingchun HospitalZhejiang UniversityHangzhouChina Jinan Microecological Biomedicine Shandong Laboratory JinanChina

Both HIV infection and antiretroviral therapy(ART)affect the oral *** successful treatment with ART in people living with HIV(PLWH),which leads to a significant decline in viral loads and immune reconstitution,is associated with changes in or recovery of the oral microbiome remains ***,we performed a cross-sectional study of 118 PLWH receiving regular ART and 40 healthy controls(HCs).Among the 118 PLWH,18 immunological nonresponders(INRs;<200 CD4^(+)T cells/μL)and 30 immunological responders(IRs;≥500 CD4^(+)T cells/μL)were *** oral microbiota composition of all participants was analyzed using 16S rRNA gene sequencing of throat swab *** abundance of bacterial genera was compared between IRs and INRs,and Pearson correlations between bacterial abundance and peripheral blood immune cell counts were *** INR group showed lower alpha diversity than the IR and HC groups,which displayed similar alpha *** genera Alloprevotella,Prevotella and Neisseria were more abundant in PLWH than in HCs,whereas the genera Rothia,Streptococcus and Fusobacterium were more abundant in HCs than in *** genus Rothia was more abundant in the INR group,whereas Prevotella,Alloprevotella,Porphyromonas and Haemophilus were more abundant in the IR *** genera Rothia and Alloprevotella were negatively and positively associated with CD4^(+)T cell counts,***,an increased abundance of Rothia in the oral microbiome is associated with unfavorable outcomes regarding immune reconstitution in PLWH receiving regular ART,whereas Prevotella,Alloprevotella,Porphyromonas and Haemophilus are associated with favorable outcomes.

关键词： HIV oral microbiome antiretroviral therapy immunological nonresponders immunological responders

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Rare earth element geochemistry in soils along arid and semiarid grasslands in northern China

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Ecological Processes 2022年第1期11卷 386-399页

作者： Yi‑Wen Cao Xiao‑Ming Liu Chao Wang Edith Bai nanping wu CAS Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China Department of Earth Marine and Environmental SciencesUniversity of North Carolina‑Chapel HillChapel HillNC 27515USA Key Laboratory of Geographical Processes and Ecological Security of Changbai Mountains School of Geographical SciencesNortheast Normal UniversityChangchun 130024China Institute of Deep‑Sea Science and Engineering Chinese Academy of SciencesSanya 572000China

Background:Rare earth elements(REE)are a group of trace elements that behave geochemically *** fractionation patterns normalized to reference materials provide a powerful tool for documenting *** processes are particularly difficult to illustrate with respect to contemporary and past climate *** this study,we characterize the rare earth element(REE)contents in bulk soils and respective geochemical fractions(e.g.,exchangeable,carbonate‑bound,reducible,and oxidizable fractions)and to decipher the relationships between REE geochemistry components and climatic factors across a large‑scale northern China transect(NCT).Results:Across the NCT,bulk REE concentrations ranged from 55.2 to 241.1μg g^(−1)with a main portion in the residual fraction(49–79%),followed by oxidizable fraction(2–40%),reducible fraction(3–22%),carbonate‑bound fraction(0.1–16%),and negligible exchangeable *** REE contents of geochemical components(carbonate‑bound,reducible,and oxidizable)in topsoils correlated to climate factors(mean annual precipitation,mean annual temperature,potential evaporation,and aridity index(AI)).The normalized abundances to the upper continental crust(UCC)composition show that the middle REE was generally enriched than the light REE and heavy REE in topsoils along the *** overall UCC‑normalized bulk REE patterns in topsoils and subsoils were similar,characterized by weak negative Ce anomalies and positive Eu ***:Our data in topsoils and depth profiles collectively suggest that cycling of REE was primarily regulated by abiotic processes in area with AI*** similar UCC normalized patterns in topsoils suggest that the REE was originated from a common source with limited influences from other sources(e.g.,atmospheric dusts and anthropogenic contribu‑tions).Our results to some extent provide evidence for

关键词： Rare earth elements Soil Grassland Northern China Aridity index

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Unusual global outbreak of monkeypox:what should we do?

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Frontiers of Medicine 2022年第4期16卷 507-517页

作者： Miaojin Zhu Jia Ji Danrong Shi Xiangyun Lu Baohong Wang nanping wu Jie wu Hangping Yao Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Jinan Microecological Biomedicine Shandong Laboratory Jinan 250117China

Recently,monkeypox has become a global concern amid the ongoing COVID-19 *** is an acute rash zoonosis caused by the monkeypox virus,which was previously concentrated in *** re-emergence of this pathogen seems unusual on account of outbreaks in multiple nonendemic countries and the incline to spread from person to *** need to revisit this virus to prevent the epidemic from getting *** this review,we comprehensively summarize studies on monkeypox,including its epidemiology,biological characteristics,pathogenesis,and clinical characteristics,as well as therapeutics and vaccines,highlighting its unusual outbreak attributed to the transformation of *** also analyze the present situation and put forward countermeasures from both clinical and scientific research to address it.

关键词： monkeypox poxviruses vaccine infectious diseases

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A reconnaissance of Cu isotopic compositions of hydrothermal vein-type copper deposit, Jinman, Yunnan, China

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Chinese Science Bulletin 2002年第3期47卷 247-250页

作者： JIANG Shaoyong Jon Woodhead YU Jimin PAN Jiayong LIAO Oiling wu nanping State Key Laboratory for Mineral Deposits Research Department of Earth SciencesNanjing UniversityNanjing 210093China School of Earth Sciences Melbourne UniversityVic 3010Australia

The Jinman deposit is a low-temperature hydrothermal vein-type copper deposit, which occurs along faults and fractures within Middle Jurassic sandstone and mudstone units of the Lanping-Simao Mesozoic-Cenozoic basin of Yunnan Province. In this note, we report for the first time the Cu isotopic compositions of Cu-sulfides from the Jinman deposit. The data show large variations and low δ65Cu values of -3.70‰ to +0.30‰, which are in sharp con-trast to the δ65Cu values of high-temperature mag-matic-hydrothermal copper deposits (-0.62‰ to +0.40‰) and the modern ocean-floor massive sulfide deposits (-0.48‰ to +1.15‰). It is suggested that the Cu isotope fractionation at Jinman is affected mainly by the following factors, i.e. a low temperature of ore formation (150-286℃); a sedimen-tary source for ore materials; various stages of ore deposition; and involvement of organic matter in the ore-forming proc-esses.

关键词： Cu isotopes Cu-sulfides hydrothermal vein-type deposit Jinman Yunnan.

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Oldhamite:a new link in upper mantle for C-O-S-Ca cycles and an indicator for planetary habitability

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National Science Review 2023年第10期10卷 44-53页

作者： Yuegao Liu I-Ming Chou Jiangzhi Chen nanping wu Wenyuan Li Leon Bagas Minghua Ren Zairong Liu Shenghua Mei Liping Wang CAS Key Laboratory for Experimental Study under Deep-sea Extreme Conditions Institute of Deep-sea Science and Engineering Chinese Academy of Sciences Hainan Deep-Sea Technology Innovation Center Xi'an Center of Geological Survey China Geological Survey Department of Geoscience University of Nevada Academy for Advanced Interdisciplinary Studies Southern University of Science and Technology

In the solar system,oldhamite(CaS) is generally considered to be formed by the condensation of solar nebula *** chondrites,one of the most important repositories of oldhamite,are believed to be representative of the material that formed ***,the formation mechanism and the evolution process of oldhamite are of great significance to the deep understanding of the solar nebula,meteorites,the origin of Earth,and the C-O-S-Ca cycles of *** now,oldhamite has not been reported to occur in mantle ***,here we show the formation of oldhamite through the reaction between sulfide-bearing orthopyroxenite and molten CaCO3at 1.5 GPa/1510 K,0.5 GPa/1320 K,and 0.3 GPa/1273 ***,this reaction occurs at oxygen fugacities within the range of upper-mantle conditions,six orders of magnitude higher than that of the solar nebula *** is easily oxidized to CaSO4or hydrolysed to produce calcium *** oxygen fugacity of magma,extremely low oxygen content of the atmosphere,and the lack of a large amount of liquid water on the celestial body’ s surface are necessary for the widespread existence of oldhamite on the surface of a celestial body otherwise,anhydrite or gypsum will exist in large *** may exist in the upper mantle beneath mid-ocean ***,oldhamites may have been a contributing factor to the early Earth’s atmospheric hypoxia environment,and the transient existence of oldhamites during the interaction between reducing sulfur-bearing magma and carbonate could have had an impact on the changes in atmospheric composition during the Permian-Triassic Boundary.

关键词： oldhamite middle-ocean ridge large igneous province Great Oxidation Event oxygen fugacity

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Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro

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Virologica Sinica 2022年第2期37卷 295-298页

作者： Danrong Shi Keda Chen Xiangyun Lu Linfang Cheng Tianhao Weng Fumin Liu nanping wu Lanjuan Li Hangping Yao State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Shulan International Medical College Zhejiang Shuren UniversityHangzhou310015China

Dear Editor,The coronavirus disease 2019(COVID-19)outbreak,has spread across the world(wu et al.,2020).The causative agent of COVID-19,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is highly pathogenic and infectious,which become a major public health hazard that has had a devastating social and economic impact worldwide(Li *** al.,2020).Variants of the virus have emerged that behave differently(CDC2021;Gobeil et al.,2020;Leung et al.,2021).Some of them show increased infectivity(Li *** al.,2020;Zhang et al.,2020)and may escape from neutralizing antibodies(Weisblum et al.,2020).

关键词： interferon acute

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成视网膜细胞瘤结合蛋白4在HIV-1潜伏细胞中的作用研究

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中华微生物学和免疫学杂志 2017年第3期37卷 188-193页

作者：王娟杨劲吴南屏浙江省立同德医院检验科杭州310012 杭州师范大学附属医院 311121 浙江大学医学院附属第一医院传染病诊治国家重点实验室杭州310003

目的探讨成视网膜细胞瘤结合蛋白4（retinoblastoma protein associated proteins 48, RBBP4）分子在HIV-1潜伏中的作用及其机制。方法25 ng/ml的肿瘤坏死因子（tumor necrosis factor alpha, TNF-α）和10 ng/ml的IL-2刺激HIV-1潜伏细胞CEM-Bru后，利用染色质免疫共沉淀（chromatin immunoprecipitation, ChIP）分别研究细胞刺激前后RBBP4以及与RBBP4关联的组蛋白脱乙酰化酶1和2（histone deacetylase, HDAC1/2）在前病毒启动子长末端重复序列（long terminal repeat, LTR）上的结合变化。电转法对潜伏细胞进行RBBP4部分干扰后，利用ChIP检测HDAC1/2以及组蛋白H3乙酰化水平和RNA聚合酶Ⅱ （RNA polymerase Ⅱ，RNA PolⅡ）在LTR的结合变化，RT-PCR检测HIV-1起始转录本和延长转录本的变化。结果在HIV-1潜伏细胞中RBBP4和HDAC1/2在LTR上结合与激活状态相比显著增加；将RBBP4部分干扰后，RBBP4在LTR上的结合明显减少，导致HDAC1和HDAC2在LTR上的结合也减少，并伴随着组蛋白3 （histone 3, H3）乙酰化水平的增加和RNA PolⅡ在LTR上结合的增加。此外，RBBP4干扰后HIV-1起始转录本明显增加。结论RBBP4能促进HIV-1潜伏，这种作用可能与组蛋白脱乙酰化酶HDAC1和HDAC2有关。

关键词： RBBP4 HDACl HDAC2 HIV-1 潜伏

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Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2384-2391页

作者： Zhijian Xu Danrong Shi Jian-Bao Han Yun Ling Xiangrui Jiang Xiangyun Lu Chuan Li Likun Gong Guangbo Ge Yani Zhang Yi Zang Tian-Zhang Song Xiao-Li Feng Ren-Rong Tian Jia Ji Miaojin Zhu nanping wu Chunhui wu Zhen Wang Yechun Xu Cheng Peng Min Zheng Junling Yang Feifei Du Junliang wu Peipei Wang Jingshan Shen Jianliang Zhang Yong-Tang Zheng Hangping Yao Weiliang Zhu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Drug Discovery and Design Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Pharmacy University of Chinese Academy of SciencesBeijing100049China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesFirst Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Kunming National High-level Biosafety Research Center for Non-human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650107China Department of Infectious Disease Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Center for Drug Safety Evaluation and Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai201203China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan650223China Jinan Microecological Biomedicine Shandong Laboratory Jinan250117China

Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by *** we report that nelfinavir,an FDA approved drug for the treatment of HIV infection,is effective against SARS-CoV-2 and *** of nelfinavir could inhibit the activity of the main protease of the SARS-CoV-2(IC50=8.26μM),while its antiviral activity in Vero E6 cells against a clinical isolate of SARS-CoV-2 was determined to be 2.93μM(EC50).In comparison with vehicle-treated animals,rhesus macaque prophylactically treated with nelfinavir had significantly lower temperature and significantly reduced virus loads in the nasal and anal swabs of the *** necropsy,nelfinavir-treated animals had a significant reduction of the viral replication in the lungs by nearly three orders of magnitude.A prospective clinic study with 37 enrolled treatment-naive patients at Shanghai Public Health Clinical Center,which were randomized(1:1)to nelfinavir and control groups,showed that the nelfinavir treatment could shorten the duration of viral shedding by 5.5 days(9.0 vs.14.5 days,P=0.055)and the duration of fever time by 3.8 days(2.8 vs.6.6 days,P=0.014)in mild/moderate COVID-19 *** antiviral efficiency and clinical benefits in rhesus macaque model and in COVID-19 patients,together with its well-established good safety profile in almost all ages and during pregnancy,indicated that nelfinavir is a highly promising medication with the potential of preventative effect for the treatment of COVID-19.

关键词： drugs infected treatment

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Retinoblastoma binding protein 4 represses HIV-1 long terminal repeat-mediated transcription by recruiting NR2F1 and histone deacetylase

Retinoblastoma binding protein 4 represses HIV-1 long termin...

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2019年浙江省检验医学学术大会

作者： juan Wang Yang Zongxing Cheng Linfang Lu Lingna Pan Kenv Yang Jin wu nanping Tongde Hospital of Zhejiang Province The Second Department of Infectious Disease Xixi Hospital of Hangzhou The First Affiliated Hospital College of MedicineZhejiang University Center for Translational Medicine The Affiliated Hospital of Hangzhou Normal University Department of Clinical Laboratory Xixi Hospital of Hangzhou

Human immunodeficiency virus(HIV) transcription is closely associated with chromatin remodeling. Retinoblastoma binding protein 4(RBBP4) is a histone chaperone implicated in chromatin remodeling. However, the role of ...

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Analysis of the immunogenicity and bioactivities of a split influenza A/H7N9 vaccine mixed with MF59 adjuvant in Balb/c mice

Analysis of the immunogenicity and bioactivities of a split ...

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浙江省免疫学会第十次学术大会

作者： Huilin Ou Wei Yao nanping wu Xiaoxin wu Chengcong Han Linfang Cheng Keda Chen Honglin Chen Hangping Yao Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalSchool of MedicineZhejiang University

Background:The H7 N9 influenza virus caused significant mortality and morbidity in infected humans during an outbreak in China in 2013 and stimulated vaccine development *** previous H7-based vaccines have been poorly immunogenic in humans,we sought to determine the immunogenic,protective properties and mechanisms of a split avian influenza A/H7 N9 vaccine mixed with MF59 adjuvant with comparison of other ***:Recombinant H7 N9 influenza seed that possess the hemagglutinin(HA)and neuraminidase(NA) gene segments from the A/Zhejiang/DTID-ZJU01/2013(H7 N9) and six internal protein gene segments from A/Puerto Rico/8/34(H1 N1)(PR8) were generated by reverse *** vaccinated Balb/c mouse with a two doses of different amounts and combinations of this new A/ZJU01/PR8/2013 split vaccine and adjuvant and subsequently challenged with A/Zhejiang/DTID-ZJU01/2013(H7 N9) by intranasal inoculation,the humoral-mediated immune responses including hemagglutination inhibition(HI),Micro-neutralization(MN),IgG antibody *** cell-mediated immune responses including NK assay,CTL assay,cytokine production *** the protection effects against H7 N9 virus were ***:Adjuvants help to increase the immune response to vaccines,achieving higher antibody titers that lead to protection with less amounts of antigen with an acceptable safety ***59 enhanced the HI,MN,IgG antibody titers to influenza antigens at least 2-6 fold higher than the same dose of this H7 N9 split vaccine alone after second immunization and virus incubation,0.05 ml MF59 even boost the response to the HA antigen concentration of 0.024μg which was ineffective alone to achieve protective ***59 has more advantages in inducing the humoral immune response and TH-2 cytokine production after virus attack compared with alum,both the MF59 and alum can increase the NK activity,CD4+ and CD8+subpopulations of splenocytes with no statistical differences between each *** there i

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