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Chemical Research in Chinese Universities 2006年第6期22卷 708-711页

作者： wu ming-jiang jiang De-zhi LIU Tie-mei ZHANG Li-ping School of Life Science Northeast Normal University Changchun 130024 P. R. China School of Life and Environment Science Wenzhou University Wenzhou 325035 P.R. China

Water-soluble crude polyseccharide（PIP） was extracted from cultured mycelium of the fungus Phellinus igniarius. After ethanol precipitation and sepharose CL-6B gel filtration, the fraction of PIP1 was obtained, which was shown to be a homogeneous polysaccharide by means of high-performance liquid chromatography. The structure of PIPt was determined by using several methods. C.,C analysis indicates that PIP1 is composed of the monosaccharides of glucose, galactose, and mannose. Their malar ratio is 3. 70： 4. 06： 1.00. The molar weight was estimated to be 17 kd via HPLC. IR, GC, partial hydrolysis with acid, pefiedate oxidation, Smith degradation, methylation, and GC-MS analysis were used for the structural analyses of PIP1. The results show that PIP1 has a small quantity of branch structure, The main glycosidic linkage of PIP1 has a β-configurafion. The main chain is made up of a large mass of glucose （ 1→3 ） and few mannose （ 1→4 ） ; the side chain is composed of glucose （ 1 →3 ） and galactose （ 1→6 ） ; the nonreduced end is composed of galactose and glucose. The side chains are branched at 6-0 of glucose（ 1→3,6） and mannose（1→4,6）. On an average, there are three branches among 20 residues. It is presumable that the existence of 1,3-linked Glc in the main and side chains is the main reason for its higher antitumor activity.

关键词： Phellinus igniarus Cultured mycelium Polysaccharide Structural analysis

Treatment of type C3 distal radius fracture resulted from high-energy injuries by volar plate in combination with external fixator

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Chinese Medical Journal 2009年第13期122卷 1517-1520页

作者： ZHANG Qiu-lin ZHU Xiao-dong LI Guo-dong TANG Hao LI ming wu Da-jiang Department of Orthopedics Changhal Hospital Second Military Medical University Shanghai 200433 China

Background With a type C3 distal radius fracture it is extremely difficult to maintain the reduction and to restore congruity of the articular surface because the support for the volar and dorsal bone cortex has been lost. An external fixator crossing wrist in combination with Kirschner wire （K-wire） fixation was popularly used by most studies in recent years. But loss of reduction often occurred especially in the volar sides. Methods A total of 30 cases of type C3 distal radius fracture were treated by a volar buttress plate combined with a transarticular external fixator and other techniques such as K-wire fixation and bone grafting if necessary. The postoperative volar tilt angles, ulnar inclinations, radial heights, range of motion, grip strength and complications were recorded to assess the therapeutic effects. Results Of the 30 patients, 27 patients were followed up for 12-29 （mean 18） months and all fractures healed in 8-13 weeks after surgery （mean 10 weeks）. The wrist function was excellent in 8 cases, good in 16 cases and fair in 3 cases according to the Sarmiento scoring system （modified by Stewart）. Conclusions For type C3 comminuted fracture with severe volar and dorsal instability, fixation by volar buttress plate combined with transarticular external fixator should be adopted. Dorsal instability could be further stabilized by other techniques such as Kirschner wire fixation, and bone grafting.

关键词： distal radius fracture internal fixation external fixator

基于聚类及简化基因组联合分析的浙江洞头栽培羊栖菜(Sargassum fusiforme)品系筛选研究

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海洋与湖沼 2021年第5期52卷 1224-1235页

作者：林立东吴明江温州市洞头区海洋与渔业发展研究中心博士后工作站温州325700 温州大学生命与环境科学学院温州325035

以浙江洞头栽培羊栖菜(Sargassum fusiforme)群体为研究对象,运用主成分分析法对其鲜重、藻体长度、茎宽、气囊形态和大小等表型特征进行分析,确定了羊栖菜簇生气囊中的“特征”大气囊为表型主成分;运用聚类分析法分析了21个羊栖菜差异... 详细信息

以浙江洞头栽培羊栖菜(Sargassum fusiforme)群体为研究对象,运用主成分分析法对其鲜重、藻体长度、茎宽、气囊形态和大小等表型特征进行分析,确定了羊栖菜簇生气囊中的“特征”大气囊为表型主成分;运用聚类分析法分析了21个羊栖菜差异表型样品的“特征”大气囊表型聚类特征,定量分析归纳了栽培羊栖菜表型品系类别;运用简化基因组分析法构建了34个羊栖菜样品的系统进化树,分析了栽培羊栖菜各样品及韩国丽水、辽宁大连、浙江舟山野生羊栖菜样品间的亲缘关系,定量分析归纳了栽培羊栖菜基因型品系类别。在栽培羊栖菜表型品系和基因型品系总重合率为86%的基础上,将浙江洞头栽培羊栖菜群体分为球囊、锥囊、宽棒囊、狭棒囊和梭镖囊等5个品系,并运用林奈的“双名法”加以学名命名。提供了一种科学的羊栖菜品系分类方法,以期为深度开展浙江洞头栽培羊栖菜的群体结构、亲缘关系、遗传稳定性和品质差异等基础研究,以及定向选育优质高产、逆境高耐受性和活性物质高富集品系等应用研究,提供方法和理论支撑。

关键词：羊栖菜(Sargassum fusiforme) 品系多样性 “特征”大气囊简化基因组联合分析

Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You wu Lijie Yang Wanrong jiang Xinyuan Zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

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2-溴-2-硝基-1,3-二丙二醇的合成

江西化工 2007年第3期23卷 63-64页

作者：巫民建江西省化学工业研究所 330029

以硝基甲烷和四醛为原料,在碱性条件下经烷基羟基化和溴化两步合成2-溴-2-硝基-1,3-二丙二醇,考虑了烷基羟基化反应,溴化反应温度,时间,对产品收率的影响。收率可达78.6%

关键词： 2-溴-2-硝基-1,3-二丙二醇烷基羟基化反应溴化反应合成

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差分动态二进制化的二进制算数编码

信息技术 2013年第8期37卷 111-113页

作者：吴江铭上海交通大学电子工程系上海200030

JCT-VC组织公布的HEVC协议草案沿用了H264的CABAC,改进了二进制化过程。在阐述高性能压缩算法CABAC的同时,创新性地提出了动态二进制化算数编码,并预先对数据进行差分。最后,通过压缩Java文件实验证实差分动态二进制化算数编码在压缩率... 详细信息

JCT-VC组织公布的HEVC协议草案沿用了H264的CABAC,改进了二进制化过程。在阐述高性能压缩算法CABAC的同时,创新性地提出了动态二进制化算数编码,并预先对数据进行差分。最后,通过压缩Java文件实验证实差分动态二进制化算数编码在压缩率方面有较大的提高,高于PAQ和CABAC。

关键词：二进制算数编码二进制化霍夫曼编码

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无人机测绘数据处理关键技术及应用探究

智能建筑与智慧城市 2020年第4期 109-110页

作者：吴江明义乌市大地数字测绘有限公司

无人机测绘作为新兴技术,能够展示出机动灵活、精确等特点。文章根据以往工作经验,对无人机测绘数据处理关键技术内容进行总结,并从在环境监测中的应用、国土测绘中的应用和灾情救援中的应用三方面,论述无人机测绘数据处理的关键技术内容。

关键词：无人机数据处理关键技术

Pilot-scale test of flow-solidification of marine dredged sludge

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Yantu Lixue/Rock and Soil Mechanics 2020年 41卷 132-142页

作者： Chen, Wei Gao, Wen-Bo Yue, Shao-Lin Zhang, Feng-Kun wu, ming-jiang Lu, Yang CCCC Road & Bridge Special Engineering Co. Ltd. Wuhan 430072 China CCCC Tian Jin Dredging Co. Ltd. Tianjin 300461 China

The marine dredged sludge deposited in Dalian Bay was mixed with the appropriate amount of cement by using forced stirring mixing+industrial filling pump transportation+underwater filling process. The pilot-scale test on the filling of flowing solidified soil was conducted. The excavation sampling test, in-situ static cone penetration test and plate loading test were carried out to investigate the variation of unconfined compressive strength, shear strength, specific penetration resistance and bearing capacity of solidified soil with the amount of cement and curing period. The intrinsic connections between these factors are studied. The results show that there is a linear relationship between the characteristic value of bearing capacity of the solidified soil from dredged sludge and the unconfined compressive strength and specific penetration resistance. The modified empirical formula can be used as a reference for the design, construction and testing of flow-solidified soil. Compared with the layered filling process, the overall filling process has a much better uniformity and integrity. The applicability of different cements is different. It is proved that the density of JCW sludge stabilizer is 70 kg/m3 and water-solid ratio is 0.85, showing the optimal mix ratio of marine dredged sludge. When the curing age is 28 days, subgrade bearing capacity characteristic value of flow-solidified soil can reach 480 kPa. © 2020, Science Press. All right reserved.

关键词： Bearing capacity

民营企业成长环境及可持续发展机制研究——以瑞安市为例

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特区经济 2010年第1期 131-133页

作者：郑关定吴晓明姜明伦浙江万里学院商学院浙江宁波315000

民营企业是我国社会主义市场经济的重要组成部分,它已经成为衡量地区经济发展程度的重要指标,而民营企业的成长环境直接影响民营企业的健康发展,这则要求政府相关部门为民营企业的发展创造良好的外部环境,同时企业自身也应该优化企业内... 详细信息

民营企业是我国社会主义市场经济的重要组成部分,它已经成为衡量地区经济发展程度的重要指标,而民营企业的成长环境直接影响民营企业的健康发展,这则要求政府相关部门为民营企业的发展创造良好的外部环境,同时企业自身也应该优化企业内部环境。但是就目前民营企业成长发展的环境而言,还存在着诸多制约和影响民营企业发展的因素。本文以瑞安为例,通过分析制约民营企业成长的环境因素,探讨政府在民营企业成长中的角色定位以及构建可持续发展机制的路径。

关键词：民营企业成长环境可持续发展瑞安

杭州市淳安县山区儿童甲状腺肿大率回升原因调查

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中国地方病学杂志 2006年第5期25卷 547-549页

作者：金行一徐卫民吴黎明吴明奖谢晓敏宋姝娟杭州市疾病预防控制中心地方病防治所 310006 杭州市淳安县疾病预防控制中心杭州市红会医院

目的调查杭州市淳安县儿童碘营养状况,分析山区儿童甲状腺肿大率(甲肿率)回升的原因。方法采用随机整群抽样的方法抽取8～10岁儿童642名。用触诊法对每个儿童检查甲状腺,部分儿童检测尿碘、盐碘、智商、血清总蛋白及调查其膳食情况。结... 详细信息

目的调查杭州市淳安县儿童碘营养状况,分析山区儿童甲状腺肿大率(甲肿率)回升的原因。方法采用随机整群抽样的方法抽取8～10岁儿童642名。用触诊法对每个儿童检查甲状腺,部分儿童检测尿碘、盐碘、智商、血清总蛋白及调查其膳食情况。结果山区学生甲肿率为10．28%,明显高于城镇学生(3．32%),两组比较差异有统计学意义(P＜0．05)；山区住校生甲肿率(13．81%)与山区未住校生(6．90%)差异有统计学意义(P＜0．05)；城镇学生与山区未住校生甲肿率差异无统计学意义(P＞0．05)；山区住校生的食物种类和每日碘摄入量平均分别为4．9种和26．01μg/d,均低于城镇学生(11．5种、38．05μg/d)。结论山区儿童特别是山区住校生碘摄入量低且不持续及食物中蛋白质较少是导致甲肿率回升的主要原因,应采取措施改善其营养状况。

关键词：甲状腺肿地方性碘营养调查