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Biomedical and Environmental Sciences 2024年第6期37卷 565-580页

作者： meng wu Jialu Zhou Zhe Zhang Yuanguang meng School of Medicine Nankai UniversityTianjin 300071China Department of Obstetrics and Gynecology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Obstetrics and Gynecology Chinese PLA Medical SchoolBeijing 100853China Department of Obstetrics and Gynecology The Seventh Medical Center of Chinese PLA General HospitalBeijing 100700China

Objective Genomic alterations and potential neoantigens for cervical cancer immunotherapy were identified in a cohort of Chinese patients with cervical squamous cell carcinoma(CSCC).Methods Whole-exome sequencing was used to identify genomic alterations and potential neoantigens for CSCC *** Sequencing was performed to analyze neoantigen *** Systematic bioinformatics analysis showed that C>T/G>A transitions/transversions were dominant in *** mutations were the most frequent types of somatic mutation in the coding sequence *** signature analysis detected signature 2,signature 6,and signature 7 in CSCC ***3CA,FBXW7,and BICRA were identified as potential driver genes,with BICRA as a newly reported *** variation profiling identified 4,960 potential neoantigens,of which 114 were listed in two neoantigen-related *** The present findings contribute to our understanding of the genomic characteristics of CSCC and provide a foundation for the development of new biotechnology methods for individualized immunotherapy in CSCC.

关键词： Cervical squamous cell carcinoma Genome alteration Neoantigens Immunotherapy

Phase-field lattice-Boltzmann study on fully coupled thermal-solute-convection dendrite growth of Al-Cu alloy

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China Foundry 2024年第2期21卷 125-136页

作者： Yin-qi Qiu meng-wu wu Xun-peng Qin Shou-mei Xiong Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Longzhong Laboratory Xiangyang 441000HubeiChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

Dendrite growth is a complex liquid-solid phase transition process involving multiple physical factors.A phase-field lattice-Boltzmann method was developed to simulate the two-and three-dimension dendrite growth of Al-Cu *** effect of fully coupled thermal-solute-convection interaction on the dendrite growth was investigated by incorporating a parallel-adaptive mesh refinement algorithm into the numerical *** accurately reproducing the latent heat release,solute diffusion and convective transport behaviors at the liquidsolid interface,the interaction mechanism among thermal-solute-convection transport as well as their coupling effects on the dendrite growth dynamics were *** simulation results show that the release of latent heat slows down the dendrite growth rate,and both natural and forced convection disrupt the symmetrical growth of *** combination makes the growth of dendrites more complex,capturing important physical aspects such as recalescence,dendrite tip splitting,dendrite tilting,dendrite remelting,and solute plume in the simulation *** on the robustness and powerful ability of the numerical model,the formation mechanisms of these physical aspects were revealed.

关键词： simulation phase field dendrite growth thermal-solute-convection interaction

Effect of Mn addition on microstructure and mechanical properties of GX40CrNiSi25-12 austenitic heat resistant steel

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China Foundry 2024年第3期21卷 205-212页

作者： Guan-yu Jiang meng-wu wu Xiao-guang Yang Hui Wang Yu-yuan Zhu Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Longzhong Laboratory Xiangyang 441000HubeiChina Wescast Industries(China)Co. Ltd.Wuhan 430100China

Three types of steels were designed on the basis of GX40CrNiSi25-12 austenitic heat resistant steel by adding different Mn contents(2wt.%,6wt.%,and 12wt.%).Thermodynamic calculation,microstructure characterization and mechanical property tests were conducted to investigate the effect of Mn addition on the microstructure and mechanical properties of the austenitic heat resistant *** show that the matrix structure in all the three types of steels at room temperature is completely *** NbC and M_(23)C_(6)precipitate at grain boundaries of austenite *** the increase of Mn content,the number of carbides increases and their distribution becomes more *** the Mn content increases from 1.99%to 12.06%,the ultimate tensile strength,yield strength and elongation increase by 14.6%,8.0%and 46.3%,*** improvement of the mechanical properties of austenitic steels can be explained by utilizing classic theories of alloy strengthening,including solid solution strengthening,precipitation strengthening,and grain *** increase in alloy strength can be attributed to solid solution strengthening and precipitation strengthening caused by the addition of *** improvement of the plasticity of austenitic steels can be explained from two aspects:grain refinement and homogenization of precipitated phases.

关键词： austenitic heat resistant steel manganese microstructure mechanical properties

Efficient degradation of aqueous dichloromethane by an enhanced microbial electrolysis cell:Degradation kinetics,microbial community and metabolic mechanisms

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Journal of Environmental Sciences 2024年第5期139卷 150-159页

作者： meng wu Di Zhao Bing Gu ZiruWang Jun Hu Zhiliang Yu Jianming Yu College of Environment College of Biotechnology and BioengineeringCollaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhou 310014China Shentuo Environment(Hangzhou)Co.Ltd. Hangzhou 311121China Zhejiang Tianyi Environmental Co.Ltd. Hangzhou 310000China

Dichloromethane(DCM)has been listed as a toxic and harmful water pollutant,and its re moval needs *** electrolysis cells(MECs)are viewed as a promising alterna tive for pollutant removal,which can be strengthened from two aspects:microbial inocula tion and *** this study,the MEC for DCM degradation was inoculated with the ac tive sludge enhanced by Methylobacterium rhodesianum H13(strain H13)and then acclimated in the form of a microbial fuel cell(MFC).Both the introduction of strain H13 and the initi ation in MFC form significantly promoted DCM *** degradation kinetics were fitted by the Haldane model,with V_(max),K_(h),K_(i)and v_(max)values of 103.2 mg/L/hr,97.8 mg/L268.3 mg/L and 44.7 mg/L/hr/cm^(2),*** cyclic voltammogram implies that DCM redox reactions became easier with the setup of MEC,and the electrochemical impedance spectrogram shows that the acclimated and enriched microbes reduced the charge transfe resistance from the electrode to the *** the biofilm,the dominant genera shifted from Geobacter to Hyphomicrobium in acclimation ***,Methylobacterium played an increasingly important *** metabolism mainly occurred through the hydrolytic glutathione S-transferase pathway,given that the gene dcmA was identified rather than the dhlA and P450/*** exogenous electrons facilitated the reduction of GSSG,directly o indirectly accelerating the GSH-catalyzed *** study provides support fo the construction of an efficient and stable MEC for DCM removal in water environment.

关键词： Dichloromethane Microbial electrolysis cells Metabolic pathways Electron transfer Degradation kinetics

Carbon-based nanomaterials cause toxicity by oxidative stress to the liver and brain in Sprague-Dawley rats

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Nuclear Science and Techniques 2024年第6期35卷 54-64页

作者： Ying-Ying Xu Chan Jin meng wu Jian-Ye Zhou Hui-Ling Wei Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Institute of Particle and Nuclear Physics College of PhysicsHenan Normal UniversityXinxiang 453007China

Carbon-based nanomaterials have important research significance in various disciplines,such as composite materials,nanoelectronic devices,biosensors,biological imaging,and drug ***,the human and ecological risks associated with carbon-based nanomaterials have received increasing ***,the biological safety of carbon based nanomaterials has not been systematically *** this study,we used different types of carbon materials,namely,graphene oxide(GO),single-walled carbon nanotubes(SWCNTs),and multiwalled carbon nanotubes(MWCNTs),as models to observe their distribution and oxidative damage in *** results of Histopathological and ultrastructural examinations indicated that the liver and lungs were the main accumulation targets of these ***-μ-XRF analysis revealed that SWCNTs and MWCNTs might be present in the *** shows that the three types of carbon-based nanomaterials could cross the gas-blood barrier and eventually reach the liver *** addition,SWCNTs and MWCNTs could cross the blood-brain barrier and accumulate in the cerebral *** increase in ROS and MDA levels and the decrease in GSH,SOD,and CAT levels indicated that the three types of nanomaterials might cause oxidative stress in the *** suggests that direct instillation of these carbon-based nanomaterials into rats could induce ROS *** addition,iron(Fe)contaminants in these nanomaterials were a definite source of free ***,these nanomaterials did not cause obvious damage to the rat brain *** deposition of selenoprotein in the rat brain was found to be related to oxidative stress and Fe *** information may support the development of secure and reasonable applications of the studied carbon-based nanomaterials.

关键词： Carbon-based nanomaterials Oxidative stress Trace element distribution TEM SR-μ-XRF

Ultra-high-temperature application of MXene: Stabilization of 2D Ti_(3)C_(2)T_(x) for cross-scale strengthening and toughening of 3D TiC

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Journal of Advanced Ceramics 2024年第1期13卷 1-10页

作者： Lu Liu Guobing Ying Quanguo Jiang Dong Wen Peng Wang meng wu Ziying Ji Yongting Zheng Xiang Wang Department of Materials Science and Engineering College of Mechanics and MaterialsHohai UniversityNanjing 211100China Key Laboratory of Superlight Materials&Surface Technology Ministry of EducationHarbin Engineering UniversityHarbin 150001China Shenzhen Key Laboratory for Advanced Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150001China

Transition metal carbide/nitride cores within MXenes make them considerably useful for ultra-high-temperature ***,extensive research on Ti_(3)C_(2)T_(x) MXene has revealed its tendency to undergo a phase transition to TiCy at temperatures above 800℃due to high activity of a superficial Ti atomic ***,spark plasma sintering of Ti_(3)C_(2)T_(x) and TiC is performed to prevent the Ti_(3)C_(2)T_(x) phase transition at temperatures up to 1900℃through the fabrication of composites at a pressure of 50 *** a focused ion beam scanning electron microscope to separate layered substances in the composites and examining selected area diffraction spots in a transmission electron microscope enabled identification of non-phase-transitioned ***-principles calculations based on density functional theory indicated the formation of strong chemical bonding interfaces between Ti_(3)C_(2)T_(x) and TiC,which imposed a stability constraint on the Ti atomic layer at the Ti_(3)C_(2)T_(x) *** performance tests,such as three-point bending and fracture toughness analysis,demonstrated that the addition of Ti_(3)C_(2)T_(x) can effectively improve the cross-scale strengthening and toughening of the TiC matrix,providing a new path for designing and developing two-dimensional(2D)carbides cross-scale-enhanced three-dimensional(3D)carbides with the same elements relying on a wide variety of MXenes.

关键词： MXene ultra-high-temperature phase stability interface bonding cross-scale strengthening and toughening structural ceramic composites

南水北调中线工程受水区灰水足迹荷载系数时空变化及驱动因素研究

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长江流域资源与环境 2024年第5期33卷 971-981页

作者：吴梦南阳师范学院经济与管理学院河南南阳473061

控制水污染程度、提高水环境质量有利于南水北调中线工程高质量发展。在核算南水北调中线工程20个受水城市灰水足迹的基础上,计算各受水城市灰水足迹荷载系数,分析其时空分布特征,并利用对数平均迪氏指数(Logarithmic Mean Divisia Inde... 详细信息

控制水污染程度、提高水环境质量有利于南水北调中线工程高质量发展。在核算南水北调中线工程20个受水城市灰水足迹的基础上,计算各受水城市灰水足迹荷载系数,分析其时空分布特征,并利用对数平均迪氏指数(Logarithmic Mean Divisia Index,LMDI)模型对其驱动因素进行分解。结果表明:(1)2009~2020年南水北调中线工程受水区灰水足迹降幅达到24.54%,水环境质量得到一定改善;从灰水足迹的构成来看,农业占比最高,其次是生活,工业占比最低,且农业源、工业源污染的有效控制是受水区灰水足迹总量整体下降的主要原因。(2)在中线工程通水后,受水区灰水足迹荷载系数有所降低,但是水资源总量仍然远远不能满足水污染物的稀释需求,水环境压力巨大;各受水城市灰水足迹荷载系数存在显著不同,地区内部尤其是河南省内部的差异是受水区灰水足迹荷载系数不平衡的主要来源。(3)资本深化效应、资源禀赋效应及经济活度效应对灰水足迹荷载系数主要表现为正向驱动效应,而资本产出效应、经济环境效应则表现为负向驱动效应。各受水城市要继续走绿色发展道路,促进南水北调中线工程水资源可持续利用。

关键词：南水北调中线工程灰水足迹荷载系数 LMDI模型驱动因素

Reinforced concrete-like Na_(3.5)V_(1.5)Mn_(0.5)(PO_(4))_(3)@graphene hybrids with hierarchical porosity as durable and high-rate sodium-ion battery cathode

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Chinese Chemical Letters 2024年第4期35卷 214-219页

作者： Tao Long Peng Chen Bin Feng Caili Yang Kairong Wang Yulei Wang Can Chen Yaping Wang Ruotong Li meng wu Minhuan Lan Wei Kong Pang Jian-Fang wu Yuan-Li Ding College of Materials Science and Engineering Hunan UniversityChangsha 410082China Department of Physics Xiamen UniversityXiamen 361005China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Institute for Superconducting&Electronic Materials Faculty of EngineeringUniversity of WollongongWollongongNSW 2522Australia

Realizing high-rate capability and high-efficiency utilization of polyanionic cathode materials is of great importance for practical sodium-ion batteries(SIBs) since they usually suffer from extremely low electronic conductivity and limited ionic diffusion kinetics. Herein, taking Na_(3.5)V_(1.5)Mn_(0.5)(PO_(4))_(3)(NVMP) as an example, a reinforced concrete-like hierarchical and porous hybrid(NVMP@C@3DPG) built from 3D graphene(“rebar”) frameworks and in situ generated carbon coated NVMP(“concrete”) has been developed by a facile polymer assisted self-assembly and subsequent solid-state method. Such hybrids deliver superior rate capability(73.9 m Ah/g up to 20 C) and excellent cycling stability in a wide temperature range with a high specific capacity of 88.4 m Ah/g after 5000 cycles at 15 C at room temperature, and a high capacity retention of 97.1% after 500 cycles at 1 C(-20 ℃), and maintaining a high reversible capacity of 110.3 m Ah/g in full cell. This work offers a facile and efficient strategy to develop advanced polyanionic cathodes with high-efficiency utilization and 3D electron/ion transport systems.

关键词： Sodium-ion battery Polyanionic cathode Hybrid structure Interconnected structure Energy storage

Characteristics of the microbial communities regulate soil multi-functionality under different cover crop amendments in Ultisol

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Journal of Integrative Agriculture 2024年第6期23卷 2099-2111页

作者： Guilong Li Xiaofen Chen Wenjing Qin Jingrui Chen Ke Leng Luyuan Sun Ming Liu meng wu Jianbo Fan Changxu Xu Jia Liu Soil and Fertilizer&Resources and Environment Institute Jiangxi Academy of Agricultural SciencesNanchang 330200China Key Laboratory of Acidified Soil Amelioration and Utilization Ministry of Agriculture and Rural AffairsNanchang 330200China Ecological Experimental Station of Red Soil Chinese Academy of SciencesYingtan 335211China

The use of cover crops is a promising strategy for influencing the soil microbial consortium,which is essential for the delivery of multiple soil functions(i.e.,soil multifunctionality).Nonetheless,relatively little is known about the role of the soil microbial consortium in mediating soil multifunctionality under different cover crop amendments in dryland ***,we assessed the multifunctionality of soils subjected to four cover crop amendments(control,non-amended treatment;RD,radish monoculture;HV,hairy vetch monoculture;and RDHV,radish-hairy vetch mixture),and we investigated the contributions of soil microbial richness,network complexity,and ecological clusters to soil *** results demonstrated that cover crops whose chemical composition differed from that of the main plant crop promoted higher multifunctionality,and the radish-hairy vetch mixture rendered the highest *** obtained evidence that changes in soil microbial richness and network complexity triggered by the cover crops were associated with higher soil ***,specialized microbes in a key ecological cluster(ecological cluster 2)of the soil microbial network were particularly important for maintaining soil *** results highlight the importance of cover crop-induced variations in functionally important taxa for promoting the soil multifunctionality of dryland Ultisols.

关键词： cover crops soil multifunctionality microbial richness network complexity ecological cluster

Development and Validation of Diagnostic Criteria for Elderly Atopic Dermatitis

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International Journal of Dermatology and Venereology 2024年第1期7卷 1-5页

作者： Shang-Shang Wang Zheng Li Chao-Ying Gu Hui-Bin Yin Yue-meng wu Xu Yao Wei Li Department of Dermatology Shanghai Institute of DermatologyHuashan HospitalFudan UniversityShanghai 200040China Department of Allergy and Rheumatology Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIsHospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China

Objective:Elderly atopic dermatitis(AD)is a newly identified subtype of *** specific diagnostic criteria are needed for elderly AD has been *** study aimed to propose diagnostic criteria for elderly AD and evaluate the ***:A hospital-based study was *** screened the clinical features of 1,312 patients with AD of different ages in 1 cohort and proposed a set of diagnostic criteria for elderly *** criteria were then validated in another cohort of 223 patients clinically diagnosed with elderly AD by dermatologists specialized in AD to examine the diagnostic sensitivity compared with other criteria by chi-square ***:Based on the patients’clinical features,a set of diagnostic criteria for elderly AD were *** new diagnostic criteria showed significantly higher sensitivity than the classical diagnostic criteria(P<0.001),especially for mild and moderate AD(P<0.001).Of all 223 patients with elderly AD,93.3%fulfilled our criteria,while only 43.5%,65.5%,and 52.0%fulfilled the Hanifin and Rajka criteria,the Japanese Dermatology Academy criteria,and the United Kingdom Working Party criteria,***:The newly proposed criteria for elderly AD yielded high diagnostic sensitivity,particularly for mild and moderate AD.

关键词： atopic dermatitis elderly diagnostic criteria sensitivity clinical features atypical