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Targeting neuroinflammation in Alzheimer's disease:from mechanisms to clinical applications

Neural Regeneration Research 2023年第4期18卷 708-715页

作者： Zi-Zhen Si Chen-Jun Zou Xi Mei Xiao-Fang Li Hu Luo Yao Shen Jun Hu Xing-Xing Li lun wu Yu Liu Pharmacy Department The Affiliated Hospital of Medical SchoolNingbo UniversityNingboZhejiang ProvinceChina Department of Physiology and Pharmacology School of MedicineNingbo UniversityNingboZhejiang ProvinceChina Department of Geriatric Psychiatry Ningbo Kangning HospitalNingboZhejiang ProvinceChina Key Laboratory Office of Sleep Medicine Ningbo Kangning HospitalNingboZhejiang ProvinceChina Department of Psychology Collage of Teacher EducationNingbo UniversityNingboZhejiang ProvinceChina Department of Preventive Medicine School of MedicineNingbo UniversityNingboZhejiang ProvinceChina

Alzheimer’s disease is characterized by sustained neuroinflammation leading to memory loss and cognitive *** past decade has witnessed tremendous efforts in Alzheimer’s disease research;however,no effective treatment is available to prevent disease *** increasing body of evidence suggests that neuroinflammation plays an important role in Alzheimer’s disease pathogenesis,alongside the classical pathological hallmarks such as misfolded and aggregated proteins(e.g.,amyloid-beta and tau).Firstly,this review summarized the clinical and pathological characteristics of Alzheimer’s ***,we outlined key aspects of glial cell-associated inflammation in Alzheimer’s disease pathogenesis and provided the latest evidence on the roles of microglia and astrocytes in Alzheimer’s disease ***,we revealed the double-edged nature of inflammatory cytokines and inflammasomes in Alzheimer’s *** addition,the potential therapeutic roles of innate immunity and neuroinflammation for Alzheimer’s disease were also discussed through these *** the final section,the remaining key problems according to the current research status were discussed.

关键词： Alzheimer’s disease astrocytes immune signaling inflammatory cytokines microglia neuroinflammation neurotoxicity therapeutic strategies

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A preliminary analysis of arcuate structures-relationship of the island arc and deep-sea trench to the dip angle of Benioff zone

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Acta Oceanologica Sinica 1989年第1期8卷 125-136页

作者： wu lun, Liang Haihua, Ren Fuhu and Li Maosong The Department of Geography, Peking University, Beijing, China The Department of Geology, Peking University, Beijing, China China

The origin of arcuate islands and deep-sea trenches has been studied for a long time and various interpretations have been proposed. In this paper, some analytical models are put forward from a geometrical viewpoint and then the theoretical dip angles of the underthrusting slabs of circum-Pacific island arcs are computed and compared with those of the Benioff zone. As a result, it is found that the dip angle of the underthrusting slab is one of the main factors determining the curvature of the arcuate structure. The authors consider that this result may contribute to the plate theory.

关键词： A preliminary analysis of arcuate structures-relationship of the island arc and deep-sea trench to the dip angle of Benioff zone deep

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A Productivity Review Study on Theory of Reasoned Action Literature Using Bibliometric Methodology

A Productivity Review Study on Theory of Reasoned Action Lit...

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2011 International Conference on Management and Service Science（ICMSS 2011）

作者： Chih-lun wu Jiann-Min Yang Department of Management Information Systems National Chengchi UnivesityTaipeiTaiwan

This study aimed to describe literature growth and author productivity using a bibliometric evaluation-Lotka’s Law of the publication output associated with research on Theory of Reasoned Action （TRA） during the 28-year period of *** study is a productivity review on the literature gleaned from SSCI *** research indicated that the number of literature productions on TRA is still *** main research development country is the United States,and from the analysis of the distribution of language,English is the most popular language for TRA *** research results show that a relatively large percentage of authors （86.76%） contributed one article,which is a much higher percentage than the 60% found in Lotka’s original *** to the K-S test,the distribution of frequency indexes of author productivity match Lotka’s law.

关键词： Theory of Reasoned Action Lotka’s Law Bibliometrics

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Service Innovation:A Case Study of Taiwanese Firm

Service Innovation:A Case Study of Taiwanese Firm

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2010 International Conference on E-business,Management and Economics(ICEME2010)

作者： Yih-Yuh Lee Chih-lun wu Department of Business Administration National Chengchi University Taipei 116 Taiwan"R.O.C."

The service sector plays an important role in the modern economies of the developed countries and Taiwan as *** innovation has been one of the critical determinants to the success of the business performance and is the essential element to meet the customers’ needs and *** this paper,a concept is proposed to depict a leading brand in the kitchen design and appliances ***-based company-Sakura Corporation has developed and plans to implemented a 3D kitchen furniture design and ordering systems as well as new service mode throughout the Kitchen Life Stores across Taiwan starting from *** successful factors for the service innovation project are top management support,technological readiness,knowledge management capabilities,external focus and internal *** 3D kitchen furniture design and ordering systems are the crucial and enabling roles to enhance the level of customer satisfaction.

关键词： service innovation project management customer satisfaction

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面对不确定性:亚马逊Kindle在中美电子书市场的差异境遇研究

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编辑之友 2023年第9期 26-34页

作者：吴申伦华东政法大学传播学院上海201620

亚马逊Kindle退出中国不仅直接反映了其经营策略的得失,其背后逻辑也涉及电子书市场的共性规律与问题。由于边际成本低且法律定性模糊,电子书消费具有较高的不确定性,导致读者购买意愿低下。在美国,亚马逊通过完整生态系统、自助出版扩... 详细信息

亚马逊Kindle退出中国不仅直接反映了其经营策略的得失,其背后逻辑也涉及电子书市场的共性规律与问题。由于边际成本低且法律定性模糊,电子书消费具有较高的不确定性,导致读者购买意愿低下。在美国,亚马逊通过完整生态系统、自助出版扩充内容存量、低价策略、硬件终端过渡,成功降低不确定性/增强确定性,从而培养起读者阅读和消费习惯以建立产业主导。但进入中国后,亚马逊的生态系统、内容存量、定价标准、Kindle阅读器受到了本土平台、网络文学、读者低估价、新型移动终端的挑战,由此造成的高不确定性使之难以在电子书市场竞争中占优。亚马逊Kindle在中美电子书市场获得差异境遇的启示在于,电子书产业需要以应对不确定性为发展方向。因此,我国应当充分利用各方资源并协作努力,完善电子书产业链体系的互操作性,加速网络文学向电子书转化与整合,提高产品附加值并细分定价,优化公共电子书阅读服务体系。

关键词：不确定性亚马逊Kindle 生态系统内容存量定价终端

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作品与制度:中国网络文学的两种海外出版模式

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编辑之友 2021年第7期 18-24页

作者：吴申伦华东政法大学传播学院上海201620

面对日益庞大的全球年轻人市场,中国网络文学正成为我国文化海外出版的新名片。当前中国网络文学作品出海的渠道主要是自发性的翻译网站与文学网站海外平台,为此可进一步构建作品与制度输出两种互补的出版模式。作品模式是将版权产业的... 详细信息

面对日益庞大的全球年轻人市场,中国网络文学正成为我国文化海外出版的新名片。当前中国网络文学作品出海的渠道主要是自发性的翻译网站与文学网站海外平台,为此可进一步构建作品与制度输出两种互补的出版模式。作品模式是将版权产业的既有经验升级再造,形成围绕作品版权的小说、影视、游戏、动漫等整体性出版方案,包括多媒介形态作品的互文、影视先行策略与引导读者参与次级传播。制度模式是基于中国网络文学产业实践经验,在海外建立作者培养与作品挖掘制度,主动构建技术、政策、法律与本土资本多元一体的商业环境。网络文学生产共同体可在跨文化交流中培养海外年轻人的中国认同感。

关键词：中国网络文学海外出版作品模式制度模式生产共同体

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适应平台经济:我国有声书产业现状与发展研究

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编辑之友 2022年第1期 17-24页

作者：吴申伦华东政法大学传播学院上海201620

在社会各行业接轨平台经济的过程中,出版阅读相关平台正在改写出版产业结构,围绕移动平台的数字阅读习惯已然形成。文章借助平台经济的原理及影响解释有声书产业的源流与现状,提出发展方向。联结作用与经济生态系统是平台经济的核心,下... 详细信息

在社会各行业接轨平台经济的过程中,出版阅读相关平台正在改写出版产业结构,围绕移动平台的数字阅读习惯已然形成。文章借助平台经济的原理及影响解释有声书产业的源流与现状,提出发展方向。联结作用与经济生态系统是平台经济的核心,下沉用户、剩余资源、衍生服务等优势促使有声书产业向移动平台整体迁移,全球市场前景良好。基于平台的中间人功能,整体解决方案包括著作权集体管理预授权机制、平台关联全媒体互动阅读、PUGC模式的行业标准与监管体系、未成年人电子阅读"去屏化"项目。

关键词：平台经济有声书接入用户版权管理盈利模式出版社

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Dimensional regulation in gigantic molybdenum blue wheels featuring{(W)Mo_(5)}motifs for enhanced proton conductivity

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Nano Research 2024年第9期17卷 8261-8268页

作者： Yu-lun wu Jing Du Hai-Ying Zhang Ming-Jun Hou Qiao-Yue Li Wei-Chao Chen Kui-Zhan Shao Bo Zhu Chao Qin Xin-Long Wang Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Department of ChemistryNortheast Normal UniversityChangchun 130024China Hebei Key Laboratory of Organic Functional Molecules National Demonstration Center for Experimental Chemistry EducationTesting and Analysis CenterCollege of Chemistry and Materials ScienceHebei Normal UniversityShijiazhuang 050024China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China

Dimensional regulation in polyoxometalates is an effective strategy during the design and synthesis of polyoxometalates-based high proton conductors,but it is not available to ***,the precise regulation of dimensionality has been realized in an unprecedented gigantic molybdenum blue wheel family featuring pentagonal{(W)Mo5}motifs through optimizing the molar ratio of Mo/W,including[Gd_(2)Mo_(124)W_(14)O_(422)(H_(2)O)62]38-(0D-{Mo_(124)W_(14)},1),[Mo_(126)W_(14)O441(H_(2)O)51]^(70-)(1D-{Mo_(126)W_(14)}n,2),and[Mo_(124)W_(14)O_(430)(H_(2)O)50]60-(2D-{Mo_(124)W_(14)}n,3).Such important{(W)Mo5}structural motif brings new reactivity into gigantic Mo blue *** are different numbers and sites of{Mo2}defects in each wheel-shaped monomer in 1-3,which leads to the monomers of 2 and 3 to form 1D and 2D architectures via Mo-O-Mo covalent bonds driven by{Mo2}-mediated H_(2)O ligands substitution process,respectively,thus achieving the controllable dimensional *** expected,the proton conductivity of 3 is 10 times higher than that of 1 and 1.7 times higher than that of *** continuous proton hopping sites in 2D network are responsible for the enhanced proton conductivity with lower activation *** study highlights that this dimensional regulation approach remains great potential in preparing polyoxometalates-based high proton conductive materials.

关键词： polyoxometalate molybdenum blue wheels Mo/W mixed-addenda polyoxometalates dimensional regulation proton conduction

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Robust structure from motion with afne camera via low-rank matrix recovery

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Science China(Information Sciences) 2013年第11期 174-183页

作者： wu lun WANG YongTian LIU Yue WANG YuXi Key Laboratory of Photoelectronic Imaging Technology and System Ministry of Education of ChinaSchool of Optoelectronics Beijing Institute of Technology

We present a novel approach to structure from motion that can deal with missing data and outliers with an afne *** model the corruptions as sparse *** the structure from motion problem is reduced to the problem of recovering a low-rank matrix from corrupted *** frst decompose the matrix of trajectories of features into low-rank and sparse components by nuclear-norm and1-norm minimization,and then obtain the motion and structure from the low-rank components by the classical factorization *** pervious methods,which have some drawbacks such as depending on the initial value selection and being sensitive to the large magnitude errors,our method uses a convex optimization technique that is guaranteed to recover the low-rank matrix from highly corrupted and incomplete *** results demonstrate that the proposed approach is more efcient and robust to large-scale outliers.

关键词： robust PCA structure from motion low rank matrix sparse errors

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对整体论的新认识

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中国人民大学学报 2007年第3期21卷 1-9页

作者：金吾伦蔡仑中国社会科学院哲学研究所北京市人事局教育培训处

整体论越来越受到广泛的重视,整体论的整体不能归结为其组成部分,整体就是整体。在对整体论概念的生成、发展历程及其基本含义的演变做出简要回顾的基础上,对几种重要的整体论作剖析与评述,指出系统整体论的局限,预示整体论可能发展的... 详细信息

整体论越来越受到广泛的重视,整体论的整体不能归结为其组成部分,整体就是整体。在对整体论概念的生成、发展历程及其基本含义的演变做出简要回顾的基础上,对几种重要的整体论作剖析与评述,指出系统整体论的局限,预示整体论可能发展的新方向,特别强调生成整体论的内涵、机理以及对未来文化发展的重大而深远的意义。

关键词：整体论系统论生成论中心文化思想和谐社会

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