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Differential mRNA expression in peripheral blood is associated with oral squamous cell carcinoma:Recent advances and future challenges

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BIOCELL 2023年第7期47卷 1449-1458页

作者： XIA MU YUBING HU dandan wu HONGYU YANG Department of Stomatology Zunyi Medical UniversityZunyi563000China Department of Oral and Maxillofacial Surgery Peking University Shenzhen Hospital Stomatology CenterShenzhen518000China Department of Nursing Henan UniversityKaifeng475000China

Oral squamous cell carcinoma(OSCC)is a malignant tumor triggered by the accumulation of multiple gene mutations in oral epithelial *** OSCC-related biomarkers have been reported in circulation in the peripheral blood that support the occurrence and development of *** advances in high-throughput and highly sensitive detection methods have overcome the limitation of the low concentration of most peripheral blood ***,blood biomarker detection has become an efficient screening tool for the early diagnosis of *** growing data available in public cancer and gene databases have provided new foundations for OSCC *** particular,the identification of OSCC biomarkers using bioinformatic tools has shed new light on the underlying mechanisms as well as on the genetic landscape of *** recently,mRNA targeting therapies have emerged as valuable anticancer treatment strategies,as they allow for the regulation of the expression of certain functional proteins to reverse genetic abnormalities or induce tissue ***,mRNA-targeting therapies can be used to regulate the expression of antigens,antibodies,or cellular receptors by immune ***,anti-cancer cellular immunotherapy carrying specific mRNAs has attracted significant attention in OSCC ***,we review the present knowledge on the role of peripheral blood mRNAs in the diagnosis,treatment,development,and prognosis of ***,we address future research prospects of mRNAs in the peripheral blood in OSCC and the opportunities and challenges that may arise in future clinical therapeutic applications.

关键词： Diagnosis mRNA therapy Peripheral blood biomarker

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Layered CuNi-Cu_(2)O/NiAlO_(x) nanocatalyst for rapid conversion of p-nitrophenol to p-aminophenol

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Nano Research 2021年第12期14卷 4616-4624页

作者： Lin Fu Wei Zhou Ming Wen Qingsheng wu Weiying Li dandan wu Quanjing Zhu Jiaqi Ran Panpan Ren School of Chemical Science and Engineering College of Environmental Science and EngineeringKey Laboratory of Yangtze River Water EnvironmentMinistry of EducationShanghai Key Laboratory of Chemical Assessment and SustainabilityTongji UniversityShanghai200092China School of Materials Science and Engineering Shanghai Institute of TechnologyShanghai201418China

In order to well arrange active sites and avoid byproducts, the reasonable structured carrier nanocatalyst plays a crucial role in high catalytic performance, but still remains a challenge. Herein, the layered CuNi-Cu_(2)O/NiAlO_(x) nanosheets have been constructed through hydrothermal synthesis followed by calcination and H_(2) reduction treatment process. The in-situ formed CuNi nanoalloys (NAs) and nano-Cu_(2)O were evenly distributed on the bilateral surface of layered NiAlOx nanosheets. Based on the planar structure of nanosheet, the synergy between catalytic active CuNi NAs and photocatalytic active nano-Cu_(2)O endows CuNi-Cu_(2)O/NiAlO_(x) nanosheets with rapid conversion efficiency for catalyzing p-nitrophenol (p-NP, 14 mg·L^(−1)) to p-aminophenol (p-AP) in 32 s with the reaction rate constant k up to 0.1779 s−1, and no obvious performance decay can be observed even over 27 cycles. Moreover, high concentration of p-NP at 10 and 20 g·L^(−1) could be reduced to p-AP within 14 and 20 min, respectively. Such designed nanoalloy/bimetal-oxide heterostructure can provide a solution for rapid conversion of aminoaromatics from nitroaromatics wastewater even at a large concentration range.

关键词： layered CuNi-Cu_(2)O/NiAlO_(x) heterostructure catalyst p-nitrophenol p-aminophenol

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An aqueous zinc-ion hybrid super-capacitor for achieving ultrahigh-volumetric energy density

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Chinese Chemical Letters 2021年第2期32卷 926-931页

作者： Li Zhang dandan wu Gaowei Wang Yongtai Xu Hongxia Li Xingbin Yan Department of Physics School of ScienceLanzhou University of TechnologyLanzhou 730050China Laboratory of Clean Energy Chemistry and Materials State Key Laboratory of Solid LubricationLanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100080China School of Petrochemical Engineering Lanzhou University of TechnologyLanzhou 730050China Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116000China

Zinc-ion hybrid super-capacitors are regarded as promising safe energy storage systems,However,the relatively low volumetric energy density has become the main bottlenecks in practical applications of portable electronic devices,In this work,the zinc-ion hybrid super-capacitor with high volumetric energy density and superb cycle stability had been constructed which employing the high-density threedimensional graphene hydrogel as cathode and Zn foil used as anode in 1 mol/L ZnSO4 *** from the abundant ion transport paths and the abundant active sites for graphene hydrogel with high density and porous structure,the zinc-ion hybrid super-capacitor exhibited an extremely high volumetric energy density of 118.42 Wh/L and a superb power density of 24.00 kW/L,as well as an excellent long cycle life(80% retention after 30,000 cycles at 10 A/g),which was superior to the volumetric energy density of the reported zinc-ion hybrid *** device,based on the fast ion adsorption/deso rption on the capacitor-type graphene cathode and reversible Zn^(2+) plating/stripping on the battery-type Zn anode,which will inspire the development of zinc-ion hybrid super-capacitor in miniaturized devices.

关键词： Zinc-ion hybrid super-capacitors Volumetric energy density Dense three-dimensional grapheme Ultralong cycle stability Energy storage mechanism

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Immunotoxicity and hepatotoxicity of PFOS and PFOA in tilapia(Oreochromis niloticus)

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Chinese Journal Of Geochemistry 2012年第4期31卷 424-430页

作者： HAN Zhaoxiang LIU Yurong wu dandan ZHU Zhen Lu Chunxia School of Chemical Engineering Huaihai Institute of TechnologyLianyungang 222005China Chongqing Key Laboratory of Micro/Nano Materials Engineering and Technology Chongqing 402160China Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection Yancheng 224002China Jiaonan Agricultural Bureau of China Qingdao 266400China

Perfluorinated organic compounds(PFOCs) are emerging persistent organic pollutants(POPs) widely distributed in the environment,wildlife and *** studied the toxicology of perfluorooctane sulfonate(PFOS) and perfluorooctanoic acid(PFOA) on immunotoxicity and hepatotoxicity in primarily cultured hepatocytes of freshwater tilapia(Oreochromis niloticus).Cultured hepatocytes were exposed to PFOS or PFOA(0,10,20 and 30 mg/L) for 24,48,72,96,120 and 144 hours,*** doses of these compounds that induce significantly detectable immunotoxicity and hepatotoxicity were employed in the *** response to PFOS,the leukocytes,B cells,granulocytes,and macrophages among the isolation of intrahepatic immune cells(IHIC) from PFOS-treated tilapia produced significant levels of immune cells compared with that of the control *** numbers of leukocytes,B cells,granulocytes,and macrophages for PFOS-treated tilapia increased with the incremental exposure ***,similar to the findings in PFOA toxicity effects,the erythropoietin levels in tilapia increased with the increase of the PFOS and PFOA *** lowest doses(10 mg/L) of PFOS exposure led to a marked inhibition in the hepatocyte viability in ***,tilapia exposed to PFOA demonstrated a similar pattern,and a dose-dependent decrease in the hepatocyte viability was observed in the following treatment of *** the 72 h exposures,ethoxy-resorufin-O-deethylase(EROD) activity was significantly induced with the increase concentrations in tilapia liver(p<0.05).Tilapia showed a strong EROD induction in livers,and significantly difference in EROD activity was observed between control,PFOS and PFOA-exposed *** liver glycogen content showed that PFOS and PFOA exposure caused significant changes in the liver glycogen content,which depended on the duration of *** it appeared that the decrease in blood glucose level during the acclimation was followed by significant incr

关键词：尼罗罗非鱼 PFOA PFOS 免疫毒性肝毒性持久性有机污染物促红细胞生成素全氟辛烷

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Asymmetric supercapacitors based on high capacitance Ni6MnO8 and graphene

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Chinese Chemical Letters 2019年第6期30卷 1329-1334页

作者： Mingyang Zeng Li Zhang dandan wu Jun Ma Cao Zhang Shujuan Li Department of Physics School of Science Lanzhou University of Technology Lanzhou 730050 China Institute for Mathematics Free University of Berlin Berlin D-14195 Germany

Supercapacitors with high energy density and high power density have attracted numerous attentions. Here, we successfully synthesized Ni6MnO8 material by a fast, facile, and cost-effective method, which the area specific capacitance was found to be as high as 1113 mF/cm^2 at a current density of 1 mA/cm^2. Further, the asymmetric supercapacitor was assembled by using Ni6MnO8 as the positive electrode and graphene as the negative electrode with an operation potential from 0 to 1.4 V. It exhibited an area specific capacitance of 69.1m F/cm^2 at 0.5 mA/cm^2 and stable cycling performance which presented about 80% capacitance retention after 5000 cycles at 5 mA/cm^2. The energy density of graphene//Ni6MnO8 supercapacitors was calculated to be 18.81 mWh/cm^2 at a power density of 350.1 mW/cm^2 and still remained 5.8 mWh/cm^2 at a power density of 6990.7 mW/cm^2, meaning that the asymmetric supercapacitor combine excellent power density and energy density.

关键词： Ni6MnO8 Electrode Asymmetric supercapacitors Power density Energy density

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Microarray Analysis of Gene Expression Changes in Neuroplastin 65-Knockout Mice: Implications for Abnormal Cognition and Emotional Disorders

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Neuroscience Bulletin 2018年第5期34卷 779-788页

作者： Huanhuan Li Jiujiang Zeng Liang Huang dandan wu Lifen Liu Yutong Liu Qionglan Yuan Department of Neurology Shanghai Tongji Hospital Tongji University School of Medicine Department of Radiology University of Nebraska Medical Center

Neuroplastin 65 （Np65） is an immunoglobulin superfamily cell adhesion molecule involved in synaptic formation and plasticity. Our recent study showed that Np65-knockout （KO） mice exhibit abnormal cognition and emotional disorders. However, the underlying mechanisms remain unclear. In this study, we found 588 differentially- expressed genes in Np65-KO mice by microarray analysis. RT-PCR analysis also revealed the altered expression of genes associated with development and synaptic structure, such as Cdhl, Htr3a, and Kcnj9. In addition, the expression of Wnt-3, a Wnt protein involved in development, was decreased in Np65-KO mice as evidenced by western blotting. Surprisingly, MRI and DAPI staining showed a significant reduction in the lateral ventricular volume of Np65-KO mice. Together, these findings suggest that ablation of Np65 influences gene expression, which may contribute to abnormal brain development. These results provide clues to the mechanisms underlying the altered brain functions of Np65-deficient mice.

关键词： Neuroplastin 65 Microarray analysis Gene expression profile Htr3a Wnt

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Artificial intelligence algorithms for cyberspace security applications:a technological and status review

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Frontiers of Information Technology & Electronic Engineering 2023年第8期24卷 1117-1142页

作者： Jie CHEN dandan wu Ruiyun XIE School of Cybersecurity Northwestern Polytechnical UniversityXi’an710000China China Electronics Technology Network Information Security Co. Ltd.Chengdu610000China

Three technical problems should be solved urgently in cyberspace security:the timeliness and accuracy of network attack detection,the credibility assessment and prediction of the security situation,and the effectiveness of security defense strategy *** intelligence(AI)algorithms have become the core means to increase the chance of security and improve the network attack and defense ability in the application of cyberspace ***,the breakthrough and application of AI technology have provided a series of advanced approaches for further enhancing network defense *** work presents a comprehensive review of AI technology articles for cyberspace security applications,mainly from 2017 to *** papers are selected from a variety of journals and conferences:52.68%are from Elsevier,Springer,and IEEE journals and 25%are from international *** a specific focus on the latest approaches in machine learning(ML),deep learning(DL),and some popular optimization algorithms,the characteristics of the algorithmic models,performance results,datasets,potential benefits,and limitations are analyzed,and some of the existing challenges are *** work is intended to provide technical guidance for researchers who would like to obtain the potential of AI technical methods for cyberspace security and to provide tips for the later resolution of specific cyberspace security issues,and a mastery of the current development trends of technology and application and hot issues in the field of network *** also indicates certain existing challenges and gives directions for addressing them effectively.

关键词： Artificial intelligence(AI) Machine learning(ML) Deep learning(DL) Optimization algorithm Hybrid algorithm Cyberspace security

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Aluminum neurotoxicity effects on intracellular Ca^(2+) homeostasis in the rat cerebral cortex

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Neural Regeneration Research 2010年第15期5卷 1180-1184页

作者： Rui Ren Yang Zhang Xiaofeng Zhang Yanping wu dandan Zhang Baixiang Li Department of Toxicology Public Health College of Harbin Medical University Harbin 150081 Heilongjiang Province China

Studies have suggested that aluminum, a neurotoxic metal, is involved in the progression of neurodegenerative diseases. Previous studies have confirmed that aluminum influences intracellular Ca^2＋ homeostasis. However, it remains unclear whether aluminum increases or decreases intracellular Ca^2＋ concentrations. The present study demonstrated that Al^3＋ competitively binds to calmodulin （CAM）, together with Ca^2＋, which resulted in loss of capacity of CaM to bind to Ca^2＋, leading to increased [Ca^2＋]i. Al^3＋ stimulated voltage-gated calcium channels on cell membranes, which allowed a small quantity of Ca^2＋ into the cells. Al^3＋ also promoted calcium release from organelles by stimulating L-Ca^2＋αlc to trigger calcium-induced calcium release. Although Al^3＋ upregulated expression of Na＋/Ca^2＋exchanger mRNA, increased levels of Ca^2＋ and Na＋/Ca^2＋ exchanger did not maintain a normal Ca^2＋ balance. Al^3＋ resulted in disordered intracellular calcium homeostasis by affecting calcium channels, calcium buffering, and calcium expulsion.

关键词： aluminum chloride Ca^2+ concentration calcium homeostasis neurotoxicity

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Synergistic CO_(2)reduction and tetracycline degradation by CuInZnS-Ti_(3)C_(2)T_(x)in one photoredox cycle

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Nano Research 2022年第9期15卷 8010-8018页

作者： Lijing Wang Zhan Zhang Renquan Guan dandan wu Weilong Shi Limin Yu Pan Li Wei Wei Zhao Zhao Zaicheng Sun Henan Engineering Center of New Energy Battery Materials Henan D&A Engineering Center of Advanced Battery MaterialsCollege of Chemistry and Chemical EngineeringInstitute of Architectural EngineeringShangqiu Normal UniversityShangqiu 476000China Faculty of Physics Faculty of ChemistryNortheast Normal UniversityChangchun 130024China Center of excellence for environmental safety and biological effects Beijing Key Lab for Green Catalysis and SeparationDepartment of Chemistry and Chemical EngineeringCollege of Environmental and Energy EngineeringBeijing University of TechnologyBeijing 100124China School of Material Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Optimizing photocatalytic CO_(2)reduction with simultaneous pollutant degradation is highly ***,the photocatalytic efficiency is restricted by the unmatched redox ability,high carriers’recombination rate,and lack of reactive sites of the present ***,the CuInZnS-Ti_(3)C_(2)T_(x)hybrid with matched redox ability and suitable CO_(2)adsorption property was rationally *** nucleation and growth process of CuInZnS was interfered by the addition of Ti_(3)C_(2)T_(x)with a negative charge,resulting in thinner nanosheets and richer reactive ***,the Schottky heterojunction built in the hybrid simultaneously improved the photoexcited charge transfer property,sunlight absorption range,and CO_(2)adsorption ***,upon exposure to sunlight,CuInZnS-Ti_(3)C_(2)T_(x)exhibited an efficient photocatalytic CO_(2)reduction performance(10.2μmol·h^(−1)·g^(−1))with synergetic tetracycline degradation,obviously higher than that of pure *** on the combination of theoretical calculation and experimental characterization,the photocatalytic mechanism was investigated *** work offers a reference for the remission of worldwide energy shortage and environmental pollution problems.

关键词： CuInZnS-Ti_(3)C_(2)T_(x) photocatalysis CO_(2)reduction tetracycline degradation

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Onto CSD: an ontology-based security model for an integrated solution of cyberspace defense

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Frontiers of Information Technology & Electronic Engineering 2024年第9期25卷 1209-1225页

作者： dandan wu Jie CHEN Ruiyun XIE Ke CHEN School of Computer Science Chengdu College of University of Electronic Science and Technology of ChinaChengdu 610731China School of Cybersecurity Northwestern Polytechnical UniversityXi'an 710000China China Electronics Technology Cyber Security Co. Ltd.Chengdu 610000China

The construction of an integrated solution for cyberspace defense with dynamic, flexible, and intelligent features is a new idea. To solve the problem whereby traditional static protection methods cannot respond to various network attacks or security demands in an adversarial network environment in time, and to form a complete integrated solution from “threat discovery” to “decision-making generation,” we propose an ontology-based security model, Onto CSD, for an integrated solution of cyberspace defense that uses Web ontology language(OWL) to represent the ontology classes and relationships of threat monitoring, decision-making, response, and defense in cyberspace, and uses semantic Web rule language(SWRL) to design the defensive reasoning rules. Onto CSD can discover potential relationships among network attacks, vulnerabilities, the security state, and defense strategies. Further, an artificial intelligence(AI) expert system based on case-based reasoning(CBR) is used to quickly generate a detailed and comprehensive decision-making scheme. Finally, through Kendall ' s coefficient of concordance(W) and four experimental cases in a typical computer network defense(CND) system, which reasons on represented facts and the ontology, Onto CSD ' s consistency and its feasibility to solve the issues in the field of cyberspace defense are validated. Onto CSD supports automatic association and reasoning, and provides an integrated solution framework of cyberspace defense.

关键词： Cyberspace defense Integrated solution Ontology Case-based reasoning(CBR) Computer network defense(CND)

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