Immunotoxicity and hepatotoxicity of PFOS and PFOA in tilapia(Oreochromis niloticus)

作     者：HAN Zhaoxiang LIU Yurong WU Dandan ZHU Zhen Lu Chunxia HAN Zhaoxiang;LIU Yurong;WU Dandan;ZHU Zhen;Lü Chunxia

作者机构：School of Chemical EngineeringHuaihai Institute of TechnologyLianyungang 222005China Chongqing Key Laboratory of Micro/Nano Materials Engineering and TechnologyChongqing 402160China Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental ProtectionYancheng 224002China Jiaonan Agricultural Bureau of ChinaQingdao 266400China 

出 版 物：《Chinese Journal Of Geochemistry》 (中国地球化学学报)

年 卷 期：2012年第31卷第4期

页      面：424-430页

核心收录：

学科分类：090801[农学-水产养殖] 0908[农学-水产] 08[工学] 09[农学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by Chongqing Key Laboratory of Micro/Nano Materials Engineering and Technology (No. KFJJ1106) Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection (No.JLCBE11004) Jiangsu Marine Resources Development Research Institute (No. JSIMR10E04) 

主　　题：尼罗罗非鱼 PFOA PFOS 免疫毒性 肝毒性 持久性有机污染物 促红细胞生成素 全氟辛烷 

摘      要：Perfluorinated organic compounds(PFOCs) are emerging persistent organic pollutants(POPs) widely distributed in the environment,wildlife and *** studied the toxicology of perfluorooctane sulfonate(PFOS) and perfluorooctanoic acid(PFOA) on immunotoxicity and hepatotoxicity in primarily cultured hepatocytes of freshwater tilapia(Oreochromis niloticus).Cultured hepatocytes were exposed to PFOS or PFOA(0,10,20 and 30 mg/L) for 24,48,72,96,120 and 144 hours,*** doses of these compounds that induce significantly detectable immunotoxicity and hepatotoxicity were employed in the *** response to PFOS,the leukocytes,B cells,granulocytes,and macrophages among the isolation of intrahepatic immune cells(IHIC) from PFOS-treated tilapia produced significant levels of immune cells compared with that of the control *** numbers of leukocytes,B cells,granulocytes,and macrophages for PFOS-treated tilapia increased with the incremental exposure ***,similar to the findings in PFOA toxicity effects,the erythropoietin levels in tilapia increased with the increase of the PFOS and PFOA *** lowest doses(10 mg/L) of PFOS exposure led to a marked inhibition in the hepatocyte viability in ***,tilapia exposed to PFOA demonstrated a similar pattern,and a dose-dependent decrease in the hepatocyte viability was observed in the following treatment of *** the 72 h exposures,ethoxy-resorufin-O-deethylase(EROD) activity was significantly induced with the increase concentrations in tilapia liver(p0.05).Tilapia showed a strong EROD induction in livers,and significantly difference in EROD activity was observed between control,PFOS and PFOA-exposed *** liver glycogen content showed that PFOS and PFOA exposure caused significant changes in the liver glycogen content,which depended on the duration of *** it appeared that the decrease in blood glucose level during the acclimation was followed by significant incr