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Influence of Chemical Composition on Phase Transformation Temperature and Thermal Expansion Coefficient of Hot Work Die Steel

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Journal of Iron and Steel Research International 2008年第6期15卷 56-61页

作者： XIE Hao-jie wu xiao-chun min Yong-an School of Material Science and Engineering Shanghai University Shanghai 200072 China

On the basis of the uniform design method, six kinds of martensitic hot work die steels were designed. The phase transformation temperatures including Ac1 , Ac3 , and Ms were measured by DIL805A quenching dilatometer. The influences of the main elements on phase transformation temperatures were analyzed by quadratic stepwise regression analysis, and three corresponding equations were obtained. These equations, in which the interactions of the elements were considered, showed more effectiveness than the traditional ones. In addition, the thermal expansion coefficients of these steels in annealed state and quenched state were also obtained during the tests. The influences of chemical composition and temperature on the thermal expansion coefficient were analyzed; the equations obtained were verified by using several kinds of steels. The predicted values were in accordance with the results of the experiments.

关键词： phase transformation temperature thermal expansion coefficient hot work die steel uniform design quadratic stepwise regression analysis

外周血IFN-γ、PCT及OPN水平对活动性肺结核的诊断价值及其与抗结核治疗预后的相关性分析

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中国现代药物应用 2024年第19期18卷 10-15页

作者：王若涛吴敏校杨虹陈宗云福建医科大学附属闽东医院检验科 355000

目的探讨外周血γ-干扰素(IFN-γ)、降钙素原(PCT)及骨桥蛋白(OPN)水平对活动性肺结核的诊断价值及其与抗结核治疗预后的相关性。方法选取210例活动性肺结核患者作为活动性肺结核组,选择同期60例健康体检者作为健康对照组。对活动性肺... 详细信息

目的探讨外周血γ-干扰素(IFN-γ)、降钙素原(PCT)及骨桥蛋白(OPN)水平对活动性肺结核的诊断价值及其与抗结核治疗预后的相关性。方法选取210例活动性肺结核患者作为活动性肺结核组,选择同期60例健康体检者作为健康对照组。对活动性肺结核患者予以2HRZE/4HR方案进行抗结核治疗。根据患者是否治愈将活动性肺结核患者分为治愈组(161例)和未治愈组(49例)。比较活动性肺结核组治疗前与健康对照组血清IFN-γ、PCT及OPN水平,基于IFN-γ、PCT及OPN构建活动性肺结核的二元Logistic回归分析及联合诊断模型,分析IFN-γ、PCT、OPN单独及联合诊断模型的预测效能,比较治愈组和未治愈组患者治疗前后血清IFN-γ、PCT及OPN水平,分析活动性肺结核患者治疗前血清IFN-γ、PCT及OPN水平与治疗预后的相关性。结果活动性肺结核组患者治疗前血清IFN-γ、PCT及OPN水平分别为(23.20±10.01)pg/ml、(1.46±0.60)ng/ml、(721.79±303.62)ng/ml,明显高于健康对照组的(5.69±2.74)pg/ml、(0.25±0.11)ng/ml、(171.99±68.53)ng/ml,差异具有统计学意义(P0.05);治疗6个月后,治愈组患者血清IFN-γ、PCT及OPN水平明显低于未治愈组,差异具有统计学意义(P<0.05)。Pearson相关性分析表明,活动性肺结核患者治疗前血清IFN-γ、PCT及OPN水平与抗结核治愈呈负相关关系(P<0.05)。结论外周血IFN-γ、PCT及OPN水平升高不仅与活动性肺结核的发病密切相关,且可能是患者抗结核治疗疗效和预后评估的潜在生物标志物。

关键词：活动性肺结核 γ-干扰素降钙素原骨桥蛋白诊断价值预后

山羊CIDEa基因过表达对乳腺脂质合成的影响

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农业生物技术学报 2024年第3期32卷 587-594页

作者：孙雨婷李佩韦苏丽娜胡罕吴晓民李君陕西省动物研究所河南牧业经济学院动物科技学院

诱导细胞死亡的DNA片段化因子-α样效应因子a (cell-death-inducing DNA fragmentation factor-α-like effector a, CIDEa)是一种脂滴相关蛋白，参与调节脂代谢和维持机体能量平衡。为了进一步探讨CIDEa在奶山羊(Capra hircus)乳腺脂... 详细信息

诱导细胞死亡的DNA片段化因子-α样效应因子a (cell-death-inducing DNA fragmentation factor-α-like effector a, CIDEa)是一种脂滴相关蛋白，参与调节脂代谢和维持机体能量平衡。为了进一步探讨CIDEa在奶山羊(Capra hircus)乳腺脂质代谢中的功能，本研究以奶山羊乳腺上皮细胞为模型，通过构建pcDNA3.1-CIDEa过表达载体研究CIDEa基因对乳腺细胞脂质合成的影响。结果发现，乳腺上皮细胞转染pcDNA3.1-CIDEa过表达载体48 h后，CIDEa基因表达量上升了近10倍(P<0.01)；甘油三酯(triacylglycerol, TAG)检测和油红O染色结果显示，过表达CIDEa基因后乳腺上皮细胞中甘油三酯的含量显著升高(P<0.05)且脂滴积累增多；实时定量PCR检测结果显示，过表达CIDEa基因后脂代谢相关基因乙酰辅酶A羧化酶α (acetyl-CoA carboxylase alpha, ACACA)、抗原分化簇36 (cluster of differentiation 36,CD36)和固醇调节元件结合蛋白1 (sterol regulatory element binding protein1, SREBP1)的表达量显著升高(P<0.05)，二酰基甘油酰基转移酶2 (diacylglycerolacyltransferase2, DGAT2)的表达量极显著升高(P<0.01)。以上结果表明，CIDEa基因能促进乳腺上皮细胞脂质的合成。本研究为深入研究CIDEa基因在奶山羊乳脂代谢调控中的作用提供了理论参考。

关键词：山羊诱导细胞死亡的DNA片段化因子-α样效应因子a (CIDEa)基因过表达脂质合成

Development of Non-Quenched Prehardened Steel for Large Section Plastic Mould

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Journal of Iron and Steel Research International 2009年第2期16卷 61-67页

作者： LUO Yi wu xiao-chun min Yong-an ZHU Zhu WANG Hong-bin School of Material Science and Engineering Shanghai University Shanghai 200072 China

In order to meet the demand of prehardened steel for large section plastic mould and save energy, a nonquenched prehardened （NQP） steel is developed. The temperature field of a large block is researched by finite element method simulation and 9 test steels are designed in the laboratory. Their microstructures and hardness are investigated when they are air cooled and control cooled at cooling rate similar to the simulation. The result shows that the hardness uniformity through section is closely correlated to bainitic hardenability for the NQP steel, and the hardness of one test steel （0.27C-1.95Mn-1.04Cr-0.45Mo-0.1V） fluctuates between HRC 40 and 43 under both cooling conditions. The test steel has better machinability compared with C45 steel, and the NQP steel is produced successfully in the factory based on the laboratory results. Its microstructure is bainite, and it is distributed uniformly through the size of 460 mm×800 mm×3 200 mm.

关键词： NQP steel large section plastic mould temperature estimation chemical composition microstructure machinability

Phylogenetic and Structural Analysis of Major Surface Proteins Hemagglutinin and Neuraminidase of Novel Avian Influenza Virus A H7N9 from Chinese Patient

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Chemical Research in Chinese Universities 2013年第5期29卷 934-940页

作者： YUAN xiao-hui WANG Ying-chen QU Zhang-yi REN Jia-yi wu xiao-min WANG Jing-fei Department of Microbiology Public Health College Harbin Medical University Harbin 150081 P. R. China Institute of Pathogen Biology Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100176 P R. China Key Laboratory of Resource and Plant Biology of Anhui Province College of Life Science Huaibei Normal University Huaibei 235000 P. R. China Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150081 P R. China

This research reveals the phylogenetic history and structural information of the hemagglutinin（HA） and neuraminidase（NA） from novel avian influenza virus A/Hangzhou/1/2013（HTN9_2013） strain from human infected in China. Strains closely related to the HTN9 2013 strain were obtained from Nation Center for Biotechnology Information（USA）-basic local alignment search tool（NCBI-BLAST） searching, and the phylogenetic trees were con- structed. The 3D structures of HA and NA from H7N9 2013 strain were built by homology modeling technology, and molecular dynamics（MD） simulations were performed on the high-performance computer cluster. Characteristic amino acid sites were then screened from multiple sequence alignment（MSA） via home-made Python script and mapped onto the 3D structures. The thermodynamic characteristic root-mean-square-fluctuation （RMSF） of these sites in the structure was also analyzed with MD trajectories. The HA of HTN9_2013 strain is closely related to the A/duck/Zhejiang/12/2011 strain isolated in China, while the NA of HTN9 2013 strain is mostly related to the A/mallard/Czech Republic/13438-29K/2010 strain isolated in Europe. The 3D structures of HA and NA from H7N9 2013 stain are mostly identical to the existing structure of H7 and N9. A total of 11 and 14 characteristic ami- no acid sites were identified in HA and NA, respectively, in HTN9_2013. Structural analysis indicates that certain sites in the top region of HA are important, at which the mutation of some amino acids can impact the receptor bin- ding that may be related to its infection of human beings.

关键词： Avian influenza virus Hemagglutinin Neuraminidase Homology modeling Phylogenetic

安徽省2022年小兽携带汉坦病毒基因序列分析

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中国媒介生物学及控制杂志 2024年第3期35卷 261-267页

作者：陈晴晴侯银续陆皖行吴小珉吴磊徐庆华安徽省疾病预防控制中心微生物检验室/消毒杀虫科安徽合肥230601

目的了解安徽省小兽携带汉坦病毒情况及病毒基因型特征。方法2021年9月-2022年12月,安徽省按照《全国病媒生物病原学监测方案(试行)》采集小兽样本,运用反转录实时荧光定量PCR方法检测小兽肺标本汉坦病毒核酸,对阳性标本进行S片段全长... 详细信息

目的了解安徽省小兽携带汉坦病毒情况及病毒基因型特征。方法2021年9月-2022年12月,安徽省按照《全国病媒生物病原学监测方案(试行)》采集小兽样本,运用反转录实时荧光定量PCR方法检测小兽肺标本汉坦病毒核酸,对阳性标本进行S片段全长扩增、测序及基因序列分析。结果全省16个地市共检测4075份样本,包括8种小兽,其中褐家鼠、小家鼠、黄胸鼠和黑线姬鼠为优势种,分别占32.15%、21.87%、21.72%和20.86%。汉坦病毒核酸阳性率为1.47%(60/4075),包含汉滩病毒和首尔病毒。60份阳性标本通过交叉PCR法扩增获得19条S序列,遗传进化分析显示汉滩病毒属于H5亚型,首尔病毒为S3亚型,序列之间核苷酸相似性为72.00%~100%,氨基酸相似性为83.00%~100%。结论安徽省小兽中存在汉滩病毒和首尔病毒感染,应加强对小兽汉坦病毒的监测工作,为肾综合征出血热传染病防控提供科学依据。

关键词：肾综合征出血热汉坦病毒基因型 S片段

Nonlocal coherence harvesting from quantum vacuum

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Communications in Theoretical Physics 2024年第7期76卷 44-51页

作者： Rui-Di Wang Shu-min wu xiao-Li Huang Department of Physics Liaoning Normal UniversityDalian 116029China

It is well known that nonlocal coherence reflects nonclassical correlations better than quantum entanglement. Here, we analyze nonlocal coherence harvesting from the quantum vacuum to particle detectors adiabatically interacting with a quantum scalar field in minkowski *** find that the harvesting-achievable separation range of nonlocal coherence is larger than that of quantum entanglement. As the energy gap grows sufficiently large, the detectors harvest less quantum coherence, while the detectors could extract more quantum entanglement from the vacuum state. Compared with the linear configuration and the scalene configuration, we should choose the model of equilateral triangle configuration to harvest tripartite coherence from the vacuum. Finally, we find a monogamous relationship, which means that tripartite l_(1)-norm of coherence is essentially bipartite types.

关键词： nonlocal coherence quantum vacuum monogamous relationship

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蒸汽管回转干燥机出料箱故障研究分析

广州化工 2024年第3期52卷 142-145页

作者：吴晓敏巩乐徐澍马瑞韩东钊浙江逸盛新材料有限公司浙江宁波315000 天华化工机械及自动化研究设计院有限公司甘肃兰州730060

某厂PTA蒸汽管回转干燥机出料箱前后壁在运行过程中出现了规律性和间歇性的鼓包现象,导致出料密封内外两侧填料函间隙不均匀,密封密封效果不佳,出现漏料情况。经初步分析,认为是出料箱受到了的间歇性超压操作,过大的压力将出料箱挤压变... 详细信息

某厂PTA蒸汽管回转干燥机出料箱前后壁在运行过程中出现了规律性和间歇性的鼓包现象,导致出料密封内外两侧填料函间隙不均匀,密封密封效果不佳,出现漏料情况。经初步分析,认为是出料箱受到了的间歇性超压操作,过大的压力将出料箱挤压变形,出现鼓包现象,过量的弹性变形改变了填料函与轴套密封间隙的均匀性,填料出现挤压磨损,密封性变差。本文通过有限元数值方法对出料箱进行计算分析,发现出料箱在运行过程中若出现超压运行,就会导致出料箱前后壁位置出现较大的弹性变形。事后对现场操作流程进行了详细的梳理论证,发现干燥机出料箱下方的转阀离料仓距离较远,工艺人员加大了转阀的输送气量,导致从转阀处泄露到干燥机出料箱内的气量增大,造成出料箱内出现局部高压,引起“鼓包”现象。为了不影响干燥机密封效果,在装置建设时需要考虑干燥机和料仓之间的距离。本文的计算方法和分析结果可为此类设备的设计和生产人员参考。

关键词：蒸汽管回转干燥机出料箱密封鼓包应力泄露

A LESO Based Backstepping Controller Considering Coal Seam Hardness for Rotary Speed in Coal mine Tunnel Drilling Process

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Journal of Systems Science & Complexity 2024年第5期37卷 1789-1808页

作者： CHEN Luefeng LIU xiao wu min LU Chengda PEDRYCZ Witold HIROTA Kaoru School of Automation China University of GeosciencesWuhan 430074China Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan 430074China Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of EducationWuhan 430074China Department of Electrical and Computer Engineering University of AlbertaEdmontonAB T6R2G7Canada The Tokyo Institute of Technology Yokohama 226-8502Japan

In the process of coal mine drilling,controlling the rotary speed is important as it determines the efficiency and safety of *** this paper,a linear extended state observer(LESO)based backstepping controller for rotary speed is proposed,which can overcome the impact of changes in coal seam hardness on rotary ***,the influence of coal seam hardness on the drilling rig’s rotary system is considered for the first time,which is reflected in the numerical variation of load torque,and a dynamic model for the design of rotary speed controller is *** an LESO is designed to observe the load torque,and feedforward compensation is carried out to overcome the influence of coal seam *** on the model of the compensated system,a backstepping method is used to design a controller to achieve tracking control of the rotary ***,the effectiveness of the controller designed in this paper is demonstrated through simulation and field experiments,the steady-state error of the rotary speed in field is 1 r/min,and the overshoot is reduced to 5.8%.This greatly improves the stability and security,which is exactly what the drilling process requires.

关键词： Backstepping extended state observer hydraulic tunnel drilling machine rotary speed