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Biomedical and Environmental Sciences 2012年第2期25卷 210-215页

作者： CHEN Hao ZHENG Zhou CHEN Peng wu xiang gen ZHAO Ge State Key Lab Cultivation Base Shandong Provincial Key Lab of OphthalmologyShandong Eye InstituteQingdao 266071ShandongChina Key Laboratory of Marine Bio-active Substances First Institute of OceanographyState Oceanic AdministrationQingdao 266061ShandongChina.

Objective Fungal keratitis（FK） is a vision-threatening infection,whose treatment requires more effective and safer anti-fungal agent exploitation *** this aim,we focused on the effect of an extracellular polysaccharide on fungal adhesion to human corneal epithelial *** We performed the cytotoxicity assays of the extracellular polysaccharide EPS-II from an antarctic bacterium Pseudoaltermonas and evaluated its inhibitory effect on Candida albicans cells＇ adherence to human corneal epithelial cells（HCECs）.Results EPS-II,which displayed minor cytotoxicity but also promoted proliferation of HCECs,could inhibit the adherence of yeast cells to HCECs in a dose-dependent ***-II could also suppress the subsequent PI3K/AKT signaling pathway,and thereby decrease the expression of early inflammatory *** ExtracellularpolysaccharideEPS-IIwassuggestedasanewnaturalagentforattenuatingFK.

关键词： Extracellular polysaccharide EPS-II Candida albicans Cornea Adhesion Inhibitory effect

Correction to:Assembly-level analysis on temperature coefficient of reactivity in a graphite-moderated fuel salt reactor fueled with low-enriched uranium

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Nuclear Science and Techniques 2024年第2期35卷 234-235页

作者： Xiao-Xiao Li De-Yang Cui Chun-Yan Zou Jian-Hui wu xiang-Zhou Cai Jin-gen Chen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China CAS Innovative Academy in TMSR Energy System Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

Following publication of the original article,the authors observed that both Fig.5 and Fig.4 depict the same *** 5 was inaccurately referenced and *** correct Fig.5 is copied below:The original article has been updated.

关键词： fuel enriched reactivity

云南省保山卫生学校3号楼东侧滑坡成因研究及防治措施

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水文地质工程地质 2007年第1期34卷 86-89页

作者：李强吴香根云南地质工程第二勘察院有限公司昆明650051

受2004年10月19日发生的地震的影响,云南省保山卫生学校3号楼东侧处的老滑坡复活变形,楼后庭院平台上产生多条拉张裂缝。在分析滑坡特征和成因后,采取了抗滑支挡结合排水护坡的处治方案,处治效果较好。

关键词：地震滑坡抗滑桩排水孔

Preliminary safety analysis for heavy water-moderated molten salt reactor

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Nuclear Science and Techniques 2024年第6期35卷 202-217页

作者： Gao-Ang Wen Jian-Hui wu Chun-Yan Zou xiang-Zhou Cai Jin-gen Chen Man Bao College of Science University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

The heavy water-moderated molten salt reactor(HWMSR)is a newly proposed reactor concept,in which heavy water is adopted as the moderator and molten salt dissolved with fissile and fertile elements is used as the *** arising from graphite in traditional molten salt reactors,including the positive temperature coefficient and management of highly radio-active spent graphite waste,can be addressed using the *** now,research on the HWMSR has been centered on the core design and nuclear fuel cycle to explore the viability of the HWMSR and its advantages in fuel ***,the core safety of the HWMSR has not been extensively ***,we evaluate typical accidents in a small modular HWMSR,including fuel salt inlet temperature overcooling and overheating accidents,fuel salt inlet flow rate decrease,heavy water inlet temperature overcooling accidents,and heavy water inlet mass flow rate decrease accidents,based on a neutronics and thermal-hydraulics coupled *** results demonstrated that the core maintained safety during the investigated accidents.

关键词： Heavy water-moderated molten salt reactor Neutronics and thermal-hydraulics coupling Transient analysis Accident analysis

Exploring noncoding variants in genetic diseases:from detection to functional insights

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Journal of genetics and genomics 2024年第2期51卷 111-132页

作者： Ke wu Fengxiao Bu Yang wu gen Zhang Xin Wang Shunmin He Mo-Fang Liu Runsheng Chen Huijun Yuan Institute of Rare Diseases West China Hospital of Sichuan UniversityChengduSichuan 610041China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China Key Laboratory of RNA Biology Center for Big Data Research in HealthInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Molecular Biology State Key Laboratory of Cell BiologyShanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China

Previous studies on genetic diseases predominantly focused on protein-coding variations, overlooking the vast noncoding regions in the human genome. The development of high-throughput sequencing technologies and functional genomics tools has enabled the systematic identification of functional noncoding variants. These variants can impact gene expression, regulation, and chromatin conformation, thereby contributing to disease pathogenesis. Understanding the mechanisms that underlie the impact of noncoding variants on genetic diseases is indispensable for the development of precisely targeted therapies and the implementation of personalized medicine strategies. The intricacies of noncoding regions introduce a multitude of challenges and research opportunities. In this review, we introduce a spectrum of noncoding variants involved in genetic diseases, along with research strategies and advanced technologies for their precise identification and in-depth understanding of the complexity of the noncoding genome. We will delve into the research challenges and propose potential solutions for unraveling the genetic basis of rare and complex diseases.

关键词： Noncoding variation genetic disease Research approach Challenge

Room-temperature Self-healing and Recyclable PDMS Elastomers with Superior Mechanical Properties for Triboelectric Nanogenerators

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Chinese Journal of Polymer Science 2024年第10期42卷 1566-1577,I0014页

作者： Shu-Juan Wang Lu Wang Hong-Zhe Su Zhi-Cheng wu Qiao-gen Zhang Wei Fan Xin-Li Jing School of Chemistry Joint Innovation Center of Thermal Protection MaterialsXi’an Jiaotong UniversityXi’an710049China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an710049China School of Textile Science and Engineering Xi’an Polytechnic UniversityXi’an710048China

Polydimethylsiloxane(PDMS)is an electron-withdrawing material that is widely used in triboelectric nanogenerators(TENGs).However,PDMS has poor mechanical properties after curing and is easily damaged when subjected to long-term ***,the long-term stable operation of TENGs under mechanical deformation cannot be *** this work,multiple hydrogen bonds and aromatic disulfide bonds were introduced into PDMS *** elastomers exhibited high toughness(a tensile strength of 1.91 MPa and an elongation at break of 340%),good recyclability,and room-temperature self-healing properties(healing efficiency of 96.4%in 24 h).Recyclable sandwich-like triboelectric nanogenerators with excellent electrical output performance(13.5 V)and room-temperature self-healing performance(24 h,98%recovery of self-generating performance)were prepared by utilizing the hydrogen bonding between the PDMS elastomer and *** work reported herein offers theoretical guidance and a compelling strategy for developing high-performance TENG negative friction layers.

关键词： Polydimethylsiloxane Aromatic disulfide bonds Hydrogen bonds Room temperature self-healing Triboelectric nanogenerator

Thiomers/GSH体系——新型多肽类药物吸收促进剂

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中国药学杂志 2005年第5期40卷 328-330页

作者：吴祥根斯陆勤李高华中科技大学同济医学院药学院药剂系湖北武汉430030

目的　介绍一类新型多肽类药物胃肠道吸收促进剂Thiomers/GSH体系的作用原理及应用。方法　参阅相关文献 ,对其进行综合、分析和归纳。结果与结论　Thiomers/GSH体系能够有效提高多肽类药物口服吸收。该体系作为一类全新的黏膜吸收促进... 详细信息

目的　介绍一类新型多肽类药物胃肠道吸收促进剂Thiomers/GSH体系的作用原理及应用。方法　参阅相关文献 ,对其进行综合、分析和归纳。结果与结论　Thiomers/GSH体系能够有效提高多肽类药物口服吸收。该体系作为一类全新的黏膜吸收促进剂 ,有望使许多的多肽类药物口服成为可能。

关键词：巯基化聚合物谷胱甘肽多肽类药物吸收促进剂

纳米混悬剂的制备方法及在药剂学中应用的研究进展

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中国医药工业杂志 2006年第3期37卷 196-200页

作者：朱建芬吴祥根青岛市食品药品监督管理局山东青岛266001 军事医学科学院毒物药物研究所北京100850

纳米混悬剂可增大难溶性药物的溶解度,改变药物的体内动力学特征,提高安全性和有效性。综述了纳米混悬剂的制备方法及其在药剂学中应用的研究进展。

关键词：纳米混悬剂难溶性药物粒径溶解度综述

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纳美芬乳酸-羟乙酸共聚物缓释微球的制备

中国药学杂志 2007年第3期42卷 201-205页

作者：吴祥根高永良李高华中科技大学同济医学院药学院药剂系武汉430030 军事医学科学院毒物药物研究所北京100850

目的使用星点设计-效应面法优化纳美芬乳酸-羟乙酸共聚物缓释微球的制备工艺,提高可预测性。方法微球用O/O型乳化溶剂挥发法制备,自变量为外相Span80浓度、内相乳酸-羟乙酸共聚物(PLGA)浓度和理论载药量,以微球载药量、包封率、平均粒... 详细信息

目的使用星点设计-效应面法优化纳美芬乳酸-羟乙酸共聚物缓释微球的制备工艺,提高可预测性。方法微球用O/O型乳化溶剂挥发法制备,自变量为外相Span80浓度、内相乳酸-羟乙酸共聚物(PLGA)浓度和理论载药量,以微球载药量、包封率、平均粒径、跨距和第1天微球释药百分数(F1d)为因变量对自变量的各水平进行多元线性回归和二项式拟合,根据因变量效应面法选取较佳工艺条件并于较优区进行预测分析。结果5个方程均采用二项式拟合的效果较好,选择的较佳工艺为Span80浓度1.5%、PLGA浓度175g.L-1、理论载药量6%,按优化工艺制备的微球球形圆整,载药量、包封率、平均粒径、跨距和F1d分别为4.37%,72.8%,64.1μm,1.36和8.93%,微球具有显著的体外缓释特性。结论星点设计-效应面法优化微球制备工艺预测性良好。

关键词：纳美芬乳酸-羟乙酸共聚物微球星点设计-效应面法

高效液相色谱法测定乳酸羟醋酸共聚物微球中纳美芬的含量

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中国医院药学杂志 2007年第1期27卷 70-72页

作者：吴祥根高永良李高华中科技大学同济医学院药学院药剂系湖北武汉430030 军事医学科学院毒物药物研究所北京100850

目的：建立高效液相色谱法测定纳美芬缓释微球载药量的方法。方法：色谱柱为C18柱，流动相为甲醇-0．02mol·L^-1，磷酸缓冲液（pH4．0）-三乙胺（40：60：0．2），检测波长为284mm。结果：在5．24～83．84mg·L^-1范围内，峰面积对质... 详细信息

目的：建立高效液相色谱法测定纳美芬缓释微球载药量的方法。方法：色谱柱为C18柱，流动相为甲醇-0．02mol·L^-1，磷酸缓冲液（pH4．0）-三乙胺（40：60：0．2），检测波长为284mm。结果：在5．24～83．84mg·L^-1范围内，峰面积对质量浓度有良好的线性关系，日内RSD≤0．77％，日间RSD≤1．10％，回收率为92．8％。结论：HPLC法专属性强，结果准确。

关键词：纳美芬微球高效液相色谱法