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Defining and tracing subtypes.of patient-derived xenograft models in pancreatic ductal adenocarcinoma

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Cancer Communications 2024年第8期44卷 915-920页

作者： sangyeop Hyun Youngmin Han Jae yun Moon Young-Ah suh won-Gun yun Wooil Kwon Jong-Eun Lee Daeun Kim Ja-Lok Ku Jin-Young Jang Daechan Park Department of Molecular science and Technology Ajou UniversitySuwonRepublic of Korea Department of surgery and Cancer Research Institute Seoul National University College of MedicineSeoulRepublic of Korea Molecular science and Technology Research Center Ajou UniversitySuwonRepublic of Korea DNA Link Inc. SeoulRepublic of Korea Korean Cell Line Bank Laboratory of Cell BiologyCancer Research InstituteSeoul National University College of MedicineSeoulRepublic of Korea

Patient-derived xenograft(PDX)models have been used to explore therapeutic opportunities for pancreatic ductal adenocarcinoma(PDAC)[1].Although original tumor characteristics are altered by cancer-stromal interactions... 详细信息

关键词： adenocarcinoma ductal xenograft

Gria:an efficient deterministic concurrency control protocol

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Frontiers.of Computer science 2024年第4期18卷 25-37页

作者： Xinyuan WANG yun PENG Hejiao HUANG school of Computer science and Technology Harbin Institute of TechnologyShenzhen 518055China Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou 510006China

Deterministic databases are able to reduce coordination costs in a *** property has fostered a significant interest in the design of efficient deterministic concurrency control ***,the state-of-the-art deterministic concurrency control protocol Aria has three ***,it is impractical to configure a suitable batch size when the read-write set is ***,Aria running in low-concurrency scenarios,e.g.,a single-thread scenario,suffers from the same conflicts as running in high-concurrency ***,the single-vers.on schema brings write-after-write *** address these issues,we propose Gria,an efficient deterministic concurrency control *** has the following ***,the batch size of Gria is ***,Gria’s conflict probability in low-concurrency scenarios is lower than that in high-concurrency ***,Gria has no write-after-write conflicts by adopting a multi-vers.on *** further reduce conflicts,we propose two optimizations:a reordering mechanism as well as a rechecking *** evaluation result on two popular benchmarks s.ows that Gria outperforms Aria by 13x.

关键词： deterministic concurrency control transaction processing

surgical Repair of Ventricular septal Defect in Neonates: Indications and outcomes

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Congenital Heart Disease 2024年第1期19卷 69-83页

作者： Jae Hong Lee sungkyu Cho Jae Gun Kwak Hye won Kwon Woong-Han Kim Mi Kyoung song sang-yun Lee Gi Beom Kim Eun Jung Bae Department of Thoracic and Cardiovascular surgery Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanKorea Department of Thoracic and Cardiovascular surgery Seoul National University Children’s HospitalSeoulKorea Department of Pediatrics Seoul National University Children’s HospitalSeoulKorea

Background:The optimal surgical timing and clinical outcomes.of ventricular septal defect(VsD)closure in neo-nates remain *** aimed to evaluate the clinical outcomes.of VsD closure in neonates(age≤30 days).Methods:We retrospectively reviewed 50 consecutive neonates who underwent VsD closure for isolated VsDs between August 2003 and June *** for the procedure included congestive heart failure/failure to thrive and pulmonary *** adverse events(MAEs)were deﬁned as the composite of all-cause mortality,reoperation,persistent atrioventricular block,and signiﬁcant(≥grade 2)valvular ***:The median age and body weight at operation were 26.0 days(interquartile range[IQR],18.8–28.3)and 3.7 kg(IQR,3.3–4.2),*** median follow-up duration was 110.4 months(IQR,56.8–165.0).seven patients required preoperative respiratory support,andﬁve had signiﬁcant(≥grade 2)preoperative valvular *** early mortality occurred due to irreversible cardiogenic s.ock;no late mortality was *** reopera-tion was due to hemodynamically signiﬁcant residual VsD at 103.8 months *** overall survival,freedom from reoperation,and freedom from MAE at 15-years were 98.0%,96.3%,and 94.4%,***-operative mechanical ventilation was as.ociated with a longer duration of pos.operative mechanical ventilation(ponger length of intensive care unit stay(ponclus.ons:VsD closure with favorable outcomes without morbidities is feasible even in ***,neonates requiring preoperative respiratory support may require careful pos.operative management considering the long-term pos.operative ***,surgical VsD closure might be indicated earlier in neonates with respiratory compromise.

关键词： Ventricular septal defect neonate early surgery neonatal surgery

Capture Efficiency Analysis in the Circular Restricted Three-body Problem

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Research in Astronomy and Astrophysics 2024年第5期24卷 198-210页

作者： Yu-Xuan Miao Xi-yun Hou Department of Astronomy and space science Nanjing UniversityNanjing 210023China Institute of space Environment and Astrodynamics Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics Ministry of EducationNanjing 210023China

Temporary capture efficiency is studied in the framework of the circular restricted three-body problem in two ***, a non-uniform distribution of test particles around the secondary's.orbit is.obtained by fully accounting the secondary's gravitational influence. second, the capture efficiency is computed based on the non-uniform distribution. several factors influencing the result are discussed. By studying the capture efficiency in the circular restricted three-body problem of different mass ratios, a power-law relation between the capture efficiency(p) and the mass ratio(μ) is established, which is given by p ≈ 0.27 × μ^(0.53), within the range of 3.0035 ×10^(-6)≤ μ ≤ 3.0034 × 10^(-5). Taking the sun–Earth system as an example, the influence from the orbit eccentricity of the secondary on the non-uniform distribution and the capture efficiency is studied. our studies find that the secondary's.orbit eccentricity has a negative influence on the capture efficiency.

关键词： methods numerical-celestial mechanics-planets and satellites dynamical evolution and stability

A spleen Tyrosine Kinase’s sky in Neuronal Degeneration

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Neuroscience Bulletin 2024年第2期40卷 273-276页

作者： Wan-yun Zhang sen Lin Department of Neurology Xinqiao HospitalThe Second Afliated HospitalArmy Medical UniversityChongqing 400042China Chongqing Institute for Brain and Intelligence Guangyang Bay LaboratoryChongqing 400064China

With the growing elderly population,neurodegenerative disorders like Alzheimer's disease(AD)are emerging as a significant public health *** is widely acknowledged in the scientific community that the accumulation of neurotoxic aggregates,such as amyloid beta(Aβ),within the central nervous system is a major factor in the development of these ***,human genome-wide as.ociation studies have identified mutations in microglial receptors that may be linked to a number of neurodegenerative diseases[1].

关键词： Aβ spleen Alzheimer

Role of aminopeptidase N-like in the acquisition of begomoviruses by Bemisia tabaci,the whitefly vector

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Insect science 2024年第3期31卷 707-719页

作者： yun-yun Fan Yao Chi Na Chen Wilmer J.Cuellar Xiao-Wei Wang Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang ProvinceInstitute of Insect SciencesZhejiang UniversityHangzhouChina Zhejiang Tianmushan National Nature Reserve Administration HangzhouChina Institute of Plant Protection Liaoning Academy of Agricultural SciencesShenyangChina Virology Laboratory Cassava ProgramInternational Center for Tropical Agriculture(CIAT)PalmiraColombia

sri Lankan cassava mosaic virus(sLCMV)is a prominent causative agent of cassava mosaic disease in Asia and relies.on the whitefly Bemisia tabaci cryptic complex for its ***,the molecular mechanisms involved in sLCMV transmiss.on by *** have yet to be *** this study,we identified an aminopeptidase N-like protein(BtAPN)in *** Asia II 1,an efficient vector of sLCMV,which is involved in the sLCMV transmiss.on *** the use of glutathione s-transferase pull-down assay and LC-Ms/Ms analysis,we demonstrated the interaction between BtAPN and the coat protein(CP)of *** interaction was further confirmed in vitro,and we observed an induction of BtAPN gene express.on following sLCMV *** interfering with the function of BtAPN,the quantities.of sLCMV were significantly reduced in various parts.of *** Asia II 1,including the whole body,midgut,hemolymph,and primary salivary ***,we dis.overed that BtAPN is conserved in *** Middle East-Asia Minor 1(MEAM1)and interacts with the CP of tomato yellow leaf curl virus(TYLCV),a begomovirus known to cause severe damage to tomato *** BtAPN with antibody led to a significant reduction in the quantities.of TYLCV in whitefly whole body and organs/*** results demonstrate that BtAPN plays a generic role in interacting with the CP of begomoviruses and positively regulates their acquisition by the whitefly.

关键词： BtAPN coat protein sLCMV TYLCV virus acquisition whitefly

Theoretical study of kinetic isotope effects for vacancy diffus.on of impurity in solids

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Acta Geochimica 2024年第5期43卷 959-970页

作者： Yuxi Jing Xuefang Li yun Liu Research Center for Planetary science College of Earth and Planetary SciencesChengdu University of TechnologyChengdu 610059China state Key Laboratory of ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China CAs Center for Excellence in Comparative Planetology Hefei 230026China

Theoretical studies.of the diffus.onalisotope effect in solids are still stuck in the 1960s and *** the development of high spatial resolution mass spectrometers,isotopic data of mineral grains are rapidly *** dig up information from these data,molecularlevel theoretical models are urgently *** on the micros.opic definition of the diffus.on coe fficient(D),a new theoretical framework for calculating the diffus.onal isotope effect(DIE(v))(intermsofD*/D)forvacancy-mediated impurity diffus.on in solids is provided based on statistical mechanics *** newly derived equation s.ows that theDIE(v)can be easily calculated as long as the vibration frequencies.of isotope-substituted solids are *** calculatedDIE(v)values.of^(199)Au/^(195)Au and^(60)Co/^(57)Co during diffus.on in Cu and Au metals are all within 1%of errors compared to the experimental data,which s.ows that this theoretical model is reasonable and precise.

关键词： Vacancy diffus.on Diffus.onal isotope effect statistical mechanics

Adaptive 5G-and-beyond network-enabled interpretable federated learning enhanced by neuroevolution

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science China(Information sciences) 2024年第7期67卷 107-132页

作者： Bin CAo Jianwei ZHAo Xin LIU yun LI state Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of Technology school of Artificial Intelligence Hebei University of Technology school of Economics and Management Hebei University of Technology Industrial Artificial Intelligence Centre Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of China

Mobile telemedicine systems based on the next-generation communication will significantly enhance deep fus.on of network automation and federated learning(FL), but data privacy is a paramount issue in sectors like healthcare. This work hence considers FL augments 5G-and-beyond networks by training deep learning(DL) models without the need to exchange raw data. The substantial communication loads imposed on by extensive parameters involved in DL models are managed through adaptive scheduling mechanisms effectively. To address the opaque nature of DL models and to improve the interpretability of FL models, we introduce a convolutional fuzzy rough neural network specifically designed for medical image processing. We also develop a multiobjective memetic evolutionary algorithm to streamline and optimize the neural network architectures. our comprehensive FL framework integrates smart scheduling, interpretable fuzzy rough logic,and neuroevolution. This framework is s.own to improve communication efficiency, increase interpretability of diagnosis with protected privacy, and generate low-complexity neural architectures.

关键词： 5G-and-beyond network interpretable federated learning mobile telemedicine system fuzzy rough set theory neuroevolution

GNss gyros.opes:determination of angular velocity and acceleration with very high-rate GNss

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satellite Navigation 2024年第1期5卷 74-90页

作者： yun shi Peiliang Xu Yuanming shu Xiaolin Meng school of Geomatics Xi’an University of Science and TechnologyXi’an710054People’s Republic of China Disaster Prevention Research Institute Kyoto UniversityUjiKyoto611-0011Japan College of Marine Geosciences Ocean University of ChinaQingdaoPeople’s Republic of China school of Instrument science and Engineering Southeast UniversityNanjing210096People’s Republic of China

Although global navigation satellite systems(GNss)have been routinely applied to determine attitudes,there exists no literature on determining angular velocity and/or angular acceleration from *** by the invention of computerized accelerometers.of the corres.ondence author and following the success.of accurately recovering translational velocity and acceleration waveforms from very high-rate GNss precise positioning by Xu and his collaborators in 2021,we propose the concept of GNss gyros.opes and reconstruct angular velocity and acceleration from very high-rate GNss attitudes by applying regularization under the criterion of minimum mean squared *** major results from the experiments can be summarized in the following:(i)angular velocity and acceleration waveforms computed by applying the difference methods to high-rate GNss attitudes are too noisy and can be physically not meaningful and numerically *** same can be said about inertial measurement unit(IMU)attitudes,if IMU gyros are not of very high accuracy;(ii)regularization is successfully applied to reconstruct the high-rate angular velocity and acceleration waveforms from 50 Hz GNss attitudes and significantly outperforms the difference methods,validating the proposed concept of GNss *** comparing the angular velocity and acceleration results by using the difference methods and regularization,we find that the peak values.of angular velocity and acceleration by regularization are much smaller by a maximum factor of 1.57 in the angular velocity to a maximum factor of 8662.53 times in the angular acceleration in the case of high-rate GNss,and by a maximum factor of 1.26 in the angular velocity to a maximum factor of 2819.85 times in the angular acceleration in the case of IMU,respectively;and(iii)the IMU attitudes apparently lead to better regularized angular velocity and acceleration waveforms than the high-rate GNss attitudes,which can well be explained by the fact that the

关键词： Angular velocity Angular acceleration High-rate GNss GNss attitudes GNss gyros.opes Regularization