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Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells

BIOCELL 2022年第3期46卷 677-687页

作者： ABDELKADER HASSANI SITI ASLINA HUSSAIN MOTHANNA SADIQ AL-QUBAISI MOHAMED LAKHDER BELFAR HAKIM BELKHALFA HAMID HAMMAD ENEZEI HAMID ZENTOU wisam nabeel ibrahim ABD ALMONEM DOOLAANEA Department of Pharmaceutical Technology Faculty of PharmacyInternational Islamic University MalaysiaKuantanMalaysia Department of Chemical and Environmental Engineering University Putra MalaysiaSerdang43400Malaysia Department of Chemistry Faculty of Mathematics and Material SciencesUniversity of kasdi MurbahOuarglaAlgeria UPM-MAKNA Cancer Research Laboratory Institute of BioscienceUniversity Putra MalaysiaSerdangMalaysia Scientific and Technical Research Center in Physicochemical Analysis Bou-IsmailTipazaAlgeria Department of Oral&Maxillofacial Surgery College of DentistryUniversity of AnbarRamadiIraq Department of Biomedical Sciences College of Health SciencesQU HealthQatar UniversityDohaQatar Pharmaceutical Research Unit QU HealthQatar UniversityDohaQatar

The main purpose of the study was to enhance the stability and therapeutic effects of Curcumin(Cur)through nanoformulation with gum Arabic(GA)as a coating agent through an efficient synthetic *** antioxidant properties of the developed nanoparticles(Cur/GANPs)were assessed through several in vitro assays,such asβ-carotene bleaching activity,DPPH,and nitric oxide scavenging activities in addition to evaluating its inhibitory activity on angiotensinconverting enzyme(ACE).The cytotoxicity of Cur/GANPs was evaluated in vitro using different types of human cancer cells including breast cancer(MCF7,MDA-MB231),liver cancer(HepG2),and colon cancer(HT29)*** prepared particles displayed an elliptical shape with a size ranging between 20–260 nm and a potential difference of–15 *** Cur/GANPs exhibited significant antioxidant activity compared to free curcumin when using concentrations between 31.5 and 500μg/*** Cur/GANPs also had inhibited the growth of all cancer cell lines in a proportional trend with concentrations ***,the encapsulation with gum Arabic has augmented the antioxidant and anti-neoplastic effects of ***,Cur/GANPs may have effective therapeutic properties in diseases attributed to oxidative stress like cancer and hypertension.

关键词： Curcumin Gum arabic Nanoparticles Cancer cells Antioxidants

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Yield of alarm features in predicting significant endoscopic findings among hospitalized patients with dyspepsia

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World Journal of Gastroenterology 2024年第26期30卷 3210-3220页

作者： Lama ibrahim Maamoun Basheer Tawfik Khoury wisam Sbeit Department of Internal Medicine Galilee Medical CenterNahariya 22001Israel Department of Gastroenterology Galilee Medical CenterNahariya 22001Israel Azrieli Faculty of Medicine Bar-Ilan UniversitySafed 1311502Israel

BACKGROUND Dyspepsia is a very prevalent upper gastrointestinal tract symptoms *** of these symptoms might arise from serious underlying diseases,so the promotion of evidence-based guidelines could potentially better align evaluation and *** To determine the value of alarm features as a predictive factor for significant endoscopic findings(SEFs)among hospitalized patients presenting with *** We conducted a retrospective case-control study including information about 6208 endoscopic procedures performed for hospitalized *** were divided into two groups,with and without SEFs,and compared to elucidate the ability of the different alarm features to predict *** During the study,605 patients fulfilled the inclusion *** the demographics and clinical characteristics of the two groups were compared,tachycardia(P<0.05),normocytic anemia,(P<0.05),leukocytosis(P<0.05),and hypoalbuminemia(P<0.05)documented on admission prior to endoscopy were strong predictors of *** the alarm features,upper gastrointestinal bleeding,persistent vomiting,odynophagia[odds ratio(OR)=3.81,P<0.05;OR=1.75,P=0.03;and OR=7.81,P=0.07,respectively]were associated with *** weight loss was strongly associated with malignancy as an endoscopic finding(OR=2.05;P<0.05).In addition,long-term use of anti-aggregate medications other than aspirin(P<0.05)was correlated to *** Novel predictors of SEFs were elucidated in this *** parameters could be used as an adjunctive in decision making regarding performing upper endoscopy in hospitalized patients with dyspepsia.

关键词： Dyspepsia Endoscopy Weight loss Anti-aggregate medications Persistent vomiting Odynophagia

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A Neuro-Fuzzy Approach to Road Traffic Congestion Prediction

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Computers, Materials & Continua 2022年第10期73卷 295-310页

作者： Mohammed Gollapalli Atta-ur-Rahman Dhiaa Musleh Nehad ibrahim Muhammad Adnan Khan Sagheer Abbas Ayesha Atta Muhammad Aftab Khan Mehwash Farooqui Tahir Iqbal Mohammed Salih Ahmed Mohammed Imran BAhmed Dakheel Almoqbil Majd nabeel Abdullah Omer Department of Computer Information System(CIS) College of Computer Science and Information Technology(CCSIT)Imam Abdulrahman Bin Faisal UniversityDammam31441Saudi Arabia Department of Computer Science(CS) College of Computer Science and Information Technology(CCSIT)Imam Abdulrahman Bin Faisal UniversityDammam31441Saudi Arabia Pattern Recognition and Machine Learning Lab Department of Software EngineeringGachon UniversityInchonKorea Department of Computer Science National College of Business Administration and EconomicsLahorePunjab54000Pakistan Department of Computer Science Government College University(GCU)LahorePunjab54000Pakistan Department of Computer Engineering(CE) College of Computer Science and Information Technology(CCSIT)Imam Abdulrahman Bin Faisal UniversityDammam31441Saudi Arabia College of Business Administration Imam Abdulrahman Bin Faisal UniversityDammam31441Saudi Arabia Department of Networks and Communications(NC) College of Computer Science and Information Technology(CCSIT)Imam Abdulrahman Bin Faisal UniversityDammam31441Saudi Arabia

The fast-paced growth of artificial intelligence applications provides unparalleled opportunities to improve the efficiency of various *** as the transportation sector faces many obstacles following the implementation and integration of different vehicular and environmental aspects *** congestion is among the major issues in this regard which demands serious attention due to the rapid growth in the number of vehicles on the *** address this overwhelming problem,in this article,a cloudbased intelligent road traffic congestion prediction model is proposed that is empowered with a hybrid Neuro-Fuzzy *** aim of the study is to reduce the delay in the queues,the vehicles experience at different road junctions across the *** proposed model also intended to help the automated traffic control systems by minimizing the congestion particularly in a smart city environment where observational data is obtained from various implanted Internet of Things(IoT)sensors across the *** due preprocessing over the cloud server,the proposed approach makes use of this data by incorporating the neuro-fuzzy ***,it possesses a high level of accuracy by means of intelligent decision making with minimum error *** results reveal the accuracy of the proposed model as 98.72%during the validation phase in contrast to the highest accuracies achieved by state-of-the-art techniques in the literature such as 90.6%,95.84%,97.56%and 98.03%,*** far as the training phase analysis is concerned,the proposed scheme exhibits 99.214% accuracy. The proposed prediction modelis a potential contribution towards smart cities environment.

关键词： Neuro-fuzzy machine learning congestion prediction AI cloud computing smart cities

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Assessment of circulating levels of microRNA-326,microRNA-424,and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians

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World Journal of Hepatology 2022年第8期14卷 1562-1575页

作者： Samar Samir Youssef Asmaa Elfiky Mohamed M nabeel Hend ibrahim Shousha Tamer Elbaz Dalia Omran Mohammad Saeed Marie Mohammad A Elzahry Amr Abul-Fotouh Ahmed Hashem Mohamed F Guda Ashraf O Abdelaziz Department of Microbial Biotechnology National Research CentreCairo 1211Egypt Department of Environmental and Occupational Medicine National Research CentreCairo 1211Egypt Department of Endemic Medicine and Hepatogastroenterology Faculty of MedicineCairo UniversityCairo 11562 Egypt Department of Endemic Medicine Faculty of MedicineCairo UniversityCairo 1256Egypt Theodor Bilharz Research Institute Cairo 1256Egypt

BACKGROUND Hepatocellular carcinoma(HCC)is the fifth most common *** expression of microRNAs(miRNAs)-326,miRNA-424,and miRNA-511 has been associated with the diagnosis and prognosis of HCC in different ***,limited information is available regarding their expression in Egyptian HCC *** To assess the role of circulating miRNAs-326,miRNA-424,and miRNA-511 in Egyptian HCC *** This prospective observational study included 70 HCC patients and 25 healthy *** circulating levels of these three miRNAs were evaluated by real-time *** operating characteristic curve analysis was used to test the diagnostic accuracy of micro RNA expression *** All miRNAs were differentially expressed in HCC patients;miRNAs326 and miRNA-424 were upregulated,while miRNA-511 was *** miRNA-326 and miRNA-424 showed sensitivity and specificity of 97%,71.4%,and 52%,60%,respectively,to differentiate HCC from ***,miRNA-326 was associated with survival and could differentiate between Child grades(A vs B);miRNA-424 significantly differentiated early vs intermediate stages of HCC;while miRNA-511 was significantly correlated with response to modified Response Evaluation Criteria in Solid Tumors(m RECIST).CONCLUSION We conclude that miRNA-326,miRNA-424,and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management.

关键词： Hepatocellular carcinoma miRNAs-326 miRNA-424 miRNA-511 Modified response evaluation criteria in solid tumors

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3D Multi-gate Transistors： Concept, Operation, and Fabrication

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Journal of Electrical Engineering 2015年第1期3卷 1-14页

作者： Nader Shehata Abdel-Rahman Gaber Ahmed Naguib Ayman E. Selmy Hossam Hassan ibrahim Shoeer Omar Ahmadien Rewan nabeel Department of Engineering Mathematics and Physics Faculty of Engineering Alexandria University Alexandria 21544 Egypt CSNP (Center of Smart Nanotechnology and Photonics) Smart CI Research Center Alexandria University Alexandria 21544Egypt Department of Electrical Engineering Faculty of Engineering Alexandria University Alexandria 21544 Egypt School of Sciences and Engineering the American University in Cairo P.O. Box 74 New Cairo 11835 Egypt

The multi-gate transistors such as Fin-FETs, Tri-gate FETs, and Gate-all-around （GAA） FETs are remarkable breakthrough in the electronic industry. 3D Transistor is taking the place of the conventional 2D planar transistor for many reasons. 3D transistors afford more scalability, energy efficient performance than planar transistors and increase the control on the channel region to reduce the short channel effect, which enables us to extend Moore＇s law to further extent. In this paper, we will present a review about their structure, operation, types and fabrication.

关键词： Fin-FET transistor fabrication.

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