检索结果-南通市图书馆

Oncology Research 2024年第6期32卷 1093-1107页

作者： ZHILI ZHUO DONGNI ZHANG wenping lu XIAOQING WU YONGJIA CUI WEIXUAN ZHANG MENGFAN ZHANG Department of Oncology China Academy of Chinese Medical Sciences Guang’anmen HospitalBeijingChina

Breast cancer is the leading cause of cancer-related deaths in women worldwide,with Hormone Receptor(HR)+being the predominant ***(TAM)serves as the primary treatment for HR+breast ***,drug resistance often leads to recurrence,underscoring the need to develop new therapies to enhance patient quality of life and reduce recurrence ***(ART)has demonstrated efficacy in inhibiting the growth of drug-resistant cells,positioning art as a viable option for counteracting endocrine *** study explored the interaction between artemisinin and tamoxifen through a combined approach of bioinformatics analysis and experimental *** characterized genes(ar,cdkn1a,erbb2,esr1,hsp90aa1)and seven drug-disease crossover genes(cyp2e1,rorc,mapk10,glp1r,egfr,pgr,mgll)were identified using WGCNA crossover *** functional enrichment analyses were *** findings confirm a significant correlation between key cluster gene expression and immune cell infiltration in tamoxifen-resistant and-sensitized ***-seq analysis revealed high expression of key cluster genes in epithelial cells,suggesting artemisinin’s specific impact on tumor cells in estrogen receptor(ER)-positive BC *** target docking and in vitro experiments with artemisinin on LCC9 cells demonstrated a reversal effect in reducing migratory and drug resistance of drug-resistant cells by modulating relevant drug resistance *** results indicate that artemisinin could potentially reverse tamoxifen resistance in ER-positive breast cancer.

关键词： Artemisinin Tamoxifen resistance Breast cancer

益气活血解毒方治疗铂类耐药卵巢癌患者的作用机制探究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国医药 2024年第5期19卷 654-658页

作者：吴晓晴卢雯平中国中医科学院广安门医院肿瘤科北京100053

目的探究益气活血解毒方治疗铂类耐药卵巢癌(PROC)患者的作用机制。方法选取2022年9月至2023年3月就诊于中国中医科学院广安门医院肿瘤科门诊的PROC患者12例,根据治疗方式不同,将患者分为中医组和对照组,各6例。对照组接受医师选择的方... 详细信息

目的探究益气活血解毒方治疗铂类耐药卵巢癌(PROC)患者的作用机制。方法选取2022年9月至2023年3月就诊于中国中医科学院广安门医院肿瘤科门诊的PROC患者12例,根据治疗方式不同,将患者分为中医组和对照组,各6例。对照组接受医师选择的方案,中医组在接受医师选择的方案的基础上接受益气活血解毒方治疗。采集外周血,提取外周血中RNA,质控合格后逆转录并纯化cDNA,使用Illumina测序平台进行转录组测序,使用DESeq2软件筛选2组的差异长链非编码RNA(lncRNA)和差异表达基因(DEG),使用顺式调控的方式预测lncRNA作用的靶基因,将预测靶基因与测序DEG结果取交集,得出重要靶基因和调控它们的lncRNA,进行基因本体论、京都基因与基因组百科全书和蛋白质相互作用网络(PPI)分析。结果溶质运载家族3成员2(SLC3A2)、BCL2样蛋白11(BCL2L11)是可能由益气活血解毒方调控的重要靶基因,它们由lncRNA SNHG1、MIR4435-2HG、AC108463.3调控。益气活血解毒方调控的DEG在细胞代谢、细胞自噬、蛋白-DNA结合功能中富集。血管内皮生长因子受体信号通路、凋亡、自噬、癌症中胆碱代谢、哺乳动物雷帕霉素靶蛋白信号通路中富集。PPI发现益气活血解毒方以调控具有凋亡、细胞代谢、DNA修复功能的蛋白为主,以及经典的致癌蛋白肉瘤基因、丝裂原活化蛋白激酶3等。结论益气活血解毒方治疗PROC患者的靶点是由lncRNA SNHG1、MIR4435-2HG、AC108463.3调控的SLC3A2、BCL2L11,从而调控了癌细胞的程序性死亡等生物学行为和癌症的经典通路。

关键词：卵巢癌转录组测序铂类耐药益气活血解毒方

疏肝调神法治疗原发性乳腺癌合并广泛性焦虑障碍的随机对照研究

在线全文

学校读者我要写书评

暂无评论

北京中医药大学学报 2024年第2期47卷 277-287页

作者：梅荷婷卢雯平常磊吴晓晴崔永佳北京中医药大学北京100029 中国中医科学院广安门医院肿瘤科

目的评价疏肝调神法治疗原发性乳腺癌合并广泛性焦虑障碍患者的临床疗效与安全性,探索其免疫机制。方法采用随机对照研究,纳入2022年8月—2023年2月就诊于中国中医科学院广安门医院符合纳入标准的患者,按照随机原则1∶1∶1分为中药组(n=... 详细信息

目的评价疏肝调神法治疗原发性乳腺癌合并广泛性焦虑障碍患者的临床疗效与安全性,探索其免疫机制。方法采用随机对照研究,纳入2022年8月—2023年2月就诊于中国中医科学院广安门医院符合纳入标准的患者,按照随机原则1∶1∶1分为中药组(n=30)、耳针组(n=30)和对照组(n=28)。对照组仅接受西医规范治疗,中药组在西医规范治疗基础上给予疏肝调神加减方,耳针组在西医规范治疗基础上给予疏肝调神耳针疗法。疗程8周。评价治疗前后3组间汉密尔顿焦虑量表(HAMA)、焦虑自评量表(SAS)、世界卫生组织生活质量测定简表(WHOQOL⁃BREF)评分的变化,以及免疫指标白细胞介素(IL)⁃1β、IL⁃8、IL⁃10、IL⁃6、IL⁃2、IL⁃4、干扰素⁃γ(IFN⁃γ)、肿瘤坏死因子⁃α(TNF⁃α)含量的变化。计算3组治疗后HAMA评分减分率,比较总有效率。结果治疗后,中药组、耳针组HAMA、SAS、WHOQOL⁃BREF家庭摩擦得分均低于治疗前,WHOQOL⁃BREF生理领域、社会关系领域、环境领域、自评分得分均高于治疗前(P<0.05)。3组治疗后HAMA,SAS,WHOQOL⁃BREF生理领域、社会关系领域、环境领域、自评分、家庭摩擦得分差异有统计学意义(P<0.05)。中药组HA⁃MA、SAS、WHOQOL⁃BREF家庭摩擦得分低于对照组,WHOQOL⁃BREF生理领域、社会关系领域、环境领域、自评分得分高于对照组(P<0.05);耳针组HAMA、SAS得分低于对照组,WHOQOL⁃BREF生理领域、社会关系领域、环境领域得分高于对照组(P<0.05);中药组与耳针组治疗后各量表得分比较差异均无统计学意义。中药组治疗后IL⁃1β、IL⁃8、IL⁃10、IL⁃2、IFN⁃γ、TNF⁃α含量低于治疗前(P<0.05),耳针组治疗前后差异无统计学意义。中药组HAMA量表总有效率为83.3%,耳针组为76.7%,对照组为10.7%,3组比较差异有统计学意义(P<0.05);中药组、耳针组HAMA量表总有效率比较差异无统计学意义。结论疏肝调神中医疗法,包括方剂和耳针,均可以有效缓解乳腺癌患者的焦虑情绪,提升生活质量,且安全、无不良反应,具有一定的临床价值。

关键词：疏肝调神法乳腺癌焦虑耳针

在线全文

学校读者我要写书评

暂无评论

中医全程管理卵巢癌思路探析

中国中医药信息杂志 2024年第5期31卷 157-161页

作者：张炜玄姜奕慈卢雯平宋清雅中国中医科学院广安门医院北京100053 北京核工业医院北京100045

卵巢癌的中医全程管理从未病先防、既病防变2个角度出发。预防方面审病求因、把握摄生,避寒、畅情志、调整生活方式;急病阶段从围手术期与化疗期不同的不良反应入手,急治其标以改善症状、减毒增效;维持治疗阶段治病求本,辨证论治,以提... 详细信息

卵巢癌的中医全程管理从未病先防、既病防变2个角度出发。预防方面审病求因、把握摄生,避寒、畅情志、调整生活方式;急病阶段从围手术期与化疗期不同的不良反应入手,急治其标以改善症状、减毒增效;维持治疗阶段治病求本,辨证论治,以提高患者生存质量,延长生存期。本文分阶段探讨中医全程管理卵巢癌思路,并附验案一则。

关键词：卵巢癌中医药全程管理

同方期刊数据库

益气活血解毒法促进卵巢癌由“冷”向“热”转化基于免疫-炎性微环境的理论探讨分析

在线全文

学校读者我要写书评

暂无评论

中国医药 2024年第5期19卷 649-653页

作者：梅荷婷卢雯平姜奕慈宋清雅常磊中国中医科学院广安门医院肿瘤科北京100053 北京核工业医院中医科北京100053

卵巢癌是致死率高居首位的妇科恶性肿瘤,探索有效的治疗方法预防转移成为亟待解决的临床难题。免疫治疗是肿瘤治疗的新视野,然而卵巢癌由于普遍缺乏细胞毒性T细胞的浸润,并且浸润的T细胞并不能识别所有的肿瘤抗原,属于“冷肿瘤”范畴,... 详细信息

卵巢癌是致死率高居首位的妇科恶性肿瘤,探索有效的治疗方法预防转移成为亟待解决的临床难题。免疫治疗是肿瘤治疗的新视野,然而卵巢癌由于普遍缺乏细胞毒性T细胞的浸润,并且浸润的T细胞并不能识别所有的肿瘤抗原,属于“冷肿瘤”范畴,对免疫治疗并不敏感。中医认为气虚血瘀毒浊是卵巢癌的关键病机,益气活血解毒法是重要治法,有必要在理论研究上进一步阐明。免疫抑制和慢性炎症构成肿瘤微环境两大核心特征,共同促进肿瘤发生、发展及转移。本文分析了免疫-炎性微环境与中医“阴阳”“毒邪”理论的高度契合性:阳化气不足,如同正性免疫细胞如细胞毒性T细胞不足;阴成形太过,一方面,如同过多的免疫抑制性细胞、因子、代谢产物浸润,另一方面,如同人体的因虚致毒,维持并放大了炎性微环境,炎症促进肿瘤进展,炎症反过来又可促进免疫抑制。从免疫-炎症的角度阐明该法的治疗思路:“温阳扶正,平衡阴阳”以激活正性免疫;“活血、化痰、散寒、清热”以驱散阴邪,解化毒滞,从而缓解免疫抑制,调控炎性微环境;“以毒攻毒”以抗炎治疗,完善了该法转化“冷”“热”免疫原性的理论基础,为进一步物质研究提供理论依据。

关键词：卵巢癌益气活血解毒法冷肿瘤免疫-炎性微环境中医

Precipitates Generation Mechanism and Surface Quality Improvement for Aluminum Alloy 6061 in Diamond Cutting

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 150-159页

作者：王海龙 DENG wenping 王素娟 State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Key Laboratory of Micro-Nano Manufacturing Technology and Equipment School of Electromechanical EngineeringGuangdong University of TechnologyGuangzhou 510006China

To improve the surface quality for aluminum alloy 6061(Al6061) in ultra-precision machining, we investigated the factors affecting the surface finish in single point diamond turning(SPDT)by studying influence of the precipitates generation of Al6061 on surface integrity and surface *** on the Johnson-Mehl-Avrami solid phase transformation kinetics equation, theoretical and experimental studies were conducted to build the relationship between the aging condition and the type, size and number of the precipitates for Al6061. Diamond cutting experiments were conducted to machine Al6061 samples under different aging conditions. The experimental results show that, the protruding on the chip surface is mainly Mg_(2)Si and the scratches on the machined surface mostly come from the iron-containing phase(α-, β-AlFeSi).Moreover, the generated Mg_(2)Si and α-, β-AlFeSi affect the surface integrity and the diamond turned surface roughness. Especially, the achieved surface roughness in SPDT is consistent with the variation of the number of AlFeSi and Mg_(2)Si with the medium size(more than 1 μm and less than 2 μm) in Al6061.

关键词： Al6061 precipitates aging treatment diamond cutting surface roughness

A BBS4 mutation causes autosomal dominant polycystic liver disease

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 72-75页

作者： Yalu Cui wenping Xu Jinpei Liu Shuqing Liu Wei Huang Yihai Shi Xin Zhang Cuihua lu Weifen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Gastroenterology Gongli Hospital of Shanghai Pudong New AreaShanghai 200135China Department of Gastroenterology Affiliated Hospital of Nantong UniversityNantong UniversityNantongJiangsu 226001China

Autosomal dominant polycystic liver disease(ADPLD)refers to a condition characterized by the presence of numerous cholangiocytes-lined and fluid-filled cysts in the liver and the absence of polycystic kidney disease.1 Although patients with ADPLD may be asymptomatic,some patients suffer from abdominal pain,gastroesophageal reflux,and nausea,because of hepatomegaly.

关键词： liver polycystic patients

Study of 160 breast cancer patients with distant metastasis after operation by way of TCM syndromes classification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Chinese-German Journal of Clinical Oncology 2007年第1期6卷 59-61页

作者： wenping lu Hongsheng Lin Department of Oncology Guang＇anmen Hospital TCM Academy Beijing 100053 China

Objective: To discuss the relationship between the postoperative breast cancer with distant metastasis and the TCM syndromes classification. Methods: 160 postoperative 5-year breast cancer patients from 1995 to 2000 were tracked, summed up and analysized TCM syndromes as stagnation of hepatic qi, deficiency of spleen and pathogenic phlegm reten- tion, blood stasis and toxin stagnation, deficiencies of both blood and qi. Results: (1) For blood stasis and toxin stagnation TCM syndrome, the metastatic rate raised to 45% during 5 years. However, the metastatic rates of other three TCM syn- dromes are 15%, 17.5% and 22.5% respectively. The general distant metastasis rate was 27.5% (P0.05). Conclu- sion: (1) TCM syndrome classification has close relation with breast cancer distant metastasis. Distant metastasis have close relationship with blood stasis and toxin stagnation syndrome. (2) Lymph node metastasis, tumor size, Her-2 and its receptor have no obvious relation with TCM syndromes classification, which suggested that metastatic ability has been programmed in the early stage of carcinoma initiation. (3) Significantly enlightening for predict the prognosis under the guide of TCM syn- drome classification and take right therapeutic strategy: attack pathogen and activate blood circulation against cancer.

关键词：乳腺癌患者手术后远部转移 TCM症候分类病例报告

Polymer: Non-fullerene acceptor heterojunction-based phototransistor for short-wave infrared photodetection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 3087-3095页

作者： Jing Li Weigang Zhu Yang Han Yanhou Geng wenping Hu Key Laboratory of Organic Integrated Circuits of Ministry of Education&Key Laboratory of Molecular Optoelectronic Sciences School of Science&Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin UniversityTianjin 300072China Key Laboratory of Organic Integrated Circuits of Ministry of Education&Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300072China

It remains full of challenge for extending short-wave infrared(SWIR)spectral response and weak-light detection in the context of broad spectral responses for *** this work,a novel poly(2,5-bis(4-hexyldodecyl)-2,5-dihydro-3,6-di-2-thienyl-pyrrolo[3,4-c]pyrrole-1,4-dione-alt-thiophene)(PDPPT3-HDO):COTIC-4F organic bulk-heterojunction is prepared as active layer for bulk heterojunction ***3-HDO serves as a hole transport material,while COTIC-4F enhances the absorption of SWIR light to 1020 *** a result,smooth and connected PDPPT3-HDO film is fabricated by blade coating method and exhibits high hole mobility up to 2.34 cm^(2)·V^(-1)·s^(-1) with a current on/off ratio of 4.72×10^(5) in organic thin film ***3-HDO:COTIC-4F heterojunction phototransistors exhibit high responsivity of 2680 A·W^(-1) to 900 nm and 815 A·W^(-1) to 1020 nm,with fast response time(rise time~20 ms and fall time~100 ms).The photosensitivity of the heterojunction phototransistor improves as the mass ratio of non-fullerene acceptors increases,resulting in an approximately two orders of magnitude enhancement compared to the bare polymer ***,the phototransistor exhibits decent responsivity even under ultra-weak light power of 43μW·cm^(-2) to 1020 *** work represents a highly effective and general strategy for fabricating efficient and sensitive SWIR light photodetectors.

关键词： photodetection phototransistor organic semiconductor heterojunction non-fullerene acceptor

基于癌毒性质及强弱探析中医分型论治乳腺癌临床思路

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国中医药信息杂志 2024年第8期31卷 176-181页

作者：卓至丽宋清雅卢雯平吴晓晴崔永佳张冬妮常磊梅荷婷中国中医科学院广安门医院北京100053 北京中医药大学研究生院北京100029

癌毒是导致乳腺癌异质性的特异病机。癌毒的性质和毒力的强弱变化决定了乳腺癌异质性的差异变化,其可随时间、空间动态演变,表现为肿瘤的侵袭能力和侵袭特点不一致。原发灶的癌细胞具备靶向特定脏腑转移的“毒性”,癌毒可影响不同分型... 详细信息

癌毒是导致乳腺癌异质性的特异病机。癌毒的性质和毒力的强弱变化决定了乳腺癌异质性的差异变化,其可随时间、空间动态演变,表现为肿瘤的侵袭能力和侵袭特点不一致。原发灶的癌细胞具备靶向特定脏腑转移的“毒性”,癌毒可影响不同分型乳腺癌的转移嗜性。基于癌毒理论的乳腺癌治疗策略强调全程攻伐癌毒,重在辨癌毒强弱和性质,先安未受邪之地,以证为态,识态定靶,以对抗源自肿瘤内异质性的阻力。文章旨在为不同分型乳腺癌的治疗策略提供新的理论基础。

关键词：乳腺癌癌毒分型论治异质性临床思路