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Chinese Chemical Letters 2003年第8期14卷 790-793页

作者： Xin Yong LIU wen Fang xu Jing De WU School of Pharmacy Shandong UniversityJinan 250012

A series of novel 3-alkylthio-4-arylideneamino-5-(2-furyl)-1, 2, 4-triazole derivatives were synthesized. Their chemical structures were confirmed with elemental analysis and spectral data. Endothelin(ET) receptor c... 详细信息

关键词： Triazole derivatives ET antagonist.

Transcriptional regulation of wheat VER2 promoter in rice in response to abscisic acid,jasmonate,and light

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Journal of Genetics and Genomics 2009年第6期36卷 371-377页

作者： Hong Feng wen-Zhong xu Hong-Hui Lin Kang Chong College of Life Science Sichuan University Chendu 610064 China Research Center of Molecular and Developmental Biology Key Laboratory of Photosynthesis and Environmental Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China Sichuan College of Education Chengdu 610041 China

VER2 is a key gene associated with vernalization process in winter wheat. The expression of VER2 can be induced by low temperature treatment. To further understand how the expression of this gene is mediated by various external and internal factors, different lengths of the VER2 promoter region have been transcriptionally fused with a reporter gene, green fluorescence protein （GFP）, and transformed into the model plant, rice （Oryza sativa L.）. Using confocal and Western blot analyses, we determined several possible response elements in the promoter region, which could sense ABA, JA, and other environmental cues.

关键词： VER2 promoter ABA JA

Fractional squeezing-Hankel transform based on the induced entangled state representations

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Chinese Physics B 2018年第9期27卷 301-305页

作者： Cui-Hong Lv Su-Qing Zhang and wen xu Faculty of Science Jiangsu UniversityZhenjiang 212013China

Based on the fact that the quantum mechanical version of Hankel transform kernel（the Bessel function） is just the transform between ｜q, r〉 and（s, r′｜, two induced entangled state representations are given, and working with them we derive fractional squeezing-Hankel transform（FrSHT） caused by the operator e（-iα）（a1-a-2-＋a-1a-2）e-（-iπa2-a2）, which is an entangled fractional squeezing transform operator. The additive rule of the FrSHT can be explicitly proved.

关键词： induced entangled state representation entangled fractional squeezing transform fractional squeezing-Hankel transform

Robust time reversal focusing based on Maximin criterion in a waveguide with uncertain water depth

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Science China(Physics,Mechanics & Astronomy) 2013年第10期56卷 1822-1832页

作者： PAN Xiang WANG Nan ZHANG JiangFan xu wen GONG XianYi Department of Information Science and Electronic Engineering Zhejiang University Hangzhou Applied Acoustic Research Institute

Time reversal processing （TRP） might be regarded as matched field processing with known environmental knowledge. However, the performance of TRP is degraded in an uncertain environment. A technique based on the Maximin criterion is pro- posed for enhancing the robustness of TRP in a waveguide with uncertain water depth. The relationship between the water depth and the focal spot translation is examined based on the waveguide-invariant theory. Then the time reversal transmissiou scheme with the Maximin criterion is performed to maximize the minimum transmission power on a target of interest. At the receiving end, coherent summation operation is carried out over the received data by a reception focusing bank. If it is neces- sary to enhance the target echo further, the iterative time reversal can be considered where the target echo corresponding to the first time reversal transmission is regarded as a secondary source. Numerical simulations and experimental results of the target localization in a waveguide tank have verified the effectiveness of robust TRP.

关键词： robustness time reversal processing uncertain water depth waveguide sonar

Synthesis and Properties of pH and Temperature Responsive Copolymer with Pesudorotaxane Structure

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Chemical Research in Chinese Universities 2012年第6期28卷 1101-1106页

作者： MA Qiang YANG Hui xu wen-chao TAN Ye-bang Key Laboratory of Special Functional Aggregated Materials Ministry of EducationSchool of Chemistry and Chemical Engineering Shandong University Jinan 250100 P. R. China

pH and temperature responsive copolymers PNAM4VBCB of N-isopropyl acrylamide（NAM） and complex pseudorotaxane monomer N 1-（4-vinylbenzyl）-1,4-diaminobutane dihydrochloride with cucurbit[6]uril（CB[6]） threaded（4VBCB） were prepared via free-radical polymerization in aqueous *** copolymers were characterized by 1 H NMR,Fourier transform infrared（FTIR） spectrometry,elemental analysis,and static light *** thermodynamic properties of the copolymers were studied by thermogravimetric analysis（TGA）,and the effects of pH and the concentration of the copolymer on the average hydrodynamic radius（R h） were studied by dynamic light scattering（DLS）.In addition,the thermal sensitivities of the copolymers were studied by DLS and *** experiment data show that CB[6] beads are localized on 1,4-diaminobutane units in the side chains of the *** data show that thermal stability of the copolymers increases with the adding of CB[6] threaded because of the enhanced rigidity and the bulky steric hindrance of 4VBCB in the side chain of *** data show that the average hydrodynamic radius of copolymer increases with the increase of the copolymer concentration and has a jump with adjusting pH due to the existing of the small size CB[6] dethreaded from the copolymer with increasing *** pH and electrical conductivity curves of the solution of PNAM4VBCB-4 have a jump because CB[6] could dethread from the copolymers with the addition of *** addition,the copolymers have thermal sensitivity and their phase-change temperatures could be controlled by adjusting the molar ratio of NAM to 4VBCB in the copolymers.

关键词： Cucurbituril Thermal sensitivity Water soluble copolymer Polypseudorotaxane

320-fold luminescence enhancement of [Ru(dpp)3]Cl2 dispersed on PMMA opal photonic crystals and highly improved oxygen sensing performance

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Light(Science & Applications) 2014年第1期3卷 53-61页

作者： Pingwei Zhou Donglei Zhou Li Tao Yongsheng Zhu wen xu Sai xu Shaobo Cui Lin xu Hongwei Song State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China College of Physics Jilin UniversityChangchun 130012China

Ru complexes([Ru(dpp)3]Cl2)were spin coated on poly(methyl methacrylate)(PMMA)opal photonic crystals(PhCs),and a,320-fold luminescence enhancement was observed compared to that on glass,which is the largest luminescence enhancement of dye molecules by the modulation of three-dimensional(3D)PhCs reported until *** enhancement mechanism was carefully examined and it was shown that the luminescence of[Ru(dpp)3]Cl2 depended on the molecule concentration and *** can be concluded that the suppressed non-radiative relaxation among the molecules and the field enhancement both contribute significantly to the luminescence *** PMMA PhC/Ru complex composites were then tested for their intracellular oxygen sensing and cell imaging properties;these composites effectively improved the limit of detection(LOD)and the brightness of the cell images.

关键词： cell imaging fluorescence enhancement oxygen sensing photonic crystals

Intracavity Optical Deposition of Graphene Saturable Absorber for Low-Threshold Passive Mode-Locking of a Fiber Laser

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Chinese Physics Letters 2013年第2期30卷 121-123页

作者： LUO Zhi-Chao CAO wen-Jun LUO Ai-Ping xu wen-Cheng Laboratory of Nanophotonic Functional Materials and Devices School of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006

A compact,intracavity optical deposition of graphene saturable absorber(SA)for low-threshold passively mode-locked fiber laser is proposed and *** optical deposition is implemented in the laser cavity by using a slot *** the fabricated graphene SA,the fiber laser achieves self-starting,passively mode-locked operation at a low threshold of 32 mW pump power,delivering a 13.1-MHz 2.36-ps pulse train.

关键词： passive fiber laser

3D Graphene Nanosheets Crosslinked Core-Shell FeS_(2)@N,S Co-Doped Porous Carbon for Improved Lithium/Sodium Storage Performance

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Acta Metallurgica Sinica(English Letters) 2024年第10期37卷 1680-1688页

作者： Liang Chen Lan-Yun Yang Li-Ying Hu xu Liu Chen-Xi xu Ying Liu Wei Wang wen-Yuan xu Zhao-Hui Hou Key Laboratory of Hunan Province for Advanced Carbon-Based Functional Materials School of Chemistry and Chemical EngineeringHunan Institute of Science and TechnologyYueyang414006China College of Materials Science and Engineering Central South University of Forestry and TechnologyChangsha410004China

Transition metal sulfides(TMS)hold great promise as anode materials for Li^(+)/Na^(+)***,their practical application still faces several challenges,such as inadequate electrical conductivity,substantial volume changes and a propensity for *** tackle these challenges,a 3D composite structure composed of graphene nanosheets crosslinked core−shell FeS_(2)@N,S co−doped porous carbon(FeS_(2)@NSC/GNs)is created by combining self−template polymerization with the graphene encapsulation *** characterization and analysis demonstrate the effectiveness of the self−template polymerization strategy in generating a porous core−shell structure,which facilitates the uniform dispersion and optimal contact of the FeS_(2) core within the carbon ***,the integration of graphene,alongside the porous carbon shell,introduces a sophisticated dual−protection mechanism against volume expansion and undesirable FeS_(2) ***,the resulting 3D architecture enables efficient electron/ion transport and provides abundant sites for Li^(+)/Na^(+)*** these inherent benefits,the FeS_(2)@NSC/GNs composite exhibits significantly improved lithium/sodium storage performance in comparison to the ***,our proposed approach offers valuable guidance for the construction of advanced anodes for lithium/sodium−ion batteries.

关键词： Transition metal sulfides Self-template polymerization Graphene encapsulation Porous core-shell structure Lithium/sodium storage performance

KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer

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Acta Pharmaceutica Sinica B 2023年第10期13卷 4217-4233页

作者： Cancan Zheng Xiaomei Yu Taoyang xu Zhichao Liu Zhili Jiang Jiaojiao xu Jing Yang Guogeng Zhang Yan He Han Yang Xingyuan Shi Zhigang Li Jinbao Liu wen wen xu Key Laboratory of Biological Targeting Diagnosis Therapy and Rehabilitation of Guangdong Higher Education Institutesthe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University.Shanghai 200030China Department of Radiation Oncology the Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Thoracic Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China Guangdong Provincial Key Laboratory of Protein Modification and Degradation State Key Laboratory of Respiratory Diseaseand School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhou 511495China

Increasing evidences suggest the important role of calcium homeostasis in hallmarks of cancer,but its function and regulatory network in metastasis remain unclear.A comprehensive investigation of key regulators in cancer metastasis is urgently *** sequencing(RNA-seq)of primary esophageal squamous cell carcinoma(ESCC)and matched metastatic tissues and a series of gain/loss-of-function experiments identified potassium channel tetramerization domain containing 4(KCTD4)as a driver of cancer ***4 expression was found upregulated in metastatic *** KCTD4 expression is associated with poor prognosis in patients with ESCC and contributes to cancer metastasis in vitro and in ***,KCTD4 binds to CLIC1 and disrupts its dimerization,thus increasing intracellular Ca^(2+)level to enhance NFATc1-dependent fibronectin ***4-induced fibronectin secretion activates fibroblasts in a paracrine manner,which in turn promotes cancer cell invasion via MMP24 signaling as positive ***,a lead compound K279-0738 significantly suppresses cancer metastasis by targeting the KCTD4-CLIC1 interaction,providing a potential therapeutic *** together,our study not only uncovers KCTD4 as a regulator of calcium homeostasis,but also reveals KCTD4/CLIC1-Ca^(2+)-NFATc1-fibronectin signaling as a novel mechanism of cancer *** findings validate KCTD4 as a potential prognostic biomarker and therapeutic target for ESCC.

关键词： Cancermetastasis Calcium homeostasis NFAT signaling Fibroblasts Esophageal cancer

Current status of human adenovirus infection in China

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World Journal of Pediatrics 2022年第8期18卷 533-537页

作者： Nai‑Ying Mao Zhen Zhu Yan Zhang wen‑Bo xu NHC Key Laboratory of Medical Virology and Viral Diseases WHO WPRO Regional Reference Laboratory of Measles and RubellaChinese Center for Disease Control and PreventionMeasles Laboratory in National Institute for Viral Disease Control and Prevention155#Changbai RoadChangping DistrictBeijing 102206China

Background Outbreaks of severe,acute hepatitis among children have recently attracted global *** pathogen causing the outbreak remains unknown,but there is growing evidence that it may be associated with human adenovirus(HAdV).Data sources A review of adenovirus-related clinical studies,epidemiological studies,etiological studies,and case reports was conducted by reviewers *** HAdV can cause a wide variety of clinical *** the Mainland of China,HAdV infection accounts for 5.8%–13%of patients with acute respiratory infections,and these infections are mainly caused by species B,C,and E of *** acute conjunctivitis,39.8%–74.9%of sporadic cases were infected by B and D species of *** of keratoconjunctivitis and pharyngoconjunctival fever related to HAdV infection could be found throughout the *** pediatric patients with acute gastroenteritis,HAdV-41 was the predominant HAdV type,followed by HAdV species B and *** types of HAdV,including HAdV-5,HAdV-7,HAdV-1,and HAdV-2,have previously been reported as potential pathogens associated with HAdV hepatitis in immunocompromised ***,few HAdV-related hepatitis cases have been reported in China to *** There are no systematic surveillance and clinical studies on HAdV hepatitis in ***,it is imperative to establish a nationwide HAdV virological surveillance system to collect relevant clinical,epidemiological and virological surveillance data and risk factor information as soon as possible to assess the potential risk of HAdV hepatitis among children.

关键词： Acute respiratory tract infections Conjunctivitis Gastroenteritis Human adenovirus Hepatitis Unknown etiology