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Selection of Heat Treatment Process and Wear Mechanism of High Wear Resistant Cast Hot-Forging Die Steel

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Journal of Iron and Steel Research International 2012年第5期19卷 50-57页

作者： wei min-xian wang shu-qi wang lan CUI xiang-hong chen kang-min School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

Dry sliding wear tests of a Cr-Mo-V cast hot-forging die steel was carried out within a load range of 50--300 N at 400℃ by a pin-on-disc high temperature wear machine. The effect of heat treatment process on wear resistance was systematically studied in order to select heat treatment processes of the steel with high wear resistance. The morphology, structure and composition were analyzed using scanning electron microscopy （SEM）, X-ray diffraction （XRD） and energy dispersive spectroscopy （EDS） ; wear mechanism was also discussed. Tribo-oxide layer was found to form on worn surfaces to reduce wear under low loads, but appear inside the matrix to increase wear under high loads. The tribo-oxides were mainly consisted of Fe3O4 and Fe2O3, FeO only appeared under a high load. Oxidative mild wear, transition of mild-severe wear in oxidative wear and extrusive wear took turns to operate with increasing the load. The wear resistance strongly depended on the selection of heat treatment processes or microstructures. It was found that bainite presented a better wear resistance than martensite plus bainite duplex structure, martensite structure was of the poorest wear resistance. The wear resistance increased with increasing austenizing temperature in the range of 920 to 1 120 ℃, then decreased at up to 1 220 ℃. As for tempering temperature and microstructure, the wear resistance increased in following order： 700℃ （tempered sorbite）, 200 ℃ （tempered martensite）, 440 to 650 ℃ （tempered troostite）. An appropriate combination of hardness, toughness, microstructural thermal stability was re- quired for a good wear resistance in high-temperature wear. The optimized heat treatment process was suggested for the cast hot-forging steel to be austenized at 1020 to 1 120 ℃, quenched in oil, then tempered at 440 to 650℃ for 2 h.

关键词： cast hot-forging die steel heat treatment process high-temperature wear mechanism wear behavior microstructure

Wear Behavior and Mechanism of Spheroidal Graphite Cast Iron

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Journal of Iron and Steel Research International 2013年第10期20卷 81-86页

作者： YANG Zi-run LI Dong-sheng wang lan wang shu-qi wei min-xian School of Materials Engineering Yancheng Institute of Technology School of Materials Science and Engineering Jiangsu University

Wear behavior and mechanism of spheroidal graphite cast iron were studied on a pin on-disk elevated tem- perature wear tester. The phase and morphology of worn surfaces were examined by X ray diffraction and scanning electron microscopy. Results show that with an increase of load, wear rate of spheroidal graphite cast iron gradually increases under low loads, rapidly increases or potentially increases under high loads; wear rate increases with in- creasing ambient temperature. At 25 200 ℃, adhesive wear prevails; oxidative wear and adhesive wear coexist at 400 ℃. As load surpasses 150 N at 400 ℃, extrusive wear appears. The elevated-temperature wear of spheroidal graphite cast iron is a physical and chemical process including the following reactions： xFe＋y/2O2-FexOy , 2C＋ O2- 2CO and Fex Oy ＋yCO-xFe＋yCO2. Hence, at 400 ℃, the amount of graphite and tribo oxides are substan- tially reduced because of reductive function of graphite. It can be suggested that wear reduced effect of graphite and tribo-oxides is impaired.

关键词： spheroidal graphite cast iron wear behavior wear mechanism tribo oxide microstructure

Cytokine release syndrome complicated with rhabdomyolysis after chimeric antigen receptor T-cell therapy:A case report

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World Journal of Clinical Cases 2022年第26期10卷 9398-9403页

作者： lan Zhang wei chen Xiao-min wang shu-qing Zhang Department of Hematology The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROUND Chimeric antigen receptor T-Cell(CAR-T)therapy is an effective new treatment for hematologic *** release syndrome(CRS)and neurologic toxicity are main ***-induced rhabdomyolysis(RM)followed by CART therapy treatment has not been previously *** SUMMARY We report a case of a 22-year-old woman with relapsed acute lymphoblastic leukemia obtained sequential cluster of differentiation(CD)19 and CD22 CAR-T *** patient experienced grade 3 CRS with RM,mild hypotension requiring intravenous fluids,and mild hypoxia and was managed effectively with the IL-6 receptor antagonist *** patient had no signs of immune effector cell-associated neurologic *** scans 30 d postCAR-T therapy demonstrated a complete remission,and the symptoms of muscle weakness improved through *** Myalgia is an easily overlooked symptom of severe CRS after CAR-T *** is necessary to monitor myoglobin levels when a patient presents with symptoms of myalgia or acute renal insufficiency.

关键词： Cytokine release syndrome Rhabdomyolysis Chimeric antigen receptor-T cell therapy Relapsed acute lymphoblastic leukemia Case report

Transgenic plants expressing the AalT/GNA fusion protein show increased resistance and toxicity to both chewing and sucking pests

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Insect Science 2016年第2期23卷 265-276页

作者： shu-min Liu Jie Li Jin-qi Zhu Xiao-wei wang cheng-shu wang shu-Sheng Liu Xue-Xin chen Sheng Li Key Laboratory of Insect Developmental and Evolutionary Biology Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai State Key Laboratory of Rice Biology and ministry of Agriculture Key Laboratory of Agricultural Entomology Institute of Insect Sciences Zhejiang University Hangzhou China

The adoption of pest-resistant transgenic plants to reduce yield losses and de- crease pesticide use has been successful. To achieve the goal of controlling both chewing and sucking pests in a given transgenic plant, we generated transgenic tobacco, Arabidopsis, and rice plants expressing the fusion protein, AalT/GNA, in which an insecticidal scor- pion venom neurotoxin （Androctonus australis toxin, AalT） is fused to snowdrop lectin （Galanthus nivalis agglutinin, GNA）. Compared with transgenic tobacco and Arabidop- sis plants expressing AaIT or GNA, transgenic plants expressing AalT/GNA exhibited increased resistance and toxicity to one chewing pest, the cotton bollworm, Helicoverpa armigera. Transgenic tobacco and rice plants expressing AalT/GNA showed increased resistance and toxicity to two sucking pests, the whitefly, Bemisia tabaci, and the rice brown planthopper, Nilaparvata lugens, respectively. Moreover, in the field, transgenic rice plants expressing AalT/GNA exhibited a significant improvement in grain yield when infested with N. lugens. This study shows that expressing the AalT/GNA fusion protein in transgenic plants can be a useful approach for controlling pests, particularly sucking pests which are not susceptible to the toxin in Bt crops.

关键词： AalT AalT/GNA chewing pest GNA fusion protein pest control resistance sucking pest toxicity transgenic plant

Kai Xin San ameliorates scopolamine-induced cognitive dysfunction

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Neural Regeneration Research 2019年第5期14卷 794-804页

作者： Yu-min Xu Xin-chen wang Ting-Ting Xu Hong-Ying Li Shang-Yan Hei Na-Chuan Luo Hong wang wei Zhao shu-Huan Fang Yun-Bo chen Li Guan Yong-qi Fang Shi-Jie Zhang qi wang wei-Xiong Liang Institute of Clinical Pharmacology Guangzhou University of Chinese Medicine First Affiliated Hospital of Henan University of Chinese Medicine School of Food and Pharmaceutical Engineering Zhaoqing University First Affiliated Hospital of Guangzhou University of Chinese Medicine Department of Neurology The First Affiliated Hospital Guangzhou Medical University Guangdong Provincial Hospital of Chinese Medicine

Kai Xin San(KXS, containing ginseng, hoelen, polygala, and acorus), a traditional Chinese herbal compound, has been found to regulate cognitive dysfunction; however, its mechanism of action is still unclear. In this study, 72 specific-pathogen-free male Kunming mice aged 8 weeks were randomly divided into a vehicle control group, scopolamine group, low-dose KXS group, moderate-dose KXS group, high-dose KXS group, and positive control group. Except for the vehicle control group and scopolamine groups(which received physiological saline), the doses of KXS(0.7, 1.4 and 2.8 g/kg per day) and donepezil(3 mg/kg per day) were gastrointestinally administered once daily for 2 weeks. On day 8 after intragastric treatment, the behavioral tests were carried out. Scopolamine group and intervention groups received scopolamine 3 mg/kg per day through intraperitoneal injection. The effects of KXS on spatial learning and memory, pathological changes of brain tissue, expression of apoptosis factors, oxidative stress injury factors, synapse-associated protein, and cholinergic neurotransmitter were measured. The results confirmed the following.(1) KXS shortened the escape latency and increased residence time in the target quadrant and the number of platform crossings in the Morris water maze.(2) KXS increased the percentage of alternations between the labyrinth arms in the mice of KXS groups in the Y-maze.(3) Nissl and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining revealed that KXS promoted the production of Nissl bodies and inhibited the formation of apoptotic bodies.(4) Western blot assay showed that KXS up-regulated the expression of anti-apoptotic protein Bcl-2 and inhibited the expression of pro-apoptotic protein Bax. KXS up-regulated the expression of postsynaptic density 95, synaptophysin, and brain-derived neurotrophic factor in the cerebral cortex and hippocampus.(5) KXS increased the level and activity of choline acetyltransferase, acetylcholi

关键词： Kai Xin San cognitive dysfunction scopolamine hydrobromide neuroprotection oxidative stress synaptic dysfunction apoptosis cholinergic system dysfunction donepezil neural regeneration

The putative elongator complex protein Elp3 is involved in asexual development and pathogenicity by regulating autophagy in the rice blast fungus

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Journal of Integrative Agriculture 2021年第11期20卷 2944-2956页

作者： ZHANG Li-mei chen shu-ting qi min CAO Xue-qi LIANG Nan LI qian TANG wei LU Guo-dong ZHOU Jie YU Wen-ying wang Zong-hua ZHENG Hua-kun State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Life SciencesFujian Agriculture and Forestry UniversityFuzhou 350002P.R.China Fujian Universities Key Laboratory for Plant–Microbe Interaction College of Life SciencesFujian Agriculture and Forestry UniversityFuzhou 350002P.R.China Meishan Vocational and Technical College Meishan 620010P.R.China Institute of Oceanography Minjiang UniversityFuzhou 350108P.R.China National Engineering Research Center of JUNCAO Technology College of Life SciencesFujian Agriculture and Forestry UniversityFuzhou 350002P.R.China

Autophagy is responsible for maintaining fundamental cellular homeostasis and is,therefore,essential for diverse development *** study reported that PoElp3,the putative catalytic subunit of Elongator complex,is involved in the maintenance of autophagy homeostasis to facilitate asexual development and pathogenicity in the rice blast fungus Pyricularia *** was found that the ΔPoelp3 strains were defective in vegetative growth,conidiation,stress response,and *** mutants exhibited hyper-activated autophagy in the vegetative hyphae under both nutrient-rich and nutrient-deficient *** hyper-activation of autophagy possibly suppressed the production of vegetative hyphae in the ΔPoelp3 ***,the ΔPoelp3 strains were found to be more sensitive to rapamycin during vegetative-and invasive-hyphal growth but have no effect on Target-of-Rapamycin(TOR)signaling *** together,these results demonstrated that PoElp3 is involved in asexual development and pathogenicity by regulating autophagy in the rice blast fungus.

关键词： elongator Elp3 autophagy asexual development pathogenicity Pyricularia oryzae

Microwave-responsive gadolinium metal-organic frameworks nanosystem for MRI-guided cancer thermotherapy and synergistic immunotherapy

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Bioactive Materials 2024年第3期33卷 532-544页

作者： Hao Cui Yu-Yue Zhao qiong Wu Yan You Zhou lan Ke-Long Zou Guo-wang cheng Hao chen Yan-Hua Han Yan chen xiang-Dong qi xian-wei Meng Li-min Ma Guang-Tao Yu Stomatological Hospital School of StomatologySouthern Medical UniversityGuangzhou510280China Medical Research Center Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou510080China Laboratory of Controllable Preparation and Application of Nanomaterials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhou510405China Department of Plastic Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou510280China Department of Endodontics Southern Medical University-Shenzhen Stomatology Hospital(Pingshan)Shenzhen518118China

The clinical application of cancer immunotherapy is unsatisfied due to low response rates and systemic immune-related adverse *** hyperthermia can be used as a synergistic immunotherapy to amplify the antitumor ***,we designed a Gd-based metal-organic framework(Gd-MOF)nanosystem for MRI-guided thermotherapy and synergistic immunotherapy,which featured high performance in drug loading and tumor tissue *** PD-1 inhibitor(aPD-1)was initially loaded in the porous Gd-MOF(Gd/M)***,the phase change material(PCM)and the cancer cell membrane were further sequentially modified on the surface of Gd/MP to obtain Gd-MOF@aPD-1@CM(Gd/MPC).When entering the tumor microenvironment(TME),Gd/MPC induces immunogenic death of tumor cells through microwave thermal responsiveness,improves tumor suppressive immune microenvironment and further enhances anti-tumor ability of T cells by releasing ***,Gd/MPC can be used for contrast-enhanced *** data revealed that the downregulation of MSK2 in cancer cells leads to the downregulation of c-fos and c-jun,and ultimately leads to the apoptosis of cancer cells after *** general,Gd/MPC nanosystem not only solves the problem of system side effect,but also achieves the controlled drug release via PCM,providing a promising theranostic nanoplatform for development of cancer combination immunotherapy.

关键词： Immunotherapy Microwave Metal-organic framework Thermotherapy Cancer imaging

Lorentz transmission electron microscopy studies on topological magnetic domains

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Chinese Physics B 2018年第6期27卷 47-61页

作者： Li-Cong Peng Ying Zhang shu-lan Zuo min He Jian-wang Cai Shou-Guo wang Hong-xiang wei Jian-qi Li Tong-Yun Zhao Bao-Gen Shen Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

Lorentz transmission electron microscopy（TEM） is a powerful tool to study the crystal structures and magnetic domain structures in correlation with novel physical properties. Nanometric topological magnetic configurations such as vortices, bubbles, and skyrmions have received enormous attention from the viewpoint of both fundamental science and potential applications in magnetic logic and memory devices, in which understanding the physical properties of magnetic nanodomains is essential. In this review article, several magnetic imaging methods in Lorentz TEM including the Fresnel and Foucault modes, electron holography, and differential phase contrast（DPC） techniques are discussed, where the novel properties of topological magnetic domains are well addressed. In addition, in situ Lorentz TEM demonstrates that the topological domains can be efficiently manipulated by electric currents, magnetic fields, and temperatures, exhibiting novel phenomena under external fields, which advances the development of topological nanodomain-based spintronics.

关键词： in situ Lorentz TEM magnetic vortices magnetic bubbles magnetic skyrmions

Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus

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World Journal of Pediatrics 2020年第3期16卷 240-246页

作者： Zhi-min chen Jun-Fen Fu qiang shu Ying-Hu chen Chun-Zhen Hua Fu-Bang Li Ru Lin lan-Fang Tang Tian-Lin wang wei wang Ying-shuo wang wei-Ze Xu Zi-Hao Yang Sheng Ye Tian-ming Yuan chen-Mei Zhang Yuan-Yuan Zhang Children's Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052China

Since December 2019,an epidemic caused by novel coronavirus (2019-nCoV) infection has occurred unexpectedly in *** of 8 pm,31 January 2020,more than 20 pediatric cases have been reported in *** these cases,ten patients were identified in Zhejiang Province,with an age of onset ranging from 112 days to 17 *** the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCo V (the 4th edition) and current status of clinical practice in Zhejiang Province,recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health,the National Children's Regional Medical Center,Children's Hospital,Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV.

关键词： New coronavirus Respiratory infection Child Diagnosis Treatment Recommendation