检索结果-南通市图书馆

PEG400-mediated nanocarriers improve the delivery and therapeutic efficiency of mRNA tumor vaccines

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第5期35卷 314-319页

作者： Wen Xiao Fazhan Wang Yangzhuo Gu Xi He Na Fan Qian Zheng Shugang Qin Zhongshan He Yuquan wei xiangrong Song Department of Critical Care Medicine Frontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Medical Research Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450000China

Dendritic cell(DC)-targeted delivery of mRNA is a prominent method to boost the efficacy of mRNA tumor *** targeting ligands are often modified on nanocarriers by polyethylene glycol(PEG)linker in mRNA delivery *** the PEG linker length influences the targeting delivery efficiency of mRNA nanocarrier in vivo remains ***,we designed and constructed DC-targeted mRNA delivery systems modified by mannose via different PEG linker lengths(100/400/1000/2000)(MPn-LPX).The top candidate MP_(400)-LPX(the linker was PEG400)showed the optimal mRNA expression and antigen presentation owing to the highly efficient uptake by ***,MP_(400)-LPX could better inhibited tumor growth and extended survival in the E.G7-OVA lymphoma and TC-1 cervical tumor mouse ***,these results demonstrated that PEG400 was the optimal linker for the PEGylated DC-targeted mRNA *** findings provided a new platform for the rational design of targeted mRNA nanovaccines with shorter-length PEG.

关键词： Cancer immunotherapy mRNA vaccines DC-targeted delivery PEGylated liposomes Cellular uptake

TB与SBS复合改性沥青及其混合料性能研究

在线全文

学校读者我要写书评

暂无评论

公路工程 2016年第5期41卷 249-255页

作者：魏相荣根河公路养护管理处内蒙古呼伦贝尔022350

评价了SBS、Terminal Blend胶粉掺量对Terminal Blend／SBS复合改性沥青性能的改性效果和改性机理，研究了SBS与TB复合改性沥青混合料的路用性能、抗疲劳性能和长期使用性能。试验结果表明：SBS与TB复合改性剂对于石油沥青的改性效果不... 详细信息

评价了SBS、Terminal Blend胶粉掺量对Terminal Blend／SBS复合改性沥青性能的改性效果和改性机理，研究了SBS与TB复合改性沥青混合料的路用性能、抗疲劳性能和长期使用性能。试验结果表明：SBS与TB复合改性剂对于石油沥青的改性效果不是简单的叠加，而是非线性的增强作用。增大SBS掺量能有效提高复合改性沥青的软化点、延度和PG高温分级，降低其针入度，增大TB胶粉有效改善了复合改性沥青的低温性能，SBS与TB复合改性沥青兼顾了TB改性沥青混合料优良的低温性能、抗疲劳性能以及SBS改性沥青混合料优良的高低温、水稳定性和抗疲劳性能。推荐用于TB与SBS复合改性沥青中适宜的SBS掺量为2％-3％，TB胶粉掺量为15％-20％。3％SBS＋15％TB、2．5％SBS＋18％TB、2．0％SBS＋20％TB3种复配方案的低温抗裂性能是SBS改性沥青混合料的1．58、1．63、1．61倍，高温性能可与4．5％SBS相媲美。工程实践表明，SBS／TB复合改性沥青混凝土可比4．5％SBS改性沥青混凝土节省造价约13％，2．5％SBS＋18％TB、3％SBS＋15％TB2种复配方案抗疲劳性能和高低温性能均优于SBS改性沥青混合料，Terminal Blend／SBS复合改性沥青混合料推广、应用前景广阔。

关键词：道路工程 SBS和TB胶粉复合改性沥青路用性能改性机理

Intranasal boosting with RBD-HR protein vaccine elicits robust mucosal and systemic immune responses

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 327-339页

作者： Li Chen Wenyan Ren Hong Lei Jiayu Wang Haiying Que Dandan Wan Aqu Alu Dandan Peng Minyang Fu weiqi Hong Yuhe Huang xiangrong Song Guangwen Lu Xiawei wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China

The emergence of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants has decreased the efficacy of SARs-CoV-2 vaccines in containing coronavirus disease 2019(CoVID-19)over time,and booster vaccination strategies are urgently necessitated to achieve sufficient *** immunization can improvemucosal immunity,offer-ing protection against the infection and sustaining the spread of *** this study,an intranasal booster of the RBD-HR vaccine after two doses of the mRNA vaccine significantly increased the levels of specific binding antibodies in serum,nasal lavage fluid,and bronchoal-veolar lavage fluid compared with only two doses of mRNA *** intranasal boosting with the RBD-HR vaccine,the levels of serum neutralizing antibodies against prototype and variant strains of SARS-Cov-2 pseudoviruses weremarkedly higher than those in mice receiving mRNA vaccine alone,and intranasal boosting with the RBD-HR vaccine also inhibited the bind-ing of RBD to hACE2 ***,the heterologous intranasal immunization regimen promoted extensive memory T cell responses and activated CD103+dendritic cells in the respiratory mucosa,and potently enhanced the formation of T follicular helper cells and germinal center B cells in vital immune organs,including mediastinal lymph nodes,inguinal lymph nodes,and ***,these data infer that heterologous intranasal boosting with the RBD-HR vaccine elicited broad protective immunity against SARS-CoV-2 both locallyandsystemically.

关键词： Heterologous immunization Intranasal immunization mRNA vaccine SARS-CoV-2 Subunitprotein vaccine

Relationship between tea pigments and health: A bibliometric and visual analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Polyphenols 2024年第1期6卷 33-41页

作者： Xiaoya Pan Fangyuan wei Mengyuan Zhao xiangrong Zhang Faculty of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China

Tea pigments have significant effects on human ***,more attention have been paid to their physiological *** aim of this study was to analyze the quantitative and qualitative impact of tea pigments on human health,together with their current and potential future research *** study searched and screened 520 publications on WOS from January 2002 to December *** article collected and collated literature published in the last 20 years and analyzed it bibliometrically for years,journals,countries,authors,topics,keywords and strongest citation *** findings of keywords and strongest citation bursts revealed that the most discussed research topics were anticancer,black tea polyphenol,antioxidant,activator inhibitor,in vivo,gut microbiota,and summarize the relevant *** a reference for future research,the literature pointed out current shortcomings and speculated future development trend of tea pigments.

关键词： tea pigment health visual bioactivity

Preparation and release of curcumin/silk fibroin/sodium alginate film

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Polyphenols 2024年第1期6卷 1-10页

作者： Yerong Yuan Jun’an Zheng Zunchao Liu wei Li Jiaqing Cao xiangrong Zhang Faculty of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China

The aim of this study was to prepare silk fibroin/sodium alginate composite film containing curcumin by casting *** test was used to optimize the formulation according to the values of tensile strength and elongation at *** release of curcumin in the optimal film was studied in order to explore its application as wound *** results showed that the optimum composition of curcumin/silk fibroin/sodium alginate composite film was as follows:Silk fibroin(70 mg/mL)2.7 g,sodium alginate(24 mg/mL)0.84 g,span 40(5.0 mg/mL)0.4 g,glycerol(3.75%,V/V)3 mL,curcumin(0.2 mg/mL)0.016 *** optimum film showed the tensile strength and the elongation at break was(0.628±0.032)MPa and(0.794±0.046)%,respectively.

关键词： curcumin silk fibroin sodium alginate composite film

鄂南宗祠建筑装饰艺术研究——以咸宁市通山县白泥村王氏宗祠为例

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

艺术科技 2021年第3期34卷 142-144页

作者：韦向荣董黎武汉科技大学湖北武汉430000

本文通过对咸宁市通山县白泥村王氏宗祠的实地考察与调研,对其宗族历史、装饰部位、装饰手法等方面进行梳理与比较,研究宗族祠堂建筑中的装饰艺术特征,归纳王氏宗祠建筑装饰艺术中的美学表征,并以此探究鄂南地区地域文化在宗祠建筑装饰... 详细信息

本文通过对咸宁市通山县白泥村王氏宗祠的实地考察与调研,对其宗族历史、装饰部位、装饰手法等方面进行梳理与比较,研究宗族祠堂建筑中的装饰艺术特征,归纳王氏宗祠建筑装饰艺术中的美学表征,并以此探究鄂南地区地域文化在宗祠建筑装饰中的表达。

关键词：鄂南宗族祠堂装饰艺术

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

5种干燥方式对木薯酸淀粉性能的影响

食品工业科技 2024年第8期45卷 134-142页

作者：李明娟王颖张雅媛游向荣周葵卫萍韦林艳广西壮族自治区农业科学院农产品加工研究所广西南宁530007 广西果蔬贮藏与加工新技术重点实验室广西南宁530007

为探究不同干燥方法对木薯酸淀粉性能的影响,本研究以木薯淀粉为原料,经乳酸菌发酵后,采用热风干燥、热泵干燥、真空冷冻干燥、喷雾干燥和太阳光晒干5种干燥方法制备木薯酸淀粉,对其性能进行测定分析,并采用变异系数法对性能进行综合评... 详细信息

为探究不同干燥方法对木薯酸淀粉性能的影响,本研究以木薯淀粉为原料,经乳酸菌发酵后,采用热风干燥、热泵干燥、真空冷冻干燥、喷雾干燥和太阳光晒干5种干燥方法制备木薯酸淀粉,对其性能进行测定分析,并采用变异系数法对性能进行综合评分。结果表明,热风干燥的木薯酸淀粉粒径跨度最大,为2.36,透明度、碘蓝值和持油性最小,分别为21.57%、8.96和1.74 g/g;热泵干燥的木薯酸淀粉比表面积最小,为351.83 m2/kg,堆积密度、析水率和凝沉性最高,分别为0.87 g/mL、33.02%和74.89%;真空冷冻干燥的木薯酸淀粉堆积密度、休止角和析水率最低,分别为0.73 g/mL、37.49°和4.64%,透明度、碘蓝值和持水性最高,分别为27.03%、19.64和1.43 g/g,溶解性最高;喷雾干燥的木薯酸淀粉比表面积、休止角和持油性最高,分别为407.43 m2/kg、54.11°和2.33 g/g,凝沉性最低,为67.00%;晒干的木薯酸淀粉跨度和持水性最低,分别为1.73和1.08 g/g。综合评分结果显示,真空冷冻、喷雾、晒干、热风和热泵干燥的木薯酸淀粉性能综合评分分别为0.60、0.38、0.18、-0.50和-0.64。综合分析,真空冷冻干燥制备的木薯酸淀粉性能最好,其次为喷雾干燥,晒干次之,热风和热泵干燥的最差。

关键词：木薯酸淀粉热风干燥热泵干燥真空冷冻干燥喷雾干燥晒干淀粉性能

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

景观之美与美感

中国园林 2024年第7期40卷 2-3页

作者：王向荣不详

美是什么?古希腊的哲学家们在两千多年前就已经开始了对什么是美的追问。毕达哥拉斯从数的关系上论证美,认为“美在数的和谐”“美是和谐与比例”,赫拉克利特认为美在于和谐,柏拉图认为美是一个主观理念,而亚里士多德则认为,美是有一定... 详细信息

美是什么?古希腊的哲学家们在两千多年前就已经开始了对什么是美的追问。毕达哥拉斯从数的关系上论证美,认为“美在数的和谐”“美是和谐与比例”,赫拉克利特认为美在于和谐,柏拉图认为美是一个主观理念,而亚里士多德则认为,美是有一定客观性的,美是外部对象的一种和谐,但是美也来自人的感知。中国先秦时期的思想家也开始了对美的探讨。春秋时期文学家左丘明在《伍举论台美而楚殆》中说:“夫美也者,上下、内外、大小、远近皆无害焉,故曰美。”《论语》里有“里仁为美”之说,意为能够达到仁的境界为美,或居住在有仁爱的地方才是美。《孟子》曰:“充实之谓美”,也就是说,美好的品德充实于内心就是美。可见,中国古人总是将美与善结合在一起,强调美与善的统一。

关键词：毕达哥拉斯中国先秦时期美与善春秋时期赫拉克利特左丘明数的和谐

Rapid monotectic solidification under free fall condition

在线全文

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2004年第4期47卷 409-420页

作者： LIU xiangrong LU Xiaoyu wei Bingbo Laboratory of Materials Science in Space Department of Applied Physics Northwestern Polytechnical University Xi'an 710072 China Laboratory of Materials Science in Space Department of Applied Physics Northwestern Polytechnical University Xi'an 710072 China Laboratory of Materials Science in Space Department of Applied Physics Northwestern Polytechnical University Xi'an 710072 China

Fe-48.8% Sn monotectic, Fe-40% Sn hypomonotectic and Fe-58% Sn hypermonotectic alloys have been rapidly solidified during free fall processing in drop tube. For droplets of 100–1000 μm, the maximum undercooling for Fe-48.8% Sn, Fe-40% Sn and Fe-58% Sn alloys is 270, 282 and 288 K respectively. For Fe-48.8% Sn monotectic alloy, a homogeneously dispersed microstructure can be obtained when the droplet diameter is small, and the Marangoni migration velocity Vm is 37 times as fast as Stokes velocity Vs when the dispersion sphere radius is 6 μm and undercooling is 30 K. For Fe-40% Sn hypomonotectic alloy, the microstructure undergoes a transition from columnar α-Fe dendrites distributed in Sn-rich matrix to α-Fe particles. The growth velocity of α-Fe dendrite changes from 0.45 to 4.65 m/s when the droplet diameter varies from 1000 to 100 μm. For Fe-58.8% Sn hypermonotectic alloy, the grain size of primary α-Fe dendrites decreases remarkably when undercooling increases. Keywords monotectic solidification - phase separation - undercooling - containerless processing

关键词： monotectic solidification, phase separation, undercooling, containerless processing.