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Journal of Energy Chemistry 2024年第5期92卷 74-86页

作者： Yuxuan Li Lihua Jiang Ningjie Zhang Zesen wei wenxin Mei Qiangling Duan Jinhua Sun Qingsong Wang State Key Laboratory of Fire Science University of Science and Technology of ChinaAnhui 230026HefeiChin

Early warning of thermal runaway(TR)of lithium-ion batteries(LIBs)is a significant challenge in current application scenarios.Timely and effective TR early warning technology is urgently required considering the current fire safety situation of LIBs.In this work,we report an early warning method of TR with online electrochemical impedance spectroscopy(EIS)monitoring,which overcomes the shortcomings of warning methods based on traditional signals such as temperature,gas,and pressure with obvious delay and high cost.With in-situ data acquisition through accelerating rate calorimeter(ARC)-EIS test,the crucial features of TR were extracted using the RReliefF algorithm.TR mechanisms corresponding to the features at specific frequencies were analyzed.Finally,a three-level warning strategy for single battery,series module,and parallel module was formulated,which can successfully send out an early warning signal ahead of the self-heating temperature of battery under thermal abuse condition.The technology can provide a reliable basis for the timely intervention of battery thermal management and fire protection systems and is expected to be applied to electric vehicles and energy storage devices to realize early warning and improve battery safety.

关键词： Online EIS measurement Lithium-ion batterysafety Multistage thermal runaway early warning Sensitivityanalysis

Direct Analysis of Whole Blood by a Disposable Monolithic Column Mass Spectrometry Analysis Kit

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Chinese Journal of Chemistry 2024年第10期42卷 1073-1078页

作者： wenxin Wang Jin Han Yutong Zheng Haijie Wang Chengbiao Zhu Yongyi Li Yuqi Feng Zhenwei wei Xiangyu Wang College of Chemistry and Molecular Science Wuhan UniversityWuhanHubei 430072China School of Public Health Wuhan UniversityWuhanHubei 430072China Schoolof Bioengineering and Health Wuhan Textile UniversityWuhanHubei 430200China

A monolithic column-based mass spectrometry(MS)analysis kit was prepared for whole blood analysis with MS.The kit is disposable and can be used for purification,storage,transportation and direct analysis of whole blood.The kit mainly consists of a capillary for quantitative microsampling,a cation exchange monolithic column for purification and storage,and a syringe for loading sample.This kit is very friendly to various users that one can easily siphon the blood in the kit followed by rapid clean-up.We established a quantitative method using the kit with a limit detection as low as 0.33 nmol/L,and achieved more than five orders of magnitude enhancement in sensitivity compared to direct nanoelectrospray ionization MS analysis.The column can avoid analyte exposure to environment,which helps the storage of the sample for laboratory analysis.The relative standard deviation of immediate blood analysis and storage blood analysis within 10 d was less than 10%.This method has been successfully applied to the quantitative analysis of procainamide hydrochloride in 2μL rat blood.These results indicate that this disposable kit does have the potential to achieve highly sensitive quantitative MS analysis in biological samples,which is expected to become a cost-effective and powerful tool for in vitro diagnostics.

关键词： Clinical Ms Whole blood analysis Porous polymers Matrix isolation Trace analysis

Mapping of powdery mildew resistance genes transferred to common wheat from wild emmer wheat revealed three functional Pm60 haplotypes

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The Crop Journal 2024年第2期12卷 540-548页

作者： wenxin wei Nannan Liu Shengnan Zhang Jing Zhang wei Pan Xiaoming Xie Zuhuan Yang Junna Sun Jun Ma Zhaorong Hu weilong Guo Qiaoling Luo Jingzhong Xie Fei He Yinghui Li Chaojie Xie Qixin Sun Key Laboratory of Crop Heterosis and Utilization(MOE)/Key Laboratory of Crop Genetic Improvement China Agricultural UniversityBeijing 100193China Institute of Advanced Agricultural Science Peking UniversityWeifang 261200ShandongChina Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Institute of Evolution University of HaifaMt.CarmelHaifa 3498838Israel

Powdery mildew(PM),caused by Blumeria graminis f.***.tritici(Bgt),is one of the destructive wheat diseases worldwide.Wild emmer wheat(Triticum turgidum ssp.dicoccoides,WEW),a tetraploid progenitor of common wheat,is a valuable genetic resource for wheat disease resistance breeding programs.We developed three hexaploid pre-breeding lines with PM resistance genes derived from three WEW accessions.These resistant pre-breeding lines were crossed with susceptible common wheat accessions.Segregations in the F2populations were 3 resistant:1 susceptible,suggesting a single dominant allele in each resistant parent.Mapping of the resistance gene in each line indicated a single locus on the long arm of chromosome 7A,at the approximate location of previously cloned Pm60 from T.urartu.Sanger sequencing revealed three different Pm60 haplotypes(Hap 3,Hap 5,and Hap 6).Co-segregating diagnostic markers were developed for identification and selection of each haplotype.The resistance function of each haplotype was verified by the virus-induced gene silencing(VIGS).Common wheat lines carrying each of these Pm60 haplotypes were resistant to most Bgt isolates and differences in the response arrays suggested allelic variation in response.

关键词： Alleles Blumeria graminus Marker-assisted selection Molecular marker Triticum dicoccoides

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Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty:a prospective,double-blind,pilot,randomised controlled trial

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General Psychiatry 2024年第2期37卷 224-233页

作者： Jie Yang Mingshu Tao Rongguang Liu Jiaxing Fang Chunyan Li Dexian Chen Qi wei Xingyu Xiong wenxin Zhao Wen Tan Yuan Han Hongxing Zhang He Liu Song Zhang Junli Cao Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Hospital of Chengdu University of Traditional Chinese Medicine&Traditional Chinese Medicine Hospital of Sichuan ProvinceChengduSichuanChina NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs&Jiangsu Province Key Laboratory of Anesthesiology&Jiangsu Key Laboratory of Applied Technology of Anesthesia and Analgesia Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthesiology Eye&ENT Hospital of Fudan UniversityShanghaiChina Department of Anesthesiology&Clinical Research Center for Anesthesia and Perioperative Medicine&Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University||Huzhou Central Hospital||The Affiliated Huzhou HospitalZhejiang University School of Medicine||Affiliated Central Hospital Huzhou UniversityHuzhouZhejiangChina Department of Anesthesiology Renji Hospital School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Postoperative sleep disturbance(PSD)is a common and serious postoperative complication and is associated with poor postoperative outcomes.Aims This study aimed to investigate the effect of transcranial direct current stimulation(tDCS)on PSD in older patients undergoing lower limb major arthroplasty.Methods In this prospective,double-blind,pilot,randomised,sham-controlled trial,patients 65 years and over undergoing lower limb major arthroplasty were randomly assigned to receive active tDCS(a-tDCS)or sham tDCS(s-tDCS).The primary outcomes were the objective sleep measures on postoperative nights(N)1 and N2.Results 116 inpatients were assessed for eligibility,and a total of 92 patients were enrolled;47 received a-tDCS and 45 received s-tDCS.tDCS improved PSD by altering the following sleep measures in the a-tDCS and s-tDCS groups;the respective comparisons were as follows:the promotion of rapid eye movement(REM)sleep time on N1(64.5(33.5-105.5)vs 19.0(0.0,45.0)min,F=20.10,p<0.001)and N2(75.0(36.0-120.8)vs 30.0(1.3-59.3)min,F=12.55,p<0.001);the total sleep time on N1(506.0(408.0-561.0)vs 392.0(243.0-483.5)min,F=14.13,p<0.001)and N2(488.5(455.5-548.5)vs 346.0(286.5-517.5)min,F=7.36,p=0.007);the deep sleep time on N1(130.0(103.3-177.0)vs 42.5(9.8-100.8)min,F=24.4,p<0.001)and N2(103.5(46.0-154.8)vs 57.5(23.3-106.5)min,F=8.4,p=0.004);and the percentages of light sleep and REM sleep on N1 and N2(p<0.05 for each).The postoperative depression and anxiety scores did not differ significantly between the two groups.No significant adverse events were reported.Conclusion In older patients undergoing lower limb major arthroplasty,a single session of anodal tDCS over the left dorsolateral prefrontal cortex showed a potentially prophylactic effect in improving postoperative short-term objective sleep measures.However,this benefit was temporary and was not maintained over time.

关键词： sleep stimulation postoperative

Promoting interactions between cognitive science and large language models

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The Innovation 2024年第2期5卷 9-10页

作者： Youzhi Qu Penghui Du wenxin Che Chen wei Chi Zhang Wanli Ouyang Yatao Bian Feiyang Xu Bin Hu Kai Du Haiyan Wu Jia Liu Quanying Liu Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055China Shanghai AI Laboratory Shanghai 200232China Tencent AI Lab Shenzhen 518057China iFLYTEK AI Research Hefei 230088China School of Medical Technology Beijing Institute of TechnologyBeijing 100081China Institute for Artificial Intelligence Peking UniversityBeijing 100871China Centre for Cognitive and Brain Sciences and Department of Psychology University of MacaoMacao 999078China Department of Psychology Tsinghua UniversityBeijing 100084China

Large language models(LLMs)have made unprecedented progress,demonstrating human-like language proficiency and an extraordinary ability to encode complex knowledge.The emergence of high-level cognitive capabilities in LLMs,such as in-context learning and complex reasoning,suggests a path toward the realization of artificial general intelligence(AGI).However,we lack scientific theories and tools to assess and interpret such an emergence of the advanced intelligence of LLMs.Artificial intelligence(AI)has been extensively applied in various areas of fundamental science to accelerate scientific research.

关键词： cognitive such language

Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (Sf9 cells) in adult recipients of inactivated vaccines

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1165-1173页

作者： wenxin Luo Jiadi Gan Zhu Luo Shuangqing Li Zhoufeng Wang Jiaxuan Wu Huohuo Zhang Jinghong Xian Ruixin Cheng Xiumei Tang Yi Liu Ling Yang Qianqian Mou Xue Zhang Yi Chen weiwen Wang Yantong Wang Lin Bai Xuan wei Rui Zhang Lan Yang Yaxin Chen Li Yang Yalun Li Dan Liu weimin Li Lei Chen Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduChina Institute of Respiratory Health Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengduChina Precision Medicine Center Precision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina State Key Laboratory of Respiratory Health and Multimorbidity West China HospitalChengduChina Institute of Respiratory Health and Multimorbidity West China HospitalSichuan UniversityChengduChina Clinical Trial Center West China HospitalSichuan UniversityChengduChina General Practice Medical Center West China HospitalSichuan UniversityChengduChina Fangcao Community Health Service Center of Chengdu High-tech Zone ChengduChina The Research Units of West China Chinese Academy of Medical SciencesWest China HospitalChengduChina West China School of Nursing Sichuan UniversityChengduChina Department of Infection Control West China HospitalSichuan UniversityChengduChina Department of Pathology West China HospitalSichuan UniversityChengduChina Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology West China HospitalSichuan UniversityChengduChina

Vaccines have proven effective in protecting populations against COVID-19,including the recombinant COVID-19 vaccine(Sf9 cells),the first approved recombinant protein vaccine in China.In this positive-controlled trial with 85 adult participants(Sf9 cells group:n=44;CoronaVac group:n=41),we evaluated the safety,immunogenicity,and protective effectiveness of a heterologous boost with the Sf9 cells vaccine in adults who had been vaccinated with the inactivated vaccine,and found a post-booster adverse events rate of 20.45%in the Sf9 cells group and 31.71%in the CoronaVac group(p=0.279),within 28 days after booster injection.Neither group reported any severe adverse events.Following the Sf9 cells vaccine booster,the geometric mean titer(GMT)of binding antibodies to the receptor-binding domain of prototype SARS-CoV-2 on day 28 post-booster was significantly higher than that induced by the CoronaVac vaccine booster(100,683.37 vs.9,451.69,p<0.001).In the Sf9 cells group,GMTs of neutralizing antibodies against pseudo SARS-CoV-2 viruses(prototype and diverse variants of concern[VOCs])increased by 22.23–75.93 folds from baseline to day 28 post-booster,while the CoronaVac group showed increases of only 3.29–10.70 folds.Similarly,neutralizing antibodies against live SARS-CoV-2 viruses(prototype and diverse VOCs)increased by 68.18–192.67 folds on day 14 post-booster compared with the baseline level,significantly greater than the CoronaVac group(19.67–37.67 folds).A more robust Th1 cellular response was observed with the Sf9 cells booster on day 14 post-booster(mean IFN-γ+spot-forming cells per 2×105 peripheral blood mononuclear cells:26.66 vs.13.59).Protective effectiveness against symptomatic COVID-19 was approximately twice as high in the Sf9 cells group compared to the CoronaVac group(68.18%vs.36.59%,p=0.004).Our study findings support the high protective effectiveness of heterologous boosting with the recombinant COVID-19 vaccine(Sf9 cells)against symptomatic COVID-19 of diverse SARS-CoV-2 variants of concern,while causing

关键词： protective vaccine boost

Cognitions and questions regarding crustal deformation and location forecasts of strong earthquakes

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Geodesy and Geodynamics 2015年第3期6卷 210-219页

作者： wei wenxin Jiang Zaisen Wu Yanqiang Institute of Earthquake Science China Earthquake Administration First Crust Deformation Monitoring and Application Center China Earthquake Administration

Using Global Positioning System(GPS) data to analyze the earthquake preparation characteristics of the Kunlun Ms8.1 and the Wenchuan Ms8.0 earthquakes, we review the main research developments of earthquake forecasting and the mechanisms of earthquake preparation using crustal deformation data from recent periods, and discuss the similarities and differences in the scientific approaches adopted by the Chinese and foreign scholars. We then analyze the deformation characteristics of earthquake preparation, with respect to slip and dip-slip faults. Our results show that, in order to understand the relationship between crustal deformation and earthquake preparation, research focus should be expanded from fault-scale to larger scale regions. Furthermore, the dynamic deformation characteristics associated with earthquake preparation must be considered as a multiscale, spatial-temporal process, in order to obtain the necessary criteria for strong earthquake forecasts.

关键词： Global Positioning System(GPS) Active fault Focal

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地磁感应电流多学科交叉研究进展

吉林大学学报（地球科学版） 2024年第1期54卷 54-67页

作者：余年张学健孔文新韦昌重庆大学电气工程学院重庆400044 重庆大学资源与安全学院重庆400044

地磁感应电流(geomagnetically induced currents,GIC)是指地球变化磁场在地球表面导体中产生的感应电流,可对电网、油气管道、高铁等人造基础设施造成严重破坏,包括电力系统失效、通信干扰和电子设备损坏等,影响其稳定运行和功能。研究... 详细信息

地磁感应电流(geomagnetically induced currents,GIC)是指地球变化磁场在地球表面导体中产生的感应电流,可对电网、油气管道、高铁等人造基础设施造成严重破坏,包括电力系统失效、通信干扰和电子设备损坏等,影响其稳定运行和功能。研究GIC的意义在于深入理解其产生机理及影响因素,为制定相应的预防和应对策略提供科学依据。论文在深入总结GIC研究进展的基础上,详细阐述了GIC的产生机理及影响因素,包括宇宙空间、地球环境和电力系统对GIC的影响;概述了GIC的研究现状,分别从空间物理、地球物理和电气工程领域对GIC进行了综合评述;进而详细介绍了GIC估算的步骤,包括地磁场数据与建模、地电场和导体中GIC的计算;并重点分析了不同地球物理参数对GIC估算结果的影响以及互相之间的差异;最后,对GIC研究面临的挑战、地球物理在相关问题解决中的潜在贡献以及研究未来进行展望。

关键词：地磁感应电流地球磁场大地电磁地磁灾害

基于自然语言需求的SCADE模型测试用例自动生成方法

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计算机科学 2024年第7期51卷 29-39页

作者：邵温欣杨志斌李维周勇南京航空航天大学计算机科学与技术学院南京211106 高安全系统的软件开发与验证技术工信部重点实验室南京211106 航空防护救生技术航空科技重点实验室湖北襄阳441003

随着安全关键软件规模和复杂性不断增加,模型驱动开发方法在安全关键领域得到了广泛应用。SCADE作为一种重要的建模方法和工具,能够表达确定性并发行为且具有精确时间语义等特性,适用于安全关键软件的建模、测试与验证。目前,已有方法... 详细信息

随着安全关键软件规模和复杂性不断增加,模型驱动开发方法在安全关键领域得到了广泛应用。SCADE作为一种重要的建模方法和工具,能够表达确定性并发行为且具有精确时间语义等特性,适用于安全关键软件的建模、测试与验证。目前,已有方法主要采用手工方式构造SCADE模型测试用例,存在需求与测试用例不一致、成本代价高且容易出错的问题。文中提出了一种基于自然语言需求的SCADE模型测试用例自动生成方法。首先,给出了基于模型检测的测试用例自动生成方法,通过自然语言需求处理生成原子命题,用于生成前提假设Assume和观察者模型,同时给出了陷阱性质(Trap Properties)生成规则来生成陷阱性质用于模型检测;其次,给出了基于覆盖分析和变异测试的测试用例质量评估方法,并在SCADE模型上进行变异测试;最后,设计和实现了原型工具,并基于一个工业界案例飞行员弹射座椅控制系统进行了案例分析,验证了所提方法的有效性。

关键词：安全关键软件模型驱动开发 SCADE 测试用例自动生成模型检测

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工艺参数对抛光渣轻质陶瓷砖性能的影响

硅酸盐通报 2024年第4期43卷 1524-1531页

作者：付思远吕文欣韦家崭柯善军有色金属及材料加工新科技教育部重点实验室桂林541004 桂林理工大学有色金属矿产勘查与资源高效利用省部共建协同创新中心桂林541004 广西工业废渣建材资源利用工程技术研究中心桂林541004 广西欧神诺陶瓷有限公司梧州543307

近年来我国陶瓷行业发展迅速,每年产生约1000万吨陶瓷抛光渣,但只有5%被利用。本文以陶瓷抛光渣作为研究对象,辅以球土、瓷片砂和中温砂等原料,以SiC为孔结构调控剂来制备轻质陶瓷砖,运用一系列正交试验得出最佳的烧结制度,并探究烧成... 详细信息

近年来我国陶瓷行业发展迅速,每年产生约1000万吨陶瓷抛光渣,但只有5%被利用。本文以陶瓷抛光渣作为研究对象,辅以球土、瓷片砂和中温砂等原料,以SiC为孔结构调控剂来制备轻质陶瓷砖,运用一系列正交试验得出最佳的烧结制度,并探究烧成温度与球磨时间对抛光渣轻质陶瓷砖的性能影响。结果表明,烧成温度的升高会改善轻质陶瓷砖内部连通孔和气孔均匀性,在1160℃时,轻质陶瓷砖的体积密度、抗压强度、显气孔率最大,分别为1.24 g/cm^(3)、35 MPa、20%,吸水率为20.38%;当球磨时间从10 min延长至110 min时,轻质陶瓷砖颗粒变细,表面能增大,液相量增多,发泡量增多,使连通孔、气孔均匀性得到改善。

关键词：陶瓷抛光渣轻质陶瓷砖烧结工艺烧成温度球磨时间抗压强度

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