检索结果-南通市图书馆

Lamin C protein deficiency in the primary fibroblasts from a new laminopathy case with ovarian cystadenoma

Chinese Medical Journal 2010年第16期123卷 2237-2243页

作者： CAI Meng-yin LIANG Hua LI Ming BI Yan CHEN Xiang SUN wei-ping WENG jian-ping Department of Endocrinology Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510630 China

Background Laminopathies are a group of rare genetic disorders characterized by multiple-tissue *** describe a new laminopathy with ovarian cystadenoma and explore its molecular *** The case is a 15-year-old girl who presents the prominent progeroid disorders, multiple system degeneration and early-onset cystadenoma of the *** genes including LMNA, ZMPSTE24, PPAR G, INSR and WRN were sequenced to screen for DNA *** mRNA and protein expression levels of LMNA were examined in primary *** pathophysiological events such as morphologic alterations, cell senescence, cell proliferation,apoptosis and pRb as well as p53 protein expressions were also investigated in primary *** No mutation was identified in the candidate genes *** abnormalities including nuclear blebs,mislocalization of lamin A/C were evident in the patient ***, nucleus exhibited nuclear herniation and almost complete loss of peripheral *** addition, lamin C protein expression was markedly reduced whereas lamin A protein level was normal and no prelamin A was detected in the primary *** the senescence-associated β-galactosidase staining of patient＇ cells was negative, cells in S phase increased in accompany with a decrease in pRb protein ***, increases in apoptotic cell death and p53 expression were *** Our data suggest that selective deficiency of lamin C protein is associated with a case of laminopathy with ovarian *** abnormalities in nuclear structure and alterations in gene expression such as the decrease in pRb and increase in p53 may be responsible for the multiple tissue degeneration.

关键词： laminopathy lamin C premature aging pRb p53

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of abrasive hardness on erosion wear of abrasive air jets

引用

Journal of Central South University 2020年第2期27卷 356-371页

作者： LIU Yong CHEN Chang-jiang wei jian-ping LIU Xiao-tian WANG Xiang-dong State Key Laboratory Cultivation Base for Gas Geology and Gas Control Henan Polytechnic UniversityJiaozuo 454000China State Collaborative Innovation Center of Coal Work Safety and Clean-efficiency Utilization Jiaozuo 454000China Safety Technology Training Institute Henan Polytechnic UniversityJiaozuo 454000China Huajin Coking Coal Co. Ltd.Lüliang 033000China

To make clear the influence of abrasive hardness on the erosion effect,the erosion experiments of abrasive air jet with the same impact energy were carried *** influence of abrasive hardness on the erosion effect is clarified by comparing the different erosion *** main conclusions are as *** the same mass flow rate and mesh number,the abrasive with a higher density needs greater pressure irrespective of *** erosion damage,the abrasive size exhibits a weibull *** shape parameterβand weibull distribution function of four types of abrasives are derived by the least squares method;moreover,βis found to have a quadratic relation with abrasive *** results of the erosion experiments show that abrasive hardness and erosion depth are quadratically *** calculating the increase in surface energy after abrasive erosion crushing,it is found that abrasive hardness has a quadratic relation with surface energy and that the increases in erosion depth and surface energy consumption are basically *** conclusion,the effect is a soft abrasive impact when the ratio of abrasive hardness(Ha)to the material hardness(Hm)is3.

关键词： abrasive air jet abrasive hardness rock erosion abrasive size distribution coal bed methane

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Overview of computation strategies on the dispersion analysis for explicit finite difference solution of acoustic wave equation

引用

Petroleum Science 2024年第4期21卷 2311-2328页

作者： jian-ping Huang wei-Ting Peng Ji-Dong Yang Lu-Feng Lou School of Geosciences China University of Petroleum (East China) Pilot National Laboratory for Marine Science and Technology (Qingdao)

Finite-difference(FD) method is the most extensively employed numerical modeling technique. Nevertheless, when using the FD method to simulate the seismic wave propagation, the large spatial or temporal sampling interval can lead to dispersion errors and numerical instability. In the FD scheme, the key factor in determining both dispersion errors and stability is the selection of the FD weights. Thus,How to obtain appropriate FD weights to guarantee a stable numerical modeling process with minimum dispersion error is critical. The FD weights computation strategies can be classified into three types based on different computational ideologies, window function strategy, optimization strategy, and Taylor expansion strategy. In this paper, we provide a comprehensive overview of these three strategies by presenting their fundamental theories. We conduct a set of comparative analyses of their strengths and weaknesses through various analysis tests and numerical modelings. According to these comparisons, we provide two potential research directions of this field: Firstly, the development of a computational strategy for FD weights that enhances stability; Secondly, obtaining FD weights that exhibit a wide bandwidth while minimizing dispersion errors.

关键词： Finite-difference scheme FD coefficients Dispersion error Forward modeling Numerical simulation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Manipulating the Phase Transition Behavior of Dual Temperature-Responsive Block Copolymers by Adjusting Composition and Sequence

引用

Chinese Journal of Polymer Science 2024年第2期42卷 176-187,I0006页

作者： Zhi Zou Xiang Xu Hai-Tao Zhao jian-Nan Cheng wei-wei He Li-Fen Zhang Zhen-ping Cheng Suzhou key Laboratory of Macromolecular Design and Precision Synthesis Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationState and Local Joint Engineering Laboratory for Novel Functional Polymeric MaterialsCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of JiangsuSoochow UniversitySuzhou215123China

Temperature-responsive polymers have garnered significant attention due to their ability to respond to external *** this work,dual temperature-responsive block copolymers are synthesized via reversible addition-fragmentation chain transfer polymerization(RAFT)polymerization utilizing zwitterionic monomer methacryloyl ethyl sulfobetaine(SBMA) and N-isopropyl acrylamide(NIPAAm) as *** thermal responsive behaviors can be easily modulated by incorporating additional hydrophobic monomer benzyl acrylate(BN) or hydrophilic monomer acrylic acid(AA),adjusting concentration or pH,or varying the degree of polymerization of the block chain *** cloud points of the copolymers are determined by UV-Vis spectrophotometry,and these copolymers exhibit both controlled upper and lower critical solu bility temperatures(LCST and UCST) in aqueous *** study analyzes and summarizes the influencing factors of dual temperature responsive block copolymers by exploring the effects of various conditions on the phase transition temperature of temperature-sensitive polymers to explore the relationship between their properties and environment and structure to make them more selective in terms of temperature application range and regulation *** is very interesting that the introduction of poly-acrylic acid(PAA) segments in the middle of di-block copolymer PSBMA_(55)-b-PNIPAAm_(80) to form PSBMA_(55)-b-PAA_(x)-b-PNIPAAm_(80) results in a reversal of temperature-responsive behaviors from 'U'(LCST UCST) type,while the copolymer PSBMA_(55)-b-P(NIPAAm_(80)-co-AA_(x)) *** work provides a clue for tuning the phase transition behavior of polymers for manufacture of extreme smart materials.

关键词： Temperature responsive polymers High critical solubility temperature(UCST) Low critical solubility temperature(LCST) Block copolymers

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Privacy-Preserving Consensus-Based Distributed Economic Dispatch of Smart Grids via State Decomposition

引用

IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1250-1261页

作者： wei Chen Guo-ping Liu The authors are with the Center for Control Science and Technology Southern University of Science and TechnologyShenzhen 518055China

This paper studies the privacy-preserving distributed economic dispatch(DED)problem of smart *** autonomous consensus-based algorithm is developed via local data exchange with neighboring nodes,which covers both the islanded mode and the grid-connected mode of smart *** prevent power-sensitive information from being disclosed,a privacy-preserving mechanism is integrated into the proposed DED algorithm by randomly decomposing the state into two parts,where only partial data is *** objective is to develop a privacy-preserving DED algorithm to achieve optimal power dispatch with the lowest generation cost under physical constraints while preventing sensitive information from being *** this end,a comprehensive analysis framework is established to ensure that the proposed algorithm can converge to the optimal solution of the concerned optimization problem by means of the consensus theory and the eigenvalue perturbation *** particular,the proposed autonomous algorithm can achieve a smooth transition between the islanded mode and the grid-connected ***,rigorous analysis is given to show privacy-preserving performance against internal and external ***,case studies illustrate the feasibility and validity of the developed algorithm.

关键词： preserving autonomous mode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Micromechanism and mathematical model of stress sensitivity in tight reservoirs of binary granular medium

引用

Petroleum Science 2024年第3期21卷 1780-1795页

作者： jian-Bang Wu Sheng-Lai Yang Qiang Li Kun Yang Can Huang Dao-ping Lv wei Zhou State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing2249China Laboratoire de G eologie Ecole Normale Sup erieure/CNRS UMR8538PSL Research UniversityParis75005France Research Institute of Exploration and Development Xinjiang Oilfield CompanyKaramay834000XinjiangChina

Research on reservoir rock stress sensitivity has traditionally focused on unary granular structures,neglecting the binary nature of real reservoirs,especially tight *** the stresssensitive behavior and mathematical characterization of binary granular media remains a challenging *** this study,we conducted online-NMR experiments to investigate the permeability and porosity evolution as well as stress-sensitive control mechanisms in tight sandy conglomerate *** results revealed stress sensitivity coefficients between 0.042 and 0.098 and permeability damage rates ranging from 65.6%to 90.9%,with an average pore compression coefficient of 0.0168—0.0208 MPa ***-scale compression occurred in three stages:filling,compression,and compaction,with matrix pores playing a dominant role in pore *** stress sensitivity of binary granular media was found to be influenced by the support structure and particle *** stress sensitivity was associated with small fine particle size,high fines content,high uniformity coefficient of particle size,high plastic deformation,and low Young's ***-supported samples exhibited a high irreversible permeability damage rate(average=74.2%)and stress sensitivity coefficients(average=0.089),with pore spaces more *** contrast,grain-supported samples showed low stress sensitivity coefficients(average=0.021)at high stress *** on the experiments,we developed a mathematical model for stress sensitivity in binary granular media,considering binary granular properties and nested interactions using Hertz contact deformation and Poiseuille *** describing the change in activity content of fines under stress,we characterized the non-stationary state of compressive deformation in the binary granular structure and classified the reservoir into three *** model was applied for production prediction using actual data from the Mahu reservoir in China,showing that the e

关键词： Stress sensitivity Binary granular medium Tight reservoir Online-NMR Reservoir energy retention rate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Formation mechanism of fault accommodation zones under combined stress in graben basin:Implications from geomechanical modeling

引用

Petroleum Science 2024年第1期21卷 54-76页

作者： Qi-Qiang Ren Jin-Liang Gao Rong-Tao jiang Jin Wang Meng-ping Li jian-wei Feng Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China jianghan Oilfield Oil and Gas Production Capacity Construction Management Center Chongqing408000China Sinopec Chongqing Fuling Shale Gas Exploration and Development Company Chongqing408000China College of Energy Chengdu University of TechnologyChengdu 610059SichuanChina School of Geoscience China University of Petroleum(East China)Qingdao 266580ShandongChina

A fault accommodation zone is a type of structure that is defined as regulating displacement and strain between faults *** numbers of fault accommodation zones are being identified in graben basins,indicating the potential exploration target and petroleum accumulation *** study aims to analyze the formation mechanism and development of fault accommodation zones under combined stress by a numerical simulation method considering geomechanical *** three-dimensional(3-D)seismic interpretation and fractal dimension method,exampled with the Dongxin fault zone,the fault activity and fault combination pattern were conducted to quantitatively characterize the activity difference in fault accommodation *** with mechanical experiment test,a geomehcanical model was established for fault accommodation zones in a graben *** the paleostress numerical simulations and structural physical simulation experiment,the developmental characteristics and genetic mechanism of fault accommodation zones were *** by multi movements and combined stresses,three significant tectonic evolution stages of the Dongxing Fault Zone(DXFZ)were distinguished:During the E_(s)^(3)sedimentary period,the large difference in the stress,strain,and rupture distribution in various faults were significant,and this stage was the key generation period for the prototype of the DXFZ,including the FAZ between large-scale *** the E_(s)^(2)sedimentary period,the EW-trending symmetric with opposite dipping normal faults and the NE-SW trending faults with large scale were furtherly *** junction area of two secondary normal faults were prone to be ruptured,performing significant period for inheriting and developing characteristics of fault accommodation *** the Es1 sedimentary period,the high-order faults in the DXFZ exhibited the obvious fault depressions and strike-slip activity,and the fault accommodation zones were

关键词： Fault accommodation zone Graben basin Fault activity Tectonic physical simulation experiment Finite element numerical simulation Dongxin fault zone

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research on thermal insulation materials properties under HTHP conditions for deep oil and gas reservoir rock ITP-Coring

引用

Petroleum Science 2024年第4期21卷 2625-2637页

作者： Zhi-Qiang He He-ping Xie Ling Chen jian-ping Yang Bo Yu Zi-Jie wei Ming-Zhong Gao State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering College of Water Resource and Hydropower Sichuan University Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green Energy College of Civil and Transportation Engineering Shenzhen University School of Mechanical Engineering Sichuan University College of Polymer Science and Engineering Sichuan University

Deep oil and gas reservoirs are under high-temperature conditions, but traditional coring methods do not consider temperature-preserved measures and ignore the influence of temperature on rock porosity and permeability, resulting in distorted resource assessments. The development of in situ temperaturepreserved coring(ITP-Coring) technology for deep reservoir rock is urgent, and thermal insulation materials are key. Therefore, hollow glass microsphere/epoxy resin thermal insulation materials(HGM/EP materials) were proposed as thermal insulation materials. The materials properties under coupled hightemperature and high-pressure(HTHP) conditions were tested. The results indicated that high pressures led to HGM destruction and that the materials water absorption significantly increased; additionally,increasing temperature accelerated the process. High temperatures directly caused the thermal conductivity of the materials to increase; additionally, the thermal conduction and convection of water caused by high pressures led to an exponential increase in the thermal conductivity. High temperatures weakened the matrix, and high pressures destroyed the HGM, which resulted in a decrease in the tensile mechanical properties of the materials. The materials entered the high elastic state at 150.C, and the mechanical properties were weakened more obviously, while the pressure led to a significant effect when the water absorption was above 10%. Meanwhile, the tensile strength/strain were 13.62 MPa/1.3%and 6.09 MPa/0.86% at 100.C and 100 MPa, respectively, which meet the application requirements of the self-designed coring device. Finally, K46-f40 and K46-f50 HGM/EP materials were proven to be suitable for ITP-Coring under coupled conditions below 100.C and 100 MPa. To further improve the materials properties, the interface layer and EP matrix should be optimized. The results can provide references for the optimization and engineering application of materials and thus technical su

关键词： Deep oil and gas reservoir rock In situ temperature-preserved coring (ITP-Coring) Hollow glass microsphere/epoxy resin thermal insulation materials (HGM/EP materials) High-temperature and high-pressure (HTHP) Physical and mechanical properties

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

MdbHLH162 connects the gibberellin and jasmonic acid signals to regulate anthocyanin biosynthesis in apple

引用

Journal of Integrative Plant Biology 2024年第2期66卷 265-284页

作者： jian-ping An Rui-Rui Xu Xiao-Na Wang Xiao-wei Zhang Chun-Xiang You Yuepeng Han Apple technology innovation center of Shandong Province College of Horticulture Science and EngineeringShandong Agricultural UniversityTai-An 271018China CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenHubei Hongshan LaboratoryThe Innovative Academy of Seed Design of Chinese Academy of SciencesWuhan 430074China College of Biology and Oceanography Weifang UniversityWeifang 261061China

Anthocyanins are secondary metabolites induced by environmental stimuli and developmental *** positive regulators of anthocyanin biosynthesis have been reported,whereas the anthocyanin repressors have been *** the signal transduction pathways of gibberellin(GA)and jasmonic acid(JA)and their regulation of anthocyanin biosynthesis have been investigated,the cross-talk between GA and JA and the antagonistic mechanism of regulating anthocyanin biosynthesis remain to be *** this study,we identified the anthocyanin repressor MdbHLH162 in apple and revealed its molecular mechanism of regulating anthocyanin biosynthesis by integrating the GA and JA ***162 exerted passive repression by interacting with MdbHLH3 and MdbHLH33,which are two recognized positive regulators of anthocyanin ***162 negatively regulated anthocyanin biosynthesis by disrupting the formation of the anthocyanin-activated MdMYB1-MdbHLH3/33complexes and weakening transcriptional activation of the anthocyanin biosynthetic genes MdDFR and MdUF3GT by MdbHLH3 and *** GA repressor MdRGL2a antagonized MdbHLH162-mediated inhibition of anthocyanins by sequestering MdbHLH162 from the MdbHLH162-MdbHLH3/33 *** JA repressors MdJAZ1 and MdJAZ2 interfered with the antagonistic regulation of MdbHLH162 by MdRGL2a by titrating the formation of the MdRGL2a-MdbHLH162 *** findings reveal that MdbHLH162 integrates the GA and JA signals to negatively regulate anthocyanin *** study provides new information for discovering more anthocyanin biosynthesis repressors and explores the cross-talk between hormone signals.

关键词： anthocyanin biosynthesis bHLH transcription factor gibberellin jasmonic acid regulatory network transcriptional regulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructures and Properties of Honeycomb Sulfur/carbon Black/MoS_(2) Composites

引用

Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1073-1078页

作者： CUI Chunjuan LIU Yue ZHAO Yanan LIU Yanyun WANG Yan wei jian HU ping School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi'an 710055China Shaanxi Metallurgical Engineering Technology Research Center Xi’an 710055China School of Materials Science and Engineering Xi’an University of Architecture and TechnologyXi’an 710055China

Microstructure and property of sulfur/carbon black composites prepared by ball milling were ***/carbon black composites were obtained by melting the mixture of sulfur and carbon black in 155℃and dispersing evenly in carbon black after hydrothermal ***,its conductive properties were ***,microstructure and property of honeycomb sulfur/carbon black/MoS_(2) prepared by hydrothermal method as a cathode material for lithium-sulfur batteries were *** initial discharge specific capacity of the material at 0.2 A/g current density is 838.495 mA·h/g,and the 55.14%after 100 weeks of *** is indicated that MoS_(2) can not only combine with polysulfides through electrostatic action or the action of chemical bonds,but also honeycomb porous ***_(2) can fix polysulfides groups and prevent their ***,the cycling performance of the battery is effectively improved.

关键词： lithium-sulfur battery honeycomb MoS_(2) charge/discharge performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：