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Interstitial fluid flow:simulation of mechanical environment of cells in the interosseous membrane

Acta Mechanica Sinica 2011年第4期27卷 602-610页

作者： wei Yao guang-hong Ding Department of Mechanics and Engineering Science Fudan University Shanghai Research Center of Acupuncture 200433 Shanghai China

In vitro experiments have shown that subtle fluid flow environment plays a significant role in living biological tissues, while there is no in vivo practical dynamical measurement of the interstitial fluid flow velocity. On the basis of a new finding that capillaries and collagen fibrils in the interosseous membrane form a parallel array, we set up a porous media model simulating the flow field with FLUENT software, studied the shear stress on interstitial cells＇ surface due to the interstitial fluid flow, and analyzed the effect of flow on protein space distribution around the ceils. The numerical simulation results show that the parallel nature of capillaries could lead to directional interstitial fluid flow in the direction of capillaries. Interstitial fluid flow would induce shear stress on the membrane of interstitial cells, up to 30 Pa or so, which reaches or exceeds the threshold values of cells＇ biological response observed in vitro. Interstitial fluid flow would induce nonuniform spacial distribution of secretion protein of mast cells. Shear tress on cells could be affected by capillary parameters such as the distance between the adjacent capillaries, blood pressure and the permeability coefficient of capillary＇s wall. The interstitial pressure and the interstitial porosity could also affect the shear stress on cells. In conclusion, numerical simulation provides an effective way for in vivo dynamic interstitial velocity research, helps to set up the vivid subtle interstitial flow environment of cells, and is beneficial to understanding the physiological functions of interstitial fluid flow.

关键词： Interstitial fluid flow Porous media. Numericalsimulation - Acupoint Sheer stress

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Flow Injection Determination of Oxalate Based on Its Catalytic Effect on the Oxidation of p-Chloride Aniline by Dichromate

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Chemical Research in Chinese Universities 2001年第3期17卷 253-258页

作者： LI Li-jun wei hong-guang ZHANG Ying guangxi Institute of Technology Liuzhou 545006P.R.China

In a sulfuric acid medium, oxalate exhibits a strong catalytic effect on the oxidation of p-chloride aniline(ClBN) by dichromate, and the red oxidation product of ClBN has a maximum absorhancy at 520 nm. Based on this founding, a new FI method for determining oxalate was developed. A calibration curve of oxalate in the range of 0.40—17.0μg/mL was obtained. The detection limit was 0.10μg/mL. Sampling rate was 103-samples/h. The possible interference by the co-existing substances or ions was examined. This new method was applied to the determination of micro amounts of oxalate in real samples with satisfactory results.

关键词： FIA Oxalate p-Chloro aniline Potassium dichromate

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Non-fragile H∞ Filtering for Discrete-time Systems with Finite Word Length Consideration

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自动化学报 2008年第8期34卷 886-892页

作者： CHE wei-wei YANG guang-hong Key Laboratory of Integrated Automation for the Process Industry Ministry of Education College of Information Science and Engineering Northeastern University Shenyang 110004 P.R. China

过滤有限的词长度(FWL ) 为线性分离时间的系统影响的问题的 nonfragile H 在这份报纸被调查。要设计的过滤器被假定与添加剂获得变化，它在过滤器实现上反映 FWL 效果。结构化的顶点隔板的一个观点被建议处理这个问题并且利用了以一套... 详细信息

过滤有限的词长度(FWL ) 为线性分离时间的系统影响的问题的 nonfragile H 在这份报纸被调查。要设计的过滤器被假定与添加剂获得变化，它在过滤器实现上反映 FWL 效果。结构化的顶点隔板的一个观点被建议处理这个问题并且利用了以一套线性矩阵不平等(LMI ) 为 nonfragile H 过滤器设计开发足够的条件。设计使扩充系统变为 asymptotically 稳定并且保证 H 变细水平不到规定水平。一个数字例子被给说明建议方法的效果。

关键词：滤波离散时间系统线性离散分析方法

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Histological and Ultrastructural Observation Reveals Significant Cellular Differences between Agrobacterium Transformed Embryogenic and Non-embryogenic Calli of Cotton

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Journal of Integrative Plant Biology 2009年第5期51卷 456-465页

作者： Hai-hong Shang Chuan-Liang Liu Chao-Jun Zhang Feng-Lian Li wei-Dong hong Fu-guang Li Key Laboratory of Cotton Genetic Improvement Ministry of Agriculture Chinese Cotton Research Institute Chinese Agricultural Academy of Sciences Anyang 455004 China

Over the past few decades genetic engineering has been applied to improve cotton breeding. Agrobacterium medicated transformation is nowadays widely used as an efficient approach to introduce exogenous genes into cotton for genetically modified organisms. However, it still needs to be improved for better transformation efficiency and higher embryogenic callus induction ratios. To research further the difference of mechanisms for morphogenesis between embryogenic callus and non-embryogenic callus, we carried out a systematical study on the histological and cellular ultrastructure of Agrobacterium transformed calli. Results showed that the embryogenic callus developed nodule-like structures, which were formed by small, tightly packed, hemispherical cells. The surface of some embryogenic callus was covered with a fibrilar-like structure named extracellular matrix. The cells of embryogenic calli had similar morphological characteristics. Organelles of embryogenic callus cells were located near the nucleus, and chloroplasts degraded to proplastid-like structures with some starch grains. In contrast, the non-embryogenic calli were covered by oval or sphere cells or small clusters of cells. It was observed that cells had vacuolation of cytoplasm and plastids with a well organized endomembrane system. This study aims to understand the mechanisms of embryogenic callus morphogenesis and to improve the efficiency of cotton transformation in future.

关键词： cell organization pattern chloroplasts embryogenic callus Gossypiurn hirsutum histological structure transformation ultrastructure

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In vitro expression of gelatinases in reconstructed melanoma model composited MV3 cells

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Chinese Medical Journal 2013年第16期126卷 3196-3197页

作者： L(U) Yu ZHANG wei LU hong-guang Department of Dermatology Affiliated Hospital of Guiyang Medical UniversityGuiyang Guizhou 550001 China

To the editor：It has been known that invasion and metastasis of skin melanoma in situ is a complex multi-step process involving in the interaction between melanoma cells and the adjacent stromal cells and basement membrane （BM）.1 Over the years,the process of melanoma invasion from epidermis to dermis was observed using animal models or human cutaneous melanoma lesions removed.2,3As for the deleted human pathological specimens,it is difficult to completely restore invasion system in ***,experimental animal is subjected to a damage or death in animal *** the animal in vivo,it contains various indefinite factors to influence tumor-cell invasion and *** the general enhance on awareness of animal protection,organized and realistic artificial tumor model is an acceptable alternative to animal melanoma research in this field,which is an important progress in observing skin melanoma *** in vitro reconstructed melanoma models made by different melanoma cell lines cultured on dermal substitute *** matrices were reported to study melanoma invasion.1 For instance,Eves et al4 reported that melanoma cells with invasive growth on acellular dermis expressed gelatinases （MMP-2,MMP-9）.However,both invasive behavior of melanoma cells and those proteases activity correlated with the invasion seem wide variations in different melanoma cell lines.4 Hence,more experiments on invasion assay in those models would be required in this field.

关键词： expression gelatinases reconstructed

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A FLUID MECHANICS MODEL OF TISSUE FLUID FLOW IN LIMB CONNECTIVE TISSUE——A MECHANISM OF ACUPUNCTURE SIGNAL TRANSMISSION

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Journal of Hydrodynamics 2009年第5期21卷 675-684页

作者： ZHANG Di YAO wei DING guang-hong YANG Jing SCHWARZ Wolfgang FEI Lun LIU Fang SHEN Xue-yong LAO Li-xing Shanghai Research Center of Acupuncture and Meridian Department of Mechanics and Engineering Science Fudan University Shanghai 200433 China Anatomy Department of the Second Medical University of PLA Shanghai 200433 China Acupuncture College Shanghai University of Traditional Chinese Medicine Shanghai 200032 China Center for Integrative Medicine University of Maryland School of Medicine Baltimore MD 21201 USA

This article explores the mechanisms of acupuncture meridians by determining characteristics of the tissue fluid flow in the connective tissue along meridians. Based on deep dissection of acupoints on the upper and lower limbs of the human body and micro and macro observation and measurement, a mathematical model of the flow of tissue fluid in interosseous membranes is constructed. It is shown that the signal transmission along acupuncture meridians may be determined by unique anatomical and physiological factors that govern the flow of tissue fluid in the connective tissue and involve mast cell degranulation. Our results provide a preliminary explanation of the phenomenon of the ＂de qi＂ sensation and the mechanism of acupuncture signal transmission along acupuncture meridians.

关键词： acupuncture meridian tissue-fluid flow mast cell

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Diagnosis and treatment of pancreatic somatostatinoma： a case report

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Chinese Medical Journal 2008年第22期121卷 2363-2365页

作者： ZHANG Zheng-yun ZHANG Rui WANG Lin SHEN Chuan YAN Ji-qi CHEN Yong-jun LI Qin-yu YANG wei-ping PENG Cheng-hong LI hong-wei ZHOU guang-wen Department of Surgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive Surgery Shanghai 200025 China

Ppancreatic somatostatinoma represents a rare group of neuroendocrine tumors, which was first reported by Ganda and Larsson in 19771 Less than 50 cases have been reported to the present. We treated a case of pancreati... 详细信息

关键词： omatostatinoma. diagnosis: therapeutics

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Preparation of gradient biomaterial used for artificial mechanical heart valve

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Chinese Journal of Biomedical Engineering(English Edition) 1999年第1期8卷 2-7页

作者： WANG hong wei,YIN guang fu,ZHENG Chang qiong, RAN Jun guo,wei Qing Sichuan Union University,Chengdu 610065,China

ＩＮＴＲＯＤＵＣＴＩＯＮＳｉｎｃｅｔｈｅａｒｔｉｆｉｃｉａｌｍｅｃｈａｎｉｃａｌｈｅａｒｔｖａｖｌｅ（ＡＭＨＶ）ｍａｄｅｏｆｍｅｔａｌｃｏａｔｅｄｗｉｔｈｃａｒｂｏｎｐｏｓｓｅｓｓｅｓｂｏｔｈｔｈｅｆａｖｏｒａｔｅｍ... 详细信息

ＩＮＴＲＯＤＵＣＴＩＯＮＳｉｎｃｅｔｈｅａｒｔｉｆｉｃｉａｌｍｅｃｈａｎｉｃａｌｈｅａｒｔｖａｖｌｅ（ＡＭＨＶ）ｍａｄｅｏｆｍｅｔａｌｃｏａｔｅｄｗｉｔｈｃａｒｂｏｎｐｏｓｓｅｓｓｅｓｂｏｔｈｔｈｅｆａｖｏｒａｔｅｍａｃｈｉｎａｂｉｌｉｔｙｏｆｔｈｅ...

关键词： gradient biomaterial adhesive strength artificial mechanical heart valve Diamond like carbon

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富勒烯与β淀粉样肽低聚体结合的分子动力学模拟

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物理化学学报 2014年第8期30卷 1587-1596页

作者：周晓颖郗文辉韦广红应用表面物理国家重点实验室计算物质科学教育部重点实验室复旦大学物理系上海200433

本文通过分子动力学模拟研究富勒烯在Aβ42低聚体表面的结合过程.在结合过程中,C60在Aβ表面经历一系列尝试过程,最终找到某个稳定的结合位点.根据结合的残基不同,这些结合位点可以分为六类,其中核心疏水区域(CHC)位点(17LVFFA21)及Turn... 详细信息

本文通过分子动力学模拟研究富勒烯在Aβ42低聚体表面的结合过程.在结合过程中,C60在Aβ表面经历一系列尝试过程,最终找到某个稳定的结合位点.根据结合的残基不同,这些结合位点可以分为六类,其中核心疏水区域(CHC)位点(17LVFFA21)及Turn 27-31位点(27NKGAI31)具有最强的结合稳定性.二者的结合主要通过范德华作用稳定,而溶剂化效应则起相反作用.在这六类位点中的两个位点,观察到C60会对Aβ二级结构起破坏作用.其一位于核心疏水区域,C60有挤入多肽β片层中间的趋势;另外一位点位于N端,C60能够破坏外侧Aβ的3-5号残基的主链氢键,瓦解其末端的β片结构.这两个过程对理解富勒烯抑制Aβ聚集的微观机制提供了帮助.此外,在Turn 27-31位点以及Y10-H14位点,发现了富勒烯与Aβ纤维样聚集体结合的沟槽滚动机制,即富勒烯能够在淀粉样低聚体表面形成的特定沟槽内滚动.这一特征有助于预测富勒烯在其它淀粉样多肽表面的结合位点及结合行为.

关键词：多位点结合结合能二级结构破坏疏水口袋沟槽滚动机制

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基于萤火虫群优化的空间非合作目标相对导航粒子滤波算法

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中国惯性技术学报 2017年第2期25卷 269-274页

作者：张大力夏红伟马广程王常虹哈尔滨工业大学航天学院哈尔滨150001

研究了空间非合作目标相对导航算法,针对标准粒子滤波的重采样过程导致的粒子贫化现象及其造成的相对导航精度下降问题,分析了萤火虫优化算法的运行机制,提出一种基于萤火虫智能优化算法的改进粒子滤波算法。改进算法通过优化粒子滤波... 详细信息

研究了空间非合作目标相对导航算法,针对标准粒子滤波的重采样过程导致的粒子贫化现象及其造成的相对导航精度下降问题,分析了萤火虫优化算法的运行机制,提出一种基于萤火虫智能优化算法的改进粒子滤波算法。改进算法通过优化粒子滤波的重采样过程,使粒子群智能的向高似然区域移动,同时在低似然区域也合理保留了部分粒子,保证了粒子的多样性,提高了样本的整体质量。仿真结果表明,改进算法导航精度较标准算法提高了39.35%,达到稳定精度所需粒子数较少,有效抑制了粒子贫化问题。

关键词：萤火虫算法粒子滤波粒子贫化相对导航

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