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Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms

World Journal of Psychiatry 2025年第1期15卷 63-71页

作者： Qi-Hui Jiang wei-dong Gong Department of Endocrinology and Metabolism Hengyang Central HospitalHengyang 421000Hunan ProvinceChina Breast Tumor Surgical Outpatient Hengyang Central HospitalHengyang 421000Hunan ProvinceChina

BACKGROUND The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia,especially thyroid *** To study the relationship between triiodothyronine(T3),thyroxine(T4),free T3(FT3),free T4(FT4),thyroid stimulating hormone(TSH)and *** In this study,100 schizophrenia patients were selected from our hospital between April 2022 and April *** clinical data were analyzed *** on the Positive and Negative Syndrome Scale(PANSS)score,patients were divided into mild(1-3 points,n=39),moderate(4 points,n=45),and severe groups(5-7 points,n=16).Additionally,55 healthy individuals served as a control *** blood samples were collected to measure T3,T4,FT3,FT4,TSH,and cortisol concentrations,analyzing their relationship with PANSS *** The serum levels of T3,FT3,FT4,TSH and cortisol in the schizophrenia group were lower than those in the control group(P<0.05).With the increase of the severity of the disease,the concentrations of T3 and T4 decreased,while the con-centrations of TSH and cortisol increased(P<0.05).The concentrations of TSH and cortisol were positively correlated with the PANSS score,while T3 and T4 were negatively correlated with the PANSS score(P<0.05).The receiver ope-rating characteristic curve results showed that T3,T4,TSH,and cortisol had good efficacy in the diagnosis of *** results showed that decreased T3 level,decreased T4 level,decreased TSH level and increased cortisol level may be independent risk factors for *** Thyroid hormone levels are associated with the severity of schizophrenia symptoms,which can provide new solutions for the diagnosis and treatment of schizophrenia.

关键词： Thyroid hormone Schizophrenia Symptom severity Positive and Negative Syndrome Scale score Cortisol

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第01期 369-376页

作者： Song-Meng Wang Hao Nian Yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-wei dong Liping Huang Xiaoping Wang wei Jiang Liu-Pan Yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression

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World Journal of Psychiatry 2025年第1期15卷 32-36页

作者： Min Xu Hai-Ying Jin Feng-Li Sun wei-dong Jin Department of Psychiatry Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Psychiatry Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Psychiatry Zhejiang Provincial Mental Health CenterHangzhou 311122Zhejiang ProvinceChina

Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent ***,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake *** studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent *** the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side *** review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.

关键词： Child depression Adolescent depression Antidepressant Switch Suicide Non-suicidal self injury

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Coupled chemical effects of carbon dioxide and hydrogen additions on premixed lean dimethyl ether flames

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Science China(Technological Sciences) 2017年第1期60卷 102-115页

作者： PAN wei LIU dong School of Energy and Power Engineering Nanjing University of Science and Technology Nanjing 210094 China

Kinetic analysis of coupled effects of CO2 and H2 additions on laminar lean premixed dimethyl ether flames is performed at atmospheric pressure. The coupled effects of H2/CO2 additions on major species, intermediate stable species and radicals are discussed and analyzed in detail. The dilution, thermal and chemical effects of H2 and CO2 are separated and identified. The results show that H2 addition can slightly mitigate the CO2 chemical effects on decreasing the temperatures, H radical concen- tration, acetylene mole fraction and formaldehyde concentration. After CO2 is added, the H2 chemical effects on increasing the temperatures are enhanced. DME oxidation is promoted by the H2 chemical effects, which is further strengthened by the CO2 addition. Moreover, CO2 addition can reduce the H2 chemical effects on increasing the H radical mole fraction, but strengthen the H2 chemical effects on increasing the production of HO2 and C2H2. CH2O formation can be promoted by the H2 chemical effects, which is enhanced by the CO2 addition. In actually, the H2/CO2 coupled chemical effects almost have no obvious in- fluence on the temperatures and HO2 mole fraction. DME consumption is delayed by the H2/CO2 coupled chemical effects. Furthermore, the H2/CO2 coupled chemical effects can decrease the H radical mole fraction, CH4 concentration, C2H2 mole fraction, CH2O concentration and CHaCHO mole fraction, but increase the CO concentration.

关键词： dimethyl ether flame H2/CO2 addition coupled effects kinetic analysis

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Scaled particle theory for bulk and confined fluids： A review

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Science China(Physics,Mechanics & Astronomy) 2018年第7期61卷 1-17页

作者： wei dong XiaoSong Chen Universite de Lyon CNRS Ecole Normale Superieure de Lyon Universite Lyon 1 Laboratoire de Chimie UMR 5182 46 Allee d'Italie 69364 Lyon Cedar 07 France State Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100190 China

More than half a century after its first formulation by Reiss, Frisch and Lebowitz in 1959, scaled particle theory(SPT) has proven its immense usefulness and has become one of the most successful theories in liquid physics. In recent years, we have strived to extend SPT to fluids confined in a variety of random porous matrices. In this article, we present a timely review of these developments. We have endeavored to present a formulation that is pedagogically more accessible than those presented in various original papers, and we hope this benefits newcomers in their research work. We also use more consistent notations for different cases. In addition, we discuss issues that have been scarcely considered in the literature, e.g., the one-fluid structure of SPT due to the isomorphism between the equation of state for a multicomponent fluid and that for a one-component fluid or the pure-confinement scaling relation that provides a connection between a confined and a bulk fluid.

关键词： fluids confined in porous media scaled particle theory hard sphere fluids

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Improved Approximation Schemes for Early Work Scheduling on Identical Parallel Machines with a Common Due Date

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Journal of the Operations Research Society of China 2024年第2期12卷 341-350页

作者： wei-dong Li School of Mathematics and Statistics Yunnan UniversityKunming650504YunnanChina

We study the early work scheduling problem on identical parallel machines in order to maximize the total early work,i.e.,the parts of non-preemptive jobs that are executed before a common due *** preprocessing and constructing an auxiliary instance which has several good properties,for any desired accuracy,we propose an efficient polynomial time approximation scheme with running time O(f(1/ε)n),where n is the number of jobs and f(1/ε)is exponential in 1/ε,and a fully polynomial time approximation scheme with running time O(1/ε^(2m+1)+n)when the number of machines is fixed.

关键词： Scheduling Early work Polynomial time approximation scheme Effcient polynomial time approximation scheme Fully polynomial time approximation scheme

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A P300 based online brain-computer interface system for virtual hand control

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第8期11卷 587-597页

作者： wei-dong CHEN Qiushi Academy for Advanced Studies Zhejiang University Hangzhou 310027 China School of Computer Science and Teehnology Zhejiang University Hangzhou 310027 China Department of Biomedical Engineering Zhejiang University Hangzhou 310027 China MRI Unit Department of Psycbiatry Columbia University College of Physicians and Surgeons New York NY 10032 USA New York State Psychiatric Institute New York NY 10032 USA

Brain-computer interface (BCI) is a communication system that can help lock-in patients to interact with the outside environment by translating brain signals into machine *** present work provides a design for a virtual reality (VR) based BCI system that allows human participants to control a virtual hand to make gestures by P300 signals,with a positive peak of potential about 300 ms posterior to the onset of target *** this virtual environment,the participants can obtain a more immersed experience with the BCI system,such as controlling a virtual hand or walking around in the virtual *** of modeling the virtual hand and analyzing the P300 signals are also described in *** matching and support vector machine were used as the P300 classifier and the experiment results showed that both algorithms perform well in the *** a short time of practice,most participants could learn to control the virtual hand during the online experiment with greater than 70% accuracy.

关键词： Brain-computer interface (BCI) Electroencephalography (EEG) P300 Virtual reality (VR) Template matching Support vector machine (SVM)

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Propagation of chaos and conditional McKean-Vlasov SDEs with regime-switching

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Frontiers of Mathematics in China 2022年第4期17卷 731-746页

作者： Jinghai SHAO dong wei Center for Applied Mathematics Tianjin UniversityTianjin300072China

We investigate a particle system with mean field interaction living in a random environment characterized by a regime-switching *** switching process is allowed to be dependent on the particle *** well-posedness and various properties of the limit conditional McKean-Vlasov SDEs are studied,and the conditional propagation of chaos is established with explicit estimate of the convergence rate.

关键词： Regime-switching propagation of chaos Wasserstein distance conditional McKean-Vlasov SDEs rate of convergence

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Numerical Investigation of the Fluid Flow Characteristics in the Hub Plate Crown of a Centrifugal Pump

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Chinese Journal of Mechanical Engineering 2018年第4期31卷 182-191页

作者： wei dong Wu-Li Chu School of Power and Energy Northwestern Polytechnical University Collaborative Innovation Center of Advanced AeroEngine

Due to the lack of understanding in the flow mechanism of the hub plate crown, the current calculation of the disc friction loss and the axial thrust in the centrifugal pump often uses empirical formulas. Research on the flow characteristics of the hub plate crown is of practical significance. The shroud and hub cavities are respectively studied with regard to tangential and radial velocities at the four different angular positions(0°, 90°, 180°, and 270°) at the four different operational points(0.6 Qsp, 0.8 Qsp, 1.0 Qsp, and 1.2 Qsp). Results indicate that at the same operational point, the smaller the volute chamber sectional area is, the higher the tangential velocity of the fluid core zone of the shroud cavity is. Radial leakage flow from the volute to the seal ring at the same operational point appears in 0° and 90° direction;when the flow is large, the tangential and radial velocities of the shroud and hub cavities with the same radius tend to be equal with axial symmetry. The axial leakage flow through the balance holes significantly affects the radial distribution of both tangential and radial velocities of fluid flow in the hub cavity. The numerical calculation results of fluid leakage through the clearance of back sealing ring are in good agreement with the test results. Accordingly, the magnitude of leakage is closely related to the fluid pressure and velocity distribution in the hub plate crown of the centrifugal pump. The analysis of the flow characteristics in the hub plate crown of the centrifugal pump could reveal the cause of the disc friction loss from the mechanism, providing a significant guidance for improving the accuracy of calculation and balancing the axial thrust in the centrifugal pump.

关键词： Centrifugal pump Shroud cavity Hub cavity Leakage of clearance Numerical simulation

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Coupled bending-torsion vibration of a homogeneous beam with a single delamination subjected to axial loads and static end moments

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Acta Mechanica Sinica 2014年第4期30卷 607-614页

作者： Yang Liu dong-wei Shu School of Mechanical and Aerospace Engineering Nanyang Technological University

Delaminations in structures may significantly reduce the stiffness and strength of the structures and may affect their vibration characteristics. As structural components, beams have been used for various purposes, in many of which beams are often subjected to axial loads and static end moments. In the present study, an analytical solution is developed to study the coupled bending-torsion vibration of a homogeneous beam with a single delamination subjected to axial loads and static end moments. Euler-Bernoulli beam theory and the ＂free mode＂ assumption in delamination vibration are adopted. This is the first study of the influences of static end moments upon the effects of delaminations on natural frequencies, critical buckling loads and critical moments for lateral instability. The results show that the effects of delamination on reducing natural frequencies, critical buckling load and critical moment for lateral instability are aggravated by the presence of static end moment. In turn, the effects of static end moments on vibration and instability characteristics are affected by the presence of delamination. The analytical results of this study can serve as a benchmark for finite element method and other numerical solutions.

关键词： Vibration · Delamination ·End moments · Nat-ural frequency · Critical moment for lateral instability

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