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Statistical Identification of Important Nodes in Biological Systems

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Journal of Systems Science & Complexity 2021年第4期34卷 1454-1470页

作者： wang pei School of Mathematics and Statistics Institute of Applied MathematicsLaboratory of Data Analysis TechnologyHenan UniversityKaifeng 475004China

Biological systems can be modeled and described by biological *** networks are typical complex networks with widely real-world *** problems arising in biological systems can be boiled down to the identification of important *** example,biomedical researchers frequently need to identify important genes that potentially leaded to disease phenotypes in animal and explore crucial genes that were responsible for stress responsiveness in *** facilitate the identification of important nodes in biological systems,one needs to know network structures or behavioral data of nodes(such as gene expression data).If network topology was known,various centrality measures can be developed to solve the problem;while if only behavioral data of nodes were given,some sophisticated statistical methods can be *** paper reviewed some of the recent works on statistical identification of important nodes in biological systems from three aspects,that is,1)in general complex networks based on complex networks theory and epidemic dynamic models;2)in biological networks based on network motifs;and 3)in plants based on RNA-seq *** identification of important nodes in a complex system can be seen as a mapping from the system to the ranking score vector of nodes,such mapping is not necessarily with explicit *** three aspects reflected three typical approaches on ranking nodes in biological systems and can be integrated into one general *** paper also proposed some challenges and future works on the related *** associated investigations have potential real-world applications in the control of biological systems,network medicine and new variety cultivation of crops.

关键词： Biological network complex network important node network motif RNA-seq

SO（d,d;Z) Transformation Property for Gauge Fluxes and Ramond-Ramond Fields in Noncommutative Geometry

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Communications in Theoretical Physics 2002年第2期37卷 173-178页

作者： wang pei Institute of Modern Physics Northwest University Xi'an 710069 China

In this paper we study the spinor constructions of gauge fluxes and Ramond Ramond fields on noncommu-tative tori Td up to d＝6. In which the spinor and conjugate spinor are distinguished and dual bases are also *** th... 详细信息

关键词：规范场 SO(d,d Z)变换不可对易几何学

电刺激诱导miR-741-3p调控Radil促进施万细胞的迁移

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中国组织工程研究 2025年第19期29卷 4038-4043页

作者：刘庆高博杨霄姜宇王培承德医学院附属医院河北省承德市067000 承德医学院河北省承德市067000

背景:越来越多的动物实验和临床研究证实电刺激可以促进周围神经损伤修复,具体的机制尚未完全明确。目的:探讨电刺激诱导miR-741-3p调控Radil对施万细胞迁移的影响。方法:①12只雄性SD大鼠,随机分为电刺激组和对照组,电刺激组在坐骨神... 详细信息

背景:越来越多的动物实验和临床研究证实电刺激可以促进周围神经损伤修复,具体的机制尚未完全明确。目的:探讨电刺激诱导miR-741-3p调控Radil对施万细胞迁移的影响。方法:①12只雄性SD大鼠,随机分为电刺激组和对照组,电刺激组在坐骨神经挤压伤后连续电刺激7 d,对照组在坐骨神经挤压后不做任何处理。术后第7天取损伤处神经,利用荧光原位杂交技术检测两组miR-741-3p的表达差异。②通过miRDB、TargetScan和miRWalk数据库预测miR-741-3p靶基因。③将miR-741-3p模拟物及其对照、miR-741-3p抑制物及其对照、Radil siRNA及其对照、miR-741-3p抑制物+Radil siRNA及miR-741-3p抑制物+siRNA对照对施万细胞进行转染,采用RT-PCR检测转染效率,Transwell小室检测施万细胞的迁移能力。结果与结论:①电刺激组神经残端miR-741-3p荧光强度低于对照组;②数据库预测结果显示有69个基因可能是miR-741-3p靶基因,Radil是预测靶基因之一,主要参与细胞黏附和迁移;③与miR-741-3p抑制物对照组相比,miR-741-3p抑制物组施万细胞迁移数增多(P<0.05);与miR-741-3p模拟物对照组相比,miR-741-3p模拟物组施万细胞迁移数减少(P<0.05);与siRNA对照组相比,Radil siRNA组施万细胞迁移数减少(P<0.05);④与miR-741-3p抑制物对照组相比,miR-741-3p抑制物组Radil的表达水平升高;与miR-741-3p模拟物对照组相比,miR-741-3p模拟物组Radil的表达水平降低;⑤与miR-741-3p抑制物+siRNA对照组相比,miR-741-3p抑制物+Radil siRNA组施万细胞迁移数减少(P<0.05)。结果表明,电刺激通过下调miR-741-3p调控Radi的表达来促进施万细胞迁移。

关键词：施万细胞电刺激 miR-741-3p Radil 细胞迁移神经再生

Effects of thermophoresis on Brownian coagulation of spherical particles over the entire particle size regime

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Particuology 2022年第8期20卷 8-17页

作者： Kaiyuan wang pei wang Suyuan Yu Institute of Applied Physics and Computational Mathematics Bejing 100094.China Center forCombustionEergy.Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Energyand PowerEngineeringTsinghua UniversityBejing 100084.China Smoore International Holdings Ltd.Shenzhen 518102 China

In many energy and combustion *** experience large temperature gradients,which can affect the coagulation process due to *** study presents a rigorous theory of thermophoretically modified Brownian coagulation in the entire particle size *** theoretical derivations are based on the kinetictheory forthe free-molecular regime and the harmonic mean method for the transition *** coagulation kernels in different size regimes can be expressed as the basic Brownian coagulation kernel times an enhancement factor,The enhancement factor represents the coagulationrate enhancement induced by thermophoresis and is a function of specific dimensionless *** on the enhancement factor,the thermophoretic enhancement effects on particle coagulation are further analyzed under a wide range of gas and particle *** results show that thermophoretic enhancement effects are ignorable in the free-molecular regime,but need to be considered in the continuum regime and the transition *** addition,the enhancement effects increase significantly with increase of gas temperature and temperature gradient while decrease with increase of gas *** present study can improve understanding ofthermophoretic effects on Brownian coagulation in the entire size regime and provide a useful tool to calculate the coagulation rates in presence of thermophoresis.

关键词： Thermophoresis Brownian coagulation Enhancement factor Knudsen number

On the Grothendieck Ring of the Sequence of Walled Brauer Algebras

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Algebra Colloquium 2023年第3期30卷 395-410页

作者： pei wang Yanbo Li Teachers'College Beijing Union UniversityBeijing 100101China School of Mathematics and Statistics Northeastern University at QinhuangdaoQinhuangdaoHebei 066004China

In this paper, we provide a diagrammatic approach to study the branching rules for cell modules on a sequence of walled Brauer algebras. This approach also allows us to calculate the structure constants of multiplicat... 详细信息

关键词： walled Brauer algebra cellular algebra cell module Grothendieck ring

WATER QUALITY MODELING AND POLLUTION CONTROL FOR THE EASTERN ROUTE OF SOUTH TO NORTH WATER TRANSFER PROJECT IN CHINA

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Journal of Hydrodynamics 2006年第3期18卷 253-261页

作者： wang Chao wang Yan-ying wang pei-fang Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes College of Environmental Science and Engineering Hohai University Nanjing 210098 China

South to North Water Transfer Project in China is the largest project over centuries to solve the water shortage problem in vast areas of northern China. It comprises of three routes： the eastern, central and western route and this study mainly focused on the eastern route. As water quality is the key factor for the eastern route, this paper examined the main factors influencing water quality of the main route south of the Yellow River, by investigating the point source, non-point source （diffusive source） and internal source pollutions along the main eastern route and in its drainage basins, and assessing the Current water quality in the waterways. According to the complicated and combined systems of rivers and lakes in this route, one-dimensional water quantity and quality model for rivers and two-dimensional model for lakes were developed to simulate the hydrodynamic and pollutant transport processes. The numerical method and model algorithm were described. The values of model parameters were estimated by using field-monitoring data along the main route and the inverse modeling technique. Established models were employed to predict the degradations of CODMn and NH4^＋-N in the main stream, under the conditions of current pollution loads and different hydrologic conditions. Schemes were present for controlling total quantities of pollutants from point source and non-point source along the main route to secure water quality for the eastern route.

关键词： South to North Water Transfer Eastern RouteProject water quality pollution loads pollution control

Role of Solute Rare Earth in Altering Phase Transformations during Continuous Cooling of a Low Alloy Cr–Mo–V Steel

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Acta Metallurgica Sinica(English Letters) 2023年第9期36卷 1523-1535页

作者： Zhonghua Jiang pei wang Dianzhong Li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

Effects of solute rare earth(RE)on continuous cooling transformation of a low-alloy Cr–Mo–V bainitic steel are investigated in detail by dilatometry,optical microscopy(OM),scanning electron microscopy(SEM)and transmission electron microscopy(TEM).Microstructures appeared in thermal dilatometric samples of both low-alloy Cr–Mo–V(RE)steels are composed of quasi-polygonal ferrite(QPF),degenerate pearlite(DP),granular bainite(GB),lath bainite(LB),and martensite(M)depending on cooling *** cooling rate is lower than 2°C/s,the addition of RE suppresses QPF transformation,and thereby inducing a broader transformation region of *** cooling rate ranges from 2 to 100°C/s,the addition of RE decreases the start temperature of bainitic transformation distinctly,which results in finer bainitic ferrite grain size and higher dislocation *** addition of RE can enhance the hardness of the low alloy Cr–Mo–V steel by affecting the aforementioned diffusional and/or partly displacive ***,when cooling rate increases up to 150°C/s,two steels have the same hardness value of about 435 HV due to only martensite obtained by displacive transformation.

关键词： Low-alloy Cr-Mo-V steel Rare earth Phase transformation Bainitic microstructures Continuous cooling transformation

Time-Varying Channel Estimation Based on Air-Ground Channel Modelling and Modulated Learning Networks

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Chinese Journal of Electronics 2022年第3期31卷 430-441页

作者： LIU Chunhui wang Meilin DONG Zanliang wang pei Institute of Unmanned System Beihang University School of Electronic and Information Engineering Beihang University

To improve the time-varying channel estimation accuracy of orthogonal frequency division multiplexing air-ground datalink in complex environment, this paper proposes a time-varying air-ground channel estimation algorithm based on the modulated learning networks,termed as MB-Chan Est-TV. The algorithm integrates the modulated convolutional neural networks(MCNN) with the bidirectional long short term memory(Bi-LSTM),where the MCNN subnetworks accomplish channel interpolation in frequency domain and compress the network model while the Bi-LSTM subnetworks achieve channel prediction in time domain. Considering the unique characteristics of airframe shadowing for unmanned aircraft systems, we propose to combine the classical 2-ray channel model with the tapped delay line model and present a more realistic channel impulse response samples generation approach, whose code and dataset have been made publicly available. We demonstrate the effectiveness of our proposed approach on the generated dataset, where experimental results indicate that the MB-Chan Est-TV model outperforms existing state-of-the-art methods with a lower estimation error and better bit error ratio performance under different signal to noise ratio *** also analyze the effect of roll angle of the aircraft and the duration percentage of the airframe shadow on the channel estimation.

关键词： OFDM modulation channel prediction realistic channel impulse response samples generation approach modulated learning networks Bi-LSTM subnetworks telecommunication computing air-ground datalink wireless channels 2-ray channel model convolutional neural nets interpolation time-varying channels MB-ChanEst-TV model air-ground channel modelling frequency domain error statistics recurrent neural nets channel estimation modulated convolutional neural networks bidirectional long short term memory learning (artificial intelligence) time-varying air-ground channel estimation algorithm network model channel interpolation MCNN tapped delay line model lower estimation error time-varying channel estimation accuracy

Mimicking the native bone regenerative microenvironment for in situ repair of large physiological and pathological bone defects

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Engineered Regeneration 2022年第4期3卷 440-452页

作者： pei wang Xiansong wang Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Thoracic surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Bone is a complex biological tissue with a complicated hierarchical nanocomposite *** native microen-vironment of the bone tissue may be significantly disrupted by large physiological and pathological bone *** defects are often treated via complex surgical procedures that involve the application of autografts or *** these grafting procedures often suffer from insufficient natural bone stock and ***,these traditional treatment methods fail to simulate a regenerative microenvironment,which plays a significant role in regeneration of bone tissue and repair of large bone *** this end,various biomimetic scaffolds have been devised to mimic the native microenvironment of bone and thereby to simultaneously re-pair bone defects and promote bone *** propose here a novel concept,in vivo bone regenerative microenvironment(BRM),which enables repair of large bone defects and enhances new bone tissue formation with external *** this review,we mainly focus on materials and methods for fabrication of biomimetic scaffolds,as well as their therapeutic efficacy in modulating the BRM of large physiological and pathological bone defects.

关键词： Bone regenerative microenvironemt(BRM) Large physiological bone defects Large pathological bone defects Biomaterial Scaffold