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Mechanical behaviours of bedded sandstone under hydromechanical coupling

Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1245-1261页

作者： Junwen Zhang Zhixiang Song Lichao Zhang Shaokang Wu Shanyong wang Yang Zhang Xukai Dong jinxin wang Yanbo Han Baohua Kan School of Energy and Mining Engineering China University of Mining and Technology (Beijing)Beijing100083China Jarud Banner Zhahanao'er Coal Industry Co. Ltd.ZhaluteqiInner Mongolia029200China Priority Research Centre for Geotechnical Science & Engineering The University of NewcastleCallaghanNSW 2308Australia

The combination of the dipping effect and hydromechanical(H-M)coupling effect can easily lead to water inrush disasters in water-rich roadways with different dip angles in coal ***,H-M coupling tests of bedded sandstones under identical osmotic pressure and various confining pressures were ***,the evolution curves of stress-strain,permeability and damage,macro-and mesoscopic failure characteristics were ***,the mechanical behaviour was characterized,and finally the failure mechanism was *** results showed that:(1)The failure of the sandstone with the bedding angle of 45°or 60°was the structure-dominant type,while that with the bedding angle of 0°,30°or 90°was the force-dominant type.(2)When the bedding angle was in the range of(0°,30°)or(45°,90°),the confining pressure played a dominant role in influencing the peak ***,withinβ∈(30°,45°),the bedding effect played a dominant role in the peak strength.(3)With the increase in bedding angle,the cohesion increased first,then decreased and finally increased,while the internal friction angle was the opposite.(4)When the bedding angle was 0°or 30°,the“water wedging”effect and the“bedding buckling”effect would lead to the forking or converging shear *** the bedding angle was 45°or 60°,the sliding friction effect would lead to the shear slipping *** the bedding angle was 90°,the combination of the“bedding buckling”effect and shear effect would lead to the mixed tension-shear *** above conclusions obtained are helpful for the prevention of water inrush disasters in water-rich roadways with different dips in coal mines.

关键词： Hydromechanical coupling Bedded sandstones Mechanical behaviour Bedding effect Failure mechanism

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New phenylbutenoids and terpene glycosides from Ginkgo biloba leaves

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Chinese Journal of Natural Medicines 2024年第2期22卷 161-170页

作者： SUN Zeshi LIN Shan WU Zhi-Li DONG Hong-Yuan XU Xi-Ke LI Hui-Liang wang jinxin School of Pharmacy Second Military Medical UniversityShanghai 200433China State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203China

Our continued works on the chemical constituents of Ginkgo biloba(***)leaves has led to the isolation of two novel phenylbutenoids(1,2),along with five previously unidentified terpene glycosides(3−7).Among them,compounds 1 and 2 represent unique(Z)-phenylbutenoids,3−6 are megastigmane glycosides,and 7 is identified as a rare bilobanone glycoside(Fig.1).This study marks the first reported isolation of phenylbutenoid and bilobanone glycoside from *** chemical structures of these compounds were elucidated through extensive spectroscopic analysis,including HR-ESI-MS and various 1D and 2D NMR ***,the absolute configurations of these molecules were determined using Mosher’s method,ECD experiments,and Cu-KαX-ray crystallographic analyses.

关键词： Ginkgo biloba Phenylbutenoid Megastigmane glycoside Bilobanone glycoside

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Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence

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Emergency and Critical Care Medicine 2024年第1期4卷 4-15页

作者： Haiying Rui Huaxiang Yu Dan Zou Kai Chi Ping Xu Xiaoshuai Song Lulu Liu Xuting Wu jinxin wang Li Xue Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinanShandongChina Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityQilu Hospital of Shandong UniversityJinanShandongChina Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinanShandongChina The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu Hospital of Shandong UniversityJinanShandongChina.

Background:Visceral adipose tissue-derived serine protease inhibitor(vaspin),a secretory adipokine,protects against insulin *** studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease and that vaspin protects against myocardial ischemia-reperfusion injury and ***,it remains unclear whether vaspin exerts specific effects on pathological cardiac ***:An in vivo study was conducted using a cardiac hypertrophy model established by subcutaneous injection of isoproterenol(ISO)in C57BL/6 and vaspin-ko *** was administered intraperitoneally to mice,for further study.H9c2 cells and neonatal rat ventricular myocytes(NRVMs)were treated with ISO to induce *** vaspin fusion protein,the proteasome inhibitor MG132,and chloroquine diphosphate were used for further mechanistic ***:Here,we provide the first evidence that vaspin knockdown results in markedly exaggerated cardiac hypertrophy,fibrosis,and cardiomyocyte senescence in mice treated with ***,the administration of exogenous recombinant human vaspin protected NRVMs in vitro against ISO-induced hypertrophy and ***,vaspin significantly potentiated the ISO-induced decrease in *** rapamycin and chloroquine diphosphate regulated autophagy in vivo and in vitro,respectively,and participated in vaspin-mediated ***,the PI3K-AKT-mTOR pathway plays a critical role in vaspin-mediated autophagy in cardiac tissues and *** data showed that vaspin downregulated the p85 and p110 subunits of PI3K by linking p85 and p110 to NEDD4L-mediated ubiquitination ***:Our results show,for the first time,that vaspin functions as a critical regulator that alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence,providing potential preventive and therapeutic targets for pathological cardiac hyper

关键词： Autophagic flux Myocardial senescence Pathological cardiac hypertrophy Ubiquitination Vaspin

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Analysis of a Typical Case of Meteorological Service in Tangpu Reservoir

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Meteorological and Environmental Research 2024年第2期15卷 44-47页

作者： Quan SHAN Yuxin DING Tingting GU jinxin wang Kai TANG Zhejiang Meteorological Service Center Hangzhou 310017China

The continuous rainy precipitation process from February to March in 2019 was selected to analyze the effect of meteorological service in Tangpu Reservoir basin,so as to sum up service experience and then lay a better foundation for subsequent *** response to the rainy weather from December 2018 to early 2019,three rounds of flood discharge were carried out in Tangpu *** February-March in 2019,the hit rate of short-term area rainfall forecast for Tangpu Reservoir was 80.0%.Compared with the median of forecast interval,the average absolute error was 7.6 mm,and the relative error was 32.7%.The large deviation in the forecast from March 27 to 28 was deeply analyzed,and it is found that the main reasons were excessive reliance on and trust in a single model,insufficient correction of the actual situation,and insufficient judgment of the nature of *** the future reservoir meteorological service,three aspects of thinking were put forward,such as further strengthening the sharing of hydrological and meteorological information,improving the forecasting ability,and deepening the research of runoff forecast models.

关键词： Tangpu Reservoir Meteorological service Continuous rain Analysis of a typical case

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试论丰特努瓦之战

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古代文明（中英文） 2024年第4期18卷 37-49,M0004页

作者：王晋新东北师范大学历史文化学院吉林长春130024

丰特努瓦之战是9世纪中叶加洛林王朝内战期间一次具有重要意义的大规模会战。从制度传统和先皇虔诚者路易生前的权力安排以及其后嗣诸位君王基本诉求等角度进行研究,可以明晰对此役爆发深层缘由的认知,进一步揭橥其本质属性,从而更深入... 详细信息

丰特努瓦之战是9世纪中叶加洛林王朝内战期间一次具有重要意义的大规模会战。从制度传统和先皇虔诚者路易生前的权力安排以及其后嗣诸位君王基本诉求等角度进行研究,可以明晰对此役爆发深层缘由的认知,进一步揭橥其本质属性,从而更深入地理解这一战役的基本态势和特征。关于此役的后果和历史意义,9世纪史家和18世纪前后的学者有诸种评说,但皆失之武断、片面。因而对其作战样态、交战过程和伤亡人数以及直接、间接后果等问题逐一加以重新审视,不仅有助于更为真实地展现此役的状貌,也有助于从战争这一特定维度来认识当时加洛林帝国政治、社会变革的基本走势。

关键词：丰特努瓦罗泰尔日耳曼路易秃头查理

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路德维希二世名号和东法兰克政治变迁

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古代文明（中英文） 2024年第2期18卷 37-48,M0004页

作者：许泽镔王晋新东北师范大学历史文化学院吉林长春130024

东法兰克国王路德维希二世拥有多种不同名号,体现出使用者对相应名号背后政权形态的不同想象。根据对路德维希自己所接受的“巴伐利亚国王”“东法兰克国王”等头衔的研究,可以看到名号与东法兰克政治变迁和国家升格的对应关系。通过与... 详细信息

东法兰克国王路德维希二世拥有多种不同名号,体现出使用者对相应名号背后政权形态的不同想象。根据对路德维希自己所接受的“巴伐利亚国王”“东法兰克国王”等头衔的研究,可以看到名号与东法兰克政治变迁和国家升格的对应关系。通过与路德维希二世名号几种他人表达形式的对比,可以进一步认识到中古早期法兰克政权存在与古典日耳曼和近代德意志不同的政治形态,因而路德维希二世政权及其民族特性的认定也宜重新评估。

关键词：路德维希二世名号德意志中古政治

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产业大数据对商贸流通业高质量发展的影响机制——考虑多重要素的中介效应

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商业经济研究 2024年第10期 5-9页

作者：邓兴平王金鑫河北地质大学管理学院河北地质大学自然资源资产资本研究中心河北石家庄050031

商贸流通业作为经济体系的关键组成部分,对于国家经济的稳定和发展至关重要。随着数字化时代的来临,产业大数据成为商贸流通业发展的重要动力。但产业大数据对商贸流通业高质量发展的影响机制尚未得到充分阐释,尤其是忽视了多重要素的... 详细信息

商贸流通业作为经济体系的关键组成部分,对于国家经济的稳定和发展至关重要。随着数字化时代的来临,产业大数据成为商贸流通业发展的重要动力。但产业大数据对商贸流通业高质量发展的影响机制尚未得到充分阐释,尤其是忽视了多重要素的中介效应。因此,本文将通过实证方式阐明产业大数据对商贸流通业高质量发展的影响机制,并特别关注多重要素的中介效应,旨在为商贸流通业发展政策的制定提供参考依据。

关键词：产业大数据商贸流通业高质量发展技术要素人力要素资本要素

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同步碎石封层技术研究及在公路养护中的应用探讨

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时代汽车 2024年第18期 188-190页

作者：王金芯甘肃省天水公路事业发展中心麦积公路段甘肃天水741020

同步碎石封层技术在公路养护领域展现出显著的优势,特别是在延长道路使用寿命方面。该技术采用精确控制的材料散布与压实过程,确保了碎石与粘合剂的同步施工,从而大幅提高了路面的均匀性。文章旨在探究同步碎石封层技术研究及在公路养... 详细信息

同步碎石封层技术在公路养护领域展现出显著的优势,特别是在延长道路使用寿命方面。该技术采用精确控制的材料散布与压实过程,确保了碎石与粘合剂的同步施工,从而大幅提高了路面的均匀性。文章旨在探究同步碎石封层技术研究及在公路养护中的应用,期望对同步碎石封层技术研究提供有益思考。

关键词：同步碎石封层技术研究公路养护

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预防性公路养护技术在现代公路养护中的应用

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时代汽车 2024年第20期 186-188页

作者：王金芯甘肃省天水公路事业发展中心麦积公路段甘肃天水741020

预防性公路养护技术是指对公路进行定期检查,处理路面潜在问题,防止损害的发生。大部分预防性养护技术还具有环保节能的特点,能够减少建筑废物的产生,节约大量的新材料,符合可持续发展的理念。文章深入探讨薄浆封层技术、微表处技术、... 详细信息

预防性公路养护技术是指对公路进行定期检查,处理路面潜在问题,防止损害的发生。大部分预防性养护技术还具有环保节能的特点,能够减少建筑废物的产生,节约大量的新材料,符合可持续发展的理念。文章深入探讨薄浆封层技术、微表处技术、薄层罩面技术等高效环保的养护方法,有效预防路面损害,延长公路的使用寿命,同时展现出环保节能的理念,为公路养护提供科学合理的技术支持。

关键词：预防性公路养护技术现代公路养护

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Association of copy number variation in X chromosome-linked PNPLA4 with heterotaxy and congenital heart disease

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中华医学杂志(英文版) 2024年第15期137卷 2024 Jul 8页

作者： Gao Han Huang Xianghui Chen Weicheng Feng Zhiyu Zhao Zhengshan Li Ping Tan Chaozhong wang jinxin Zhuang Quannan Gao Yuan Min Shaojie Yao Qinyu Qian Maoxiang Ma Xiaojing Wu Feizhen Yan Weili Sheng Wei Huang Guoying Children’s Hospital of Fudan University Shanghai China Shanghai Key Laboratory of Birth Defects Shanghai China Fujian Key Laboratory of Neonatal Diseases Xiamen Children’s Hospital Xiamen Fujian China Research Unit of Early Intervention of Genetically Related Childhood Cardiovascular Diseases Chinese Academy of Medical Sciences Shanghai China

Background: Heterotaxy (HTX) is a thoracoabdominal organ anomaly syndrome and commonly accompanied by congenital heart disease (CHD). The aim of this study was to analyze rare copy number variations (CNVs) in a HTX/CHD cohort and to examine the potential mechanisms contributing to HTX/***: Chromosome microarray analysis was used to identify rare CNVs in a cohort of 120 unrelated HTX/CHD patients, and available samples from parents were used to confirm the inheritance pattern. Potential candidate genes in CNVs region were prioritized via the DECIPHER database, andPNPLA4 was identified as the leading candidate gene. To validate, we generatedPNPLA4-overexpressing human induced pluripotent stem cell lines as well aspnpla4-overexpressing zebrafish model, followed by a series of transcriptomic, biochemical and cellular ***: Seventeen rare CNVs were identified in 15 of the 120 HTX/CHD patients (12.5%). Xp22.31 duplication was one of the inherited CNVs identified in this HTX/CHD cohort, andPNPLA4 in the Xp22.31 was a candidate gene associated with HTX/***4 is expressed in the lateral plate mesoderm, which is known to be critical for left/right embryonic patterning as well as cardiomyocyte differentiation, and in the neural crest cell lineage. Through a series ofin vivo andin vitro analyses at the molecular and cellular levels, we revealed that the biological function ofPNPLA4 is importantly involved in the primary cilia formation and function via its regulation of energy metabolism and mitochondria-mediated ATP ***: Our findings demonstrated a significant association between CNVs and HTX/CHD. Our data strongly suggested that an increased genetic dose ofPNPLA4 due to Xp22.31 duplication is a disease-causing risk factor for HTX/CHD.

关键词： PNPLA4 Copy number variations X-chromosome Heterotaxy Congenital heart diseases

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