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Mechanical behaviours of bedded sandstone under hydromechanical coupling

Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1245-1261页

作者： Junwen Zhang Zhixiang Song Lichao Zhang Shaokang Wu Shanyong wang Yang Zhang Xukai Dong jinxin wang Yanbo Han Baohua Kan School of Energy and Mining Engineering China University of Mining and Technology (Beijing)Beijing100083China Jarud Banner Zhahanao'er Coal Industry Co. Ltd.ZhaluteqiInner Mongolia029200China Priority Research Centre for Geotechnical Science & Engineering The University of NewcastleCallaghanNSW 2308Australia

The combination of the dipping effect and hydromechanical(H-M)coupling effect can easily lead to water inrush disasters in water-rich roadways with different dip angles in coal ***,H-M coupling tests of bedded sandstones under identical osmotic pressure and various confining pressures were ***,the evolution curves of stress-strain,permeability and damage,macro-and mesoscopic failure characteristics were ***,the mechanical behaviour was characterized,and finally the failure mechanism was *** results showed that:(1)The failure of the sandstone with the bedding angle of 45°or 60°was the structure-dominant type,while that with the bedding angle of 0°,30°or 90°was the force-dominant type.(2)When the bedding angle was in the range of(0°,30°)or(45°,90°),the confining pressure played a dominant role in influencing the peak ***,withinβ∈(30°,45°),the bedding effect played a dominant role in the peak strength.(3)With the increase in bedding angle,the cohesion increased first,then decreased and finally increased,while the internal friction angle was the opposite.(4)When the bedding angle was 0°or 30°,the“water wedging”effect and the“bedding buckling”effect would lead to the forking or converging shear *** the bedding angle was 45°or 60°,the sliding friction effect would lead to the shear slipping *** the bedding angle was 90°,the combination of the“bedding buckling”effect and shear effect would lead to the mixed tension-shear *** above conclusions obtained are helpful for the prevention of water inrush disasters in water-rich roadways with different dips in coal mines.

关键词： Hydromechanical coupling Bedded sandstones Mechanical behaviour Bedding effect Failure mechanism

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New phenylbutenoids and terpene glycosides from Ginkgo biloba leaves

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Chinese Journal of Natural Medicines 2024年第2期22卷 161-170页

作者： SUN Zeshi LIN Shan WU Zhi-Li DONG Hong-Yuan XU Xi-Ke LI Hui-Liang wang jinxin School of Pharmacy Second Military Medical UniversityShanghai 200433China State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203China

Our continued works on the chemical constituents of Ginkgo biloba(***)leaves has led to the isolation of two novel phenylbutenoids(1,2),along with five previously unidentified terpene glycosides(3−7).Among them,compounds 1 and 2 represent unique(Z)-phenylbutenoids,3−6 are megastigmane glycosides,and 7 is identified as a rare bilobanone glycoside(Fig.1).This study marks the first reported isolation of phenylbutenoid and bilobanone glycoside from *** chemical structures of these compounds were elucidated through extensive spectroscopic analysis,including HR-ESI-MS and various 1D and 2D NMR ***,the absolute configurations of these molecules were determined using Mosher’s method,ECD experiments,and Cu-KαX-ray crystallographic analyses.

关键词： Ginkgo biloba Phenylbutenoid Megastigmane glycoside Bilobanone glycoside

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Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence

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Emergency and Critical Care Medicine 2024年第1期4卷 4-15页

作者： Haiying Rui Huaxiang Yu Dan Zou Kai Chi Ping Xu Xiaoshuai Song Lulu Liu Xuting Wu jinxin wang Li Xue Department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinanShandongChina Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityQilu Hospital of Shandong UniversityJinanShandongChina Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinanShandongChina The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu Hospital of Shandong UniversityJinanShandongChina.

Background:Visceral adipose tissue-derived serine protease inhibitor(vaspin),a secretory adipokine,protects against insulin *** studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease and that vaspin protects against myocardial ischemia-reperfusion injury and ***,it remains unclear whether vaspin exerts specific effects on pathological cardiac ***:An in vivo study was conducted using a cardiac hypertrophy model established by subcutaneous injection of isoproterenol(ISO)in C57BL/6 and vaspin-ko *** was administered intraperitoneally to mice,for further study.H9c2 cells and neonatal rat ventricular myocytes(NRVMs)were treated with ISO to induce *** vaspin fusion protein,the proteasome inhibitor MG132,and chloroquine diphosphate were used for further mechanistic ***:Here,we provide the first evidence that vaspin knockdown results in markedly exaggerated cardiac hypertrophy,fibrosis,and cardiomyocyte senescence in mice treated with ***,the administration of exogenous recombinant human vaspin protected NRVMs in vitro against ISO-induced hypertrophy and ***,vaspin significantly potentiated the ISO-induced decrease in *** rapamycin and chloroquine diphosphate regulated autophagy in vivo and in vitro,respectively,and participated in vaspin-mediated ***,the PI3K-AKT-mTOR pathway plays a critical role in vaspin-mediated autophagy in cardiac tissues and *** data showed that vaspin downregulated the p85 and p110 subunits of PI3K by linking p85 and p110 to NEDD4L-mediated ubiquitination ***:Our results show,for the first time,that vaspin functions as a critical regulator that alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence,providing potential preventive and therapeutic targets for pathological cardiac hyper

关键词： Autophagic flux Myocardial senescence Pathological cardiac hypertrophy Ubiquitination Vaspin

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Analysis of a Typical Case of Meteorological Service in Tangpu Reservoir

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Meteorological and Environmental Research 2024年第2期15卷 44-47页

作者： Quan SHAN Yuxin DING Tingting GU jinxin wang Kai TANG Zhejiang Meteorological Service Center Hangzhou 310017China

The continuous rainy precipitation process from February to March in 2019 was selected to analyze the effect of meteorological service in Tangpu Reservoir basin,so as to sum up service experience and then lay a better foundation for subsequent *** response to the rainy weather from December 2018 to early 2019,three rounds of flood discharge were carried out in Tangpu *** February-March in 2019,the hit rate of short-term area rainfall forecast for Tangpu Reservoir was 80.0%.Compared with the median of forecast interval,the average absolute error was 7.6 mm,and the relative error was 32.7%.The large deviation in the forecast from March 27 to 28 was deeply analyzed,and it is found that the main reasons were excessive reliance on and trust in a single model,insufficient correction of the actual situation,and insufficient judgment of the nature of *** the future reservoir meteorological service,three aspects of thinking were put forward,such as further strengthening the sharing of hydrological and meteorological information,improving the forecasting ability,and deepening the research of runoff forecast models.

关键词： Tangpu Reservoir Meteorological service Continuous rain Analysis of a typical case

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Association of copy number variation in X chromosome-linked PNPLA4 with heterotaxy and congenital heart disease

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中华医学杂志(英文版) 2024年第15期137卷 2024 Jul 8页

作者： Gao Han Huang Xianghui Chen Weicheng Feng Zhiyu Zhao Zhengshan Li Ping Tan Chaozhong wang jinxin Zhuang Quannan Gao Yuan Min Shaojie Yao Qinyu Qian Maoxiang Ma Xiaojing Wu Feizhen Yan Weili Sheng Wei Huang Guoying Children’s Hospital of Fudan University Shanghai China Shanghai Key Laboratory of Birth Defects Shanghai China Fujian Key Laboratory of Neonatal Diseases Xiamen Children’s Hospital Xiamen Fujian China Research Unit of Early Intervention of Genetically Related Childhood Cardiovascular Diseases Chinese Academy of Medical Sciences Shanghai China

Background: Heterotaxy (HTX) is a thoracoabdominal organ anomaly syndrome and commonly accompanied by congenital heart disease (CHD). The aim of this study was to analyze rare copy number variations (CNVs) in a HTX/CHD cohort and to examine the potential mechanisms contributing to HTX/***: Chromosome microarray analysis was used to identify rare CNVs in a cohort of 120 unrelated HTX/CHD patients, and available samples from parents were used to confirm the inheritance pattern. Potential candidate genes in CNVs region were prioritized via the DECIPHER database, andPNPLA4 was identified as the leading candidate gene. To validate, we generatedPNPLA4-overexpressing human induced pluripotent stem cell lines as well aspnpla4-overexpressing zebrafish model, followed by a series of transcriptomic, biochemical and cellular ***: Seventeen rare CNVs were identified in 15 of the 120 HTX/CHD patients (12.5%). Xp22.31 duplication was one of the inherited CNVs identified in this HTX/CHD cohort, andPNPLA4 in the Xp22.31 was a candidate gene associated with HTX/***4 is expressed in the lateral plate mesoderm, which is known to be critical for left/right embryonic patterning as well as cardiomyocyte differentiation, and in the neural crest cell lineage. Through a series ofin vivo andin vitro analyses at the molecular and cellular levels, we revealed that the biological function ofPNPLA4 is importantly involved in the primary cilia formation and function via its regulation of energy metabolism and mitochondria-mediated ATP ***: Our findings demonstrated a significant association between CNVs and HTX/CHD. Our data strongly suggested that an increased genetic dose ofPNPLA4 due to Xp22.31 duplication is a disease-causing risk factor for HTX/CHD.

关键词： PNPLA4 Copy number variations X-chromosome Heterotaxy Congenital heart diseases

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路德维希二世名号和东法兰克政治变迁

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古代文明（中英文） 2024年第2期18卷 37-48,M0004页

作者：许泽镔王晋新东北师范大学历史文化学院吉林长春130024

东法兰克国王路德维希二世拥有多种不同名号,体现出使用者对相应名号背后政权形态的不同想象。根据对路德维希自己所接受的“巴伐利亚国王”“东法兰克国王”等头衔的研究,可以看到名号与东法兰克政治变迁和国家升格的对应关系。通过与... 详细信息

东法兰克国王路德维希二世拥有多种不同名号,体现出使用者对相应名号背后政权形态的不同想象。根据对路德维希自己所接受的“巴伐利亚国王”“东法兰克国王”等头衔的研究,可以看到名号与东法兰克政治变迁和国家升格的对应关系。通过与路德维希二世名号几种他人表达形式的对比,可以进一步认识到中古早期法兰克政权存在与古典日耳曼和近代德意志不同的政治形态,因而路德维希二世政权及其民族特性的认定也宜重新评估。

关键词：路德维希二世名号德意志中古政治

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产业大数据对商贸流通业高质量发展的影响机制——考虑多重要素的中介效应

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商业经济研究 2024年第10期 5-9页

作者：邓兴平王金鑫河北地质大学管理学院河北地质大学自然资源资产资本研究中心河北石家庄050031

商贸流通业作为经济体系的关键组成部分,对于国家经济的稳定和发展至关重要。随着数字化时代的来临,产业大数据成为商贸流通业发展的重要动力。但产业大数据对商贸流通业高质量发展的影响机制尚未得到充分阐释,尤其是忽视了多重要素的... 详细信息

商贸流通业作为经济体系的关键组成部分,对于国家经济的稳定和发展至关重要。随着数字化时代的来临,产业大数据成为商贸流通业发展的重要动力。但产业大数据对商贸流通业高质量发展的影响机制尚未得到充分阐释,尤其是忽视了多重要素的中介效应。因此,本文将通过实证方式阐明产业大数据对商贸流通业高质量发展的影响机制,并特别关注多重要素的中介效应,旨在为商贸流通业发展政策的制定提供参考依据。

关键词：产业大数据商贸流通业高质量发展技术要素人力要素资本要素

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中间像面非理想成像的近红外折反射系统光学装调方法

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红外与激光工程 2024年第5期53卷 208-217页

作者：陈太喜王金鑫黄贺张斌智李鑫丘敏艳张鑫季华实验室广东佛山528200

近年来,基于中间像面非理想成像的近红外折反射系统应用广泛,但由于该波段干涉仪的价格昂贵且难以维护,其应用并不普及,因此在该类系统集成阶段,通常只能采用传统的机械特征定位方式(例如采用中心偏测量仪辅助定位)进行装调。由于传统... 详细信息

近年来,基于中间像面非理想成像的近红外折反射系统应用广泛,但由于该波段干涉仪的价格昂贵且难以维护,其应用并不普及,因此在该类系统集成阶段,通常只能采用传统的机械特征定位方式(例如采用中心偏测量仪辅助定位)进行装调。由于传统机械定位方法无法直接借助干涉仪对系统出瞳波像差进行实时高精度监测,即不能通过观察各视场像差变化规律来指导装调,导致系统的装调效率和精度通常难以保证。针对一个口径为150 mm、焦距为450 mm的中间像面非理想成像近红外折反射系统的高精度光学装调方法开展研究,通过对系统中继透镜组透镜薄膜进行包含常用干涉仪工作波长(λ@632.8 nm)的设计,来实现利用可见光激光干涉仪对系统波像差进行高精度检测的目的,然后研究了系统各装调自由度和系统初级波像差的敏感度关系,以失调敏感度单变量分析为基础,分析了各失调维度间的耦合作用特性,在此基础上提出了次镜和中继镜组相互反复迭代联调的光学装调方案。整机装调后,光学系统各视场波前误差(RMS)和设计仿真结果数值大小大致相同,方向一致,均达到成像质量要求。

关键词：光学系统装调折反射系统迭代联调非理想成像

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渭北黄土高原不同类型人工林的生态效益评价

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水土保持学报 2024年第1期38卷 357-367页

作者：杨凯博张瑞琦王进鑫白立强西北农林科技大学水土保持研究所陕西杨凌712100 西北农林科技大学水土保持科学与工程学院陕西杨凌712100 陕西省林业科学院森林保护研究所西安710000

[目的]构建适应渭北黄土高原人工林资源与生态服务功能特点的人工林生态效益评价方法,阐明不同类型人工林建设对该地区东部、中部、西部生态环境的影响,为准确量化与科学评估不同类型、不同区域人工林的生态服务功能,优化林分结构、制... 详细信息

[目的]构建适应渭北黄土高原人工林资源与生态服务功能特点的人工林生态效益评价方法,阐明不同类型人工林建设对该地区东部、中部、西部生态环境的影响,为准确量化与科学评估不同类型、不同区域人工林的生态服务功能,优化林分结构、制定人工林生态补偿强度标准及准确计量评估人工林碳汇,将“绿色颜值”转化为“生态价值”提供理论依据。[方法]在构建渭北黄土高原生态林、生态经济林、经济林有效面积计算模型的基础上,采用典型区域调查、测定与森林二类调查资料和计量参数等收集相结合的方法,计算分析了3种不同类型,东部、中部、西部不同区域人工林涵养水源、固碳释氧、保育土壤和净化大气的生态效益。[结果](1)渭北黄土高原不同类型人工林的生态效益为生态林>经济林>生态经济林;生态效益中涵养水源价值量最高,保育土壤与固碳释氧效益次之,净化大气的价值量最低。(2)人工林单位面积生态效益为经济林>生态林>生态经济林。(3)不同区域人工林生态效益为中部>东部>西部。[结论]生态林和经济林在生态效益中发挥着重要作用,提高它们所占比重能显著提高人工林的生态效益。为提高西部人工林生态效益,生态林应加强疏林改造、未成林抚育和灌木林封育;同时适度发展经济林,方可有效提升西部乃至整个渭北黄土高原人工林的生态效益。

关键词：渭北黄土高原生态林生态经济林经济林生态效益

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不同变质程度煤的吸附瓦斯动力学特性实验研究

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煤矿安全 2024年第1期55卷 34-41页

作者：王梦露沈永星周动王辰王金鑫冯雪健太原理工大学安全与应急管理工程学院山西太原030002 太原理工大学原位改性采矿教育部重点实验室山西太原030024 华北科技学院安全工程学院河北三河065201

为了进一步揭示不同变质程度的煤在不同吸附压力下的动力学特征,利用自主研发的TQY-2型精密吸附仪和红外热成像装置对直径为8.5 mm的褐煤、焦煤和无烟煤煤样进行不同压力(0.2、0.4、0.6、0.8、1.0 MPa)下的宏观吸附试验和吸附压力为(0.3... 详细信息

为了进一步揭示不同变质程度的煤在不同吸附压力下的动力学特征,利用自主研发的TQY-2型精密吸附仪和红外热成像装置对直径为8.5 mm的褐煤、焦煤和无烟煤煤样进行不同压力(0.2、0.4、0.6、0.8、1.0 MPa)下的宏观吸附试验和吸附压力为(0.3、0.6、0.9、1.2、1.5 MPa)的煤体细观结构吸附试验,利用准一级、准二级、颗粒内扩散、Elovich以及双常数等吸附动力学模型分析吸附瓦斯规律及机理。研究表明:对比5种吸附动力学模型,准二级吸附动力学模型适合表征褐煤和焦煤的吸附瓦斯过程,而无烟煤的最优模型为颗粒内扩散模型;随着吸附压力升高,褐煤和焦煤的准二级吸附速率常数k2逐渐增加,无烟煤的颗粒内扩散速率常数kp也逐渐增加,均呈正相关;吸附压力对煤样适合的动力学模型影响较小;在宏观吸附和基于红外热成像的煤体细观结构吸附实验下,煤样适合的动力学模型一致。

关键词：不同变质程度不同压力瓦斯吸附动力学吸附速率

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