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赓续文脉、弦歌不辍:抗战时期的科学社明复图书馆

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科学 2024年第2期76卷 53-56页

作者：王云帆上海交通大学科学史与科学文化研究院上海200240

创立于1931年的中国科学社明复图书馆是近代中国第一所科学技术图书馆。抗日战争时期,明复图书馆赓续文脉、弦歌不辍,保存了北平图书馆南运的珍贵古籍,同时通过各个渠道积极筹款维持图书馆运作,给在沪高校师生提供了上课与查阅参考资料... 详细信息

创立于1931年的中国科学社明复图书馆是近代中国第一所科学技术图书馆。抗日战争时期,明复图书馆赓续文脉、弦歌不辍,保存了北平图书馆南运的珍贵古籍,同时通过各个渠道积极筹款维持图书馆运作,给在沪高校师生提供了上课与查阅参考资料的场所,从而在上海“孤岛”保存了科技交流与传播的火种,践行了“科学救国”之志。

关键词：中国科学社明复图书馆抗日战争

伴CDKN2A/B和TP53基因变异的卵巢幼年型粒层细胞瘤1例

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中华病理学杂志 2024年第9期53卷 950-952页

作者：胡阿锦汤萨杨帆王淑芳王云帆北京大学首钢医院病理科北京100144 北京积水潭医院影像科北京100032

本文报道1例伴CDKN2A/B和TP53基因变异的卵巢幼年型粒层细胞瘤(juvenile granulosa cell tumor, JGCT)。患者女, 18岁。因腹痛1个月余入院。影像学提示盆腔囊实性肿物, 与卵巢关系密切。行一侧卵巢及输卵管切除, 术中肿瘤破裂。术后病... 详细信息

本文报道1例伴CDKN2A/B和TP53基因变异的卵巢幼年型粒层细胞瘤(juvenile granulosa cell tumor, JGCT)。患者女, 18岁。因腹痛1个月余入院。影像学提示盆腔囊实性肿物, 与卵巢关系密切。行一侧卵巢及输卵管切除, 术中肿瘤破裂。术后病理诊断JGCT。镜下肿瘤被纤维分隔为巢状, 伴坏死;可见滤泡样、管囊状及乳头状结构;细胞异型及多形性显著, 可见病理性核分裂象。免疫组织化学:α-抑制素、CD99、CD56、Melan A、SF-1、WT-1、BRG1和INI1阳性;生殖细胞和神经内分泌标志物阴性。基因检测:肿瘤中检出CDKN2A/B、MTAP和TP53基因突变, 以及与DNA损伤修复、生殖细胞或性腺发育、激素调节相关的基因变异。术后12个月肿瘤复发。需要注意的是, JGCT临床病理学特征多样, 除分期外, CDKN2A/B和TP53基因变异可能提示肿瘤高复发风险。

关键词：粒层细胞瘤基因变异 CDKN2A/B 幼年型

宣肺败毒方治疗病毒性肺炎的中医理论及药理机制探讨

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中国实验方剂学杂志 2024年第19期30卷 214-224页

作者：张益豪彭鑫栾哲宇汪云帆尚佳琪封继宏天津中医药大学天津301617 天津中医药大学第二附属医院天津300250

病毒性肺炎(VP)是由一种或多种病毒经上呼吸道感染并向下蔓延造成不同程度肺实质损伤的炎性疾病,对社会经济和公共卫生构成严重威胁。目前西医多以对症支持治疗为主,缺少特异性治疗手段,临床仍处于药物缺乏的困境。从中医角度VP属“疫... 详细信息

病毒性肺炎(VP)是由一种或多种病毒经上呼吸道感染并向下蔓延造成不同程度肺实质损伤的炎性疾病,对社会经济和公共卫生构成严重威胁。目前西医多以对症支持治疗为主,缺少特异性治疗手段,临床仍处于药物缺乏的困境。从中医角度VP属“疫病”范畴,其病因责之于“疫毒、六淫”,“湿、热、毒、虚、瘀”是其病理因素,以“阴阳失衡、脏腑失调、正气亏虚”为基本病机,“扶正祛邪”为其治疗原则,以六经证治为基础立法,辅以卫气营血、三焦理论辨证施治。宣肺败毒方是张伯礼院士与刘清泉教授深入发掘经典文献研究和现代组分优化筛选总结的有效方剂,是“科技+中药”之产物,该方由麻杏石甘汤、麻杏薏甘汤、葶苈大枣泻肺汤、千金苇茎汤及不换金正气散化裁而成,具有宣肺化湿、清热透邪、泻肺解毒之效,治疗疫病之湿毒郁肺证,对防治VP具有一定临床价值。该文综述了宣肺败毒方治疗VP的一系列重要研究进展,探讨其组方结构、用药思路、证治范围及临床新用的中医相关理论,总结其抑制病毒作用、减轻炎症反应、调控免疫系统、改善肺纤维化、调节肠道菌群的药理作用机制,并就研究中存在的问题提出思考与建议,以期为防治VP包括新型冠状病毒肺炎(COVID-19)在内的临床用药及基础研究提供参考。

关键词：宣肺败毒方病毒性肺炎中医理论药理作用作用机制

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植物提取物治疗光老化的研究进展

药学进展 2024年第4期48卷 301-308页

作者：吴怡欣徐寒梅王云帆胡加亮中国药科大学生命科学与技术学院江苏南京211198 南京安吉生物科技有限公司江苏南京210046

皮肤作为覆盖整个身体表面积最大的器官,其老化是一个复杂的生理过程,受到内部和外部因素的综合影响。紫外线照射导致的光老化不仅影响皮肤外观,还会破坏肌底结构,导致皮肤疾病。如今,多源的植物提取物种类和成熟的提取技术,使得植物提... 详细信息

皮肤作为覆盖整个身体表面积最大的器官,其老化是一个复杂的生理过程,受到内部和外部因素的综合影响。紫外线照射导致的光老化不仅影响皮肤外观,还会破坏肌底结构,导致皮肤疾病。如今,多源的植物提取物种类和成熟的提取技术,使得植物提取物成为潜在的治疗皮肤光老化的热门原料。综述皮肤光老化的机制并简要介绍了几类治疗光老化的热门植物提取物及其作用机制。

关键词：光老化紫外线照射植物提取物

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

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Frontiers of Medicine 2019年第6期13卷 730-740页

作者： Yue wang Jinxia Zhang yunfan wang Shufang wang Yu Zhang Qi Miao Fei Gao Huiying He Department of Pathology Peking University Shougang HospitalBeijing 100144China Department of Pathology School of Basic Medical SciencesPeking University Third HospitalPeking University Health Science CenterBeijing 100083China

GATA binding protein 3 (GATA3) and mismatch repair (MMR) deficiency contribute to the development of urothelial carcinoma. However, the combined expression of GATA3 and microsatellite instability (MSI) in upper tract urothelial carcinoma (UTUC) and its prognostic value have not been investigated. Here, we immunohistochemically stained GATA3 and MMR proteins in 108 UTUC samples. GATA3 was positive in 74 cases, and its expression was significantly lower than in adjacent benign urothelium (P<0.001). Loss of GATA3 expression was statistically associated with adverse clinicopathologic parameters, such as advanced stage, lymphovascular invasion, neural invasion, lymph node metastasis, and extensive necrosis. Cancer-specific survival (CSS, P=0.028) and disease-free survival (DFS, P=0.024) were significantly shorter in patients with GATA3 negative tumors than in patients with GATA3 positive tumors. The absence of MMR proteins was observed in 8.3% of the cases, and focal staining was identified in 13.0%. When using “lax criteria” which resulted in counting cases as negative where MMR staining was in fact focally positive (<5%), we found that GATA3 was inversely associated with MSI (P=0.005). Moreover, GATA3−/microsatellite stability (MS) tumors were correlated with advanced pT stage (P<0.001) and poor outcome (P=0.019 for CSS, P=0.016 for DFS) compared with GATA3+/MSI ones. The GATA3−/MSI cases had unfavorable clinical outcomes compared with GATA3+/MSI cases (P=0.008 for CSS, P=0.023 for DFS). This finding raises a question as to whether GATA3 interacts with MSI through the TGF-β signaling pathway and regulates UTUC progression.

关键词： upper tract urothelial carcinoma GATA binding protein 3 mismatch repair microsatellite instability prognosis

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船用核安全级电缆研制

电线电缆 2024年第1期67卷 21-25页

作者：王云帆樊群杨佳昱于帅李永江武汉第二船舶设计研究所武汉430064 南京全信传输科技股份有限公司南京211113

通过分析特殊功能和环境适应性需求下船用核安全级电缆的分类和性能要求,进行了船用核安全级控制和仪表通信电缆的结构设计、材料选择和试制开发,后对试制电缆产品进行全性能测试。结果表明,该产品达到设计要求。

关键词：船用电缆核安全关键性能测试

On the Polygonal Wear Evolution of Heavy-Haul Locomotive Wheels due to Wheel/Rail Flexibility and Its Mitigation Measures

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 40-61页

作者： yunfan Yang Feifan Chai Pengfei Liu Liang Ling Kaiyun wang Wanming Zhai State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures Shijiazhuang Tiedao UniversityShijiazhuang 050043China State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu 610031China

Wheel polygonal wear can immensely worsen wheel/rail interactions and vibration performances of the train and track,and ultimately,lead to the shortening of service life of railway *** present,wheel/rail medium-or high-frequency frictional interactions are perceived as an essential reason of the high-order polygonal wear of railway wheels,which are potentially resulted by the flexible deformations of the train/track system or other external *** this work,the effect of wheel/rail flexibility on polygonal wear evolution of heavy-haul locomotive wheels is explored with aid of the long-term wheel polygonal wear evolution simulations,in which different flexible modeling of the heavy-haul wheel/rail coupled system is ***,the mitigation measures for the polygonal wear of heavy-haul locomotive wheels are *** results point out that the evolution of polygonal wear of heavy-haul locomotive wheels can be veritably simulated with consideration of the flexible effect of both wheelset and *** of mixed-line operation of heavy-haul trains and application of multicut wheel re-profiling can effectively reduce the development of wheel polygonal *** research can provide a deep-going understanding of polygonal wear evolution mechanism of heavy-haul locomotive wheels and its mitigation measures.

关键词： Heavy-haul locomotive Wheel polygonal wear Wheel/rail flexibility Long-term polygonal wear evolution Mitigation measures

Isotropic sintering shrinkage of 3D glass-ceramic nanolattices:backbone preforming and mechanical enhancement

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International Journal of Extreme Manufacturing 2024年第2期6卷 418-426页

作者： Nianyao Chai yunfan Yue Xiangyu Chen Zhongle Zeng Sheng Li Xuewen wang Center of Femtosecond Laser Manufacturing for Advanced Materials and Devices State Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingWuhan University of TechnologyWuhan 430070People’s Republic of China National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu LaboratoryFoshan 528000People’s Republic of China International School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070People’s Republic of China

There is a perpetual pursuit for free-form glasses and ceramics featuring outstanding mechanical properties as well as chemical and thermal *** is a promising idea to shape inorganic materials in three-dimensional(3D)forms to reduce their weight while maintaining high mechanical properties.A popular strategy for the preparation of 3D inorganic materials is to mold the organic–inorganic hybrid photoresists into 3D micro-and nano-structures and remove the organic components by subsequent ***,due to the discrete arrangement of inorganic components in the organic-inorganic hybrid photoresists,it remains a huge challenge to attain isotropic shrinkage during ***,we demonstrate the isotropic sintering shrinkage by forming the consecutive–Si–O–Si–O–Zr–O–inorganic backbone in photoresists and fabricating 3D glass–ceramic nanolattices with enhanced mechanical *** femtosecond(fs)laser is used in two-photon polymerization(TPP)to fabricate 3D green body *** subsequent sintering at 1000℃,high-quality 3D glass–ceramic microstructures can be obtained with perfectly intact and smooth ***-suit compression experiments and finite-element simulations reveal that octahedral-truss(oct-truss)lattices possess remarkable adeptness in bearing stress concentration and maintain the structural integrity to resist rod bending,indicating that this structure is a candidate for preparing lightweight and high stiffness glass–ceramic nanolattices.3D printing of such glasses and ceramics has significant implications in a number of industrial applications,including metamaterials,microelectromechanical systems,photonic crystals,and damage-tolerant lightweight materials.

关键词： 3D printing isotropic shrinkage femtosecond laser two-photon polymerization structural glass-ceramics

硫化—胺法浮选菱锌矿体系中两相和三相泡沫的性能研究

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矿产保护与利用 2024年第3期44卷 74-80页

作者：李超罗溪梅齐琳萍宋振国王云帆昆明理工大学国土资源工程学院昆明理工大学复杂有色金属资源清洁利用国家重点实验室矿物加工科学与技术国家重点实验室昆明理工大学冶金与能源工程学院

硫化—胺法是氧化锌的主要选别方法之一，在工业生产中的指标较好，但存在浮选泡沫发黏、难消泡的问题。研究了硫化-胺法浮选菱锌矿体系中两相泡沫和三相泡沫的性能，考察了硫化钠用量、十二胺用量、矿物含量、矿物粒度、矿物种类等对... 详细信息

硫化—胺法是氧化锌的主要选别方法之一，在工业生产中的指标较好，但存在浮选泡沫发黏、难消泡的问题。研究了硫化-胺法浮选菱锌矿体系中两相泡沫和三相泡沫的性能，考察了硫化钠用量、十二胺用量、矿物含量、矿物粒度、矿物种类等对泡沫稳定性的影响，并测试了不同矿物含量的矿浆黏度。结果表明，在采用硫化—胺法浮选菱锌矿时，加入硫化钠能够提高两相和三相泡沫的稳定性。不同粒度的矿物颗粒对泡沫稳定性影响不同，加入-74+37μm粒级的菱锌矿和石英颗粒均能够降低泡沫稳定性，而加入-37μm粒级的菱锌矿和石英颗粒均能够提高泡沫稳定性，-18μm的石英颗粒影响尤为明显。当十二胺与微细粒级石英共同存在时，浮选泡沫尤为稳定。加入石英颗粒后的三相泡沫半衰期均高于菱锌矿，这是由于石英矿浆的黏度高于菱锌矿，因而泡沫液膜的Marangoni效应增强，导致排液速率变慢，泡沫液膜变薄速率下降，泡沫稳定性更强。

关键词：硫化—胺浮选法十二胺菱锌矿硫化钠石英泡沫半衰期