检索结果-南通市图书馆

Chronic ankle instability is associated with proprioception deficits:A systematic review and meta-analysis

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2021年第2期10卷 182-191页

作者： Xiao’ao xue Tengjia Ma Qianru Li Yujie Song Yinghui Hua Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Background:Acute ankle injury causes damage to joint mechanoreceptors and deafferentation and contributes to proprioception deficits in patients with chronic ankle instability(CAI).We aimed to explore whether deficits of proprioception,including kinesthesia and joint position sense(JPS),exist in patients with CAI when compared with the uninjured contralateral side and healthy *** hypothesized that proprioception deficits did exist in patients with CAI and that the deficits varied by test ***:The study was a systematic review and *** identified studies that compared kinesthesia or JPS in patients with CAI with the uninjured contralateral side or with healthy ***-analyses were conducted for the studies with similar test procedures,and narrative syntheses were undertaken for the ***:A total of 7731 studies were identified,of which 30 were included for review.A total of 21 studies were eligible for *** with the contralateral side,patients with CAI had ankle kinesthesia deficits in inversion and plantarflexion,with a standardized mean difference(SMD)of 0.41 and 0.92,respectively,and active and passive JPS deficits in inversion(SMD=0.92 and 0.72,respectively).Compared with healthy people,patients with CAI had ankle kinesthesia deficits in inversion and eversion(SMD=0.64 and 0.76,respectively),and active JPS deficits in inversion and eversion(SMD=1.00 and 4.82,respectively).Proprioception deficits in the knee and shoulder of patients with CAI were not statistically ***:Proprioception,including both kinesthesia and JPS,of the injured ankle of patients with CAI was impaired,compared with the uninjured contralateral limbs and healthy *** varied depending on different movement directions and test *** use of more detailed measurements of proprioception and interventions for restoring the deficits are recommended in the clinical management of CAI.

关键词： Chronic ankle instability Joint position sense Kinesthesia Proprioception

Genomic dissection of gastrointestinal and lung neuroendocrine neoplasm

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2019年第6期31卷 918-929页

作者： Haixing wang Li Sun Hua Bao ao wang Panpan Zhang xue Wu Xiaoling Tong Xiaonan wang Jie Luo Lin Shen Yang WShao Ming Lu Department of Endoscopy Center The First Affiliated Hospital of Xiamen UniversityXiamen 361003China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China Translational Medicine Research Institute Geneseeq Technology Inc.Toronto M5G 1L7Canada Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Medical Department Nanjing Geneseeq Technology Inc.Nanjing 210032China Department of Pathology China-Japan Friendship HospitalBeijing 100029China School of Public Health Nanjing Medical UniversityNanjing 210029China

Objective:Neuroendocrine neoplasms(NENs)are relatively rare and heterogeneous malignancies with two major subtypes:low-grade neuroendocrine tumor(NET)and high-grade neuroendocrine carcinoma(NEC).Comprehensive molecular characterization of NENs is needed to refine our understanding of the biological underpinnings of different NEN subtypes and to predict disease progression more ***:We performed whole-exome sequencing(WES)of NEN samples from 49 patients(25 NETs and 24 NECs)arising from the stomach,intestines or *** features were assessed and associated with molecular ***:NENs generally harbor a low mutation burden,with TP53 being the top mutated gene found in 31%of *** with other studies,p53 signaling pathway dysfunction is significantly enriched in NECs compared to NETs(P<0.01).Other than TP53,tissue type-specific mutation profiles of NENs were observed in our cohort compared to those reported in pancreatic ***,we observed significant genomic instability,with increased copy number alterations observed across the NEN genome,which was more profound in NECs and independently correlated with poor overall survival(OS)(P<0.001).NECs could be further stratified into two molecular subtypes based on OS(P<0.001)and the chromosomal instability score(CIS).Interestingly,we discovered that the gain of whole chromosome 5 occurred at the early stage of NEN development,followed by the loss of 5 q exclusively in NECs(P<0.001).Conclusions:These findings provide novel insights into the molecular characteristics of NENs and highlight the association of genomic stability with clinical outcomes.

关键词： Neuroendocrine carcinoma whole-exome sequencing chromosomal instability

Bias Analysis and Correction of Ground Surface Temperature Observations across China

在线全文

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2020年第6期34卷 1324-1334页

作者： Yan CUI Wenhui XU Zijiang ZHOU Chunyu ZHao Yihui DING xue ao Xiaoyu ZHOU Shenyang Regional Climate Center Liaoning Meteorological BureauShenyang 110166 National Meteorological Information Center China Meteorological AdministrationBeijing 100081 National Climate Center China Meteorological AdministrationBeijing 100081

Based on the ground surface temperature(GST)and snow surface temperature(SST)measurements during the period of adjustment from manual to automatic observation systems in China,the influence of observation methods on GST and its relationship with snow cover is *** is corrected by SST,and the correction effect is *** results show that,during the parallel observation period,the winter GSTs from automatic observations are generally higher than those from manual observations,with the automatically observed national daily GST 1.18°C *** adjustment has a greater impact on GSTs at 0200,0800,and 2000 Beijing Time(BT)than at 1400 BT,and it has the greatest impact in Northeast and Northwest China,with deviations of 5.24 and 2.09°C,*** GST deviation is closely related to the snow depth and annual snow *** average daily GST deviation increases at the rate of 0.66°C per 1-cm increase of snow depth when it is<15 cm,while it tends to be stable at around 10°C for snow depth over 15 *** GST deviation at a station is affected by its winter snow totals in Northeast and Northwest China,where the largest deviations are found where snow totals are all above 1000 *** the correction with SST,the mean deviation between the automatic and manual observations as well as the false trend can be effectively *** the correction,the mean deviation of daily GST decreases by 5.8°C,and its trend decreases from 1.87 to 0.65°C decade-1.

关键词： ground surface temperature(GST)in winter snow cover correction China

偕胺肟基接枝聚酰胺微孔膜吸附材料的制备及其盐湖水提铀性能研究

在线全文

学校读者我要写书评

暂无评论

化学研究与应用 2024年第5期36卷 1056-1066页

作者：高思凡蒋纪宇骆微廖学品石碧四川大学轻工科学与工程学院四川成都610065

以聚酰胺微孔膜为基材,通过自由基引发将丙烯腈接枝于膜表面,并用盐酸羟胺肟化得到偕胺肟基接枝聚酰胺微孔膜吸附材料(PA-ao),该膜吸附材料结合了膜分离处理量大和吸附分离选择性高的优点。研究结果表明,在纯水体系中,当pH=6.0,铀初始... 详细信息

以聚酰胺微孔膜为基材,通过自由基引发将丙烯腈接枝于膜表面,并用盐酸羟胺肟化得到偕胺肟基接枝聚酰胺微孔膜吸附材料(PA-ao),该膜吸附材料结合了膜分离处理量大和吸附分离选择性高的优点。研究结果表明,在纯水体系中,当pH=6.0,铀初始浓度为1.0mmol·L^(-1),303K条件下,PA-ao对UO_(2)^(2+)的平衡吸附量可达0.47mmol·g^(-1)。吸附过程符合Langmuir模型和准二级动力学方程,盐湖水中存在的阴离子以及阳离子对铀吸附的影响很小,PA-ao对铀表现出较高的吸附选择性。使用1.0mol·L^(-1)的Na2CO3和0.1mol L-1的H_(2)O_(2)的混合溶液可将铀从PA-ao上解吸下来,解吸率达到90.2%,且重复利用性能较好。连续吸附实验表明,当铀的初始进料浓度为0.05mmol·L^(-l),流速为4.0mL·min^(-1)时,PA-ao的处理能力达到275.02L·m^(-2),对铀的回收率达到90%以上。将PA-ao用于提取1L模拟盐湖水中的铀,铀的提取量达到了235.59μg,提取率达81.0%,这表明PA-ao可用于盐湖水中铀的高效提取。

关键词：偕胺肟基铀膜吸附分离聚酰胺微孔膜盐湖水

Overexpression of IbSINA5 Increases Cold Tolerance through a CBF SINA-COR Mediated Module in Sweet Potato

在线全文

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2021年第3期90卷 761-772页

作者： Shiyang Li xue-ao Liu Lizi Zhao Huiqing Huang Bei Li Zhizhong Song Meixia Liang Hongxia Zhang Limin wang Shenglin Zhou Shandong Technology and Business University Yantai264005China The Engineering Research Institute of Agriculture and Forestry Ludong UniversityYantai264025China School of Life Sciences Ludong UniversityYantai264025China

Seven in absentia(SINA)family proteins play a central role in plant growth,development and resistance to abiotic ***,their biological function in plant response to cold stress is still largely *** this work,a seven in absentia gene IbSINA5 was isolated from sweet *** real-time polymerase chain reaction(qRT-PCR)analyses demonstrated that IbSINA5 was ubiquitously expressed in various tissues and organs of sweet potato,with a predominant expression in fibrous roots,and was remarkably induced by cold,drought and salt *** localization assays revealed that IbSINA5-GFP fusion protein was mainly localized in cytoplasm and *** of IbSINA5 in sweet potato led to dramatically improved resistance to cold stress in transgenic plants,which was associated with the up-regulated expression of IbCOR(cold-regulated)genes,increased proline production,and decreased malondialdehyde(MDA)and H2O2 accumulation in the leaves of transgenic ***,transient expression of IbCBF3,a C-repeat binding factor(CBF)gene,in the leaf protoplasts of wild type sweet potato plants up-regulated the expression of both IbSINA5 and IbCOR *** results suggest that IbSINA5 could function as a positive regulator in the cold signaling pathway through a CBF-SINA-COR mediated module in sweet potato,and have a great potential to be used as a candidate gene for the future breeding of new plant species with improved cold resistance.

关键词： Cold stress IbSINA5 seven in absentia sweet potato transgenic plant

Comparative analysis of four active compounds of Baikal skullcap and its classical TCM prescriptions according to different clinical curative effects

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2017年第1期3卷 22-30页

作者： Guang-Wei Zhu Sheng-Jun Ma ao-xue Liu Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences School of Food Sciences and Pharmacy Xinjiang Agriculture University School of Chinese Materia Beijing University of Chinese Medicine

Objective: A sensitive HPLC-DAD detection method was established for the comparative analysis of the four active compounds(including baicalin, baicalein, wogonoside and wogonin) of Baikal Skullcap and its classical TCM prescriptions according to different clinical curative effects. And analyze the relationship between compatibility of medicines, content and clinical curative ***: Water extracts were analyzed by high-performance liquid chromatography-diode array detection(HPLC-DAD), using an Agilent extend-C_(18)(4.6 mm×250 mm,5μm) column by using solvent A(0.2% phosphoric acid water) and solvent B(methanol) in the ratio of 52:48(v/v) at a flow rate of 1 ml/min. The column temperature was maintained at 25°C and the detection wavelength was set at 280 ***: In quantitative analysis, the four selected markers showed good regression(R^2>0.999) within test ranges. The average recoveries were between 99.75~100.60% and their RSD values were between 0.97%~1.71%. The proportions of the four chemical compounds for different efficacy were 33.51~35.76: 6.78~6.87: 3.45~3.64: 1; 18.6~23.64: 3.63~4.27: 1.36~1.53: 1; 29.94~31.78: 5.14~5.23: 3.28~3.56: 1; 33.99~41.91:5.83~7.42: 2.83~3.39: ***: Clinical practice of thousands of years have proved that the curative effect of Traditional Chinese Medicine depends on the compatibility of different kinds of medicine material crude slices. According to this study we found that different compatibility of medicines leads to different proportions of the chemical compounds. We assume that there is a certain correlation between therapeutical effect of TCM and compatibility of medicines.

关键词： Baikal skullcap Couplet medicine Clinical curative effect Compatibility of medicines Proportions of the chemical compounds

在线全文

学校读者我要写书评

暂无评论

光伏玻璃压延段成型机理研究

安徽化工 2024年第2期50卷 55-59页

作者：刘澳坤周化光汪徐春张雪梅陈俊明叶坤马明慧郑胜彪张文强卢淑华梁俊英安徽科技学院化学与材料工程学院安徽滁州233000 安徽省石英砂纯化与光伏玻璃工程研究实验中心安徽滁州233000 凤阳硅谷智能有限公司安徽滁州239000

中光伏压延玻璃成型段成型的机理一直是光伏压延玻璃研究和生产的难点和热点。在光伏玻璃压延制作过程时,研究采用了有限元分析方法,探索压延辊转速、玻璃液温度以及压延辊壁厚度对其成型温度场的影响。研究显示,如果其他变量保持不变(... 详细信息

中光伏压延玻璃成型段成型的机理一直是光伏压延玻璃研究和生产的难点和热点。在光伏玻璃压延制作过程时,研究采用了有限元分析方法,探索压延辊转速、玻璃液温度以及压延辊壁厚度对其成型温度场的影响。研究显示,如果其他变量保持不变(玻璃液温度在900℃~1100℃之间,压延辊壁厚度在22.5~32.5 mm,压延辊转速在12~18 r/min),玻璃液温度越高,模拟温度场发生的重热现象时间越长(大约0~2 s),且温度场温度越高;压延辊壁厚越厚,压延辊通过冷却水带走的热量越多,温度场的温度越低;压延辊转速对温度场的影响较大,转速越快,0~3 s内的重热现象越明显,且温度场温度越高,降温曲线越不平稳。

关键词：有限元分析光伏玻璃压延成型 ANSYS软件玻璃液

维普期刊数据库博看期刊

Effect of Phosphorus Fertilization to P Uptake and Dry Matter Accumulation in Soybean with Different P Efficiencies

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2014年第2期13卷 326-334页

作者： ao xue GUO Xiao-hong ZHU Qian ZHANG Hui-jun wang Hai-ying MA Zhao-hui HAN Xiao-ri ZHao Ming-hui XIE Fu-ti College of Agronomy Shenyang Agricultural University College of Land and Environment Shenyang Agricultural University

Phosphorus （P） is an essential element for plant growth and yield. Improving phosphorus use efficiency of crops could potentially reduce the application of chemical fertilizer and alleviate environmental damage. Soybean （Glycine max （L.） Merr.） is sensitive to phosphorus （P） in the whole life history. Soybean cultivars with different P efficiencies were used to study P uptake and dry matter accumulation under different P levels. Under low P conditions, the P contents of leaf in high P efficiency cultivars were greater than those in low P efficiency cultivars at the branching stage. The P accumulation in stems of high P efficiency cultivars and in leaves of low P efficiency cultivars increased with increasing P concentration at the branching stage. At the late podding stage, the P accumulation of seeds in high and low P efficiency cultivars were 22.5 and 26.0%, respectively; and at the mature stage were 69.8 and 74.2%, respectively. In average, the P accumulation in whole plants and each organ was improved by 24.4% in high P efficiency cultivars compared to low P efficiency cultivars. The biomass between high and low P efficiency cultivars were the same under extended P condition, while a significant difference was observed at late pod filling stage. At the pod setting stage, the biomass of high P efficiency cultivars were significant greater （17.4%） than those of low P efficiency cultivars under high P condition. Meanwhile, under optimum growth conditions, there was little difference ofbiomass between the two types of cultivars, however, the P agronomic efficiency and P harvest index were significant higher in high P efficiency cultivars than those in low P efficiency cultivars.

关键词： Glycine max (L.) Merr. soybean phosphorus use efficiency

在线全文

学校读者我要写书评

暂无评论

槲寄生UPLC指纹图谱研究

神经药理学报 2024年第3期14卷 1-8页

作者：张奡锴李文杰董扬扬褚寒冰董学海赵丽艳张万明张元元河北北方学院药学院河北省神经药理学重点实验室张家口075000

目的:建立槲寄生超高效液相色谱(ultra performance liquid chromatography,UPLC)指纹图谱并进行相似度评价,结合聚类分析(cluster analysis,CA)和主成分分析(principal component analysis,PCA)化学计量学分析方法,为槲寄生药材质量一致性评价提供参考。方法:色谱柱为Waters ACQUITY UPLC HSS T3(2.1×100 mm,1.8μm);流动相为乙腈(A)-0.5%乙酸水(B),梯度洗脱;检测波长254 nm;柱温30℃;进样量3μL。采用《中药色谱指纹图谱相似度评价系统软件(2012版)》建立槲寄生指纹图谱,标定其共有峰,并进行相似度评价;采用SPSS 26.0对14批不同产地的槲寄生进行聚类分析和主成分分析。结果:槲寄生指纹图谱的方法学考察结果良好,确定了14个共有峰,通过与对照品比对,指认了其中4号峰为紫丁香苷、9号峰为高圣草素-7-O-β-D-葡萄糖苷。相似度评价结果显示,11批样品的相似度在0.950以上,其余3批相似度小于0.950;通过聚类分析将样品聚为3类,S5单独为一类,S12,S7,S9为一类,其余样品聚为一类;主成分分析得到的4个主成分因子的累计方差贡献率为88.732%,其中S5、S10、S3、S11样品的主成分因子在综合得分位于前四位,整体质量良好。结论:该研究所建立的指纹图谱方法分离度、精密度、稳定性良好,分析时间短,并且结合相似度评价、聚类分析和主成分分析,为槲寄生药材的质量控制提供理论基础。

关键词：槲寄生 UPLC 指纹图谱聚类分析主成分分析相似度评价质量控制