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α-Lipoic Acid Exerts Its Antiviral Effect against Viral Hemorrhagic Septicemia Virus(VHSV) by Promoting Upregulation of Antiviral Genes and Suppressing VHSV-Induced Oxidative Stress

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Virologica Sinica 2021年第6期36卷 1520-1531页

作者： Wanwan Zhang Xiaoqi Chen Fangzhao Yu Fengquan Li wangdong Li Meisheng Yi Kuntong Jia School of Marine Sciences Sun Yat-Sen UniversityGuangzhou 510275China Modern Agricultural Development Center of Zhuhai City Zhuhai 519000China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519000China Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering Guangzhou 510275China Pearl River Estuary Marine Ecosystem Research Station Ministry of EducationZhuhai 519000China

Viral hemorrhagic septicemia virus(VHSV), belonging to the genus Novirhabdovirus, Rhabdoviridae family, is a causative agent of high mortality in fish and has caused significant losses to the aquaculture industry. Currently, no effective vaccines, Food and Drug Administration-approved inhibitors, or other therapeutic intervention options are available against VHSV. α-Lipoic Acid(LA), a potent antioxidant, has been proposed to have antiviral effects against different viruses. In this study, LA(CC_(50)= 472.6 lmol/L) was repurposed to exhibit antiviral activity against VHSV. In fathead minnow cells,LA significantly increased the cell viability post-VHSV infection(EC_(50)= 42.7 lmol/L), and exerted a dose-dependent inhibitory effect on VHSV induced-plaque, cytopathic effects, and VHSV glycoprotein expression. The time-of-addition assay suggested that the antiviral activity of LA occurred at viral replication stage. Survival assay revealed that LA could significantly upregulated the survival rate of VHSV-infected largemouth bass in both co-injection(38.095% vs. 1.887%,P < 0.01) and post-injection manner(38.813% vs. 8.696%, P < 0.01) compared with the control group. Additional comparative transcriptome and q RT-PCR analysis revealed LA treatment upregulated the expression of several antiviral genes, such as IRF7, Viperin, and ISG15. Moreover, LA treatment reduced VHSV-induced reactive oxygen species production in addition to Nrf2 and SOD1 expression. Taken together, these data demonstrated that LA suppressed VHSV replication by inducing antiviral genes expression and reducing VHSV-induced oxidative stress. These results suggest a new direction in the development of potential antiviral candidate drugs against VHSV infection.

关键词： Viral hemorrhagic septicemia virus(VHSV) α-Lipoic acid(LA) Antiviral IFN response Oxidative stress

Influence of group—velocity mismatch on soliton switching in a nonlinear fibre coupler

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Chinese Physics B 2003年第4期12卷 415-418页

作者： LiHong HuangDe-Xiu wangdong-Ning DepartmentofOptoelectronicEngineering HuazhongUniversityofScienceandTechnologyWuhan430074China DepartmentofElectricalEngineering TheHongKongPolytechnicUniversityHungHomKowloonHongKongChina

In this work, the influence of group-velocity mismatch on soliton self-routing pulse switching in a nonlinear fibrecoupler is discussed in detail by the use of both variational approach and numerical simulation. The results obtainedshow that the group-velocity mismatch leads to the relative displacement between the two orthogonal polarizationmodes, increase of the critical power, and reduction of the elimination-light ratio. For sub-ps pulse, the influence cannot be neglected.

关键词： self-routing pulse switching group-velocity mismatch fibre coupler soliton

Analysis of parental strain DNA fragments existing in GEMs-Fhhh

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Journal of Environmental Sciences 2003年第5期15卷 590-594页

作者： HAOChun-bo YANJun QUMeng-meng wangdong CHENGShu-pei GUJi-dong QIUWan-fei WANGYin-yin TheNationalKeyLaboratoryofPollutionControlandResourceReuse SchoolofEnvironmentalScienceNanjingUniversityNanjing210093China DepartmentofEcology&Biodiversity TheUniversityofHongKongPokfulamRoadHongKongChina

There were 6 target DNA fragments of the three parental strains existing in the cell of GEMs(genetically engineered microorganism strain) Fhhh measured in this research by PCR(polymerase chain reaction). The determination showed that GEMs Fhhh contained all the 6 target DNA fragments, mnp 1, mnp 2、 lip 1、 lip 2, FLO 1 and 16S rDNA, and had the molecular genetic stability. Meanwhile the PCR production of each parental strain could only had its target DNA fragments and was different from each other. It may illustrate that the technique of the inter kingdom protoplast fusion for the construction of GEMs Fhhh through the process of intercellular gene recombination could be used as a reliable bioengineering technique to create the specific functional stain for the pollution control.

关键词： GEMs protoplast fusion target gene DNA fragment PCR pollution control

A Distributed Approach of Big Data Mining for Financial Fraud Detection in a Supply Chain

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Computers, Materials & Continua 2020年第8期64卷 1091-1105页

作者： Hangjun Zhou Guang Sun Sha Fu Xiaoping Fan wangdong Jiang Shuting Hu Lingjiao Li Hunan University of Finance and Economics Changsha410205China College of Engineering The University of AlabamaTuscaloosaUSA

Supply Chain Finance(SCF)is important for improving the effectiveness of supply chain capital operations and reducing the overall management cost of a supply *** recent years,with the deep integration of supply chain and Internet,Big Data,Artificial Intelligence,Internet of Things,Blockchain,etc.,the efficiency of supply chain financial services can be greatly promoted through building more customized risk pricing models and conducting more rigorous investment decision-making ***,with the rapid development of new technologies,the SCF data has been massively increased and new financial fraud behaviors or patterns are becoming more covertly scattered among normal *** lack of enough capability to handle the big data volumes and mitigate the financial frauds may lead to huge losses in supply *** this article,a distributed approach of big data mining is proposed for financial fraud detection in a supply chain,which implements the distributed deep learning model of Convolutional Neural Network(CNN)on big data infrastructure of Apache Spark and Hadoop to speed up the processing of the large dataset in parallel and reduce the processing time *** training and testing on the continually updated SCF dataset,the approach can intelligently and automatically classify the massive data samples and discover the fraudulent financing behaviors,so as to enhance the financial fraud detection with high precision and recall rates,and reduce the losses of frauds in a supply chain.

关键词： Big data mining deep learning fraud detection supply chain Internet of Things

Anti-depression effect of Kai Xin San and research of its compatibility

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Chinese Medical Journal 2005年第14期118卷 1214-1216页

作者： CHENYi-hong wangdong-xiao LIUPing WANGJin-liang DAIChang CHENGGui-fang InstituteofMatefiaMedica ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollegeBeijing100050China ResearchInstituteforClinicalPharmacology. GeneralHospitalofPLABeijing100853China

Kai Xin San (KXS) is a category of traditional complex prescription that wasfirst recorded in Bei Ji Qian Jin Yao Fang by SUN Si-miao in the Tang Dynasty and then also recordedin Tai Ping Hui Min He Ji Ju Fang, Qian Jin Yao Fang and Gu Jin Lu Yan in later generations. It wasmainly used by herbalist doctors to treat symptoms including desolation, moodiness, forgetfulnessetc. , which are similar to the neurosis such as depression, anxiety and difficulty in studying andmemory in the West medicine. The former recorded formulas were all composed of ginseng, polygala,hoelen and acori graminei with different proportion. But there are no systematic studies on theclinical adaptive symptom corresponding to different matching and the best anti-depressive matchingso far. In this study, the classical anti-depressive animal model, namely, ' force swimming model'and 'suspend tail model' were adopted to appraise the anti-depressive effect of the aforementionedformulas and the pharmacodynamical distinction between the whole formula decoction and the activecombination made up with each effective component from ginseng, polygala, hoelen and acori graminewere also investigated, which would provide scientific evidence for properly using KXS in clinic.

关键词： kai xin san anti-depression force swimming suspend tail

Lubrication and tribology in seawater hydraulic piston pump

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Journal of Marine Science and Application 2003年第1期2卷 35-40页

作者： wangdong LIZhuang-yun ZHUYu-quan DepartmentofAutomation WuhanInstituteofScience＆TechnologyWuhan430073China HuazhongUniversityofScience＆Technology Wuhan430074China

Water hydraulic systems have provoked major interest because of the human friendly and environmental safety aspects. Piston pump is one of the most frequently used hydraulic units in recent engineering technique. In water hydraulic piston pump, poor lubrication is more likely to happen than in oil hydraulic one because of difference in properties between water and oil. So there are some key problems such as corrosive wear and erosion, which are investigated briefly. Many new materials have been developed, which give longer life expectancies with water without corrosion and erosion. A new type of seawater hydraulic piston pumps with better suction characteristics had been developed at HUST. Much of this research has concentrated on new materials, structure and experiments, which are also specially introduced.

关键词： water hydraulics piston pump lubrication test material

The study for the damage and mechanism of bladder relaxation function in type 2 diabetes mellitus rats

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The study for the damage and mechanism of bladder relaxation...

Brief Talk About Big Data Graph Analysis and Visualization

第十三届全国泌尿外科学术会议暨第八届全球华人泌尿外科学术会议

作者： wangdong wen hucao yang shuang weibing

Objective To study the change and signifinance of detrusor relaxation function in the type 2 diabetes mellitus rats(DM).To investigate the expression of β-receptor and G-protein in the type 2 diabetes mellitus rats′... 详细信息

关键词： detrusor relaxation function β-receptor G-protein diabetes mellitus.

来源： cnki会议评论

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Journal on Big Data 2019年第1期1卷 25-38页

作者： Guang Su Fenghua Li wangdong Jiang Hunan University of Finance and Economics Changsha410001China The University of Alabama Tuscaloosa 35401USA

Graphical methods are used for *** analysis and visualization are an important area of applications of big *** the same time,visual analysis is also an important method for big data *** visualization refers to data that is presented in a visual form,such as a chart or map,to help people understand the meaning of the *** visualization helps people extract meaning from data quickly and *** can be used to fully demonstrate the patterns,trends,and dependencies of your data,which can be found in other *** data visualization analysis combines the advantages of computers,which can be static or interactive,interactive analysis methods and interactive technologies,which can directly help people and effectively understand the information behind big *** is indispensable in the era of big data visualization,and it can be very intuitive if used *** analysis also found that valuable information becomes a powerful tool in complex data relationships,and it represents a significant business *** the rise of big data,important technologies suitable for dealing with complex relationships have *** come in a variety of shapes and sizes for a variety of business *** analysis is first in the *** step is to get the right data and answer the *** short,to choose the right method,you must understand each relative strengths and weaknesses and understand the *** steps to get data:target;collect;clean;connect.

关键词： Big data visualization information visualization graph analysis

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南江地区灯影组白云岩优质储层形成机制研究

南江地区灯影组白云岩优质储层形成机制研究

作者：王东成都理工大学

学位级别：硕士

南江地区灯影组位于叠合盆地底部,形成时代最老,经历了多期次构造运动,成岩作用复杂。因而,国外针对构造简单盆地所总结的白云岩优质储层形成机制已不再适用。本文综合研究了灯影组白云岩优质储层岩石学特征、孔隙流体充注特征、成岩作... 详细信息

南江地区灯影组位于叠合盆地底部,形成时代最老,经历了多期次构造运动,成岩作用复杂。因而,国外针对构造简单盆地所总结的白云岩优质储层形成机制已不再适用。本文综合研究了灯影组白云岩优质储层岩石学特征、孔隙流体充注特征、成岩作用类型及特征等,得出以下主要结论:南江地区灯影组时期以局限台地的潮坪-泻湖沉积环境为主,常见沉积微相可以划分为:藻泥坪,藻坪,藻粒屑滩,泻湖,混合坪,粒屑滩。常见的岩石类型为:藻白云岩类、晶粒白云岩、砂屑白云岩、砂质(砂屑)白云岩、硅质白云岩等。白云岩成因主要为原生白云岩(石)、成岩早期白云石化白云岩,局部可见热液改造特征。研究表明,灯影组白云岩现存孔隙类型基本都是与溶解作用和重结晶作用相关的次生孔洞,而这些孔隙大多数是在早期岩溶孔洞基础上改造而成。主要包括晶间(溶)孔、粒间溶孔、特大溶孔、缝合线溶孔、晶内溶孔及大量的残余孔洞等。原始沉积微相和岩石类型控制着现存孔洞的分布和发育。同位素地球化学特征和储层岩石学特征表明,研究区灯影组白云岩存在灯影组中期和灯影组末期两次大气淡水岩溶作用。灯影组中期的岩溶作用表现为灯一段葡萄状构造白云石和碳氧同位素的明显负偏特征;灯影组末期的岩溶作用表现为灯三段大量的次生溶孔和碳氧同位素的明显负偏特征,古岩溶作用显著提高了原岩的孔隙度。灯影组白云岩的孔隙(洞)充填矿物世代关系十分复杂,通过不同孔洞的充填矿物对比研究建立了灯影组储层的流体充注序列:第一世代纤柱状白云石→第二世代石英→第三世代细-粗粒白云石→第一世代沥青→第四世代石英/粗粒白云石→第二世代沥青→第五世代巨晶白云石。其中,纤柱状白云石为灯影组中期表生岩溶作用产物,第一世代沥青形成于加里东末期的泥盆纪-石炭纪,第二世代沥青形成于三叠纪。南江地区灯影组沉积期后作用主要划分为5个阶段,其主要的成岩作用类型有压实-压溶作用、白云石化作用、溶解作用(大气淡水岩溶作用和深埋岩溶作用)、重结晶作用、硅化作用、构造破裂作用等。按照成岩作用对储层物性的影响,可以简单分为建设性、破坏性和破坏-建设性成岩作用三种类型。白云石化使得白云石体积缩小,产生大量微孔,有利于后期溶孔的形成和保存。压实、压溶作用使早期未固结的沉积物压实脱水,对沉积物的原生孔隙有致命的破坏性作用。大气淡水岩溶作用产生大量的溶蚀孔洞,埋藏溶蚀-沉淀作用产生溶蚀孔洞的同时产生矿物充填使得部分孔隙丢失,热液活动及其所引起的重结晶作用和硅化作用都是在前期的岩溶孔洞的基础上进行的。通过原生和后生控制因素研究表明,灯影组优质储层主控因素为表生期大气淡水岩溶作用及深埋期埋藏溶蚀作用。原始的沉积微相和岩石类型控制着岩溶作用的强度,埋藏溶蚀作用主要是对岩溶孔洞的溶蚀扩大或充填破坏。

关键词：南江地区灯影组白云岩优质储层成岩作用形成机制