Anti-depression effect of Kai Xin San and research of its compatibility

作     者：CHENYi-hong WANGDong-xiao LIUPing WANGJin-liang DAIChang CHENGGui-fang 

作者机构：InstituteofMatefiaMedicaChineseAcademyofMedicalSciencesandPekingUnionMedicalCollegeBeijing100050China ResearchInstituteforClinicalPharmacology.GeneralHospitalofPLABeijing100853China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2005年第118卷第14期

页      面：1214-1216页

核心收录：

学科分类：1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：ThisprojectwassupportedbyagrantfromtheNationalNaturaScienceFoundationofChina(No.90209036) 

主　　题：kai xin san anti-depression force swimming suspend tail 

摘      要：Kai Xin San (KXS) is a category of traditional complex prescription that wasfirst recorded in Bei Ji Qian Jin Yao Fang by SUN Si-miao in the Tang Dynasty and then also recordedin Tai Ping Hui Min He Ji Ju Fang, Qian Jin Yao Fang and Gu Jin Lu Yan in later generations. It wasmainly used by herbalist doctors to treat symptoms including desolation, moodiness, forgetfulnessetc. , which are similar to the neurosis such as depression, anxiety and difficulty in studying andmemory in the West medicine. The former recorded formulas were all composed of ginseng, polygala,hoelen and acori graminei with different proportion. But there are no systematic studies on theclinical adaptive symptom corresponding to different matching and the best anti-depressive matchingso far. In this study, the classical anti-depressive animal model, namely, force swimming model and suspend tail model were adopted to appraise the anti-depressive effect of the aforementionedformulas and the pharmacodynamical distinction between the whole formula decoction and the activecombination made up with each effective component from ginseng, polygala, hoelen and acori graminewere also investigated, which would provide scientific evidence for properly using KXS in clinic.