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Optimization Design of the Multi-Layer Cross-Sectional Layout of An Umbilical Based on the GA-GLM

China Ocean Engineering 2024年第2期38卷 247-254页

作者： YANG zhi-xun YIN Xu FAN zhi-rui YAN jun LU Yu-cheng SU Qi MAO Yandong wang Hua-lin Institute of marine machinery College of Mechanical and Electrical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDepartment of Engineering MechanicsDalian University of TechnologyDalian 116024China Ningbo Institube of Dalian University of Technology Ningbo 315040China

Marine umbilical is one of the key equipment for subsea oil and gas exploitation,which is usually integrated by a great number of different functional components with *** layout of these components directly affects manufacturing,operation and storage performances of the *** the multi-layer cross-sectional layout design of the umbilical,a quantifiable multi-objective optimization model is established according to the operation and storage *** the manufacturing factors,the multi-layering strategy based on contact point identification is introduced for a great number of functional ***,the GA-GLM global optimization algorithm is proposed combining the genetic algorithm and the generalized multiplier method,and the selection operator of the genetic algorithm is improved based on the steepest descent *** algorithm is used to find the optimal solution in the global space,which can converge from any initial layout to the feasible layout *** feasible layout solution is taken as the initial value of the generalized multiplier method for fast and accurate ***,taking umbilicals with a great number of components as examples,the results show that the cross-sectional performance of the umbilical obtained by optimization algorithm is better and the solution efficiency is ***,the multi-layering strategy is effective and *** design method proposed in this paper can quickly obtain the optimal multi-layer cross-sectional layout,which replaces the manual design,and provides useful reference and guidance for the umbilical industry.

关键词： umbilical cross-sectional layout multi-layers GA-GLM optimization

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BL03HB: a Laue microdiffraction beamline for both protein crystallography and materials science at SSRF

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Nuclear Science and Techniques 2024年第7期35卷 68-78页

作者： zhi-jun wang Si-Sheng wang Zheng-Huang Su Li Yu Yu-Zhu wang Bo Sun Wen Wen Xing-Yu Gao Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China University of Chinese Academy of Science Beijing100049China

A Laue microdiffraction beamline(BL03HB) was constructed at the Shanghai Synchrotron Radiation Facility(SSRF).This beamline features two consecutive focusing points in two different sectors within its end station, the first dedicated to protein crystallography and the other tailored to materials science applications. Based on a superbend dipole magnet with a magnetic field of 2.29 T, a two-stage focusing design was implemented with two sets of Kirkpatrick-Baez mirrors to achieve a micro white beam as small as 4.2 μ m ×4.3 μ m at the first sector and 0.9 μ m ×1.3 μ m at the second sector in the standard beamline operation mode at SSRF. The X-ray microbeam in the two sectors can be easily switched between monochromatic and white beams by moving a four-bounce monochromator in or out of the light path, respectively. In the protein crystallography sector, white-beam Laue microdiffraction was demonstrated to successfully determine the structure of protein crystals from only a few images of diffraction data collected by a Pilatus 2 M area detector. In the materials science sector,the white-beam Laue diffraction was collected in a reflection geometry using another Pilatus 2 M area detector, which could map the microstructural distribution on the sample surface by scanning the samples. In general, the BL03HB beamline promotes the application of Laue microdiffraction in both protein crystallography and materials science. This paper presents a comprehensive overview of the BL03HB beamline, end station, and the first commission results.

关键词： Crystallography White-beam Laue microdiffraction Beamline Synchrotron

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Particle-in-cell mode beam dynamics simulation of the low energy beam transport for the SSC-linac injector

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Chinese Physics C 2011年第5期35卷 500-504页

作者： XIAO Chen HE Yuan YUAN You-Jin YAO Qing-Gao wang zhi-jun CHANG Wei LIU Yong XIA Jia-Wen Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China Graduate University of Chinese Academy of Sciences Beijing 100049 China The School of Nuclear Science and Technology Lanzhou University Lanzhou 730000 China

A new SSC-linac system （injector into separated sector cyclotron） is being designed in the HIRFL （heavy ion research facility of Lanzhou）. As part of SSC-Linac, the LEBT （low energy beam transport） consists of seven solenoids, four quadrupoles, a bending magnet and an extra multi-harmonic buncher. The total length of this segment is about 7 meters. The beam dynamics in this LEBT has been studied using three-dimensional PIC （particle-in-cell） code BEAMPATH. The simulation results show that the continuous beam from the ion source is first well analyzed by a charge-to-mass selection system, and the beam of the selected charge-to-mass ratio is then efficiently pre-bunched by a multi-harmonic buncher and optimally matched into the RFQ （radio frequency quadrupole） for further acceleration. The principles and effects of the solenoid collimation channel are discussed, and it could limit the beam emittance by changing the aperture size.

关键词： SSC-linac LEBT PIC mode optimal injection collimation

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Research on IGBT Drive Circuit Based on 2QD30A17K-I Driver

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电力电子技术 2012年第12期46卷 60-61,66页

作者： HE Wei-wei wang zhi-han FU jun-yin LI Yan-fei Shenzhen Bronze Technologies Ltd. Shenzhen 518057 China

The insulated gate bipolar transistor(IGBT) has become the most popular controllable power switching device in the design of power electronics *** the interface of power circuit and control circuit in power source, the IGBT drive circuit should be with short transition time and the function of isolating safely and monitoring correctly the short-circuit and over-voltage *** paper presents the short-circuit protection theory and relative parameter selecting rules,based on the research on 2QD30A17K-I,the representative of high voltage and high power driver.

关键词： IGBTs 电力电子技术 MOSFET 晶体管

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Graphdiyne(C_(n)H_(2n-2))as an"electron transfer bridge"boosting photocatalytic hydrogen evolution over Zn_(0.5)Co_(0.5)S/MoS_(2)S-scheme heterojunction

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Rare Metals 2024年第5期43卷 1999-2014页

作者： Mei Li Jing-zhi wang zhi-Liang Jin School of Chemistry and Chemical Engineering North Minzu UniversityYinchuan 750021China School of Chemistry and Chemical Engineering Ningxia Key Laboratory of Solar Chemical Conversion TechnologyKey Laboratory for Chemical Engineering and TechnologyState Ethnic Affairs CommissionNorth Minzu UniversityYinchuan 750021China

In the process of photocatalytic water cracking,the migration rate and utilization rate of photogenerated charges determine the hydrogen evolution performance of the *** this paper,a carbon isotope superconducting material graphdiyne(GDY)is prepared by mechanical ball milling and introduced into the S-scheme heterojunction Zn_(0.5)Co_(0.5)S/MoS_(2)inorganic *** terms of hydrogen evolution kinetics,GDY acts as an electron bridge,not only accelerating the migration of photogenerated carriers but also improving the utilization of photogenerated ***,the large twodimensional layer provides more loading and anchoring points for Zn_(0.5)Co_(0.5)S/MoS_(2),which increases the number of active *** ternary composite catalyst 20%GDY/Zn_(0.5)Co_(0.5)S/MoS_(2)(20-GCSM)generates 69.94μmol of hydrogen(5 h)in triethanolamine *** is 2.97 and1.80 times higher than Zn_(0.5)Co_(0.5)S and Zn_(0.5)Co_(0.5)S/MoS_(2),*** the cyclic experiment,it still has stable hydrogen evolution performance after standing for24 h(under dark conditions).In addition,the potential mechanism of photocatalytic hydrogen evolution is demonstrated through in-situ X-ray photoelectron *** work provides a reference for further research in the field of introducing carbon materials into photocatalytic systems and improving the utilization of photogenerated charges.

关键词： Graphdiyne S-scheme heterojunction Electron transfer bridge Hydrogen production

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超声引导下精索阻滞麻醉对阴囊急诊手术患者应激反应和并发症的影响

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现代生物医学进展 2024年第2期24卷 372-375页

作者：李林周洁浩刘红杰王志军刘洪波阜阳市人民医院急诊外科安徽阜阳236000 阜阳市人民医院中心功能室安徽阜阳236000

目的:探究超声引导下精索阻滞麻醉对阴囊急诊手术患者应激反应和并发症的影响。方法:选择2020年10月至2022年12月来我院行阴囊急诊手术的急诊患者60例,按照随机数表法,分为观察组(n=30)和对照组(n=30)。两组均行精索阻滞麻醉,其中对照... 详细信息

目的:探究超声引导下精索阻滞麻醉对阴囊急诊手术患者应激反应和并发症的影响。方法:选择2020年10月至2022年12月来我院行阴囊急诊手术的急诊患者60例,按照随机数表法,分为观察组(n=30)和对照组(n=30)。两组均行精索阻滞麻醉,其中对照组采用盲探穿刺法,观察组采用超声引导的方式。比较两组患者阻滞成功率、麻醉方式更改人数、麻醉药物追加人数及并发症发生人数,比较不同时间点两组的疼痛(VAS)评分,比较术前及术后两组的应激反应[皮质醇(Cor)]、抗氧化指标[超氧化物歧化酶(SOD)]、炎性因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)]水平。结果:观察组患者阻滞成功率为90.00%,高于对照组的66.67%(P0.05);手术开始5 min及术后4、8、12 h时,观察组患者的VAS评分均低于对照组的(P<0.05);两组患者术后24 h时的Cor、IL-6、IL-8水平均高于术前,但是观察组为低于对照组(P<0.05),两组术后24 h的SOD均低于术前,而观察组为高于对照组(P<0.05);观察组的血肿、刺破血管发生率分别为6.67%、10.00%,均低于对照组的30.00%、36.67%(P<0.05)。结论:精索阻滞麻醉对阴囊急诊手术患者具有较好的阻滞效果,能够为患者带来更好的镇痛效果,降低术后应激及炎症反应。

关键词：精索阻滞麻醉阴囊手术应激反应并发症

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Reversible solid-liquid conversion enabled by self-capture effect for stable non-flow zinc-bromine batteries

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Green Energy & Environment 2024年第6期9卷 1035-1044页

作者： Xixi Zhang Xiaoke wang Guangmeng Qu Tairan wang Xiliang Zhao jun Fan Cuiping Han Xijin Xu Chunyi zhi Hongfei Li School of Physics and Technology University of JinanShandong250022China Songshan Lake Materials Laboratory DongguanGuangdong523808China Department of Materials Science and Engineering City University of Hong Kong83 Tat Chee AvenueHong KongChina Faculty of Materials Science and Engineering and Low Dimensional Energy Materials Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong518055China School of System Design and Intelligent Manufacturing Southern University of Science and TechnologyShenzhenGuangdong518055China

Non-flow aqueous zinc-bromine batteries without auxiliary components(e.g.,pumps,pipes,storage tanks)and ion-selective membranes represent a cost-effective and promising technology for large-scale energy ***,they generally suffer from serious diffusion and shuttle of polybromide(Br^(-),Br^(3-))due to the weak physical adsorption between soluble polybromide and host carbon materials,which results in low energy efficiency and poor cycling ***,we develop a novel self-capture organic bromine material(1,10-bis[3-(trimethylammonio)propyl]-4,4'-bipyridinium bromine,NVBr4)to successfully realize reversible solid complexation of bromide components for stable non-flow zinc-bromine battery *** quaternary ammonium groups(NV^(4+)ions)can effectively capture the soluble polybromide species based on strong chemical interaction and realize reversible solid complexation confined within the porous electrodes,which transforms the conventional“liquid-liquid”conversion of soluble bromide components into“liquid-solid”model and effectively suppresses the shuttle ***,the developed non-flow zinc-bromide battery provides an outstanding voltage platform at 1.7 V with a notable specific capacity of 325 mAh g^(-1)NVBr4(1 A g^(-1)),excellent rate capability(200 mAh g^(-1)NVBr4 at 20 A g^(-1)),outstanding energy density of 469.6 Wh kg^(-1)and super-stable cycle life(20,000 cycles with 100%Coulombic efficiency),which outperforms most of reported zinc-halogen *** mechanism analysis and DFT calculations demonstrate that the chemical interaction of quaternary ammonium groups and bromide species is the main reason for suppressing the shuttle *** developed strategy can be extended to other halogen batteries to obtain stable charge storage.

关键词： Solid-liquid conversion Self-capture Non-ﬂow zinc-bromine batteries Quaternary ammonium

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Middle Devonian ostracods from Jiwozhai patch reef(Dushan,Guizhou Province,South China):Biostratigraphic and palaeoecological implication

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Journal of Palaeogeography 2024年第3期13卷 581-593页

作者： jun-jun Song Jia-Yuan Huang Wen Guo Kun Liang Yu-Cong Sun zhi-Hong wang Wen-Kun Qie State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008Jiangsu ProvinceChina Hubei Key Laboratory of Paleontology and Geological Environment Evolution Wuhan Center of China Geological SurveyWuhan 430205Hubei ProvinceChina University of Chinese Academy of Sciences NanjingNanjing 211135Jiangsu ProvinceChina

The Middle Devonian ostracods from the Jiwozhai patch reef in Dushan, Guizhou Province, South China were described for the first time in this study. Twenty-nine species belonging to 20 genera were identified and figured, including a new species named wangshangkia jiwozhaiensis sp. nov. The ostracod fauna in the Jiwozhai patch reef represents a Givetian age. The ostracod assemblage belongs to the smooth-podocopid association, which is also ecologically equivalent to the Eifelian Mega-Assemblage Ⅲ. This association is indicative of shallow open-marine environments. The Jiwozhai patch reef fauna is primarily comprised of suspension feeders, including filter-feeding ostracods, corals, brachiopods and bryozoans. Ostracods from the Jiwozhai patch reef were compared to the ostracod faunas from Laurentia-Baltica at generic level, which reveals limited faunal exchanges between South China and Laurentia-Baltica during the Middle Devonian.

关键词： Ostracods Givetian Jiwozhai patch reef Dushan Palaeoecology

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γδT细胞受体在小鼠心肺脑复苏后全脑缺血再灌注损伤中的作用机制

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现代免疫学 2024年第1期44卷 26-31页

作者：薄海美曹新营李东琦李建民王志军华北理工大学临床医学院唐山063000 华北理工大学附属医院心血管科唐山063000

为探究γδT细胞受体在小鼠心肺脑复苏(cardiopulmonary-cerebral resuscitation,CPCR)后全脑缺血再灌注损伤中的作用机制,将成年雄性C57BL/6小鼠随机分为3组:空白组、CPCR组和CPCR+γδT受体拮抗组。采用窒息法建立CPCR后全脑缺血再灌... 详细信息

为探究γδT细胞受体在小鼠心肺脑复苏(cardiopulmonary-cerebral resuscitation,CPCR)后全脑缺血再灌注损伤中的作用机制,将成年雄性C57BL/6小鼠随机分为3组:空白组、CPCR组和CPCR+γδT受体拮抗组。采用窒息法建立CPCR后全脑缺血再灌注模型,制作脑组织石蜡切片,进行H-E和末端脱氧核苷酸转移酶介导的dUTP缺口末端标记(terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling,TUNEL)染色,分别观察各组小鼠脑组织受损和神经元凋亡程度。用Western blotting和免疫组化法检测各组小鼠脑组织内IL-17A、IL-23p19蛋白的表达,用RT-PCR检测各组小鼠脑组织内IL-17A、IL-23p19 mRNA表达。结果显示,与空白组比较,CPCR组小鼠脑缺血灶中心区出现大量死细胞或细胞呈不规则状态肿大,核膜破裂,细胞结构消失,且神经元细胞凋亡程度增加,而CPCR+γδT受体拮抗组小鼠较CPCR组上述现象变轻;CPCR组小鼠较空白组脑组织损伤评分、细胞凋亡率、IL-17A和IL-23p19表达水平均显著升高(P<0.01),而CPCR+γδT受体拮抗组小鼠较CPCR组脑组织损伤评分、细胞凋亡率、IL-17A和IL-23p19表达水平均显著降低(P<0.05)。该研究提示,γδT细胞受体可能通过影响γδT细胞IL-17A及IL-23p19的水平在小鼠CPCR后全脑缺血再灌注损伤的致病机制中发挥促炎作用。

关键词：心肺脑复苏全脑缺血再灌注损伤 γδT细胞

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A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2324-2340页

作者： Xin wang Qian Liu Hai-tao Yu Jia-zhao Xie jun-ning Zhao zhi-ting Fang Min Qu Yao Zhang Ying Yang Jian-zhi wang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Fundamental Medicine Wuxi School of MedicineJiangnan UniversityWuxiJiangsu 214122China Hubei Provincial Key Laboratory for Applied Toxicology Hubei Provincial Center for Disease Control and PreventionHubei Provincial Academy of Preventive MedicineWuhan 430000China Endocrine Department of Liyuan Hospital Key Laboratory of Ministry of Education of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226000China

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease(AD);however,the fundamental mechanism is *** this study,we found a substantial decline in isocitrate dehydrogenase 3β(IDH3β)levels,a critical tricarboxylic acid cycle enzyme,in AD patients and AD-transgenic mice’s *** investigations demonstrated that the knockdown of IDH3βinduced oxidation-phosphorylation uncoupling,leading to reduced energy metabolism and lactate *** resulting increased lactate,a source of lactyl,was found to promote histone lactylation,thereby enhancing the expression of paired-box gene 6(PAX6).As an inhibitory transcription factor of IDH3β,the elevated PAX6 in turn inhibited the expression of IDH3β,leading to tau hyperphosphorylation,synapse impairment,and learning and memory deficits resembling those seen in *** AD-transgenic mice,upregulating IDH3βand downregulating PAX6 were found to improve cognitive functioning and reverse AD-like ***,our data suggest that impaired oxidative phosphorylation accelerates AD progression via a positive feedback inhibition loop of IDH3β-lactate-PAX6-IDH3β.Breaking this loop by upregulating IDH3βor downregulating PAX6 attenuates AD neurodegeneration and cognitive impairments.

关键词： metabolism Alzheimer impaired

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