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Identification of a novel coronavirus causing severe pneumonia in human:a descriptive study

Chinese Medical Journal 2020年第9期133卷 1015-1024页

作者： Li-Li Ren Ye-Ming wang Zhi-Qiang Wu Zi-Chun xiang Li guo Teng Xu Yong-zhong Jiang yan Xiong Yong-Jun Li Xing-wang Li hui Li guo-hui Fan Xiao-Ying Gu yan Xiao Hong Gao Jiu-yang Xu Fan yang Xin-Ming wang Chao Wu Lan Chen Yi-Wei liu Bo liu Jian yang Xiao-Rui wang Jie dong Li Li Chao-Lin huang Jian-Ping zhao Yi Hu Zhen-Shun Cheng Un-Lin liu zhao-hui Qian Chuan Qin Qi Jin Bin Cao Jian-Wei wang National Health Commission of the People’s Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesChina-Japan Friendship HospitalBeijing 100029China Institute of Respiratory Medicine Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100029China National Health Commission of the People’s Republic of China Key Laboratory of Systems Biology of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Vision Medicals Co. LtdGuangzhouGuangdong 510000China Hubei Provincial Center for Disease Control and Prevention WuhanHubei 430079China Wuhan Center for Disease Control and Prevention WuhanHubei 430022China Clinical and Research Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Institute of Clinical Medical Sciences China-Japan Friendship HospitalBeijing 100029China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China Department of Basic Medical Sciences Tsinghua University School of MedicineBeijing 100084China Wuhan Jinyintan Hospital WuhanHubei 430022China Department of Pulmonary and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Sciences and TechnologyWuhanHubei 430030China Department of Pulmonary and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430014China Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China

Background:Human infections with zoonotic coronaviruses(CoVs),including severe acute respiratory syndrome(SARS)-CoV and Middle East respiratory syndrome(MERS)-CoV,have raised great public health concern ***,we report a novel batorigin CoV causing severe and fatal pneumonia in ***:We collected clinical data and bronchoalveolar lavage(BAL)specimens from five patients with severe pneumonia from Wuhan Jinyintan Hospital,Hubei province,*** acids of the BAL were extracted and subjected to next-generation *** isolation was carried out,and maximum-likelihood phylogenetic trees were ***:Five patients hospitalized from December 18 to December 29,2019 presented with fever,cough,and dyspnea accompanied by complications of acute respiratory distress *** radiography revealed diffuse opacities and *** of these patients *** results revealed the presence of a previously unknownβ-CoV strain in all five patients,with 99.8%to 99.9%nucleotide identities among the *** isolates showed 79.0%nucleotide identity with the sequence of SARS-CoV(GenBank NC_004718)and 51.8%identity with the sequence of MERS-CoV(GenBank NC_019843).The virus is phylogenetically closest to a bat SARS-like CoV(SL-ZC45,GenBank MG772933)with 87.6%to 87.7%nucleotide identity,but is in a separate ***,these viruses have a single intact open reading frame gene 8,as a further indicator of bat-origin ***,the amino acid sequence of the tentative receptor-binding domain resembles that of SARS-CoV,indicating that these viruses might use the same ***:A novel bat-borne CoV was identified that is associated with severe and fatal respiratory disease in humans.

关键词： Bat-origin Coronavirus Zoonotic transmission Pneumonia Etiology Next-generation sequencing

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AIWW:a new nutrition-screening tool for the oncologic population

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Science China(Life Sciences) 2023年第8期66卷 1831-1840页

作者： Yi-zhong Ge Zhen-Ming Fu Qi Zhang Meng-Meng Song guo-Tian Ruan Xi Zhang Xiao-Wei Zhang xiang-Rui Li Kang-Ping Zhang Meng Tang Xiao-Yue liu Ming yang Tong liu Hai-Lun Xie He-yang Zhang Zi-Wen wang Chun-Lei Hu Shi-Qi Lin Rui Zhang Hong-Xia Xu Wei Li Chun-hua Song Ming liu Jun-Qiang Chen Kun-hua wang Li Bo Ming-hua Cong Zeng-Ning Li Zeng-Qin guo Xiao-Bin wang Bin-yan wang Benjamin Xu Xian-hui Qin Xi-Ping Xu Rocco Barazzoni Qing-hua Yao Min Weng Xian Shen Han-Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group Department of Gastrointestinal Surgery/Department of Clinical Nutrition Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou 325000China National Clinical Research Center for Geriatric Diseases Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing 100038China Key Laboratory of Cancer FSMP for State Market Regulation Beijing 100038China Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Colorectal Surgery Cancer Hospital of University of Chinese Academy of SciencesZhejiang Cancer HospitalHangzhou 310022China Department of Clinical Nutrition Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Cancer Center of the First Hospital of Jilin University Changchun 130021China Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou450001China Department of Colorectal Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Gastrointestinal Surgery First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Yunnan University Kunming 650091China General Surgery Clinical Medical Center of Yunnan Province Kunming 650032China Affiliated Hospital of Yunnan University Kunming 650091China Comprehensive Oncology Department Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China Department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuang 050031China Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014China Department of Population Family and Reproductive HealthJohns Hopkins University Bloomberg School of Public HealthBaltimore MD 21228USA Shenzhen Evergreen Medical Institute Shenzhen 518052China Department of Epid

Malnutrition is a common comorbidity among patients with ***,no nutrition-screening tool has been recognized in this population.A quick and easy screening tool for nutrition with high sensitivity and easy-to-use is *** on the previous 25 nutrition-screening tools,the Delphi method was made by the members of the Chinese Society of Nutritional Oncology to choose the most useful item from each *** to these results,we built a nutrition-screening tool named age,intake,weight,and walking(AIWW).Malnutrition was defined based on the scored patient-generated subjective global assessment(PG-SGA).Concurrent validity was evaluated using the Kendall tau coefficient and kappa consistency between the malnutrition risks of AIWW,nutritional risk screening 2002(NRS-2002),and malnutrition screening tool(MST).Clinical benefit was calculated by the decision curve analysis(DCA),integrated discrimination improvement(IDI),and continuous net reclassification improvement(c NRI).A total of 11,360 patients(male,n=6,024(53.0%)were included in the final study cohort,and 6,363 patients had malnutrition based on *** on AIWW,NRS-2002,and MST,7,545,3,469,and1,840 patients were at risk of malnutrition,*** sensitivities of AIWW,NRS-2002,and MST risks were 0.910,0.531,and 0.285,and the specificities were 0.768,0.946,and *** Kendall tau coefficients of AIWW,NRS-2002,and MST risks were 0.588,0.501,and 0.326,*** area under the curve of AIWW,NRS-2002,and MST risks were0.785,0.739,and 0.630,*** IDI,c NRI,and DCA showed that AIWW is non-inferior to NRS-2002(IDI:0.002(-0.009,0.013),c NRI:-0.015(-0.049,0.020)).AIWW scores can also predict the survival of patients with *** missed diagnosis rates of AIWW,NRS-2002,and MST were 0.09%,49.0%,and 73.2%,*** showed a better nutritionscreening effect than NRS-2002 and MST for patients with cancer and could be recommended as an alternative nutritionscreening tool

关键词： nutrition-screening AIWW NRS-2002 MST cancer

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Introduction to cognitive assessment scales in screening for mild cognitive impairment after stroke: A review

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TMR Integrative Nursing 2019年第5期3卷 166-172页

作者： Luo yang Hong guo yan-Ling Shen Li Li Hai-yan wang Shao-hua Gong You-hua liu Xiao-Ping Yi Dan zhao hui Ju School of Nursing Beijing University of Chinese MedicineBeijingChina Surgical Intensive Care Unit China-Japan Friendship HospitalBeijingChina Department of Neurology China-Japan Friendship HospitalBeijingChina.

Objective:In order to improve the quality of life of patients more effectively,this paper introduces the types and usages of scales for screening mild cognitive dysfunction after stroke and provides a basis for early identification of mild cognitive ***:Read,analyze,summarize,and sort out relevant ***:The mild cognitive impairment assessment scales are broadly divided into two categories:the comprehensive rating scales and the special assessment *** are 7 comprehensive assessment scales for the comprehensive rating scales,among which the Mini-mental State of Examination and the Montreal Cognitive Assessment Scale are the most widely *** special assessment scales are mainly evaluated by the symptoms of cognitive dysfunction and can be divided into five ***:Early diagnosis and intervention in patients with cognitive dysfunction will help improve the prognosis of *** assessment scale has its advantages and limitations in both sensitivity and *** use of appropriate scales to diagnose cognitive dysfunction and to screen early,to prevent early,to treat early can effectively improve the quality of life of elderly patients.

关键词： Stroke Mild cognitive dysfunction Rating scale

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Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province

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Chinese Medical Journal 2020年第9期133卷 1025-1031页

作者： Kui liu Yuan-Yuan Fang yan Deng Wei liu Mei-Fang wang Jing-Ping Ma Wei Xiao Ying-Nan wang Min-hua zhong Cheng-Hong Li Guang-Cai Li hui-guo liu Department of Respiratory and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Respiratory and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Respiratory and Critical Care Medicine Taihe HospitalAffiliated Hospital of Hubei University of MedicineShiyanHubei 442000China Department of Respiratory and Critical Care Medicine Jingzhou Central HospitalJingzhouHubei 434020China Department of Respiratory and Critical Care Medicine The First People’s Hospital of JingzhouJingzhouHubei 434000China Department of Respiratory and Critical Care Medicine The People’s Hospital of China Three Gorges UniversityThe First People’s Hospital of YichangYichangHubei 443000China Department of Respiratory and Critical Care Medicine Xiaogan Hospital Affiliated to Wuhan University of Science and TechnologyThe Central Hospital of XiaoganXiaoganHubei 432100China Department of Respiratory and Critical Care Medicine The Sixth Hospital of WuhanJianghan UniversityWuhanHubei 430015China Department of Respiratory and Critical Care Medicine The Central Hospital of Enshi Tujia and Miao Autonmous PrefectureEnshi Clinical College of Wuhan UniversityEnshi Tujia and Miao Autonomous PrefectureHubei 445000China

Background:The 2019 novel coronavirus(2019-nCoV)causing an outbreak of pneumonia in Wuhan,Hubei province of China was isolated in January *** study aims to investigate its epidemiologic history,and analyze the clinical characteristics,treatment regimens,and prognosis of patients infected with 2019-nCoV during this ***:Clinical data from 1372019-nCoV-infected patients admitted to the respiratory departments of nine tertiary hospitals in Hubei province from December 30,2019 to January 24,2020 were retrospectively collected,including general status,clinical manifestations,laboratory test results,imaging characteristics,and treatment ***:None of the 137 patients(61 males,76 females,aged 20-83 years,median age 57 years)had a definite history of exposure to huanan Seafood Wholesale *** initial symptoms included fever(112/137,81.8%),coughing(66/137,48.2%),and muscle pain or fatigue(44/137,32.1%),with other,less typical initial symptoms observed at low frequency,including heart palpitations,diarrhea,and *** 80%of the patients had normal or decreased white blood cell counts,and 72.3%(99/137)had *** involvement was present in all cases,with most chest computed tomography scans showing lesions in multiple lung lobes,some of which were dense;ground-glass opacity co-existed with consolidation shadows or cord-like *** the lack of effective drugs,treatment focused on symptomatic and respiratory *** G was delivered to some critically ill patients according to their *** corticosteroid treatment did not show significant ***,early respiratory support facilitated disease recovery and improved *** risk of death was primarily associated with age,underlying chronic diseases,and median interval from the appearance of initial symptoms to ***:The majority of patients with 2019-nCoV pneumonia present with fever as the first symptom,and most

关键词： Coronavirus 2019 Novel coronavirus(2019-nCoV) Clinical characteristics Treatment Hubei province

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Extracellular vesicles from human urine-derived stem cells prevent osteoporosis by transferring CTHRC1 and OPG

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Bone Research 2019年第3期7卷 296-309页

作者： Chun-Yuan Chen Shan-Shan Rao Yi-Juan Tan Ming-Jie Luo Xiong-Ke Hu Hao Yin Jie huang Yin Hu zhong-Wei Luo Zheng-zhao liu Zhen-Xing wang Jia Cao Yi-Wei liu Hong-Ming Li yang Chen Wei Du Jiang-hua liu yan Zhang Tuan-hui Chen Hao-Ming liu Ben Wu Tao Yue Yi-Yi wang Kun Xia Peng-Fei Lei Si-Yuan Tang hui Xie Department of Orthopedics Xiangya Hospital Central South University Changsha Hunan 410008 China Movement System Injury and Repair Research Center Xiangya Hospital Central South University Changsha Hunan 410008 China xiangya School of Nursing Central South University Changsha Hunan 410013 China Department of Sports Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Rehabilitation Xiangya Hospital Central South University Changsha Hunan 410008 China Hunan Key Laboratory of Organ Injury Aging and Regenerative Medicine Changsha Hunan 410008 China Hunan Key Laboratory of Bone Joint Degeneration and Injury Changsha Hunan 410008 China National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha Hunan 410008 China

Osteoporosis is a debilitating bone disease affecting millions of people. Here, we used human urine-derived stem cells(USCs),which were noninvasively harvested from unlimited and easily available urine, as a "factory" to obtain extracellular vesicles(USCEVs) and demonstrated that the systemic injection of USC-EVs effectively alleviates bone loss and maintains bone strength in osteoporotic mice by enhancing osteoblastic bone formation and suppressing osteoclastic bone resorption. More importantly, the anti-osteoporotic properties of USC-EVs are not notably disrupted by the age, gender, or health condition(with or without osteoporosis) of the USC donor. Mechanistic studies determined that collagen triple-helix repeat containing 1(CTHRC1) and osteoprotegerin(OPG) proteins are enriched in USC-EVs and required for USC-EV-induced pro-osteogenic and anti-osteoclastic effects. Our results suggest that autologous USC-EVs represent a promising novel therapeutic agent for osteoporosis by promoting osteogenesis and inhibiting osteoclastogenesis by transferring CTHRC1 and OPG.

关键词： stem cells USCs bone loss

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3-to 24-month Follow-up on COVID-19 with Pulmonary Tuberculosis Survivors after Discharge:Results from a Prospective,Multicenter Study

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Biomedical and Environmental Sciences 2022年第12期35卷 1091-1099页

作者： wang Jing Ya ZONG Xing Yu WU Gui hui QI Yuan Lin LI hui Zhen JI Xin Yu TONG Lin ZHANG Lei yanG Ming Bo yanG Pu Ye LI Ji Ke XIAO Fu Rong ZHANG Lin Song HU Yun Hong liu Hong De XU Shou Fang SUN Sheng WU Wei MAO Ya LI Min Qing HOU Hao hua GONG zhao Yuan guo yang JIAO Li Wen QIN Jin wang Ding Yi wang Fang GUAN Li LIN Gang MA yan wang yan Ping SHI Nan Nan Community Health Service Management Center Dongcheng DistrictBeijing 100700China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Public Health Clinical Center of Chengdu Chengdu 610066SichuanChina Yiyuan TCM Hospital Zibo 256199ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Xi’an Eighth Hospital Xi’an 710000ShaanxiChina Harbin Infectious Disease Hospital Harbin 150000HeilongjiangChina Hospital(T.C.M)Affiliated to Southwest Medical University Luzhou 646000SichuanChina Xingtai Hospital of Chinese Medicine Xingtai 054000HebeiChina Shijiazhuang Fifth Hospital Shijiazhuang 050000HebeiChina Jiamusi Infectious Disease Hospital Jiamusi 154000HeilongjiangChina Chengde Hospital of Traditional Chinese Medicine Chengde 067040HebeiChina Hanzhong Central Hospital Hanzhong 723000ShaanxiChina Ankang Hospital of Traditional Chinese Medicine Ankang 725000ShaanxiChina Department of Traditional Chinese medicine Dazhou Central HospitalDazhou 635000SichuanChina China National Medicines Corporation Ltd Beijing 100077China Beijing University of Chinese Medicine Beijing 101121China Infectious Disease Hospital of Heilongjiang Province Harbin 150030HeilongjiangChin

Objective Coronavirus disease 2019(COVID-19)and tuberculosis(TB)are major public health and social issues *** long-term follow-up of COVID-19 with pulmonary TB(PTB)survivors after discharge is *** study aimed to comprehensively describe clinical outcomes,including sequela and recurrence at 3,12,and 24 months after discharge,among COVID-19 with PTB *** From January 22,2020 to May 6,2022,with a follow-up by August 26,2022,a prospective,multicenter follow-up study was conducted on COVID-19 with PTB survivors after discharge in 13 hospitals from four provinces in *** outcomes,including sequela,recurrence of COVID-19,and PTB survivors,were collected via telephone and face-to-face interviews at 3,12,and 24 months after *** Thirty-two COVID-19 with PTB survivors were *** median age was 52(45,59)years,and 23(71.9%)were *** them,nearly two-thirds(62.5%)of the survivors were moderate,three(9.4%)were severe,and more than half(59.4%)had at least one comorbidity(PTB excluded).The proportion of COVID-19 survivors with at least one sequela symptom decreased from 40.6%at 3 months to 15.8%at 24 months,with anxiety having a higher proportion over a *** and amnesia recovered at the 12-month follow-up,while anxiety,fatigue,and trouble sleeping remained after ***,one(3.1%)case presented two recurrences of PTB and no re-positive COVID-19during the follow-up *** The proportion of long symptoms in COVID-19 with PTB survivors decreased over time,while nearly one in six still experience persistent symptoms with a higher proportion of *** recurrence of PTB and the psychological support of COVID-19 with PTB after discharge require more attention.

关键词： COVID-19 Pulmonary tuberculosis Long-term Sequela Recurrence Re-positive

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Fluorescence polarization assay improves the rapid detection of human brucellosis in China

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Infectious Diseases of Poverty 2021年第2期10卷 85-85页

作者： Shuai-Bing dong Di Xiao Jing-Yao liu hui-Mei Bi Zun-Rong Zheng Li-Da wang Xiao-Wen yang guo-zhong Tian Hong-yan zhao dong-Ri Piao Zhi-Feng Xing Hai Jiang State Key Laboratory for Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina 不详

Background:Brucellosis is an infectious-allergic zoonotic disease caused by bacteria of the genus *** diagnosis is the key to preventing,treating,and controlling *** polarization immunoassay(FPA)is a new immunoassay for relatively rapid and accurate detection of antibodies or antigens based on antigen-antibody ***,there is no report on FPA-based detection of human brucellosis in ***,this study is to evaluate the value of FPA for the diagnosis of human brucellosis in China.

关键词： Human brucellosis Fluorescence polarization assay Diagnosis

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Effects of Niaoduqing Particles(尿毒清颗粒)on Delaying Progression of Renal Dysfunction:A Post-trial,Open-Label,Follow-up Study

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Chinese Journal of Integrative Medicine 2019年第3期25卷 168-174页

作者： ZHENG Ying wang Nian-song liu Yu-ning HE Li-qun JIAN Gui-hua liu Xu-sheng NI zhao-hui CHENG Xiao-hong LIN Hong-li ZHOU Wen-hua wang Ya-ping FANG Jing-ai HE Ya-ni yanG Hong-tao zhao Li-juan DING Han-lu wang Li-hua YU Ren-huan LI Wen-ge YE Zhi-ming guo wang ZHAN Yong-li MAO hui-juan HU zhao YAO Chen CAI Guang-yan CHEN xiang-mei Department of Nephrology Chinese People's Liberation Army General Hospital Chinese People's Liberation Army Institute of Nephrology State Key Laboratory of Kidney Diseases (2011DAV00088) National Clinical Research Center for Kidney Diseases Department of Nephrology and Rheumatology Affiliated Sixth People's Hospital Shanghai Jiaotong University Department of Nephrology Dongzhimen Hospital The First Affiliated Hospital of Beijing University of Chinese Medicine Department of Nephrology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Department of Nephrology Guangdong Provincial Hospital of Chinese Medicine Department of Nephrology Renji Hospital Shanghai Jiaotong University Department of Nephrology Shaanxi Traditional Chinese Medicine Hospital Department of Nephrology First Affiliated Hospital of Dalian Medical University Department of Nephrology Second Hospital of Jilin University Department of Nephrology Army General Hospital Department of Nephrology First Affiliated Hospital of Shanxi Medical University Department of Nephrology Daping Hospital Army Medical University Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Department of Nephrology Xijing Hospital Air Force Medical University Department of Nephrology University of Electronic Science and Technology Sichuan Academy of Sciences and Sichuan Provincial People's Hospital Department of Nephrology Second Affiliated Hospital of Shanxi Medical University Department of Nephrology Xiyuan Hospital China Academy of Chinese Medical Sciences Department of Nephrology China-Japan Friendship Hospital Department of Nephrology Guangdong General Hospital Guangdong Academy of Medical Sciences Department of Nephrology Beijing Friendship Hospital Capital Medical University Department of Nephrology Guang'anmen Hospital of China Academy of Traditional Chinese Medical Sciences Department of Nephrology Jiangsu Province Hospital First Affiliated Hospital of Nan

Objective: To follow up the participants of the randomized clinical trial "Efficacy and Safety of Niaoduqing Particles(尿毒清颗粒) for Delaying Moderate-to-Severe Renal Dysfunction", and assess the long-term effects of Niaoduqing Particles on delaying the progression of renal dysfunction. Methods: Participants, who had previously been randomly assigned to receive Niaoduqing Particles or placebo for 24 weeks(146 cases in each group), were invited to follow-up and all were administered Niaoduqing Particles 5 g thrice daily and 10 g before bedtime for 24 weeks. The primary endpoints were changes in baseline serum creatinine(Scr) and estimated glomerular filtration rate(e GFR) after completion of the open-label treatment period. Results: After the double-blind period, the median(interquartile range) changes in Scr were 1.1(–13.0–24.1) and 11.7(–2.6–42.9) μmol/L for the Niaoduqing Particle and placebo groups, respectively(P=0.008), and the median changes in e GFRs were –0.2(–4.3–2.7) and –2.21(–5.7–0.8) mL·min^(-1)·1.73 m^(-2), respectively(P=0.016). There were significant differences in the double-blind period changes in renal function between groups. After the open-label period, the median changes in Scr were 9.0(–10.0–41.9) and 17.5(–6.0–50.0) μmol/L for the Niaoduqing Particle and placebo groups according to baseline grouping, respectively(P=0.214), and the median changes in eGFRs were –2.3(–6.4–1.9) and –3.7(–7.5–1.1) mL·min^(-1)·1.73 m^(-2), respectively(P=0.134). There were no statistical differences in the open-label period changes in renal function between groups. The eGFR reduction of participants who accepted Niaoduqing Particle treatment for 48 weeks was projected to 2.5 m L·min^(-1)·1.73 m(-2) per year. Conclusions: Niaoduqing Particles appear to have long-term efficacy for patients with moderate-to-severe renal dysfunction. Although there was no statistical difference, the early use of Niaoduqing Paticles seems to ameliorate the worsening of renal function.

关键词： chronic kidney disease moderate-to-severe renal dysfunction Niaoduqing Particles post-trial follow-up Chinese medicine

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Efficacy and Safety of Niaoduqing Particles for Delaying Moderate-to-severe Renal Dysfunction： A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Study

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Chinese Medical Journal 2017年第20期130卷 2402-2409页

作者： Ying Zheng Guang-yan Cai Li-Qun He Hong-Li Lin Xiao-Hong Cheng Nian-Song wang Gui-hua Jian Xu-Sheng liu Yu-Ning liu zhao-hui Ni Jing-Ai Fang Han-Lu Ding wang guo Ya-Ni He Li-hua wang Ya-Ping wang Hong-Tao yang Zhi-Ming Ye Ren-huan YU Li-Juan zhao Wen-hua Zhou Wen-Ge Li hui-Juan Mao Yong-Li Zhan zhao Hu Chen Yao Ri-Bao Wei xiang-Mei Chen Department of Nephrology Chinese People's Liberation Army General Hospital Chinese People's Liberation Army Institute of Nephrology State Key Laboratory of Kidney Diseases (2011DAVO0088) National Clinical Research Center for Kidney Diseases Beijing 100853 China Department of Nephrology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200021 China Department of Nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of Nephrology Shaanxi Traditional Chinese Medicine Hospital Xi'an Shaanxi 710003 China Department of Nephrology and Rheumatology Affiliated Sixth People's Hospital Shanghai Jiao Tong University Shanghai 200233 China Department of Nephrology Guangdong Provincial Hospital of Chinese Medicine Guangzhou Guangdong 510120 China Department of Nephrology Dongzhimen Hospital The First Affiliated Hospital of Beijing University of Chinese Medicine Beijing 100700 China Department of Nephrology Renji Hospital Shanghai Jiao Tong University Shanghai 200127 China Department of Nephrology First Affiliated Hospital of Shanxi Medical University Taiyuan Shanxi 030001 China Department of Nephrology University of Electronic Science and Technology Sichuan Academy of Sciences and Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of Nephrology Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Nephrology Daping Hospital Third Military Medical University Chongqing 400042 China Department of Nephrology Second Affiliated Hospital of Shanxi Medical University Taiyuan Shanxi 030001 China Department of Nephrology Army General Hospital Beijing 100700 China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tiaojin 300192 China Department of Nephrology Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong 510030 China Department o

Background： Chronic kidney disease （CKD） with moderate-to-severe renal dysfunction usually exhibits an irreversible course, and available treatments for delaying the progression to end-stage renal disease are limited. This study aimed to assess the efficacy and safety of the traditional Chinese medicine, Niaoduqing particles, for delaying renal dysfunction in patients with stage 3b-4 ***： The present study was a prospective, randomized, double-blind, placebo-controlled, naulticentcr clinical trial. Frorn May 2013 to December 2013,300 CKD patients with an estimated glomerular filtration rate （eGFR） between 20 and 45 ml ＂rain ~＂ 1.73 m 2, aged 18-70 years were recruited from 22 hospitals in 11 Chinese provinces. Patients were randomized in a 1：1 ratio to either a test group, which was administered Niaoduqing particles 5 g thrice daily and 10 g before bedtime for 24 weeks, or a control group, which was administered a placebo using the same methods. The primary endpoints were changes in baseline serum creatinine （Scr） and eGFR after completion of treatment. The primary endpoints were analyzed using Student＇s t-test or Wilcoxon＇s rank-sum test. The present study reported results based on an intention-to-treat （ITT） analysis. Results： A total of 292 participants underwent the ITT analysis. At 24 weeks, the median （interquartile range） change in Scr was 1.1 （-13.0-24.1） and 11.7 （-2.6-42.9） p, mol/L for the test and control groups, respectively （Z = 2.642, P = 0.008）, and the median change in eGFR was -0.2 （-4.3-2.7） and -2.2 （-5.7-0.8） ***-1·1.73 m-2, respectively （Z = -2.408, P = 0.016）. There were no significant differences in adverse events between the groups. Conclusions： Niaoduqing particles safely and effectively delayed CKD progression in patients with stage 3b-4 CKD. This traditional Chinese medicine may be a promising alternative medication for patients with moderate-to-severe renal dysfunction.

关键词： Chronic Kidney Disease Moderate-to-severe Renal Dysfunction Niaoduqing Particles Randomized Controlled Trial Traditional Chinese Medicine

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Anti-cyclic citrullinated peptide antibody predicts the development of rheumatoid arthritis in patients with undifferentiated arthritis

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Chinese Medical Journal 2019年第24期132卷 2899-2904页

作者： Chun Li yan Zhang hui Song Jie Gao dong-Bao zhao Qi Zhu dong-Yi He Li wang xiang-Pei Li Xu-dong liu Wei-guo Xiao Xin-Yu Wu hua-xiang Wu Wei Tu Shao-Xian Hu Xin wang Zhi-Jun Li Zhi-Min Lu Zhan-Yun Da Bo Liang Xiao-Min liu Jin-Wei zhao Ling Li Feng Han Wu-Fang Qi Wei Wei Xu Ma Zhen-Bin Li Gui-Min Zheng Feng-Xiao Zhang Yi Li You-Lian wang Guang-hui Ling Jin-Wei Chen Xiao-Qiang Hou Jing Zhang Qing-Ping Chen Chang-Lian liu yan Zhang Jia-Shun Zeng Qing-hua Zou Yong-Fei Fang Yin Su Zhan-guo Li Department of Rheumatology and Immunology Peking University People's HospitalBeijing 100044China Department of Rheumatology and Immunology Beijing Jishuitan HospitalBeijing 100035China Department of Rheumatology and Immunology Changhai HospitalShanghai 200433China Department of Rheumatology Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western MedicineShanghai 200052China Department of Rheumatology and Immunology Anhui Provincial HospitalHefeiAnhui 230001China Department of Rheumatology and Immunology The First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Rheumatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China Department of Rheumatology and Immunology Tongji HospitalWuhanHubei 430030China Department of Rheumatology The First Affiliated Hospital of Bengbu Medical CollegeBengbuAnhui 233004China Department of Rheumatology and Immunology Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China Department of Rheumatology and Immunology The Hospital of Shunyi District BeijingBeijing 101300China Department of Infection and Immunology Tianjin Union Medical CenterTianjin 300121China Department of Rheumatology and Immunology Tianjin First Central HospitalTianjin 300192China Department of Rheumatology and Immunology Tianjin Medical University General HospitalTianjin 300052China Department of Rheumatology and Immunology Peace HospitalShijiazhuangHebei 050000China Department of Rheumatology and Immunology Hebei General HospitalShijiazhuangHebei 050051China Department of Rheumatology Jiangxi Provincial People's HospitalNanchangJiangxi 330006China Division of Rheumatology and Immunology The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Rheumatology and Immunology The First College of Clinical Medical Science of China Three Gorges University&Yichang Central People's HospitalYichangHubei 443003China Department of Rheu

Background:Clinical outcomes of undifferentiated arthritis(UA)are diverse,and only 40%of patients with UA develop rheumatoid arthritis(RA)after 3 *** predictive markers at disease onset for further intervention is ***,our objective was to analyze the clinical outcomes of UA and ascertain the predictors for RA ***:We performed a prospective,multi-center study from January 2013 to October 2016 among Chinese patients diagnosed with UA in 22 tertiary-care *** and serological parameters were obtained at ***-up was undertaken in all patients every 12 weeks for 2 *** factors of disease progression were identified using multivariate Cox proportional hazards ***:A total of 234 patients were recruited in this study,and 17(7.3%)patients failed to follow up during the *** the 217 patients who completed the study,83(38.2%)patients went into *** patients who developed RA had a higher rheumatoid factor(RF)-positivity(42.9%vs.16.8%,χ^2=8.228,P=0.008),anti-cyclic citrullinated peptide(CCP)antibodypositivity(66.7%vs.10.7%,χ^2=43.897,P<0.001),and double-positivity rate of RF and anti-CCP antibody(38.1%vs.4.1%,χ^2=32.131,P<0.001)than those who did ***-CCP antibody but not RF was an independent predictor for RA development(hazard ratio 18.017,95%confidence interval:5.803–55.938;P<0.001).Conclusion:As an independent predictor of RA,anti-CCP antibody should be tested at disease onset in all patients with UA.

关键词： Anti-cyclic citrullinated peptide antibody Arthritis,Rheumatoid Rheumatoid factor Undifferentiated arthritis

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