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Needle Sensation and Personality Factors Influence Therapeutic Effect of Acupuncture for Treating Bell＇s Palsy： A Secondary Analysis of a Multicenter Randomized Controlled Trial

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Chinese Medical Journal 2016年第15期129卷 1789-1794页

作者： Chen-yan Zhang Sha-bei Xu Bo Huang Peng Du Gui-Bin Zhang Xiang Luo Guang-ying Huang Min-Jie Xie Zong-Kui Zhou Wei wang School of Psychology Central China Normal University Wuhan Hubei 430079 China Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU) Ministry of Education Wuhan Hubei 430079 China Department of Neurology Tongji Hospital Tongji Medical CoLlege Huazhong University of Science and Technology Wuhan Hubei 430030 China Department of Neurology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Neurology Xiangyang Hospital Affiliated to Hubei University of Medicine Xiangyang Hubei 441000 China Institute of Integrated Traditional Chinese and Western Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China Key Laboratory of Neurological Diseases of Chinese Ministry of Education Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China

Background： It has not been solved what kind of needle sensation might influence outcomes of acupuncture treatment. Effects of personality factors on the therapeutic effect of acupuncture have not been investigated. This study aimed to find the effects of the traits of personality on the objective outcome when different acupuncture techniques were used in treating patients with Bell＇s palsy. Methods： We performed a secondary analysis of a prospective multicenter randomized controlled trial of acupuncture for Bell＇s palsy. Patients were randomly assigned to the de qi and control groups, respectively. The primary outcome was facial nerve function at month 6. The intensity of each needle sensation was rated by a visual analog scale. Psychosocial thctors were assessed by the pretreatment mediator questionnaire： 16 Personality Factor Questionnaire （16PF） was used tbr assessing personality factors and digit cancellation test for assessing attention. Results： After 6 months, patients in the de qi group had better facial function （adjusted odds ratio [OR]： 4.16, 95% confidence interval [CI]： 2.23-7.78）. Path analysis showed that intensity of needle sensation of fullness had direct effect on House-Brackmann （HB） score at month 6. In de qi group, the low HB score on day I （OR： 0.13, 95% （_7： 0.03-0.45） and the low Social Boldness score （OR： 0.63, 95% CI： 0.41-0.97） in 16PF were associated with better facial function. In control group, low HB score on day 1 （OR： 0.25, 95% CI： 0.13-0.50）, low Vigilance score （OR： 0.66, 95% CI： 0.50-0.88）, and high Tension score （OR： 1.41,95% CI： 1.12 1.77） in 16PF were related to better facial function. Conclusions： The needle sensation of fullness could predict better facial function and personality traits might influence outcomes of acupuncture treatment. Both of them should be considered seriously in acupuncture treatment and research.

关键词： 16 Personality Factor Questionnaire Bell's Palsy De Qi Needle Sensation

典型有机磷酸酯在黄河入海口的分布与生物蓄积特征

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中国环境科学 2024年第1期44卷 449-461页

作者：闫振飞冯承莲王锦东吴丰昌白英臣中国环境科学研究院环境基准与风险评估国家重点实验室北京100012 河海大学环境学院江苏南京210024

以黄河入海口为研究区域,分别在地表水、沉积物、浮游生物以及12种水生生物中检测OPEs含量,结果发现共检出17种OPEs,其中氯代类检出丰度和检出频率最高,是主要的污染物成分,其次是烷基类和芳香类OPEs.同源性分析发现,在地表水与沉积物... 详细信息

以黄河入海口为研究区域,分别在地表水、沉积物、浮游生物以及12种水生生物中检测OPEs含量,结果发现共检出17种OPEs,其中氯代类检出丰度和检出频率最高,是主要的污染物成分,其次是烷基类和芳香类OPEs.同源性分析发现,在地表水与沉积物中氯代类的OPEs污染来源更为广泛.12种水生生物中较高营养级的野生鱼类(如鲢鱼、鲫鱼、梭鱼等)中∑OPEs含量高于低营养级的底栖生物(如日本沼虾等),表明OPEs在水生生物食物链上具有累积性特征,以及物种差异性特征.相比于鳃吸收,肠道摄食是野生鱼类OPEs污染的主要暴露途径.结果显示部分OPEs在黄河入海口的水生食物网中存在一定的生物蓄积和生物放大潜力.风险分析结果表明磷酸三(1,3-二氯异丙基)酯具有潜在的生态风险,需引起广泛关注.

关键词：有机磷酸酯(OPEs) 黄河入海口生物蓄积性生物放大性生态风险

草酸根及对咪唑基苯甲酸根构筑的三重互穿镉(Ⅱ)配合聚合物的合成、结构与发光性能研究

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无机化学学报 2013年第2期29卷 350-354页

作者：张艳萍王莉丽刘连利田爱香应俊渤海大学实验管理中心锦州121000

利用水热方法合成了一个新的由草酸和对咪唑基苯甲酸混合配体共同构筑的镉配合物[Cd(L)(C2O4)0.5(H2O)]n,并通过元素分析、红外光谱和X-射线单晶衍射方法确定了该化合物的晶体结构。结构分析表明该化合物属于单斜晶系,空间群P21/n,晶胞... 详细信息

利用水热方法合成了一个新的由草酸和对咪唑基苯甲酸混合配体共同构筑的镉配合物[Cd(L)(C2O4)0.5(H2O)]n,并通过元素分析、红外光谱和X-射线单晶衍射方法确定了该化合物的晶体结构。结构分析表明该化合物属于单斜晶系,空间群P21/n,晶胞参数a=1.167 60(14)nm,b=0.841 80(15)nm,c=1.246 90(15)nm,β=105.404(2),V=1.1815(3)nm3,Z=4,R1=0.0312,ωR2=0.063 1。标题化合物包含一个格子状的二维层结构,三组相同的二维层相互穿插而构筑了三重互穿的框架,同时研究了化合物的光致发光性能。

关键词：草酸对咪唑基苯甲酸水热合成晶体结构三重互穿

An-Luo-Hua-Xian Pill Improves the Regression of liver Fibrosis in Chronic hepatitis B Patients Treated with Entecavir

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Journal of Clinical and Translational hepatology 2023年第2期11卷 304-313页

作者： Yi-Qi liu Chi Zhang Jia-Wen li li-Hua Cao Zhan-Qing Zhang Wei-feng Zhao Qing-Hua Shang Da-Zhi Zhang An-lin Ma Qing Xie Hong-lian Gui Guo Zhang ying-Xia liu Jia Shang Shi-Bin Xie Jun li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang li-Hua Huang Jia-Bin li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi yan-Zhong Peng Zhi-Jin wang li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-feng liang Hui liu Hui Zhuang Hong Zhao Gui-Qiang wang Department of Infectious Disease Center for Liver DiseasePeking University First HospitalBeijingChina Department of hepatology The Third Hospital of QinhuangdaoQinhuangdaoHebeiChina Department of Infectious Disease Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Infectious Disease Xinxiang Medical University Affiliated Third HospitalXinxiangHenanChina No.88 Hospital of Chinese People’s liberation Army(PLA) JinanShandongChina Department of Infectious Diseases The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Infectious Disease China-Japan Friendship HospitalBeijingChina Department of Infectious Diseases Ruijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina Department of Gastroenterology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxiChina Department of Infectious Diseases The Third People’s Hospital of ShenzhenShenzhenGuangdongChina Department of Infectious Diseases The People’s Hospital of Henan ProvinceZhengzhouHenanChina Department of Infectious Disease The Third Affiliated Hospital of Sun-Yat Sen UniversityGuangzhouGuangdongChina Department of Infectious Diseases Jiangsu Province HospitalThe First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Infectious Diseases The Southwest Hospital of Army Medical UniversityChongqingChina yantai Infectious Diseases Hospital YantaiShandongChina Department of hepatology Baoding Infectious Diseases HospitalBaodingHebeiChina Department of Integrated Traditional Chinese Medicine(TCM)and Western Medicine Jinan Infectious Diseases HospitalShandong UniversityJinanShandongChina Department of Integrated TCM and Western Medicine in hepatology The Sixth People’s Hospital of ShenyangShenyangLiaoningChina beijing Ditan Hospital Capital Medical UniversityBeijingChina Department of Infectious Diseases Guangzhou Eighth People’s HospitalGuangzhou Medical UniversityGuangzhouGuangdon

Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and *** the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,***,laboratory,and liver histology data before and after 78 weeks of treatment were *** Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after ***:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX *** 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=*** percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=*** regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients.

关键词： Chronic hepatitis B liver fibrosis Regression Randomized controlled trial

卡介菌多糖核酸联合西替利嗪治疗慢性荨麻疹疗效观察

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临床皮肤科杂志 2014年第10期43卷 628-629页

作者：李海英王维云李衍炼徐州市第六人民医院皮肤科江苏徐州221006

目的:观察西替利嗪联合卡介菌多糖核酸治疗慢性荨麻疹的临床疗效和安全性。方法:将86例患者随机分为2组,治疗组44例给予口服西替利嗪10 mg每日1次,肌内注射卡介菌多糖核酸注射液1 mL隔日1次;对照组42例仅口服西替利嗪10 mg每日1次,疗程... 详细信息

目的:观察西替利嗪联合卡介菌多糖核酸治疗慢性荨麻疹的临床疗效和安全性。方法:将86例患者随机分为2组,治疗组44例给予口服西替利嗪10 mg每日1次,肌内注射卡介菌多糖核酸注射液1 mL隔日1次;对照组42例仅口服西替利嗪10 mg每日1次,疗程均为6周。结果:治疗组患者有效率为81.82%,对照组患者有效率为54.76%,治疗组有效率明显优于对照组(P<0.01),差异有统计学意义。两组患者的不良反应均比较轻。结论:卡介菌多糖核酸联合西替利嗪能有效地控制慢性荨麻疹的症状,提高治愈率,明显降低复发率,疗效好,且安全性高。

关键词：荨麻疹慢性卡介菌多糖核酸西替利嗪

大容量天然噬菌体抗体库的建立及多样性初步验证

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军事医学科学院院刊 2008年第4期32卷 305-308,358页

作者：王辉黄英王琰沈倍奋军事医学科学院基础医学研究所北京100850 海军总医院北京100037

目的:构建超大容量天然噬菌体抗体库。方法:从正常人外周血和新生儿脐血中分离淋巴细胞(>180份),提取RNA,用RT-PCR分别扩增抗体可变区轻重链基因(VH和VL),通过重叠PCR技术将VH和VL连接为单链抗体ScFv形式,克隆插入到pDF噬菌粒载体,转化X... 详细信息

目的:构建超大容量天然噬菌体抗体库。方法:从正常人外周血和新生儿脐血中分离淋巴细胞(>180份),提取RNA,用RT-PCR分别扩增抗体可变区轻重链基因(VH和VL),通过重叠PCR技术将VH和VL连接为单链抗体ScFv形式,克隆插入到pDF噬菌粒载体,转化XL1-Blue细菌得到ScFv初级抗体库,并以高感染复数(MOI≥100)感染Cre+菌株BS1365,利用Cre/LoxP位点特异性重组原理,使VH和VL基因定向同源重组匹配,随后以低感染复数(MOI<1)感染XL1-Blue,获取次级工作库。分别用5种不同抗原进行筛选,所获阳性克隆送测序以获取抗体基因。结果:抗体V区基因得到有效扩增,初级库库容3.6×107,工作库容1.8×1011,5种不同抗原筛选均得到特异性结合噬菌体抗体;测序结果表明,所获取抗体涵盖了不同的基因亚群,进一步证明抗体库具有良好的多样性。结论:经Cre/Loxp定位重组系统成功构建了超大容量天然噬菌体抗体库,初步尝试对5种抗原进行筛选均获成功,提示该抗体库多样性较好,可用于制备人源抗体。

关键词：噬菌体抗体库 Cre/LoxP重组系统单链抗体

Lactobacillus plantarum displaying conserved M2e and HA2 fusion antigens induces protection against influenza virus challenge

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Lactobacillus plantarum displaying conserved M2e and HA2 fus...

N′-乙基-N-哌嗪基二硫代氨基甲酸铜(Ⅱ)配合物Cu(S_2CNC_4H_8NC_2H_5)_2的晶体结构及谱学研究

中国畜牧兽医学会动物微生态学分会第五届第十三次全国学术研讨会

作者： Wen-Tao yang Gui-lian yang liang Zhao Yu-bei Jin yan-Long Jiang Hai-Bin Huang Chun-Wei Shi Jian-Zhong wang Guan wang Yuan-Huan Kang Gui-lian yang Chun-feng wang College of Animal Science and Technology Jilin Provincial Engineering Research Center of Animal ProbioticsKey Laboratory of Animal Production and Product Quality Safety of Ministry of EducationJilin Agricultural University

Avian influenza virus(AIV) can infect poultry,mammals and other hosts and causes enormous economic losses to the global poultry *** this study,to develop a novel and potent oral vaccine based on Lactobacillus plantarum(***) for controlling the spread of AIV in the poultry industry,we constructed a recombinant *** strain displaying the 3 M2 e-HA2 protein of the influenza virus and determined the effect of N/pgsA’-3 M2 e-HA2 against ATV in *** first confirmed that the 3 M2 e-HA2 fusion protein was expressed on the surface of *** via flow cytometry and immunofluorescence *** experimental results demonstrated that chicks immunized with N/pgsA’-3 M2 e-HA2 could induce specific humoral,mucosal and T cell-mediated immune responses,eliciting the host body to protect itself against ***,compared to oral administration,the intranasal immunization of chicks with N/pgsA’-3 M2 e-HA2 provided a stronger immune response,resulting in a potent protective effect that hindered the loss of body weight,decreasing pulmonary virus titers and reducing lung and throat pathological ***,our results indicate that our novel approach is an effective method of vaccine design to promote mucosal immunity.

关键词： Conserved antigen Lactobacillus plantarum influenza virus mucosal immunity

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无机化学学报 2008年第5期24卷 691-695页

作者：王瑛卢永罗成燕严莲荷陆路德南京理工大学化工学院南京210094

合成了标题化合物Cu(S_2CNC_4H_8NC_2H_5)_2,得到深棕色柱状晶体。晶体属三斜晶系,空间群为P1。中心Cu(Ⅱ)离子分别与来自2个N′-乙基-N-哌嗪基二硫代氨基甲酸的4个硫原子配位,形成略微扭曲的平面四方配位构型。4个Cu-S键的键长范围0.22... 详细信息

合成了标题化合物Cu(S_2CNC_4H_8NC_2H_5)_2,得到深棕色柱状晶体。晶体属三斜晶系,空间群为P1。中心Cu(Ⅱ)离子分别与来自2个N′-乙基-N-哌嗪基二硫代氨基甲酸的4个硫原子配位,形成略微扭曲的平面四方配位构型。4个Cu-S键的键长范围0.22010(11)～0.22034(13)nm;Cu-S键的FT-Raman伸缩振动峰在134.921cm^(-1);ESR谱表明Cu(Ⅱ)离子处于对称中心;其局部配位构型属于D_2h群;热分析表明标题化合物在753.15℃时分解为金属Cu。

关键词：铜配合物晶体结构 FT-Raman ESR

人参三七川芎提取物激活过氧化物酶体增殖物激活受体γ延缓血管内皮细胞衰老的研究

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中华中医药杂志 2015年第6期30卷 2085-2089页

作者：王铭雷燕陈连凤苗立夫李瑛重庆市中医院心内科重庆400021 中国中医科学院医学实验中心北京100700 中国医学科学院北京协和医院心内科实验室北京100730 清华大学第一附属医院心脏中心北京100016

目的:探讨血管内皮细胞衰老过程中过氧化物酶体增殖物激活受体γ(PPARγ)的表达变化和益气活血中药人参三七川芎提取物的干预作用。方法:分离人脐静脉内皮细胞(HUVEC),传代培养至第4代,血管紧张素Ⅱ(AngⅡ,10-6mol/L,48h)诱导其衰老;分... 详细信息

目的:探讨血管内皮细胞衰老过程中过氧化物酶体增殖物激活受体γ(PPARγ)的表达变化和益气活血中药人参三七川芎提取物的干预作用。方法:分离人脐静脉内皮细胞(HUVEC),传代培养至第4代,血管紧张素Ⅱ(AngⅡ,10-6mol/L,48h)诱导其衰老;分为空白对照组、AngⅡ组、中药提取物组和替米沙坦(telmisartan)组;观察不同时间点β-半乳糖苷酶染色、NO含量、PPARγm RNA及蛋白表达。结果:AngⅡ组较空白对照组β-半乳糖苷酶阳性染色细胞数增加(P<0.05),NO含量明显下降(P<0.05)。与AngⅡ组比较,中药提取物组和替米沙坦组β-半乳糖苷酶阳性染色细胞数下降(P<0.05),NO含量增加(P<0.05)。AngⅡ呈时间依赖性上调PPARγm RNA表达,但蛋白表达呈现早升后降趋势;中药提取物和替米沙坦两组PPARγ表达均明显上调(P<0.05),中药早期作用更为显著(P<0.05)。结论:益气活血中药能够延缓血管内皮细胞衰老,其机制可能与诱导PPARγ表达有关。

关键词：人参三七川芎提取物血管内皮细胞衰老过氧化物酶体增殖物激活受体γ 血管紧张素Ⅱ