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一流课程建设背景下“天然药物化学”课程建设探索

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教育教学论坛 2024年第33期 103-106页

作者：王宜海何祥久广东药科大学药学院广东广州510006

“天然药物化学”是药学相关专业的核心专业课程。在一流本科课程建设背景下,对“天然药物化学”课程也提出了新的要求。以培养一流药学人才为目标,结合一流课程建设背景,针对目前“天然药物化学”课程教学中存在的问题,就如何改变以应... 详细信息

“天然药物化学”是药学相关专业的核心专业课程。在一流本科课程建设背景下,对“天然药物化学”课程也提出了新的要求。以培养一流药学人才为目标,结合一流课程建设背景,针对目前“天然药物化学”课程教学中存在的问题,就如何改变以应试为主的教育模式,培养学生对“天然药物化学”课程的兴趣,加强课堂教学与科学研究之间的沟通,以兴趣引导教学、以科研促进教学等方面来探讨“天然药物化学”课程建设举措,以期为“天然药物化学”课程建设提供新思路。

关键词：天然药物化学一流课程课程建设

Antiproliferative piperidine alkaloids from giant taro(Alocasia macrorrhiza)

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Chinese Journal of Natural Medicines 2022年第7期20卷 541-550页

作者： GAO Wei wang yi wang Ru wang yi-hai XU Jing-Wen HE Xiang-Jiu School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Engineering Research Center for Lead Compounds&Drug Discovery Guangzhou 510006China

The rhizome of giant taro(Alocasia macrorrhiza(L.)Schott),which is a highly adaptable wild plant,is a traditional Chinese herbal *** the current study,the antiproliferative constituents of giant taro were investigated and six new(1−6)and four known piperidine alkaloids(7−10)were isolated from its *** chemical structures and absolute configurations were elucidated using various spectroscopic methods and the Mosher ester *** isolated alkaloids were screened for the antiproliferative activity through MTT *** results indicated that piperidine alkaloids exerted potential antiproliferative activity against HepG2,AGS and MCF-7 tumor *** researches showed that compounds 3−5 dose-dependently decreased the colony formation rate and induced the apoptosis of AGS cells,while compound 4 induced AGS cell death via the proapoptotic *** study demonstrates that the piperidine alkaloids isolated from giant taro exhibit significant antitumor activity,which provides phytochemical evidence for further development and utilization.

关键词： Giant taro Alocasia macrorrhiza Piperidine alkaloids Antiproliferative Apoptosis

An Expeditious Synthesis of β-Indolylketones Catalyzed by p-Toluenesulfonic Acid (PTSA) Using Ultrasonic Irradiation

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有机化学 2004年第Z1期24卷 260-261页

作者： wang,Shun-yi SHI,hai-Bin JI,Shun-Jun Key Laboratry of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical Engineering Suzhou University Suzhou 215006 Key Laboratry of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical Engineering Suzhou University Suzhou 215006 Key Laboratry of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical Engineering Suzhou University Suzhou 215006

　　The investigation of the chemistry of indoles has been, and continues to be, one of the most active areas of heterocyclic chemistry.[1] In particular, β-indolylketones have received much attention as important building blocks for the synthesis of many natural products and other biologically active compounds.[2] In continuation of our work in the synthesis of indole derivates,[3] we describe the remarkable catalytic of PTSA as a cheaper catalyst in ultrasound-accelerated Michael reaction of indole with α, β-unsaturated ketones (2), which provide one of the most efficient routes to the synthesis of β-indolyketones. In all cases, the substitution on the indole nucleus occurred exclusively at the 3-position, and N-alkylation products have not been observed. In addition, the structure of 3a was further confirmed by single crystal X-ray crystallography.……

关键词： natural products building blocks single crystal

Fangji Fuling Decoction Alleviates Sepsis by Blocking MAPK14/FOXO3A Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第3期30卷 230-242页

作者： wang yi CHEN Ming-qi DAI Lin-feng ZHANG hai-dong wang Xing Department of Critical Care Medicine Changzhou Hospital of Traditional of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineChangzhouJiangsu Province213000China Department of Critical Care Medicine Jiangsu Province Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing210029China

Objective:To examine the therapeutic effect of Fangji Fuling Decoction(FFD) on sepsis through network pharmacological analysis combined with in vitro and in vivo ***:A sepsis mouse model was constructed through intraperitoneal injection of 20 mg/kg lipopolysaccharide(LPS).RAW264.7 cells were stimulated by 250 ng/m L LPS to establish an in vitro cell *** pharmacology analysis identified the key molecular pathway associated with FFD in *** ectopic expression and depletion experiments,the effect of FFD on multiple organ damage in septic mice,as well as on cell proliferation and apoptosis in relation to the mitogen-activated protein kinase 14/Forkhead Box O 3A(MAPK14/FOXO3A) signaling pathway,was ***:FFD reduced organ damage and inflammation in LPS-induced septic mice and suppressed LPS-induced macrophage apoptosis and inflammation in vitro(P<0.05).Network pharmacology analysis showed that FFD could regulate the MAPK14/FOXO signaling pathway during *** confirmed by in vitro cell experiments,FFD inhibited the MAPK14 signaling pathway or FOXO3A expression to relieve LPS-induced macrophage apoptosis and inflammation(P<0.05).Furthermore,FFD inhibited the MAPK14/FOXO3A signaling pathway to inhibit LPS-induced macrophage apoptosis in the lung tissue of septic mice(P<0.05).Conclusion:FFD could ameliorate the LPS-induced inflammatory response in septic mice by inhibiting the MAPK14/FOXO3A signaling pathway.

关键词： sepsis Fangji Fuling Decoction mitogen-activated protein kinase 14/Forkhead Box O 3A signaling pathway inflammatory response apoptosis lung injury Chinese medicine

Isolation and Characterization of a Bensulfuron-Methyl-Degrading Strain L1 of Bacillus

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Pedosphere 2010年第1期20卷 111-119页

作者： LIN Xiao-Yan wang yi wang hai-Long T. CHIRKO DING hai-Tao ZHAO Yu-Hua Department of Microbiology College of Life Sciences Zhejiang University Hangzhou 310058 (China) China National Rice Research Institute Hangzhou 310006 (China) Ensis Rotorua Private Bag 3020 (New Zealand) College of Environmental Sciences and Technology Zhejiang Forestry University Lin'an 311300 (China)

The objectives of this study were to isolate a bensulfuron-methyl （BSM）-degrading strain of Bacillus spp. and to evaluate its effectiveness in remediation of a BSM-contaminated soil. A BSM-degrading bacterium, strain L1, was successfully isolated in this study. Strain L1 was identified as Bacillus megaterium based on its morphological, physiological, and biochemical properties, G＋C content, phylogenetie similarity of 16S rDNA, and fatty acid composition. Two experiments were used to examine BSM degradation by strain L1. When BSM was used as a sole carbon source in a mineral salt medium, the average degradation rate of BSM by strain L1 was 12.8%, which suggested that the strain was able to utilize BSM as a sole carbon and energy source. Supplement of yeast extract （200 mg L^-1） significantly （P ≤ 0.01） accelerated the degradation of BSM by strain L1. Ahnost complete degradation （97.7%） of BSM could be achieved in 84 h with addition of yeast extract. In addition, in a sterile soil with 50 mg L^-1 BSM, BSM degradation rate by strain L1 was 94.3% in 42 d, indicating the potential of using microbes for the remediation of BSM-contaminated soils in fields.

关键词： biodegradation carbon source phylogenetic analysis 16S rDNA

Oxidative Stress:Role in Acetamiprid-Induced Impairment of the Male Mice Reproductive System

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Agricultural Sciences in China 2011年第5期10卷 786-796页

作者： ZHANG Jiao-jiao wang yi XIANG hai-yang LI Meng-xue LI Wen-hao MA Kai-ge wang Xian-zhong ZHANG Jia-hua College of Animal Science and Technology Southwest University Chongqing 400716 P.R.China

Acetamiprid has a wide range of influence on physiological functions in *** objective of this study was to examine the effect of acetamiprid on the reproductive function of male mice,and to study the role of oxidative stress in acetamiprid-induced damage to the *** adult Kunmin male mice （25-30 g） were divided into five groups （n=10 per group）,i.e.,control,blank,acetamiprid alone,acetamiprid and vitamin E,and vitamin E *** groups were treated for 35 *** results showed that acetamiprid significantly decreased the body weight and the weight of testosterone-responsive organs,such as the testis,epididymis,seminal vesicle,and ***,acetamiprid also significantly reduced the serum testosterone concentration,and decreased sperm count,viability,motility,and the intactness of the acrosome （P〈0.05 for each parameter）.The mice treated with acetamiprid had damaged seminiferous tubules and Leydig cells based on the histological structure of testes;there was degeneration of the mitochondria and endoplasmic reticulum of Leydig *** deleterious effects of acetamiprid may be mediated by increasing oxidative stress,as acetamiprid increased malondialdehyde and nitric oxide in the testes,reduced the activity of catalase,glutathione peroxidase,superoxide dismutase,and activated *** concentration of acetamiprid in the testes was lower than that in liver,so did the concentrations of liver function tests,including aspartate transaminase （AST）,alanine transaminase （ALT） and alkaline phosphatase （ALP）,which suggest that male reproductive function may be affected through the indirect action of its *** E significantly ameliorated the effects of *** conclude that acetamiprid damages male reproductive function through inducing oxidative stress in the testes.

关键词： acetamiprid oxidative stress reproductive function testis

Characteristics of proppant transport and placement within rough hydraulic fractures

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Petroleum Exploration and Development 2024年第2期51卷 453-463页

作者： HUANG hai ZHENG Yong wang yi wang haizhu NI Jun wang Bin YANG Bing ZHANG Wentong School of Petroleum Engineering Xi’an Shiyou UniversityXi’an 710065China Shaanxi Key Laboratory of Carbon Dioxide Sequestration and Enhanced Oil Recovery Xi’an 710075China Shaanxi Provincial Key Laboratory of Oil and Gas Well and Reservoir Seepage and Rock Mechanics Xi’an 710065China Oil&Gas Field Production Construction Division PetroChina Tarim Oilfield CompanyKorla 841000China National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China Shaanxi Yanchang Petroleum(Group)Co. Ltd.Xi’an 710075China

A three-dimensional reconstruction of rough fracture surfaces of hydraulically fractured rock outcrops is carried out by casting process,a large-scale experimental setup for visualizing rough fractures is built to perform proppant transport *** typical characteristics of proppant transport and placement in rough fractures and its intrinsic mechanisms are investigated,and the influences of fracture inclination,fracture width and fracturing fluid viscosity on proppant transport and placement in rough fractures are *** results show that the rough fractures cause variations in the shape of the flow channel and the fluid flow pattern,resulting in the bridging buildup during proppant transport to form unfilled zone,the emergence of multiple complex flow patterns such as channeling,reverse flow and bypassing of sand-carrying fluid,and the influence on the stability of the sand *** proppant has a higher placement rate in inclined rough fractures,with a maximum increase of 22.16 percentage points in the experiments compared to vertical fractures,but exhibits poor stability of the sand *** fracture width aggravates the bridging of proppant and induces higher pumping *** the viscosity of the fracturing fluid can weaken the proppant bridging phenomenon caused by the rough fractures.

关键词： reservoir fracturing rough fracture proppant transport and placement characteristics bridging buildup

Coronal Diffusion-weighted Magnetic Resonance Imaging of the Kidney： Agreement with Axial Diffusion-weighted Magnetic Imaging in Terms of Apparent Diffusion Coefficient Values

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Chinese Medical Journal 2015年第4期128卷 499-503页

作者： hai-yi wang Jia wang Ye-Huan Tang Hui-yi Ye Lin Ma Department of Radiology Chinese People@s Liberation Army General Hospital Beijing 100853 China Department of Radiology Handan Central Hospital Handan Hebei 056001 China

Background：Coronal diffusion-weighted magnetic resonance imaging （DW-MRI） and apparent diffusion coefficient （ADC） values have gradually become applied （following conventional axial DW-MRI） in the renal *** explore whether data obtained using coronal DW-MRI are comparable with those derived using axial DW-MRI,this preliminary study sought to assess the agreement in renal ADC values between coronal DW-MRI and axial ***：Thirty-four healthy volunteers were enrolled in the study; written consents were *** subjects underwent respiratory-triggered axial and coronal DW-MRI using a 1.5-MR system with b values of 0 and 800 s/*** signal-to-noise ratios （SNRs） of the two DW-MRI sequences were measured and statistically compared using the paired *** extent of agreement of ADC values of the upper pole,mid-pole,and lower pole of the kidney; the mean ADC values of the left kidney and right kidney; and the mean ADC values of the bilateral kidneys were evaluated via calculation of intraclass correlation coefficients （ICCs） or Bland-Altman method between the two DW-MRI ***：The SNR of coronal DW-MR images was statistically inferior to that of axial DW-MR images （P ＜ 0.001）.The ICCs of the ADC values of each region of interest,and the mean ADC values of bilateral kidneys,between the two sequences,were greater than 0.5,and the mean ADCs of the bilateral kidneys demonstrated the highest ICC （0.869; 95％ confidence interval：0.739-0.935）.In addition,94.1％（32/34）,94.1％（32/34）,and 97.1％（31/34） of the ADC bias was inside the limits of agreement in terms of the mean ADC values of the left kidneys,right kidneys,and bilateral kidneys when coronal and axial DWI-MRI were ***：ADC values derived using coronal DW-MRI exhibited moderate-to-good agreement to those of axial DW-MRI,rendering the former an additional useful DW-MRI method,and causing the ADC values derived using the two types of DW-MRI to be comparable.

关键词： Apparent Diffusion Coefficient Diffusion-weighted Magnetic Resonance Imaging Humans Kidney Magnetic Resonance Imaging

Fatigue-resistant Hydrogels

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Chemical Research in Chinese Universities 2024年第1期40卷 64-77页

作者： LI Luofei LEI hai CAO yi Collaborative Innovation Center of Advanced Microstructures National Laboratory of Solid State MicrostructureDepartment of PhysicsNanjing UniversityNanjing 210093P.R.China Department of Physics Zhejiang UniversityHangzhou 310027P.R.China

Hydrogels have been extensively studied for applications in various fields, such as tissue engineering and soft robotics, as determined by their mechanical properties. The mechanical design of hydrogels typically focuses on the modulus, toughness, and deformability. These characteristics play important roles and make great achievements for hydrogel use. In recent years, a growing body of research has concentrated on the fatigue property of hydrogels, which determines their resistance to crack propagation in the networks during cyclic mechanical loads for applications. However, knowledge of hydrogel fatigue behavior remains notably deficient. Here, we present a brief overview of the fatigue behavior of hydrogels, encompassing the general experimental methods to measure the fatigue property and fundamental theoretical calculation models. Then, we highlight multiple strategies to enhance the fatigue resistance of hydrogels. Finally, we present our perspectives on fatigue-resistant hydrogels, outstanding challenges and potential directions for future research.

关键词： Hydrogel Fatigue-resistant Fracture