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基于多元统计方法的胃食管反流病患者中医证候的量化诊断研究

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中国中西医结合消化杂志 2024年第4期32卷 335-340页

作者：吕静静张世雄王彦刚杨泽祺李晓旭河北省中医院脾胃病科石家庄050011 南京中医药大学北京中医药大学第三附属医院脾胃病科河北中医药大学研究生学院

目的应用多元统计方法对胃食管反流病(gastroesophageal reflux disease,GERD)郁热阴伤证进行探讨研究,为GERD中医证候的分类和诊断标准的制定提供一定的客观依据。方法选取402例GERD患者,制定临床证候信息采集表,采集相关信息,建立中... 详细信息

目的应用多元统计方法对胃食管反流病(gastroesophageal reflux disease,GERD)郁热阴伤证进行探讨研究,为GERD中医证候的分类和诊断标准的制定提供一定的客观依据。方法选取402例GERD患者,制定临床证候信息采集表,采集相关信息,建立中医证素数据库,随机分为训练样本组和验证样本组。以训练样本组数据建立相关量化诊断模型,采用二元logistic逐步回归分析进行相关因素筛选,运用CART决策树对诊断模型进行剪枝,运用条件概率换算公式建立相关因素赋分表,通过绘制ROC曲线选择最佳诊断阈值,根据诊断性试验评价原则,分别计算训练样本组和验证样本组数据的灵敏度、特异度、准确度、阳性似然比,对量化诊断模型进行回顾性研究和前瞻性检验。结果共提取28项中医证素,经过逐步回归分析后得到16项相关因素,其中包括正相关因素8项,负相关因素8项,进一步运用CART决策树精简后得出6项中医证素,筛选出2条判断规则。训练样本组和验证样本组ROC曲线下面积、检验灵敏度、特异度、准确度、阳性似然比分别为0.993、95.0%、97.0%、96.3%、32.0和0.949、87.5%、92.7%、90.1%、12.0。模型具有较好的科学性和实用性。结论基于logistic回归分析、ROC曲线和CART决策树算法可以有效建立GERD郁热阴伤证诊断模型,为临床辨证论治提供了客观依据。

关键词：胃食管反流病郁热阴伤证 logistic回归分析分类回归树

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妊娠期糖尿病对新生儿心脏发育和功能的影响

中国妇幼健康研究 2024年第8期35卷 38-43页

作者：冯燕孙春蕾宫锦蕾邢玉萍王庆法李正浩王颜刚潍坊市益都中心医院儿内科山东青州262500 青岛大学附属医院内分泌科山东青岛266000

目的探讨母亲妊娠期糖尿病(GDM)对新生儿心脏功能的影响,并分析其超声心动图特征。方法在2019年1月至2022年1月潍坊市益都中心医院新生儿科病房收治的无高危分娩疾病的足月新生儿中,选取GDM孕母的足月新生儿95例为GDM组,非GDM孕母的新生... 详细信息

目的探讨母亲妊娠期糖尿病(GDM)对新生儿心脏功能的影响,并分析其超声心动图特征。方法在2019年1月至2022年1月潍坊市益都中心医院新生儿科病房收治的无高危分娩疾病的足月新生儿中,选取GDM孕母的足月新生儿95例为GDM组,非GDM孕母的新生儿90例为对照组。检测并比较两组新生儿的出生血糖、出生体重、出生身长、心肌损伤标志物[肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、超敏心肌肌钙蛋白T(hs-cTnT)]水平,以及对新生儿心脏的测量数据,包括升主动脉径、左心房前后径、右心室前后径、左室前后径、肺动脉径、室间隔厚度、射血分数和先天性心脏病的发生率,并对GDM组新生儿室间隔肥厚的影响因素进行多元线性回归分析。结果GDM组新生儿的出生体重、出生身长、出生血糖与对照组比较差异均有统计学意义(t值分别为-6.627、-8.378、15.561,P0.05)。GDM组新生儿先天性心脏病发生率与对照组比较差异有统计学意义(χ^(2)=5.746,P<0.05)。相关性分析表明,室间隔厚度与新生儿出生血糖水平呈负相关(r=-0.305,P<0.01),与新生儿出生体重和血清hs-cTnT均呈正相关(r值分别为0.546、0.566,P<0.01),与孕母血清C肽水平和糖化血红蛋白均呈正相关(r值分别为0.222、0.634,P<0.01)。多元线性回归分析显示,新生儿出生体重、血清hs-cTnT水平、孕母糖化血红蛋白均是室间隔厚度的影响因素(t值分别为3.628、5.777、2.538,P<0.05)。结论母亲GDM对出生新生儿的心脏功能有不良影响;监测血清心肌损伤标志物及超声心动图可作为诊断孕母GDM的新生儿心脏损伤的早期指标。

关键词：妊娠期糖尿病心脏心肌病肥厚性先天性心脏病新生儿

Honeycomb-like g-C_(3)N_(4)/CeO_(2)-x nanosheets obtained via one step hydrothermal-roasting for efficient and stable Cr(Ⅵ) photo-reduction

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Chinese Chemical Letters 2020年第10期31卷 2747-2751页

作者： Yanan Liu Zhangfeng Shen Jialing Song Huilan Qi Chaochuang Yin Xuhui Zou Qineng Xia Lifeng Cui Xi Li yangang wang College of Biological Chemical Science and Engineering Jiaxing UniversityJiaxing 314001China Department of Environmental Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China

Graphitic carbon nitride(g-C_(3)N_(4))-based materials are regarded as one of the most potential photocatalysts for utilizing solar *** this work,we reported a facile one step in-situ hydrothermal-roasting method for preparing honeycomb-like g-C_(3)N_(4)/CeO_(2) nanosheets with abundant oxygen vacancies(g-C_(3)N_(4)/CeO_(2)-x).The hydrothermal-roasting and incomplete-sealed state can(i)generate an in-situ reducing atmosphere(CO,N2,NH3) to tune the concentration of oxygen vacancies in CeO_(2);(ii) beneficial to prevent continuous growth of g-C_(3)N_(4) and results in honeycomb-like g-C_(3)N_(4)/CeO_(2)-x hybrid *** is more,the g-C_(3)N_(4)/CeO_(2)-x photocatalyst exhibited extended photoresponse range,increased specific surface area and obviously enhanced separation efficiency of photogenerated electron-hole *** a proof-of-concept application,the optimized g-C_(3)N_(4)/CeO_(2)-xnanosheets could achieve 98% removal efficiency for Cr(Ⅵ) under visible light irradiation(λ≥420 nm)within 2.5 h,which is significantly better than those of pure g-C_(3)N_(4) and CeO_(2).This work provides a new idea for more rationally designing and constructing g-C_(3)N_(4)-based catalysts for efficient extended photochemical application.

关键词： One step hydrothermal-roasting method g-C_(3)N_(4)/CeO_(2)-x O_(x)ygen vacancies Cr(Ⅵ)reduction Visible light photocatalysis

Impact of design and process variation on the fabrication of SiC diodes

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Journal of Semiconductors 2018年第11期39卷 25-30页

作者： Y. K. Sharma Huaping Jiang Changwei Zheng Xiaoping Dai yangang wang I. Deviny Dynex Semiconductor Ltd Lincoln UK Zhuzhou CRRC Times Electric Co. Ltd. Zhuzhou 412001 China

We have studied the influence of design and process variations on the electrical performance of SiC Schottky diodes. On the design side, two design variations are used in the active cell of the diode（segment design and stripe design）. In addition, there are two more design variations employed for the edge termination layout of the diodes, namely, field limiting ring（FLR） and junction termination extension（JTE）. On the process side, some diodes have gone through an N;O annealing step. The segment design resulted in a lower forward voltage drop（VF） in the diodes and the FLR design turned out to be a better choice for blocking voltages, in the reverse ***, N;O annealing has shown a detrimental effect on the diodes’ blocking performance, which have JTE as their termination design. It degrades the blocking capability of the diodes significantly.

关键词： SiC JBS diode N2O annealing hybrid SiC IGBT

术前血清HDL-C、IGF-1水平对前列腺癌根治术患者预后的预测价值研究

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中国性科学 2024年第2期33卷 18-21页

作者：李亮亮宋培星邢德福王彦刚董安涛吴亚蒙安徽医科大学附属阜阳医院泌尿外科安徽阜阳236000

目的探讨术前血清高密度脂蛋白胆固醇(HDL-C)、胰岛素样生长因子-1(IGF-1)对前列腺癌根治术患者预后的预测价值。方法回顾性选取2017年8月至2021年10月安徽医科大学附属阜阳医院治疗的90例前列腺癌患者的临床资料,分析患者术前血清HDL-C... 详细信息

目的探讨术前血清高密度脂蛋白胆固醇(HDL-C)、胰岛素样生长因子-1(IGF-1)对前列腺癌根治术患者预后的预测价值。方法回顾性选取2017年8月至2021年10月安徽医科大学附属阜阳医院治疗的90例前列腺癌患者的临床资料,分析患者术前血清HDL-C、IGF-1水平。术后对患者随访1年,评估患者预后情况,分析术前血清HDL-C、IGF-1水平对前列腺癌根治术患者预后的预测价值。结果90例前列腺癌根治术患者中预后不良20例,占比为22.22%。不同预后患者血清IGF-1、HDL-C、总胆固醇、空腹血糖水平比较,差异具有统计学意义(P<0.05)。经Logistic回归分析显示,血清HDL-C、IGF-1是前列腺癌根治术患者预后的影响因素(P<0.05);受试者工作特征(ROC)曲线显示,血清HDL-C、IGF-1单独及联合对前列腺癌根治术患者预后均有一定的预测价值,且联合预测价值更高。结论血清HDL-C、IGF-1可对前列腺癌根治术患者预后产生影响,且术前血清HDL-C与IGF-1联合检测对前列腺癌根治术患者预后具有较高的预测价值。

关键词：前列腺癌根治术高密度脂蛋白胆固醇胰岛素样生长因子-1 预后

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舰载机起飞时机辅助决策系统建模

航空学报 2009年第11期30卷 2066-2071页

作者：王延刚屈香菊北京航空航天大学航空科学与工程学院北京100191

由于航母扰动会影响舰载机起飞安全,而仅依靠个人经验决策起飞时机存在较大误差,因此提出了舰载机起飞时机辅助决策系统的概念并建立模型。通过分析航母运动对舰载机起飞的影响机理,选择飞机离舰爬升率作为评价起飞安全性的关键参数;结... 详细信息

由于航母扰动会影响舰载机起飞安全,而仅依靠个人经验决策起飞时机存在较大误差,因此提出了舰载机起飞时机辅助决策系统的概念并建立模型。通过分析航母运动对舰载机起飞的影响机理,选择飞机离舰爬升率作为评价起飞安全性的关键参数;结合舰载机起飞作业程序,确立起飞时机决策方法;在此基础上,利用人工神经网络的预测能力并结合有利/不利起飞时机的特征,建立舰载机起飞时机辅助决策系统模型。仿真结果表明,系统模型能够有效地为起飞指挥官提供辅助决策信息,提高舰载机起飞安全性。

关键词：舰载机航母运动决策建模神经网络

Contact optimisation strategy for wafer-scale field-effect transistors based on two-dimensional semiconductors

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Journal of Materials Science & Technology 2023年第2期133卷 230-237页

作者： Ling Tong Xiaojiao Guo Zhangfeng Shen Lihui Zhou Jingyi Ma Xinyu Chen Honglei Chen Yin Xia Chuming Sheng Saifei Gou Die wang Xinyu wang Xiangqi Dong Yuxuan Zhu Xinzhi Zhang David Wei Zhang Sheng Dai Xi Li Peng Zhou yangang wang Wenzhong Bao State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai 200433China College of Biological Chemical Science and EngineeringJiaxing UniversityJiaxing 314001China Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Institute of Fine ChemicalsSchool of Chemistry&Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China

Two-dimensional(2D)semiconductors can be utilized to continually miniaturize nanoscale electronic ***,achieving a practical solution for satisfying electrical contact with 2D semiconductors remains *** this study,we developed a novel contact structure with transferred multilayer(t-ML)MoS 2 by integrating both edge and top *** in-situ plasma treatment for the edge of the MoS 2 channel and successive metal deposition,we achieved 16 times lower contact resistivity(22.8 kΩμm)than that of the top contacted *** thickness-dependent electrical measurement indicates that edge contact is highly effective with thick MoS 2 due to the alleviated current-crowding effect re-sulting from the small contact *** temperature-dependent transport measurement further confirms the effective minimization of the influence from the Schottky barrier and tunnelling ***,the simplified resistor network model and energy-band diagram were proposed to understand the carrier transport *** work provides a practical strategy for achieving excellent electrical contact between bulk metals and 2D semiconductors,paving the way for future large-scale 2D electronic devices.

关键词： Edge contact 2D materials Field-effect transistors Schottky barrier Contact resistance

The Sunway Taihu Light supercomputer:system and applications

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Science China(Information Sciences) 2016年第7期59卷 113-128页

作者： Haohuan FU Junfeng LIAO Jinzhe YANG Lanning wang Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG yangang wang Chunbo ZHOU Guangwen YANG Ministry of Education Key Laboratory for Earth System Modeling and Center for Earth System ScienceTsinghua University National Supercomputing Center in Wuxi Department of Computer Science and Technology Tsinghua University College of Global Change and Earth System Science Beijing Normal University First Institute of Oceanography State Oceanic Administration Institute of Software Chinese Academy of Sciences Institute of Process Engineering Chinese Academy of Sciences Computer Network Information Center Chinese Academy of Sciences

The Sunway Taihu Light supercomputer is the world’s first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation.

关键词： supercomputer many-core high performance computing scientific computing computer architecture

面向结构动力学计算的撕裂有限元方法异构并行优化

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数值计算与计算机应用 2024年第2期45卷 115-135页

作者：聂宁明姚柯寒曾艳冯仰德王珏李顺德张纪林万健林克豪高岳王彦棡王宗国中国科学院计算机网络信息中心北京100190 杭州电子科技大学计算机学院杭州310018 中国原子能科学研究院北京102413

本文结合大规模撕裂有限元方法和Newmark积分法,对结构动力学问题进行高精细的大规模并行求解.面向异构平台,设计了结点间和结点内的多级动静结合的负载均衡策略.在结点间,根据撕裂有限元方法划分子域边界特点,采用域边界平衡的图二分算... 详细信息

本文结合大规模撕裂有限元方法和Newmark积分法,对结构动力学问题进行高精细的大规模并行求解.面向异构平台,设计了结点间和结点内的多级动静结合的负载均衡策略.在结点间,根据撕裂有限元方法划分子域边界特点,采用域边界平衡的图二分算法,均衡各个子域的计算量;在结点内,根据异构平台计算单元的性能差异,进行了计算负载的动态优化.针对核心计算模块批量矩阵向量乘进行多流并行优化,提升面向异构计算平台的利用率.本文优化已经集成到结构力学高性能数值模拟软件HARSA-feti中,实验采用真实反应堆核燃料组件的流致振动仿真作为算例,结果表明模拟性能提高了71.3%以上,首次实现了百亿网格规模的全堆芯燃料棒组件的高精细模拟,相较于1000块GPU,16000块GPU的强、弱可扩展并行效率分别达到74.1%和81.1%.

关键词：结构动力学大规模并行计算负载均衡异构计算矩阵向量乘