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Correlation of calcitonin gene-related peptide and endothelin receptor A with subarachnoid hemorrhage

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Neural Regeneration Research 2011年第1期6卷 47-54页

作者： Jinning Song Ming Zhang Qi Liang Long Sui Lei Xi wenbo wang Department of Neurosurgery First Affiliated Hospital College of Medicine Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

Numerous studies have demonstrated that endothelin-1 combines with endothelin receptor A, resulting in intense vasoconstriction. Although calcitonin gene-related peptide （CGRP） suppresses endothelin-1, CGRP and endothelin receptor A exhibit direct biological effects on brain tissue. The present study analyzed CGRP and endothelin receptor A expression following subarachnoid hemorrhage in rabbits using immunohistochemistry. CGRP expression was significant at 5 days after model establishment, and endothelin receptor A expression was significant at 3 days after model induction. The perimeter of the basilar artery was measured to determine the amount of cerebral vasospasm. Analytical results revealed a significantly shortened basilar artery perimeter following subarachnoid hemorrhage. Changes in the basilar artery perimeter were negatively associated with endothelin receptor A expression, but positively correlated with CGRP expression in vessels. These results suggest that following subarachnoid hemorrhage, CGRP and endothelin receptor A expressions dynamically changed in brain vessels and tissues, although these changes were not synchronous. Changes in endothelin receptor A expression exhibited a significant effect on the occurrence and development of delayed cerebral vasospasm and delayed neuronal death, while CGRP relaxed vessels and protected nerves.

关键词： calcitonin gene-related peptide endothelin receptor A subarachnoid hemorrhage cerebral vasospasm brain injury neural regeneration

Novel and Simple Calorimetric Methods for Quantifying Losses in Magnetic Core and GaN Transistor in a High Frequency Boost Converter

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Chinese Journal of Electrical Engineering 2016年第2期2卷 68-75页

作者： wenbo wang Frans Pansier Sjoerd de Haan J.A.Ferreira DCE&S Faculty of Electrical EngineeringMathematics and Computer ScienceDelft University of TechnologyDelftThe Netherlands

In design and implementation of a boost converter,information on loss characteristics of switching devices and magnetic materials is a prerequisite,especially in high frequency *** gather such information,testing and accurate loss quantification is *** methods for measuring magnetic core loss are either only suitable for sinusoidal wave excitations or cannot separate winding loss from inductor *** addition,existing loss measurement approaches on the newly introduced GaN transistors are not *** this paper,we present a new method to distinguish winding loss from inductor loss under practical *** method utilizes a converter to generate the actual excitation waveforms and uses a calorimetric setup to quantify the *** splitting up the inductor in a converter into an air-core inductor and a magnetic-core inductor,both equipped with exactly the same winding structure,the air-core inductor loss can be used as the reference of the magnetic-core inductor winding *** this way,losses in the magnetic core can be determined in the actual operating condition of a converter in which the inductor is to be ***,a simple calorimetric approach for obtaining loss information of GaN transistors are is also *** methods require simple setup and are easy and convenient to *** methods work well in assessing different high frequency magnetic core materials and measuring losses in GaN transistors at 1MHz.

关键词： Core loss measurement practical excitation high frequency magnetic material practical excitation transistor loss measurement calorimetric method

GROUND STATES FOR FRACTIONAL SCHRODINGER EQUATIONS WITH ELECTROMAGNETIC FIELDS AND CRITICAL GROWTH

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Acta Mathematica Scientia 2020年第1期40卷 59-74页

作者： Quanqing LI wenbo wang Kaimin TENG Xian WU Department of Mathematics Honghe UniversityMengzi 661100China Department of Mathematics and Statistics Yunnan UniversityKunming 650091China Department of Mathematics Taiyuan University of TechnologyTaiyuan 030024China Department of Mathematics Yunman Normal UniversityKunming 650092China

In this article,we study the following fractional Schrodinger equation with electromagnetic fields and critical growth(-Δ)^sAu+V(x)u=|u|^2^*s-2)u+λf(x,|u|^2)u,x∈R^n,where(-Δ)^sA is the fractional magnetic operator with 02s,λ>0,2^*s=2N/(N-2s),f is a continuous function,V∈C(R^n,R)and A∈C(R^n,R^n)are the electric and magnetic potentials,*** V and f are asymptotically periodic in x,we prove that the equation has a ground state solution for largeλby Nehari method.

关键词： fractional Schrodinger equation fractional magnetic operator critical growth

Step-wise CAG@PLys@PDA-Cu^(2+)modification on micropatterned nanofibers for programmed endothelial healing

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Bioactive Materials 2023年第7期25卷 657-676页

作者： Bingcheng Yi Boya Zhou Zhenfeng Song Lei Yu wenbo wang Wei Liu Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Department of Vascular Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China

Native-like endothelium regeneration is a prerequisite for material-guided small-diameter vascular *** this study,a novel strategy is proposed to achieve phase-adjusted endothelial healing by step-wise modification of parallel-microgroove-patterned(i.e.,micropatterned)nanofibers with polydopamine-copper ion(PDA-Cu^(2+))complexes,polylysine(PLys)molecules,and Cys-Ala-Gly(CAG)peptides(CAG@PLys@PDA-Cu^(2+)).Using electrospun poly(L-lactide-co-caprolactone)random nanofibers as the demonstrating biomaterial,step-wise modification of CAG@PLys@PDA-Cu^(2+)significantly enhanced substrate wettability and protein adsorption,exhibited an excellent antithrombotic surface and outstanding phase-adjusted capacity of endothelium regeneration involving cell adhesion,endothelial monolayer formation,and the regenerated endothelium *** in vivo implantation for segmental replacement of rabbit carotid arteries,CAG@PLys@PDA-Cu^(2+)modified grafts(2 mm inner diameter)with micropatterns on inner surface effectively accelerated native-like endothelium regeneration within 1 week,with less platelet aggregates and inflammatory response compared to those on non-modified *** observations at 6-and 12-weeks post-implantation demonstrated a positive vascular remodeling with almost fully covered endothelium and mature smooth muscle layer in the modified vascular grafts,accompanied with well-organized extracellular *** contrast,non-modified vascular grafts induced a disorganized tissue formation with a high risk of *** summary,step-wise modification of CAG@PLys@PDA-Cu^(2+)on micropatterned nanofibers can significantly promote endothelial healing without inflicting thrombosis,thus confirming a novel strategy for developing functional vascular grafts or other blood-contacting materials/devices.

关键词： Surface chemistry Anisotropic topography Step-wise modification Endothelial healing Functional vascular grafts

Effect of Solution Treatment on Recrystallization,Texture and Mechanical Properties of 7A65-T74 Aluminum Alloy Super-thick Hot Rolled Plate

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Journal of Wuhan University of Technology(Materials Science) 2022年第3期37卷 460-469页

作者： LI Chen wang Hao wang wenbo YE Chengtong JIN Zuheng ZHANG Xinquan ZHANG Hu JIA Lina The First Aircraft of Institute of AVIC Xi’an 710000China Department of Materials Science and Engineering Beihang UniversityBeijing 100191China Research Center for Lightweight Materials Ningbo Institute of TechnologyBeihang UniversityNingbo 315100China

The effects of the solution treatment on the microstructure,recrystallization,texture composition and properties of 7A65-T7451(120 mm)hot rolled plates at H/2(1/2 thickness)and H/4(1/4 thickness)were *** results show that the hot rolled microstructure mainly contains a large amount of MgZn_(2) phases and minor Al_(7)Cu_(2)Fe *** solid solution treatments,a large amount of MgZn_(2) phases are dissolved back into the aluminum *** main texture types at H/4 are R-Cube,Cube and part of Brass texture,and the main texture types at H/2 are Cube,R,and Copper *** qualitative analysis by Schmidt's law reveals that Copper texture at H/2 will deepen the anisotropy of plate metal *** the plate with the same thickness,the two-stage solution state has better mechanical properties due to the lower degree of recrystallization and stronger grain boundary strengthening *** the two-stage solution system of 460℃/165 min+477℃/165 min,the composite mechanical properties of the alloy plate at H/4 are the best and the anisotropy is not *** tensile strength,yield strength,and elongation along the rolling direction are 561.9 MPa,523.4 MPa,and 10.6%,respectively..

关键词： 7A65 thick plate solid solution treatment texture recrystallization anisotropic

Computing Power Network:A Survey

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China Communications 2024年第9期21卷 109-145页

作者： Sun Yukun Lei Bo Liu Junlin Huang Haonan Zhang Xing Peng Jing wang wenbo School of Information and Communications Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China Research Institute of China Telecom Co. Ltd.Beijing 102209China Beijing Branch of China Telecom Co. Ltd.Beijing 100032China

With the rapid development of cloud computing,edge computing,and smart devices,computing power resources indicate a trend of ubiquitous *** traditional network architecture cannot efficiently leverage these distributed computing power resources due to computing power island *** overcome these problems and improve network efficiency,a new network computing paradigm is proposed,i.e.,Computing Power Network(CPN).Computing power network can connect ubiquitous and heterogenous computing power resources through networking to realize computing power scheduling *** this survey,we make an exhaustive review on the state-of-the-art research efforts on computing power *** first give an overview of computing power network,including definition,architecture,and ***,a comprehensive elaboration of issues on computing power modeling,information awareness and announcement,resource allocation,network forwarding,computing power transaction platform and resource orchestration platform is *** computing power network testbed is built and *** applications and use cases in computing power network are ***,the key enabling technologies for computing power network are ***,open challenges and future research directions are presented as well.

关键词： computing power modeling computing power network computing power scheduling information awareness network forwarding

Directional Source Localization Based on RSS-AOA Combined Measurements

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China Communications 2020年第11期17卷 181-193页

作者： Peiliang Zuo Tao Peng Hao Wu Kangyong You Hanbo Jing Wenbin Guo wenbo wang Wireless Signal Processing and Network Laboratory Key Laboratory of Universal Wireless CommunicationMinistry of EducationBeijing University of Posts and TelecommunicationsBeijing 100876China Department of Electronic and Communication Engineering Beijing Electronic Science&Technology InstituteBeijing 100070China th Research Institute of China Electronics Technology Group Corporation(CETC) Guangzhou 510310China Beijing Institute of Remote Sensing Equipment Beijing 100854China

Source localization plays an indispensable role in many *** paper addresses the directional source localization problem in a three-dimensional(3D)wireless sensor network using hybrid received-signal-strength(RSS)and angle-of-arrival(AOA)*** the position and transmission orientation of the source are to be *** the considered positioning scenario,the angle and range measurements are respectively corresponding to the AOA model and RSS model that integrates the Gaussian-shaped radiation *** that the localization problem is non-convex and the unknown parameters therein are coupled together,this paper adopts the second-order cone relaxation and alternating optimization techniques in the proposed estimation ***,to provide a performance benchmark for any localization method,the corresponding Cramer-Rao lower bounds(CRLB)of estimating the unknown position and transmission orientation of the source are *** and simulation results demonstrate that the presented algorithm effectively resolves the problem,and its estimation performance is close to the CRLB for the localization with the hybrid measurements.

关键词： localization directional source CRLB RSS AOA wireless sensor network(WSN) second-order cone programming(SOCP)

Piezoelectric film promotes skin wound healing with enhanced collagen deposition and vessels regeneration via upregulation of PI3K/AKT

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Nano Research 2024年第8期17卷 7461-7478页

作者： Qi Xu Wufei Dai Peizhe Li Qinglin Li Zhen Gao Xiaoli Wu Wei Liu wenbo wang Department of Plastic and Reconstructive Surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Research Institute of Plastic Surgery Shandong Second Medical UniversityWeifang 261000China Department of Surgery Air Force Medical CenterPLABeijing 100142China

Skin wounds are common in accidental injuries,and the intricacies of wound repair are closely linked to endogenous electric *** stimulation plays a pivotal role in the restorative processes of skin injuries,encompassing collagen deposition,angiogenesis,inflammation,and *** electrical stimulation therapy replicates and enhances the effects of endogenous wound electric fields by applying an external electric field to the wound site,thereby promoting skin wound *** this study,we developed a self-powered repetitive mechanical impacts-electrical stimulation(RMI-ES)system utilizing a BaTiO_(3)/polydimethylsiloxane(PDMS)piezoelectric composite *** to conventional electrical stimulation devices,the fabricated piezoelectric composite film efficiently harvests energy from the pressure applied by the stimulation device and the tensile force occurring during natural rat *** results demonstrated that piezoelectric stimulation generated by the composite membrane expedited the cell cycle,promoting fibroblast ***,piezoelectric stimulation induced favorable changes in fibroblast gene expression,including increased expression of transforming growth factor-β1(TGF-β1),connective tissue growth factor(CTGF),collagen 1,collagen 3,vascular endothelial growth factor(VEGF),and alpha-smooth muscle actin(α-SMA),while reducing interleukin-6(IL-6)*** analysis revealed that piezoelectric stimulation may induce fibroblast migration,proliferation,and collagen expression by influencing PI3K/AKT serine/threonine kinase(AKT)*** confirmation through the addition of the PI3K inhibitor LY294002 validated that piezoelectric stimulation can regulate the repair process after skin injury through the ***,in vivo results demonstrated that the electric field at the wound site effectively promoted wound healing,reduced inflammation,and stimulated collagen deposition and ne

关键词： BaTiO3/polydimethylsiloxane(PDMS)nano-composite membrane piezoelectrical stimulation skin wound healing collagen deposition PI3K/AKT serine/threonine kinase(AKT)signaling pathway

Selective N-Alkylation of 2-Amino-4H-chromene-3-carbonitrile Derivatives with Alcohols Catalyzed by AlCl3 Under the Assistance of CH3COOH

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Chemical Research in Chinese Universities 2019年第6期35卷 997-1001页

作者： ZHAO Bing HE Yuqian KAN Wei KONG Fengqiao wang Liyan SONG Bo wang wenbo YIN Guangming wang Jianxin Chemistry and Chemical Engineering Institute Qiqihar UniversityQiqihar 161006P.R.China College of Material Science and Engineering Qiqihar UniversityQiqihar 161006P.R.China

A highly efficient and selective N-alkylation reaction of 2-amino-4H-chromene-3-carbonitrile derivatives using various alcohols as alkylation agent were developed in the presence of AlCl3 as a catalyst as well as CH3COOH as an additive,in which the cyano group kept inert and the amino group was alkylated in high *** the target products were characterized and determined by infrared(IR),1H NMR,13C NMR,and *** the X-ray structure of product 3ab was obtained.A bimolecular reaction mechanism catalyzed by AlCl3 was proposed under the assistance of CH3COOH.

关键词： A/-Alkylation Alcohol A1C13 CH3COOH