Correlation of calcitonin gene-related peptide and endothelin receptor A with subarachnoid hemorrhage
Correlation of calcitonin gene-related peptide and endothelin receptor A with subarachnoid hemorrhage作者机构:Department of Neurosurgery First Affiliated Hospital College of Medicine Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China
出 版 物:《Neural Regeneration Research》 (中国神经再生研究(英文版))
年 卷 期:2011年第6卷第1期
页 面:47-54页
核心收录:
学科分类:0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种]
基 金:the National 863 Project of China,No. 2006AA02Z4Z4 the National Natural Science Foundation of China,No. 30870844 the New Century Excellent Talent Support Project of Ministry of Education,No. NCET-05-0831 the "13115" Special Fund for Major Science and Technology Projects of Shaanxi Province,No. 2008ZDKG-66
主 题:calcitonin gene-related peptide endothelin receptor A subarachnoid hemorrhage cerebral vasospasm brain injury neural regeneration
摘 要:Numerous studies have demonstrated that endothelin-1 combines with endothelin receptor A, resulting in intense vasoconstriction. Although calcitonin gene-related peptide (CGRP) suppresses endothelin-1, CGRP and endothelin receptor A exhibit direct biological effects on brain tissue. The present study analyzed CGRP and endothelin receptor A expression following subarachnoid hemorrhage in rabbits using immunohistochemistry. CGRP expression was significant at 5 days after model establishment, and endothelin receptor A expression was significant at 3 days after model induction. The perimeter of the basilar artery was measured to determine the amount of cerebral vasospasm. Analytical results revealed a significantly shortened basilar artery perimeter following subarachnoid hemorrhage. Changes in the basilar artery perimeter were negatively associated with endothelin receptor A expression, but positively correlated with CGRP expression in vessels. These results suggest that following subarachnoid hemorrhage, CGRP and endothelin receptor A expressions dynamically changed in brain vessels and tissues, although these changes were not synchronous. Changes in endothelin receptor A expression exhibited a significant effect on the occurrence and development of delayed cerebral vasospasm and delayed neuronal death, while CGRP relaxed vessels and protected nerves.