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Analysis of PM2.5 and O3 Pollution Causes in Hangzhou Based on High-resolution Enhanced Observation During the Asian Games

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Huanjing Kexue/Environmental Science 2025年第3期46卷 1302-1313页

作者： Yan, Ren-Chang Lai, Yong Zhang, Tian Jin, jia-jia Lin, xu wang, Yun-Yun Shuai, Qi-Fan Fei, Luo-Lan Shen, jian-Dong Ye, xuhong Zhu, Shu-Hui Hangzhou Ecological Environment Monitoring Center of Zhejiang Hangzhou310007 China Shanghai Academy of Environmental Sciences Shanghai200003 China

Based on the high-resolution enhanced observation data of PM2.5 organic molecular tracers,aldehydes and ketone OVOC components,long-chain alkane IVOC components,and key species of atmospheric oxidation during September 1 to October 27,2023,the causes of PM2.5 and O3 pollution in Hangzhou were analyzed. Seven pollution processes were selected with the average daily concentration of PM2.5 exceeding 35 µg·m-3 or the maximum 8-hour concentration of O3 exceeding 160 µg·m-3. Then,these pollution processes were divided into four types:north-northeast transmission type(T1),east-southeast transmission type(T2),north-northwest transmission type(T3),and statically stable type(T4)by airflow trajectory. The research results indicated that the T2 pollution process exhibited strong PM2.5 and O3 composite pollution characteristics and the photochemical oxidation reaction of active VOC components,such as long-chain alkanes and terpenes in the atmospheric environment was the major pollution cause of this type. In the process of T1 and T3 pollution,the overall reactivity of VOCs was low,resulting in relatively weak O3 generation. However,the causes of PM2.5 in these two types of pollution processes were different. T1 pollution was affected by low temperature and high humidity meteorological conditions and the enhanced liquid-phase oxidation process led to a significant increase in nitrate concentration. T3 pollution was significantly affected by emissions from coal combustion,biomass combustion,and other sources,with a relatively high proportion of primary components in PM2.5. The T4 pollution process was significantly affected by local primary anthropogenic emissions,thus the control of local catering source and mobile source emissions must be strengthened. © 2025 Science Press. All rights reserved.

关键词： Coal combustion

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A novel Nance-Horan syndrome mutation identified by next-generation sequencing in a Chinese family

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 1015-1019页

作者： hong-Yan Sun hong-Jing Zhu Ru-xu Sun Ying wang jia-Nan wang Bing qin wei-wei Zhang jiang-Dong Ji Department of Ophthalmology the First People's Hospital of SuqianSuqian 223800Jiangsu ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanjing Medical UniversityNanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

AIM: To identify the disease-causing mutation in a fourgeneration Chinese family diagnosed with Nance-Horan syndrome(NHS). METHODS: A Chinese family, including four affected patients and four healthy siblings, was recruited. All family members received ophthalmic examinations with medical histories provided. Targeted next-generation sequencing approach was conducted on the two affected males to screen for their disease-causing mutations. RESULTS: Two male family members diagnosed with NHS manifested bilateral congenital cataracts microcornea, strabismus and subtle facial and dental abnormalities, while female carriers presented posterior Y-sutural cataracts. A novel frameshift mutation(c.3916_3919 del) in the NHS gene was identified. This deletion was predicted to alter the reading frame and generate a premature termination codon after a new reading frame. CONCLUSION: The study discovers a new frameshift mutation in a Chinese family with NHS. The findings broaden the spectrum of NHS mutations that can cause NHS in Chinese patients.

关键词： Nance-Horan Syndrome cataract next-generation sequencing NHS gene

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Science objectives of the Einstein Probe mission

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Science China(Physics,Mechanics & Astronomy) 2025年第3期68卷 1-60页

作者： weimin Yuan Lixin Dai Hua Feng Chichuan Jin Peter Jonker Erik Kuulkers Yuan Liu Kirpal Nandra Paul O’Brien Luigi Piro Arne Rau Nanda Rea Jeremy Sanders Lian Tao Junfeng wang xuefeng Wu Bing Zhang Shuangnan Zhang Shunke Ai Johannes Buchner Esra Bulbul Hechao Chen Minghua Chen Yong Chen Yu-Peng Chen Alexis Coleiro Francesco Coti Zelati Zigao Dai Xilong Fan Zhou Fan Susanne Friedrich He Gao Chong Ge Mingyu Ge Jinjun Geng Giancarlo Ghirlanda Giulia Gianfagna Lijun Gou Sebastien Guillot´ Xian Hou Jingwei Hu Yongfeng Huang Long Ji Shumei jia S.Komossa Albert K.H.Kong Lin Lan An Li Ang Li Chengkui Li Dongyue Li jian Li Zhaosheng Li Zhixing Ling Ang Liu Jinzhong Liu Liangduan Liu Zhu Liu jiawei Luo Ruican Ma Pierre Maggi Chandreyee Maitra Alessio Marino Stephen Chi-Yung Ng Haiwu Pan Surangkhana Rukdee Roberto Soria Hui Sun Pak-Hin Thomas Tam Aishwarya Linesh Thakur Hui Tian Eleonora Troja wei wang Xiangyu wang Yanan wang Junjie wei Sixiang Wen jianfeng Wu Ting Wu Di Xiao Dong xu Renxin xu Yanjun xu Yu xu Haonan Yang Bei You Heng Yu Yunwei Yu Binbin Zhang Chen Zhang Guobao Zhang Liang Zhang Wenda Zhang Yu Zhang Ping Zhou Zecheng Zou National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Physics University of Hong KongPokfulam RoadHong Kong 999077China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Astrophysics/IMAPP Radboud UniversityNijmegen6500 GLthe Netherlands SRON Netherlands Institute for Space ResearchLeiden2333 CAthe Netherlands ESA/ESTEC Noordwijk2201 AZthe Netherlands Max Planck Institute for Extraterrestrial Physics Garching85748Germany School of Physics and Astronomy University of LeicesterLeicesterLE17RHUK INAF-Istituto di Astrofisica e Planetologia Spaziali Rome00133Italy Institute of Space Sciences(ICE) CSICCampus UABBarcelonaE-08193Spain Institut d’Estudis Espacials de Catalunya(IEEC) BarcelonaE-08034Spain Department of Astronomy Xiamen UniversityXiamen 361005China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Sciences University of Science and Technology of ChinaHefei 230026China Nevada Center for Astrophysics University of NevadaLas VegasNV 89154USA Department of Physics and Astronomy University of NevadaLas VegasNV 89154USA Department of Astronomy School of Physics and TechnologyWuhan UniversityWuhan 430072China School of Physics and Astronomy Yunnan UniversityKunming 650500China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Universit´e Paris Cit´e CNRSAstroparticule et CosmologieParisF-75013France Department of Astronomy University of Science and Technology of ChinaHefei 230026China Institute for Frontier in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Department of Astronomy Beijing Normal UniversityBeijing 100875China INAF-Osservatorio Astronomico di Brera Merate(LC)I-23807Italy INFN-sezione di Milano-Bicocca Milano(M

The Einstein Probe(EP)is an interdisciplinary mission of time-domain and X-ray *** with a wide-field lobstereye X-ray focusing imager,EP will discover cosmic X-ray transients and monitor the X-ray variability of known sources in 0.5-4 keV,at a combination of detecting sensitivity and cadence that is not accessible to the previous and current wide-field monitoring *** can perform quick characterisation of transients or outbursts with a Wolter-I X-ray telescope *** this paper,the science objectives of the EP mission are *** is expected to enlarge the sample of previously known or predicted but rare types of transients with a wide range of *** them,fast extragalactic transients will be surveyed systematically in soft X-rays,which includeγ-ray bursts and their variants,supernova shock breakouts,and the predicted X-ray transients associated with binary neutron star *** will detect X-ray tidal disruption events and outbursts from active galactic nuclei,possibly at an early phase of the flares for *** will monitor the variability and outbursts of X-rays from white dwarfs,neutron stars and black holes in our and neighbouring galaxies at flux levels fainter than those detectable by the current instruments,and is expected to discover new objects.A large sample of stellar X-ray flares will also be detected and *** the era of multi-messenger astronomy,EP has the potential of detecting the possible X-ray counterparts of gravitational wave events,neutrino sources,and ultra-high energyγ-ray and cosmic ray *** is expected to help advance the studies of extreme objects and phenomena revealed in the dynamic X-ray universe,and their underlying physical *** EP's strength in time-domain science,its follow-up telescope,with excellent performance,will also enable advances in many areas of X-ray astronomy.

关键词： Einstein Probe X-ray astronomy X-ray telescopes time-domain astronomy transients variability

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The performance of ^(18)F-PSMA PET/CT in the detection of prostate cancer:a systematic review and meta-analysis

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Asian Journal of Andrology 2022年第4期24卷 373-379页

作者： Zhi-Qiang qin Gao-jian Pan Zheng xu Hao wang Lu-wei xu Rui-Peng jia Department of Urology Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Department of Urology Yancheng Third People's HospitalYancheng 224000China Department of Urology The Yancheng School of Clinical Medicine of Nanjing Medical UniversityYancheng 224000China.

This paper presents a meta-analysis regarding the detection rate(DR)of fluorine-18(^(18)F)-labeled prostate-specific membrane antigen positron emission tomography/computed tomography(PSMA PET/CT)in the management of patients with prostate cancer(PCa).Relevant studies regarding ^(18)F-PSMA PET/CT in the management of PCa published until June 1,2021,were electronically searched in online databases including EMBASE,PubMed,and Web of *** primary outcome was the DR of ^(18)F-PSMA PET/CT in managing PCa patients,while the secondary outcome was the DR of ^(18)F-PSMA PET/CT according to Gleason scores and serum prostate-specific antigen(PSA)*** pooled DR was calculated on a per-patient basis,with pooled odd ratios and 95%confidence intervals(CIs).In total,17 observational studies evaluating 1019 patients with PCa met the inclusion *** DR of ^(18)F-PSMA PET/CT was 0.83(95%CI:0.78-0.88),in the random-effects ***,the analysis of DR of ^(18)F-PSMA PET/CT in PCa patients using Gleason score(≤7 vs≥8),showed a significant difference in PCa *** on the above results,the higher Gleason score of PCa patients,the higher DR of ^(18)F-PSMA PET/*** DR of ^(18)F-PSMA PET/CT in PCa was 0.57 for PSA<0.5 ng ml^(-1);0.75 for PSA≥0.5 ng ml^(-1) and<1.0 ng ml^(-1);0.93 for PSA≥1.0 ng ml^(-1) and<2.0 ng ml^(-1);and 0.95 for PSA≥2.0 ng ml^(-1).Therefore,the significant diagnostic value was found in terms of the DR of ^(18)F-PSMA PET/CT in managing PCa patients and was associated with Gleason score and serum PSA level.

关键词： ^(18)F-PSMA PET/CT detection rate meta-analysis prostate cancer

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2024年胰腺癌研究及诊疗新进展

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中国癌症杂志 2025年第1期35卷 1-11页

作者：王婷秦毅徐晓武虞先濬复旦大学附属肿瘤医院胰腺外科复旦大学上海医学院肿瘤学系上海市胰腺肿瘤研究所上海市胰腺肿瘤精准诊疗重点实验室复旦大学胰腺肿瘤研究所

胰腺癌是一种恶性程度极高的恶性肿瘤，其发病率自2000年以来呈缓慢增长趋势。尽管诊疗水平的提升促使胰腺癌患者的5年生存率相较于50年前有了一定提高，但仍是预后不容乐观的恶性肿瘤之一。步入2024年，胰腺癌早期筛查策略、疾病机制... 详细信息

胰腺癌是一种恶性程度极高的恶性肿瘤，其发病率自2000年以来呈缓慢增长趋势。尽管诊疗水平的提升促使胰腺癌患者的5年生存率相较于50年前有了一定提高，但仍是预后不容乐观的恶性肿瘤之一。步入2024年，胰腺癌早期筛查策略、疾病机制探索、临床诊疗方案等研究领域取得了诸多进展，并显示出良好的临床应用前景。早期筛查方面，人工智能（artificial intelligence,AI）技术赋能胰腺癌早诊、早筛，使临床诊疗踏上新台阶；此外，液体活检等技术的准确率提升，为胰腺癌早筛提供了新方向。疾病发病机制研究方面，3D基因组映射技术揭示了胰腺导管上皮内瘤变（pancreatic intraepithelial neoplasm,PanIN）的多克隆起源和遗传异质性。基础研究方面，模拟胰腺癌独特结构特征的分支器官模拟系统为胰腺癌体外研究提供了新模型；肿瘤重要代谢物乳酸将胰腺癌代谢微环境与表观遗传学改变联系在一起，揭示了潜在治疗靶点；组蛋白H3K36三甲基转移酶SETD2缺陷导致胰腺癌内源性表观遗传失调，并促进线粒体氧化磷酸化（oxidative phosphorylation,OXPHOS）和肿瘤进展；基质细胞与癌细胞间信号分子血小板衍生生长因子受体（platelet-derived growth factor receptor,PDGFR）轴形成双向分泌回路，或能成为治疗新靶点；嵌合抗原受体巨噬细胞（chimeric antigen receptor macrophage,CAR-M）靶向c-MET的疗法展现出与化疗药物协同增效的潜力；胰腺癌微环境中的巨噬细胞通过CCL5/TRAF6/核因子-κB（nuclear factor-κB,NF-κB）通路促进胰腺癌恶病质进展，表明巨噬细胞有望成为预测及干预胰腺癌恶病质发生、发展的有效靶点。诊疗方面，新辅助化疗后手术可改善可切除与交界可切除患者的总生存（overall survival,OS），但仍需进一步优化新辅助化疗方案；首个临床有效的KRASG12D靶向药物已见报道，广谱KRAS突变体抑制剂研究不断涌现；通过糖酵解相关评分（glycolysis-related scores,GRS）进行患者分层能够进一步指导治疗方案选择；“智能外泌体”(ExoSmart)通过增强细胞摄取能力协助提高化疗效果；免疫治疗联合化疗临床试验的实施，有望协同提高胰腺癌疗效；派安普利单抗和安罗替尼联合白蛋白结合型紫杉醇/吉西他滨（PAAG）在一线转移性胰腺癌（metastatic pancreatic cancer,mPC）患者中显示出较好的疗效和安全性；靶向KRAS突变编码新抗原的癌症疫苗ELI-002 2P能够诱导抗肿瘤免疫反应；溶瘤腺病毒疗法能够协同化疗药物提高晚期胰腺导管腺癌患者的疗效。本文就2024年度胰腺癌基础研究和诊疗领域的最新重大进展进行综述。

关键词：胰腺癌流行病学基础研究临床研究

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Multistate circularly polarized luminescence switches based on dual stimuli-responsive chiral[2]rotaxanes

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Science China Chemistry 2024年第12期67卷 4202-4211页

作者： wei-Tao xu xue Li Xiao-qin xu xu-qing wang Hai-Bo Yang wei wang Wuhu Hospital East China Normal University(The Second People’s HospitalWuhu)Wuhu 241001China Shanghai Key Laboratory of Green Chemistry and Chemical Processes State Key Laboratory of Petroleum Molecular and Process EngineeringSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Shanghai Center of Brain-inspired Intelligent Materials and Devices East China Normal UniversityShanghai 200241China

Aiming at the construction of novel multistate circularly polarized luminescence(CPL)switches,dual stimuli-responsive chiral[2]rotaxanes towards anions and light have been designed and *** the light-controlled on/off F?rster resonance energy transfer(FRET)switching between the emissive stoppers and anion-induced controllable motions of the chiral wheel for the precise regulations of chirality information transfer from the chiral wheel to the emissive stoppers,precisely switching between four CPL emission states with varied emission wavelengths and dissymmetry factors has been successfully realized,making them a promising platform for practical uses such as information storage and *** proof-of-concept study not only provides a novel design strategy for multistate CPL switching but also contributes excellent candidates for the construction of novel smart chiral luminescent materials.

关键词： mechanically interlocked molecules Förster resonance energy transfer aggregation-induced emission pillararene spiropyran

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Exogenous Hydrogen Sulfide Enhanced Antioxidant Capacity, Amylase Activities and Salt Tolerance of Cucumber Hypocotyls and Radicles

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Journal of Integrative Agriculture 2013年第3期12卷 445-456页

作者： YU Li-xu ZHANG Cun-jia SHANG hong-qin wang Xiu-feng wei Min YANG Feng-juan SHI qing-hua State Key Laboratory of Crop Biology/College of Horticulture Science and Engineering Shandong Agricultural University Department of Life Sciences Heze University

In the present experiment, effects of sodium hydrosulfide （NariS）, a H2S donor, on the oxidative damage, antioxidant capacity and the growth of cucumber hypocotyls and radicles were studied under 100 mmol L^-1 NaCl stress. NaCl treatment significantly induced accumulation of H2O2 and thiobarbituric acid-reactive substances （TBARS） in cucumber hypocotyls and radicles, and application of NariS dramatically reduced the accumulation of H/O2 and lipid peroxidation. However, the alleviating effects greatly depended on the concentrations of NariS, and 400 ~tmol L-1 NariS treatment showed the most significant effects. Corresponding to the change of lipid peroxidation, higher activities of antioxidant enzymes as well as the antioxidant capacity indicated as DPPH scavenging ac＇tivity, chelating activity of ferrous ions and hydroxyl radical （.OH） scavenging activity were induced by Naris treatment under NaCI stress, especially by 400 Ixmol L-I Naris treatment. With the alleviating lipid peroxidation, the amylase activities in cotyledons were increased, and the length of cucumber hypocotyls and radicles were significantly promoted by NariS treatment under NaCI stress. Unlike the effects of NariS, pretreatment with other sodium salts including Na2S, NazSO4, NaHSO4, Na2SO3, NaHSO3 and NaAc did not show significant effects on the growth of cucumber hypocotyls and radicles. These salts do not release H2S. Based on above results, it can be concluded that the effects of NariS in the experiment depended on the H2S rather than other compounds derived from NariS, and the alleviating effects might related with its function in modulating antioxidant capacity and amylase activities.

关键词： cucumber tolerance salt stress seed priming hydrogen sulfide antioxidant capacity

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复合菌种发酵制备白芸豆多肽工艺优化及其抗氧化活性分析

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食品工业科技 2025年第3期46卷 213-221页

作者：李思楠王萌安宇王晴徐开媛王佳张智慧王玺王颖张璐黑龙江八一农垦大学食品学院黑龙江大庆163319 中国食品发酵工业研究院有限公司功能主食创制与慢病营养干预北京市重点实验室北京100015 国家杂粮工程技术中心黑龙江大庆163319 厦门海洋职业技术学院福建厦门361100

为探究复合菌种发酵制备白芸豆多肽(White kidney bean polypeptides,WKBPs)的最佳工艺条件及体外抗氧化活性,本研究以枯草芽孢杆菌和米曲霉为发酵剂,通过单因素和响应面试验对制备WKBPs的工艺进行优化,利用超滤膜进行分级分离,测定不... 详细信息

为探究复合菌种发酵制备白芸豆多肽(White kidney bean polypeptides,WKBPs)的最佳工艺条件及体外抗氧化活性,本研究以枯草芽孢杆菌和米曲霉为发酵剂,通过单因素和响应面试验对制备WKBPs的工艺进行优化,利用超滤膜进行分级分离,测定不同分子量WKBPs体外抗氧化活性,筛选活性最好的组分,并结合体外模拟消化体系评价经胃肠消化后WKBPs的体外抗氧化活性变化。结果表明:在发酵时间48 h、温度37℃、接种量9%、米曲霉和枯草芽孢杆菌复配比例1:1条件下WKBPs得率为63.47%;超滤后分子量组分WKBPs-4(Mw<3 kDa)具有较好的抗氧化活性;在WKBPs-4浓度在0.2~1.0 mg/mL范围内呈剂量依赖性,抗氧化能力随WKBPs-4浓度的增加而增加,DPPH自由基清除率、ABTS^(+)自由基清除率、羟自由基清除率和Fe^(3+)还原力IC_(50)值分别为0.47、0._(50)、0.46和0.66 mg/mL;经胃肠消化后WKBPs-4仍保持较高的抗氧化活性,在肠消化终点240 min时,其DPPH自由基清除率和ABTS^(+)自由基清除率分别为84.29%和77.34%。本研究可为白芸豆高值利用及精深加工提供理论依据及数据支撑。

关键词：白芸豆多肽复合菌种发酵超滤抗氧化活性体外消化

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WGM Lasing from Toroid-shaped ZnO Microdisk Pivoted on Si

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发光学报 2025年第1期46卷 12-22页

作者： ZHU Gangyi YAN Xinyue YE Peng qin Feifei wang Zixuan LI Binghui LU Junfeng wang Xiaoxuan xu Chunxiang College of Integrated Circuit Science and Engineering(College of Industry-Education Integration) Nanjing University of Posts and TelecommunicationsNanjing 210003China GaN Optoelectronic Integration International Cooperation Joint Laboratory of jiangsu Province College of Telecommunications and Information EngineeringNanjing University of Posts and TelecommunicationsNanjing 210003China College of Physics Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Electronic Science and Engineering Southeast UniversityNanjing 210096China

Although it has a significant advantage in gain properties,the lack of selective etching processes hinders ZnO lasing in on-chip ***,the circular ZnO microdisk pivoted on Si substrate is fabricated through depositing ZnO on patterned silicon on an insulator(SOI)*** cavity structure,morphology,and photoluminescence(PL)properties are studied *** cavity shows a well-defined circular structure with oxygen *** the synergistic action of surface tension and stress,the ZnO microdisk shows a unique toroid structure with a high sidewall surface *** ZnO microcavity(8μm in diameter)shows optically pumped whispering gallery modes(WGMs)lasing in the ultraviolet region with a Q factor exceeding *** interestingly,the quality of the toroid ZnO microdisk cavity is high enough to support the bandgap renormalization(BGR)*** the increasing pumping power,the lasing spectra will be *** lasing spectrum undergoes a Burstein-Moss(BM)effect-induced blueshift and an electron-hole plasma(EHP)effect-induced redshift.

关键词： ZnO microdisk tunable lasing molecular beam epitaxy

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Battery Storage Configuration of AC/DC Hybrid Distribution Networks

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CSEE Journal of Power and Energy Systems 2023年第3期9卷 859-872页

作者： He Meng hongjie jia Tao xu wei wei Xiaoyu wang Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin 300072China

The upscaling requirements of energy transition highlight the urgent need for ramping up renewables and boosting system ***,the stochastic nature of excessive renewable energy resources has challenged stable and efficient operation of the power *** energy storage systems(BESSs)have been identified as critical to mitigate random fluctuations,unnecessary green energy curtailment and load shedding with rapid response and flexible *** the other hand,an AC/DC hybrid distribution system can offer merged benefits in both AC and DC subsystems without additional losses during AC/DC power ***,configuring BESSs on an AC/DC distribution system is wellpositioned to meet challenges brought by carbon reductions in an efficient way.A bi-level optimization model of BESS capacity allocation for AC/DC hybrid distribution systems,considering the flexibility of voltage source converters(VSCs)and power conversion systems(PCSs),has been established in this paper to address the techno-economic issues that hindered wide *** large-scale nonlinear programming problem has been solved utilizing a genetic algorithm combined with second-order cone *** and effectiveness of the model have been verified by setting different scenarios through case *** results have demonstrated the coordinated operation of BESS and AC/DC hybrid systems can effectively suppress voltage fluctuations and improve the cost-benefit of BESSs from a life cycle angle.

关键词： AC/DC hybrid distribution network arbitrage revenue battery energy storage system life cycle cost voltage source converter

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