The performance of ^(18)F-PSMA PET/CT in the detection of prostate cancer:a systematic review and meta-analysis
作者机构：Department of UrologyNanjing First HospitalNanjing Medical UniversityNanjing 210006China Department of UrologyYancheng Third People's HospitalYancheng 224000China Department of UrologyThe Yancheng School of Clinical Medicine of Nanjing Medical UniversityYancheng 224000China.
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2022年第24卷第4期
页 面：373-379页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by grants from Nanjing Medical Science and Technology Development Foundation(YKK16138) Jiangsu Provincial Medical Youth Talent(QNRC2016072) Science and Technology Development Fund of Nanjing Medical University(NMUB2018317)
主 题：^(18)F-PSMA PET/CT detection rate meta-analysis prostate cancer
摘 要：This paper presents a meta-analysis regarding the detection rate(DR)of fluorine-18(^(18)F)-labeled prostate-specific membrane antigen positron emission tomography/computed tomography(PSMA PET/CT)in the management of patients with prostate cancer(PCa).Relevant studies regarding ^(18)F-PSMA PET/CT in the management of PCa published until June 1,2021,were electronically searched in online databases including EMBASE,PubMed,and Web of *** primary outcome was the DR of ^(18)F-PSMA PET/CT in managing PCa patients,while the secondary outcome was the DR of ^(18)F-PSMA PET/CT according to Gleason scores and serum prostate-specific antigen(PSA)*** pooled DR was calculated on a per-patient basis,with pooled odd ratios and 95%confidence intervals(CIs).In total,17 observational studies evaluating 1019 patients with PCa met the inclusion *** DR of ^(18)F-PSMA PET/CT was 0.83(95%CI:0.78-0.88),in the random-effects ***,the analysis of DR of ^(18)F-PSMA PET/CT in PCa patients using Gleason score(≤7 vs≥8),showed a significant difference in PCa *** on the above results,the higher Gleason score of PCa patients,the higher DR of ^(18)F-PSMA PET/*** DR of ^(18)F-PSMA PET/CT in PCa was 0.57 for PSA0.5 ng ml^(-1);0.75 for PSA≥0.5 ng ml^(-1) and1.0 ng ml^(-1);0.93 for PSA≥1.0 ng ml^(-1) and2.0 ng ml^(-1);and 0.95 for PSA≥2.0 ng ml^(-1).Therefore,the significant diagnostic value was found in terms of the DR of ^(18)F-PSMA PET/CT in managing PCa patients and was associated with Gleason score and serum PSA level.
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