检索结果-南通市图书馆

大型综合医院全科医疗科建设弥补现代医学裂痕

在线全文

学校读者我要写书评

暂无评论

中国继续医学教育 2019年第16期11卷 59-61页

作者：孟佳王秋军李文静林琳张明明姜礼红哈尔滨医科大学附属第二医院全科医疗科

随着医学的不断进步和发展,临床分科过细与患者就医之间的矛盾也日益增多,目前更重视的是疾病治疗而不是预防,公共卫生和临床医学从统一到分离必定会产生医学裂痕,为了避免此类现象愈演愈烈,必须在短时间内找到行之有效的解决办法。目... 详细信息

随着医学的不断进步和发展,临床分科过细与患者就医之间的矛盾也日益增多,目前更重视的是疾病治疗而不是预防,公共卫生和临床医学从统一到分离必定会产生医学裂痕,为了避免此类现象愈演愈烈,必须在短时间内找到行之有效的解决办法。目前多数专家认为弥补现代医学裂痕最好的办法就是培养高质量的全科医生,在大型综合医院全科基地规范化培养的全科医生,正在逐步成为全科医生的主流力量。当前在大型综合医院设置独立全科医疗科,以综合医院全科基地的全科师资为主体,联合专科和社区基地师资对全科规培学员进行全方位的培养应该是我国医疗改革的重中之重。

关键词：综合医院全科医疗科弥补医学裂痕全科医生培养

Long acting carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor resection

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2022年第4期16卷 536-545页

作者： Sunhui Chen qiujun Qiu Dongdong wang Dejun She Bo Yin Meihong Chai Huining He Dong Nyoung Heo Jianxin wang Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China Department of Radiology Huashan HospitalFudan UniversityShanghai 200040China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical UniversityTianjin 300070China Department of Dental Materials School of DentistryKyung Hee UniversitySeoul 02447Republic of Korea

Many scientific efforts have been made to penetrate the blood-brain barrier and target glioblastoma cells,but the outcomes have been *** attention should be given to local inhibition of recurrence after glioblastoma resection to meet real medical needs.A biodegradable wafer containing the chemotherapeutics carmustine(1,3-bis(2-chloroethyl)-1-nitrosourea,BCNU)was the only local drug delivery system approved for clinical glioblastoma treatment,but with a prolonged survival time of only two months and frequent side *** this study,to improve the sustained release and prolonged therapeutic effect of drugs for inhibiting tumor recurrence after tumor resection,both free BCNU and BCNU-poly(lactic-co-glycolic acid)(the ratio of lactic acid groups to glycolic acid groups is 75/25)nanoparticles were simultaneously loaded into natural extracellular matrix hydrogel from pigskin to prepare BCNU *** hydrogel was injected into the resection cavity of a glioblastoma tumor immediately after tumor removal in a fully characterized resection rat *** drugs were released instantly to kill the residual tumor cells,while drugs in nanoparticles were continuously released to achieve a continuous and effective inhibition of the residual tumor cells for 30 *** combined actions effectively restricted tumor growth in ***,this strategy of local drug implantation and delivery may provide a reliable method to inhibit the recurrence of glioblastoma after tumor resection in vivo.

关键词： BCNU glioblastoma recurrence tumor resection nanoparticles hydrogel

壮药白花九里明对高血压大鼠模型的心血管功能保护作用的实验研究

在线全文

学校读者我要写书评

暂无评论

右江医学 2021年第4期49卷 250-253页

作者：黎飞彤方高根王彩冰孙悦黄章南黎智丹王秋君右江民族医学院广西百色533000 右江民族医学院生理学研究室广西百色533000

目的探讨白花九里明对高血压大鼠模型的心血管功能保护作用。方法将SD大鼠48只随机均分为正常对照组和高血压模型组、替米沙坦组及白花九里明低、中、高浓度组,每组8只大鼠,每天灌胃一次,灌胃量按大鼠体重10 mL/kg计算,连续7天;同时,正... 详细信息

目的探讨白花九里明对高血压大鼠模型的心血管功能保护作用。方法将SD大鼠48只随机均分为正常对照组和高血压模型组、替米沙坦组及白花九里明低、中、高浓度组,每组8只大鼠,每天灌胃一次,灌胃量按大鼠体重10 mL/kg计算,连续7天;同时,正常对照组给予0.9%氯化钠注射液,其余各组给予5 mg/mL地塞米松注射液,每天皮下注射一次,注射量按大鼠体重3 mL/kg计算,连续7天。各组大鼠于末次用药后30 min经左侧颈总动脉插管和右侧颈外静脉插管测定收缩压(SBP)、舒张压(DBP)、心率(HR)、中心静脉压(CVP)。结果高血压模型组的SBP、DBP明显高于其余各组(P0.05)。各组的HR、CVP在组间两两比较均无统计学意义(P>0.05)。结论白花九里明能抵消地塞米松诱导高血压模型的血管收缩和高血压现象,使血压恢复正常,也能消除地塞米松对心脏生物电干扰和心泵功能降低的不良趋向,达到保护心血管功能的作用。

关键词：白花九里明高血压模型血压心率中心静脉压大鼠

Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC)

在线全文

学校读者我要写书评

暂无评论

Nano Research 2019年第3期12卷 659-667页

作者： Xin Xu Weijing Yang qiujun Liang Yanan Shi Wenxin Zhang Xiao wang Fenghua Meng Zhiyuan Zhong Lichen Yin Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) the Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University Suzhou 215123 China Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

Co-delivery of anti-inflammatory siRNA and hydrophilic drug provides a promising approach for the treatment of ulcerative colitis (UC). However, lack of a suitable and efficient co-delivery carrier poses critical challenge against their utilization. We herein developed macrophage-targeting, reversibly crossli nked polymersomes (TKPR-RCP) based on the TKPR-modified, poly(ethyle ne glycol)-b-poly(trimethylene carbonate-codithiolane trimethylene carbonate)-b-polyethylenimine (PEG-P(TMC-DTC)-PEI) triblock copolymer, which could efficiently encapsulate TNF-α siRNA and dexamethasone sodium phosphate (DSP) in their hydrophilic core. The cationic PEI segments provided additional electrostatic interactions with cargo molecules to promote the encapsulatiion, and disulfide crosslinking of the polymersome membrane endowed the TKPR-RCP with high colloidal stability. Because the cationic PEI was embedded in the hydrophilic core, the polymersomes displayed neutral surface charge and thus possessed high serum stability. The TKPR-RCP co-encapsulating TNF-α siRNA and DSP could be efficiently internalized by macrophages (~98%) and undergo redox-responsive membrane de-crosslinking to accelerate cargo release in the cytoplasm, thus inducing efficient gene silencing and anti-inflammatory effect .Intravenous injectio n of the co-delivery TKPR-RCP mediated pote nt and cooperative anti-inflammatory effect in inflamed colons of UC mice, and significantly prevented animals from colonic injury. This study therefore provides a promising approach for the co-delivery of hydrophilic drug/siRNA toward the treatment of inflammatory bowel diseases.

关键词： ulcerative colitis (UC) anti-inflammatory therapy polymersomes reversible crosslinking siRNA/drug co-delivery macrophage targeting

Selective ischemic-hemisphere targeting Ginkgolide B liposomes with improved solubility and therapeutic efficacy for cerebral ischemia-reperfusion injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2023年第2期18卷 76-93页

作者： Yang Li Miaomiao Zhang Shiyi Li Longlong Zhang Jisu Kim qiujun Qiu Weigen Lu Jianxin wang Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai201203China National Pharmaceutical Engineering and Research Center China State Institute of Pharmaceutical IndustryShanghai 201203China

Cerebral ischemia-reperfusion injury(CI/RI)remains the main cause of disability and death in stroke patients due to lack of effective therapeutic *** of the main issues related to CI/RI treatment is the presence of the blood-brain barrier(BBB),which affects the intracerebral delivery of *** B(GB),a major bioactive component in commercially available products of Ginkgo biloba,has been shown significance in CI/RI treatment by regulating inflammatory pathways,oxidative damage,and metabolic disturbance,and seems to be a candidate for stroke ***,limited by its poor hydrophilicity and lipophilicity,the development of GB preparations with good solubility,stability,and the ability to cross the BBB remains a ***,we propose a combinatorial strategy by conjugating GB with highly lipophilic docosahexaenoic acid(DHA)to obtain a covalent complex GB-DHA,which can not only enhance the pharmacological effect of GB,but can also be encapsulated in liposomes *** amount of finally constructed Lipo@GB-DHA targeting to ischemic hemisphere was validated 2.2 times that of free solution in middle cerebral artery occlusion(MCAO)*** to the marketed ginkgolide injection,Lipo@GB-DHA significantly reduced infarct volume with better neurobehavioral recovery in MCAO rats after being intravenously administered both at 2 h and 6 h *** levels of reactive oxygen species(ROS)and high neuron survival in vitro was maintained via Lipo@GB-DHA treatment,while microglia in the ischemic brain were polarized from the pro-inflammatory M1 phenotype to the tissue-repairing M2 phenotype,which modulate neuroinflammatory and *** addition,Lipo@GB-DHA inhibited neuronal apoptosis via regulating the apoptotic pathway and maintained homeostasis by activating the autophagy ***,transforming GB into a lipophilic complex and loading it into liposomes provides a promising nanomedicine strategy with excellent CI/RI therapeu

关键词： Ginkgolide B Cerebral ischemia reperfusion injury(CI/RI) Docosahexaenoic acid Liposomes Brain targeting Microglia

全科医学住院医师规范化培训专科带教模式的探索

在线全文

学校读者我要写书评

暂无评论

中国继续医学教育 2021年第9期13卷 88-91页

作者：姜礼红孟佳王秋军张明明林琳李文静姜睿张喻淇哈尔滨医科大学附属第二医院全科医疗科黑龙江哈尔滨150086

发展全科培养人才是关键,综合性医院全科基地全体师资应该承担起全科医师的培训使命。我国已经形成了较为系统的全科规范化培训体系,但是在工作中仍存在一些实际问题需要探讨,全科学员轮转过程中大部分时间是在专科轮转,专科师资的带教... 详细信息

发展全科培养人才是关键,综合性医院全科基地全体师资应该承担起全科医师的培训使命。我国已经形成了较为系统的全科规范化培训体系,但是在工作中仍存在一些实际问题需要探讨,全科学员轮转过程中大部分时间是在专科轮转,专科师资的带教模式和方法是否符合全科住培细则的要求是全科教学的重点,全科住培专科带教模式的探索是目前亟待解决的问题。文章从加快全科医生的培养、目前专科轮转现状和全科住培工作专科带教模式的探索三个方面进行论述,实践证明这种专科师资带教全科学员的培养模式有利于加强全科医学学科建设,运用全科医学思维和方式系统化、规范化培训全科医生,提高人才培养质量。

关键词：教育全科医学住院医师专科轮转带教模式全科思维

全科住院医师在风湿免疫科轮转时带教模式的探讨

在线全文

学校读者我要写书评

暂无评论

中国毕业后医学教育 2022年第4期6卷 311-314页

作者：聂英坤姜礼红孟佳姜睿王秋军张明明张喻淇张蕾哈尔滨医科大学附属第二医院风湿免疫科黑龙江哈尔滨150086 哈尔滨医科大学附属第二医院全科医疗科黑龙江哈尔滨150086

目的探索全科住院医师在风湿免疫科规范化培训的带教模式和方法。方法本文根据风湿病的特点和全科医疗的需求,从分层教学、多样化教学模式、规范管理与考核制度三方面对全科住院医师在风湿免疫科的带教方法进行阐述。结果专科分层多样... 详细信息

目的探索全科住院医师在风湿免疫科规范化培训的带教模式和方法。方法本文根据风湿病的特点和全科医疗的需求,从分层教学、多样化教学模式、规范管理与考核制度三方面对全科住院医师在风湿免疫科的带教方法进行阐述。结果专科分层多样化模式带教全科住院医师的培养效果好,能够激发住院医师学习兴趣,培养自学能力、提升基础理论和临床实践能力。结论多样化、分层教学方法,有利于培养出具有常见风湿病诊治能力的全科医师,提升社区卫生服务质量。

关键词：全科医学住院医师风湿病学带教模式

In Vitro Study of Ultrasound on Multidrug Resistance in MDR Human Hepatoma HepG_2 Cells

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Clinical Oncology 2008年第3期5卷 165-171页

作者： qiujun Qi Baojin Zhai Yumian Guo Zhihong wang Feng Wu The Traditional Chinese Medical Hospital of Tianjin Hedong District Tianjin 300162 China. Department of Neurological Surgery The Affiliated Hospital of The Medical College of Chinese People＇s Armed Police Force Tianjin 300162 China. Institute of Ultrasound and Engineering in Medicine Chongqing University of Medical Science Chongqing 400016 China.

OBJECTIVE The aim of the study was to examine the reversal effects of ultrasound （US） on the MDR in HepG2/ADM, a HepG2 cell line resistant to Adriamycin （ADM）, and to study the mechanism of US action.METHODS Using the MTT assay, the effects of US on MDR in HepG2/ADR cells were studied. Before and after the treatment with 0.5 W/cm^2 low intensity ultrasound （LIUS）, the expression of the MDR-related genes, mdrl, mrp and lrp was assayed with the reverse transcriptase polymerase chain reaction （RT-PCR） and the levels of their respective protein expression determined by flow cytometry. By using confocal laser scanning microscopy （CLSM）, we examined the intracellular daunorubicin （DNR） distribution, and the effects on the cells of treatment with US or DNR.RESULTS LIUS significantly reversed MDR in HepG2/ADR cells. After treatment with LIUS at 0.5 W/cm^2, chemosensitivity to ADM and DNR increased 3.35-fold and 2.81-fold, respectively. The reversal activity by LIUS plus verapamil （VER） was stronger than with either US or VER alone. After treatment with 0.5 W/cm^2, the expression of both the MDR1 and the MRP mRNA genes began to decline （P 〈 0.01 and P 〈 0.05, respectively）; the expression of LRP showed no significant changes. Changes in the expression of the P-glycoprotein （P-gp） and MRP were similar to those of their mRNA expressions. Results of the CLSM showed that administration of US （0. 5 W/cm^2） or VER （15.7 uM） with DNR to HepGa/ADM cells showed a significant change in the distribution of DNR in the cells.CONCLUSION Our results show that LIUS can reverse MDR. The reversal effects are stronger than those of either US or VER alone, when combined with VER administration. As LIUS is noninvasive causing no toxicity, it might have potential for clinical application. The reversal mechanism needs further study.

关键词： multidrug resistance (MDR) HepG2/ADM ultra-sound (US) reversal.

Phyto-phospholipid complexes(phytosomes): A novel strategy to improve the bioavailability of active constituents

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2019年第3期14卷 265-274页

作者： Mei Lu qiujun Qiu Xiang Luo Xinrong Liu Jing Sun Cunyang wang Xiangyun Lin Yihui Deng Yanzhi Song College of Pharmacy Shenyang Pharmaceutical UniversityShenyang110016China College of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyang110016China

Although active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholipid complexes represents a promising approach to increase the oral bioavailability of active constituents, which is consist of ‘‘label-friendly'phospholipids and active constituents. Hydrogen bond interactions between active constituents and phospholipids enable phospholipid complexes as an integral part. This review provides an update on four important issues related to phyto-phospholipid complexes: active constituents, phospholipids, solvents, and stoichiometric ratios. We also discuss recent progress in research on the preparation, characterization, structural verification, and increased bioavailability of phyto-phospholipid complexes.

关键词： Phyto-phospholipid complexes Active constituents Hydrogen bonds Bioavailability