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Inappropriate secretion of antidiuretic hormone:a rare complication after common bile duct exploration

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Hepatobiliary & Pancreatic Diseases International 2009年第5期8卷 544-546页

作者： Ruan, Yu Zhang, Wei wang, qing-qing Zhejiang Univ Sch Med Dept Endocrinol Sri Run Run Shaw Hosp Hangzhou 310016 Zhejiang Peoples R China Zhejiang Univ Sir Run Run Shaw Inst Clin Med Hangzhou 310016 Zhejiang Peoples R China Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Surg Hangzhou 310003 Zhejiang Peoples R China

BACKGROUND: The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) as a dilutional hyponatremia is due to a pathological increase of antidiuretic hormone (ADH). It is characterized by hyponatremia and decreased serum osmolarity as well as an increase in urinary osmolarity. The most common etiological factors of this syndrome include diseases or trauma of the central nervous system and malignant tumor or inflammation of the lung. SIADH following abdominal surgery is rare. METHODS: We report the case of a 68-year-old woman who developed, 24 hours after common bile duct exploration and stone removal, continuous hyponatremia for 20 days and clinical manifestations of nausea, vomiting, and lethargy without focal neurological signs. RESULT: Laboratory examinations supported the diagnosis of SIADH. After therapy with fluid restriction, the patient recovered. CONCLUSION: There are diverse causes for SIADH. It is important to have kept this clinical possibility in mind in the differential diagnosis of refractory hyponatremia under any circumstances.

关键词： inappropriate antidiuretic hormone syndrome surgery hyponatremia

Multidrug resistance protein 3 R652G may reduce susceptibility to idiopathic infant cholestasis

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World Journal of Gastroenterology 2009年第46期15卷 5855-5858页

作者： xiu-Qi Chen Lin-Lin wang qing-Wen Shan qing Tang Shu-Jun Lian Department of Pediatrics First Affiliated HospitalGuangxi Medical University Nanning 530021 Guangxi ZhuangAutonomous Region China

AIM:To evaluate the role of genetic factors in the pathogenesis of idiopathic infant ***:We performed a case-control study,in-cluding 78 infants with idiopathic infant cholestasis and 113 healthy infants as *** DNA was extracted from peripheral venous blood leukocytes us-ing phenol chloroform *** chain reaction was used to amplify the multidrug resistance protein 3(MDR3)R652G fragment,and products were sequenced using the ABI 3100 ***:The R652G single nucleotide polymorphism(SNP)was significantly more frequent in healthy infants(allele frequency 8.0%)than in patients(allele frequency 2.60%)(P < 0.05),odds ratio,0.29;95% confidence interval,*** conjugated bilirubin in patients with the AG genotype was significantly lower than in those with the AA genotype(44.70 ± 6.15 μmol/L vs 95.52 ± 5.93 μmol/L,P < 0.05).CONCLUSION:MDR3 R652G is negatively correlated with idiopathic infant *** with the R652G SNP in Guangxi of China may have reduced susceptibility to infant intrahepatic cholestasis.

关键词： Multidrug resistance protein 3 Singlenucleotide polymorphisms R652G Infant Cholestasis

Prevalence of Hyperuricemia and Associated Factors in the Yi Farmers and Migrants of Southwestern China: A Cross-sectional Study

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Biomedical and Environmental Sciences 2020年第6期33卷 448-453页

作者： wang qing qing WAN Shao Ping SHAN Guang Liang WU Wen Bo YONG Zheng Ping PEI Jiao Sichuan Cancer Hospital&Institute Chengdu 610041SichuanChina School of Medicine University of Electronic Science and Technology of ChinaChengdu 610054SichuanChina School of Basic Medicine Peking Union Medical CollegeInstitute of Basic Medical SciencesChinese Academy of Medical SciencesBeijing 100005China Sichuan Academy of Medical Science&Sichuan Provincial People's Hospital Chengdu 610072SichuanChina

Hyperuricemia(HUA) is a common metabolic disease caused by increased formation or reduced excretion of uric acid. Although HUA does not cause direct damage to the body, it is closely related to the occurrence of vario... 详细信息

关键词： Hyperuricemia damage diseases

Potential hepatic and renal toxicity induced by the biflavonoids from Ginkgo biloba

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Chinese Journal of Natural Medicines 2019年第9期17卷 672-681页

作者： LI Yun-Ying LU Xiao-Yan SUN Jia-Li wang qing-qing ZHANG Yao-Dan ZHANG Jian-Bing FAN Xiao-Hui Tianjin University of Traditional Chinese Medicine Tianjin 301617China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Zhejiang University-Wanbangde Pharmaceutical Group Joint Research Center for Chinese Medicine Modernization Hangzhou 310058China

Evidence continues to grow on potential health risks associated with Ginkgo biloba and its *** biflavonoid is a subclass of the flavonoid family in Ginkgo biloba with a plenty of pharmacological properties,the potential toxicological effects of biflavonoids remains largely ***,the aim of this study was to investigate the in vitro and in vivo toxicological effects of the biflavonoids from Ginkgo biloba(i.e.,amentoflavone,sciadopitysin,ginkgetin,isoginkgetin,and bilobetin).In the in vitro cytotoxicity test,the five biflavonoids all reduced cell viability in a dose-dependent manner in human renal tubular epithelial cells(HK-2)and human normal hepatocytes(L-02),indicating they might have potential liver and kidney *** the in vivo experiments,after intragastrical administration of these biflavonoids at 20 mg·kg^–1·d^–1 for 7 days,serum biochemical analysis and histopathological examinations were *** activity of alkaline phosphatase was significantly increased after all the bifl avonoid administrations and widespread hydropic degeneration of hepatocytes was observed in ginkgetin or b ilobetin-treated ***,the five biflavonoids all induced acute kidney injury in treated mice and the main pathological lesions were confirmed to the tubule,glomeruli,and interstitium *** the in vitro and in vivo results suggested that these biflavonoids may be more toxic to the kidney than the liver,we further detected the mechanism of biflavonoids-induced *** increased TUNEL-positive cells were detected in kidney tissues of biflavonoids-treated mice,accompanied by elevated expression of proapoptotic protein BAX and unchanged levels of antiapoptotic protein BCL-2,indicating apoptosis was involved in biflavonoids-induced *** together,our results suggested that the five biflavonoids from Ginkgo biloba may have potential hepatic and renal toxicity and more attentions should be paid to ensure Ginkgo biloba p

关键词： Biflavonoids Ginkgo biloba Potential toxicity Liver Kidney Apoptosis

Muscle hypertrophy in transgenic mice due to over-expression of porcine myostatin mutated at its cleavage site

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Journal of Integrative Agriculture 2016年第11期15卷 2571-2577页

作者： QIAN Li-li MA De-zun GAO Peng-fei JIANG Sheng-wang wang qing-qing CAI Chun-bo XIAO Gao-jun AN Xiao-rong CUI Wen-tao State Key Laboratory of Agrobiotechnology China Agricultural University State Key Laboratory for Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural Sciences

Myostatin, a member of the transforming growth factor beta（TGF-β） superfamily, is a dominant inhibitor that acts to limit skeletal muscle growth and development. In this study, we generated transgenic mice that express porcine myostatin containg mutations at its cleavage site（RSRR） to evaluate its effect on muscle mass. Results showed that the weight of four skeletal muscles including gastrocnemius, rectus femoris, tibialis anterior, and pectoralis increased by 17.83 and 28.39%, 21.76 and 28.70%, 34.31 and 41.62%, 53.21 and 27.54% in transgenic male and female mice, respectively, compared to their corresponding non-transgenic control mice. Measurement of muscle fiber size and number indicated that the mean myofiber size increased by 50.73 and 61.30% in transgenic male and female mice respectively compared to the non-transgenic controls. However, there was no difference in the number of myofiber between transgenic and non-transgenic male mice. These results clearly demonstrated that the increase in skeletal muscle mass in transgenic mice is caused by hypertrophy instead of hyperplasia.

关键词： porcine myostatin muscle mass transgenic mice mutation hypertrophy hyperplasia

Receptor-mediated gene delivery using polyethylenimine (PEI) coupled with polypeptides targeting FGF receptors on cells surface

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第11期7卷 906-911页

作者： LI Da wang qing-qing TANG Gu-ping HUANG Hong-liang SHEN Fen-ping LI Jing-zhong YU Hai Institute of lmmunology Zhejiang University Hangzhou 310058 China Institute of Chemical Biology and Pharmaceutical Chemistry Zhejiang University Hangzhou 310028 China

Objective: To construct a novel kind of nonviral gene delivery vector based on polyethylenimine (PEI) conjugated with polypeptides derived from ligand FGF with high transfection efficiency and according to tumor targeting ability. Methods: The synthetic polypeptides CR16 for binding FGF receptors was conjugated to PEI and the characters of the polypeptides in-cluding DNA condensing and particle size were determined. Enhanced efficiency and the targeting specificity of the synthesized vector were investigated in vitro and in vivo. Results: The polypeptides were successfully coupled to PEI. The new vectors PEI-CR16 could efficiently condense pDNA into particles with around 200 nm diameter. The PEI-CR16/pDNA polyplexes showed significantly greater transgene activity than PEI/pDNA in FGF receptors positive tumor cells in vitro and in vivo gene transfer, while no difference was observed in FGF receptors negative tumor cells. The enhanced transfection efficiency of PEI-CR16 could be blocked by excess free polypeptides. Conclusion: The synthesized vector could improve the efficiency of gene transfer and targeting specificity in FGF receptors positive cells. The vector had good prospect for use in cancer gene therapy.

关键词： FGF receptors Polyethylenimine Targeting Gene delivery Gene therapy

Effect of pyrite content on chalcopyrite flotation under different regrinding conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 49-57页

作者： Zejun wang qing Shi Guofan Zhang Yuxuan Zhu Binbin Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

This study aimed to investigate the effect of varying pyrite(Py)content on copper(Cu)in the presence of different regrinding conditions,which were altered using different types of grinding media:iron,ceramic balls,and their mixture,followed by flotation in the cleaner *** flotation performance of rough Cu concentrate can be improved by changing the regrinding conditions based on the Py *** electron microscopy,X-ray spectrometry,ethylenediaminetetraacetic acid disodium salt extraction,and X-ray photoelectron spectroscopy studies illustrated that when the Py content was high,the use of iron media in regrinding promoted the generation of hydrophilic Fe OOH on the surface of Py and improved the Cu *** ceramic medium with a low Py content prevented excessive Fe OOH from covering the surface of chalcopyrite(Cpy).Electrochemical studies further showed that the galvanic corrosion current of Cpy-Py increased with the addition of Py and became stronger with the participation of iron media.

关键词： chalcopyrite regrinding media pyrite galvanic corrosion flotation

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai Jian Hui Jia Yu wang Chun Cheng Yang qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

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可扩展路由器控制平面的高性能通信模型

软件学报 2007年第9期18卷 2205-2215页

作者：徐恪吴鲲王青青清华大学计算机科学与技术系北京100084 兰州大学信息科学与工程学院甘肃兰州730000

可扩展路由器控制平面节点间通信的瓶颈问题是制约软件体系结构大规模扩展的关键因素.针对此问题,在传统的软件体系结构的支撑模型中引入了传输适配子层的结构,上行的数据流经特征抽取与已注册的任务进行模式匹配,从而完成了对控制信息... 详细信息

可扩展路由器控制平面节点间通信的瓶颈问题是制约软件体系结构大规模扩展的关键因素.针对此问题,在传统的软件体系结构的支撑模型中引入了传输适配子层的结构,上行的数据流经特征抽取与已注册的任务进行模式匹配,从而完成了对控制信息流基于内容的分类与分流,提高了其有效通信率.进一步根据任务的分布率、分散数和流量率这3个特征对模型进行了性能分析,表明了适配层的引入可以消除面间冗余流量和通信的可扩展瓶颈.最后通过实验验证了理论分析的正确性.

关键词：路由器:路由器软件体系结构可扩展性传输适配子层