Multidrug resistance protein 3 R652G may reduce susceptibility to idiopathic infant cholestasis

作     者：xiu-Qi Chen Lin-Lin Wang Qing-Wen Shan Qing Tang Shu-Jun Lian 

作者机构：Department of Pediatrics First Affiliated HospitalGuangxi Medical University Nanning 530021 Guangxi ZhuangAutonomous Region China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第46期

页      面：5855-5858页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 0401[教育学-教育学] 04[教育学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：Supported by Guangxi Scientifi c Research and Technological Development Projects Funding(Ministry Science& Technology of Guangxi No.0816004-6) 

主　　题：Multidrug resistance protein 3 Singlenucleotide polymorphisms R652G Infant Cholestasis 

摘      要：AIM:To evaluate the role of genetic factors in the pathogenesis of idiopathic infant ***:We performed a case-control study,in-cluding 78 infants with idiopathic infant cholestasis and 113 healthy infants as *** DNA was extracted from peripheral venous blood leukocytes us-ing phenol chloroform *** chain reaction was used to amplify the multidrug resistance protein 3(MDR3)R652G fragment,and products were sequenced using the ABI 3100 ***:The R652G single nucleotide polymorphism(SNP)was significantly more frequent in healthy infants(allele frequency 8.0%)than in patients(allele frequency 2.60%)(P 0.05),odds ratio,0.29;95% confidence interval,*** conjugated bilirubin in patients with the AG genotype was significantly lower than in those with the AA genotype(44.70 ± 6.15 μmol/L vs 95.52 ± 5.93 μmol/L,P 0.05).CONCLUSION:MDR3 R652G is negatively correlated with idiopathic infant *** with the R652G SNP in Guangxi of China may have reduced susceptibility to infant intrahepatic cholestasis.