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The application of porous Si photonic crystals for metal-resonance enhanced fluorescence

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Optoelectronics Letters 2019年第6期15卷 439-443页

作者： wang jia-jia jiaZhen-hong Postdoctoral Station of Computer Science and Technology Xinjiang UniversityUrumqi 830046China School of Information Science and Engineering Xinjiang UniversityUrumqi 830046China

This paper has demonstrated the resonance fluorescence enhancement of R6G when gold nanoparticles(Au NPs) deposited in the porous Si photonic crystal device. Both of microcavity(MC) and distributed Bragg reflector(DBR) with different parameters are investigated for making the photon transmission of photonic crystal device play an optimal role in enhancing fluorescence resonance. While minor changes were observed on the DBR substrates, a significant change in the intensity of enhanced fluorescence varies with the defect modes of MC substrates. Particularly, the strongest enhancement has been presented as the MC defect mode wavelength located at the maximum absorption wavelength of Au NPs. In this case, the fluorescence intensity of R6G on MC device is 2.5 times of that of R6G based on DBR device.

关键词： porous resonance defect

Expression and functional characterization of platelet-derived growth factor receptor-like gene

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World Journal of Gastroenterology 2010年第12期16卷 1465-1472页

作者： Guo, Feng-Jie Zhang, Wei-jia Li, Ya-Lin Liu, Yan Li, Yue-Hui Huang, jian wang, jia-jia Xie, Ping-Li Li, Guan-Cheng Cent S Univ Xiangya Sch Med Canc Res Inst Changsha 410078 Hunan Peoples R China

AIM:To investigate the role of platelet-derived growth factor receptor-like gene(PDGFRL)in the anti-cancer therapy for colorectal cancers(CRC).METHODS:PDGFRL mRNA and protein levels were measured by reverse transcription-polymerase chain reaction(RT-PCR)and immunohistochemistry in CRC and colorectal normal *** prokaryotic expression vector was carried out in Escherichia coli(***),and purified by immobilized metal affinity *** effect of PDGFRL protein on CRC HCT-116 cells was detected by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide(MTT),clone counting,cell cycle,and wound healing ***:Both RT-PCR and immunohistochemistry showed that the expression of PDGFRL in colorectal normal tissues was higher than in cancer *** pET22b-PDGFRL prokaryotic expression vector was successfully expressed in ***,and the target protein was expressed in the form of inclusion *** purification and refolding,recombinant human PDGFRL(rhPDGFRL)could efficiently inhibit the proliferation and invasion of CRC HCT-116 cells detected by MTT,clone counting and wound healing ***,rhPDGFRL arrested HCT-116 cell cycling at the G0/G1 ***:PDGFRL is a potential gene for application in the anti-cancer therapy for CRC.

关键词： Platelet-derived growth factor receptorlike Colorectal cancer Prokaryotic expression Reverse transcription-polymerase chain reaction Immunohistochemistry

The peroxisomal matrix shuttling receptor Pex5 plays a role in FB1 production and virulence in Fusarium verticillioides

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Journal of Integrative Agriculture 2022年第10期21卷 2957-2972页

作者： YU Wen-ying LIN Mei YAN Hui-juan wang jia-jia ZHANG Sheng-min LU Guo-dong wang Zong-hua Won-Bo SHIM State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops/Fujian Universities Key Laboratory for Plant–Microbe Interaction College of Life ScienceFujian Agriculture and Forestry UniversityFuzhou 350002P.R.China Department of Plant Pathology and Microbiology Texas A&M UniversityCollege StationTX 77843-2132USA Marine Biotechnology Center Fuzhou Institute of OceanographyMinjiang UniversityFuzhou 350108P.R.China

The peroxisomal matrix oxidase,catalase and peroxidase are imported peroxisomes through the shuttling receptors,which regulates the cellular oxidative homeostasis and ***,we report that PTS1 shuttling receptor FvPex5 is involved in the localization of PTS1,utilization of carbon sources and lipids,elimination ROS,cell wall stress,conidiation,fumonisin B_(1)(FB_(1))production,and virulence in maize pathogen Fusarium ***,differential expression of PTS1-,PTS2-,PEX-and FB_(1)toxin-related genes in wild type andΔFvpex5 mutant were examined by RNA-Seq analyses and confirmed by RT-PCR *** addition,different expression of PTS1 and PTS2 genes of theΔFvpex5 mutant were enriched in diverse biochemical pathways,such as carbon metabolism,nitrogen metabolism,lipid metabolism and the oxidation balance by combining GO and KEGG ***,we showed that FvPex5 is involved in the regulation of genes associated with PTS,thereby affecting the oxidation balance,FB_(1)and virulence in *** results help to clarify the functional divergence of Pex5 orthologs,and may provide a possible target for controlling *** infections and FB_(1)biosynthesis.

关键词： Fusarium verticillioides FvPex5 PTS fumonisin B1 virulence

MPtostream:an OpenMP compiler for CPU-GPU heterogeneous parallel systems

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Science China(Information Sciences) 2012年第9期55卷 1961-1971页

作者： YANG XueJun,TANG Tao ,wang GuiBin,jia jia & XU XinHai National Laboratory for Parallel and Distributed Processing,National University of Defense Technology,Changsha 410073,China 1. National Laboratory for Parallel and Distributed Processing National University of Defense Technology Changsha 410073 China

In light of GPUs’ powerful floating-point operation capacity,heterogeneous parallel systems incorporating general purpose CPUs and GPUs have become a highlight in the research field of high performance computing(HPC).However,due to the complexity of programming on GPUs,porting a large number of existing scientific computing applications to the heterogeneous parallel systems remains a big *** OpenMP programming interface is widely adopted on multi-core CPUs in the field of scientific *** effectively inherit existing OpenMP applications and reduce the transplant cost,we extend OpenMP with a group of compiler directives,which explicitly divide tasks among the CPU and the GPU,and map time-consuming computing fragments to run on the GPU,thus dramatically simplifying the *** have designed and implemented MPtoStream,a compiler of the extended OpenMP for AMD’s stream processing *** experimental results show that programming with the extended directives deviates from programming with OpenMP by less than 11% modification and achieves significant speedup ranging from 3.1 to 17.3 on a heterogeneous system,incorporating an Intel Xeon E5405 CPU and an AMD FireStream 9250 GPU,over the execution on the Xeon CPU alone.

关键词： GPGPU stream OpenMP compiler

Monocyte chemotactic protein-inducing protein 1 negatively regulating asthmatic airway inflammation and mucus hypersecretion involvingγ-aminobutyric acid type A receptor signaling pathway in vivo and in vitro

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Chinese Medical Journal 2021年第1期134卷 88-97页

作者： Guang-Ming Dai jia-jia wang Zhi-Hong Chen Ya-Juan Ran Huo-Jin Deng Ruo-Lin Mao Tao Zhu Department of Respiratory Medicine First People's Hospital of Suining CitySuiningSichuan 629000China Department of Rheumatology Medicine Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Respiratory Medicine Zhongshan Hospital of Fudan UniversityShanghai 200032China Department of Pharmacy Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Respiratory Medicine Zhujiang Hospital of Southern Medical UniversityGuangzhouGuangdong 510280China Department of Respiratory Medicine Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Background:Mounting evidence,consistent with our previous study,showed thatγ-aminobutyric acid type A receptor(GABAAR)played an indispensable role in airway inflammation and mucus hypersecretion in *** chemotactic protein-inducing protein 1(MCPIP1)was a key negative regulator of *** studies showed that inflammation was largely suppressed by enhanced MCPIP1 expression in many inflammatory ***,the role and potential mechanism of MCPIP1 in airway inflammation and mucus hypersecretion in asthma were still not well *** study was to explore the role of MCPIP1 in asthmatic airway inflammation and mucus hypersecretion in both mice and BEAS-2B cells,and its potential ***:In vivo,mice were sensitized and challenged by ovalbumin(OVA)to induce *** inflammation and mucus secretion were *** vitro,BEAS-2B cells were ***(IL)-13 was used to stimulate inflammation and mucus hypersecretion in ***1 Lentiviral vector(LA-MCPIP1)and plasmid-MCPIP1 were used to up-regulate MCPIP1 in lung and cells,***-1,thymic stromal lymphopoietin(TSLP),mucin 5AC(MUC5AC),MCPIP1,and GABAARβ2 expressions were measured in both lung and BEAS-2B *** staining was performed to observe the expression of GABAARβ2 in ***:MCPIP1 was up-regulated by LA-MCPIP1(P<0.001)and plasmid-MCPIP1(P<0.001)in lung and cells,***-induced airway inflammation and mucus hypersecretion,OVA-enhanced MCP-1,TSLP,MUC5AC,and GABAARβ2 expressions,and OVA-reduced MCPIP1 were significantly blunted by LA-MCPIP1 in mice(all P<0.001).IL-13-enhanced MCP-1,TSLP,MUC5AC,and GABAARβ2 expressions,and IL-13-reduced MCPIP1 were markedly abrogated by plasmid-MCPIP1 in BEAS-2B cells(all P<0.001).Conclusion:The results of this study suggested that OVA and IL-13-induced airway inflammation and mucus hypersecretion were negatively regulated by MCPIP1 in both lung and BEAS-2B cells,involving GABAAR si

关键词： Airway inflammation Airway mucus hypersecretion Gamma-aminobutyric acid type A receptor GABAAR IL-13 MCPIP1 Monocyte chemotactic protein-inducing protein 1 Ovalbumin

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美国“在家上学”运动与高校的应对

复旦教育论坛 2012年第3期10卷 77-81页

作者：王佳佳江苏大学教师教育学院江苏镇江212013

随着美国"在家上学"运动的迅速发展,越来越多"在家上学"的学生开始进入高校学习或准备读大学。针对这一特殊群体,美国高校采取的政策主要有三类:完全拒斥、特别青睐以及与其他学生一视同仁;但整体而言,越来越多的美国高校开始接受和认... 详细信息

随着美国"在家上学"运动的迅速发展,越来越多"在家上学"的学生开始进入高校学习或准备读大学。针对这一特殊群体,美国高校采取的政策主要有三类:完全拒斥、特别青睐以及与其他学生一视同仁;但整体而言,越来越多的美国高校开始接受和认可这类学生。美国高校政策转变的动力在于美国高等教育的市场化机制、分权制管理体制以及对多样性的珍视。对于以"在家上学"为代表的多元化的教育形式,我国高校也应采取包容的态度,满足多元化的教育需求。

关键词：美国在家上学家庭学校高等学校

也论“多数人统治”的民主困境——以“卡潘/盖洛普对公立学校的民意调查”为例

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教育科学 2009年第2期25卷 69-73页

作者：王佳佳华东师范大学教育学系上海200062

民主要求实行"多数人统治",依据民意来做出决策。但事实上,实行"多数人统治"这种民主模式必须满足一些前提条件,包括理性的公民、充分掌握信息以及有效参与等。从"卡潘/盖洛普对公立学校的民意调查"这种较为科学的反映民意的调查手段可... 详细信息

民主要求实行"多数人统治",依据民意来做出决策。但事实上,实行"多数人统治"这种民主模式必须满足一些前提条件,包括理性的公民、充分掌握信息以及有效参与等。从"卡潘/盖洛普对公立学校的民意调查"这种较为科学的反映民意的调查手段可以发现,由于这三种前提无法充满满足,所以实行"多数人的统治"这种民主模式、依据民意来做出决策必然会面临困境。审慎起见,民意只能用于决策的参考而非依据。

关键词：卡潘/盖洛普公立学校民意调查民主

Ramsay Hunt Syndrome in a Patient with H7N9 Influenza Virus Infection

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Chinese Medical Journal 2015年第3期128卷 417-418页

作者： jia-jia wang jian-An Huang Da-Guo Zhao Jun Jin Sheng-Lan Liu DusUn R Fraidenburg Qiang Guo Departments of Respiratory Emergency and Critical Care Medicine The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China Department of Medicine Division of Pulmonary Critical Care Sleep and Allergy Medicine University of Illinois Chicago United States of America

To the Editor： We would like to present Ramsay Hunt syndrome （RHS） as a complication of H7N9 influenza virus infection. On January 22, 2014, a 57-year-old man with a history of rheumatoid arthritis was admitted to the hospital complaining of dyspnea and fever. Infection with influenza A （H7N9） virus was confirmed from a tracheal aspirate sample using polymerase chain reaction （PCR） assays. Hypoxemia led to non-invasive mechanical ventilation on the first day. Methylprednisolone （80 mg intravenous every 24 hours） and oseltamivir were administered starting from the first day. On day 11, otalgia and secretion of yellow exudate was associated with a swollen right external auditory canal. Four days later, a vesicular rash developed at the right earcanal and pinna. Symptoms progressed over the following 48 hours in which right facial palsy, dysphagia, hoarseness, hearing loss, and vertigo were all present in the patient [Figure 1 ].

关键词：耳道感染关节炎类风湿呼吸人工呼吸困难肌阵挛性小脑性协同失调聚合酶链反应面神经麻痹

论数据财产权的收益、成本与去产权化规则构造

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河北法学 2024年第10期42卷 122-148页

作者：王佳佳清华大学法学院北京100084

是否应当在数据之上确立财产权以及如何确权仍是数据基础制度建设中的重大理论问题。引入数据财产权的成本收益分析,可将数据确权与否的判断简化为效率视角下的成本与收益对比。数据财产权的收益整体有限,数据确权难以降低交易成本,静... 详细信息

是否应当在数据之上确立财产权以及如何确权仍是数据基础制度建设中的重大理论问题。引入数据财产权的成本收益分析,可将数据确权与否的判断简化为效率视角下的成本与收益对比。数据财产权的收益整体有限,数据确权难以降低交易成本,静态收益有限,而将数据财产权等同于数据投资激励是对现实的过度简化,数据投资激励存在多重驱动机制,需财产权激励的情形亦有限。与有限的收益相比,创设与实施数据财产权的成本却是不容忽视的。数据财产化确权将产生显著的交易成本、寻租成本、保护成本与创新成本。为最大限度地降低产权化成本,应当通过设置适格的客体要件、有限的权利内容以及宽泛的权利限制机制,实现数据财产权的去产权化。

关键词：数据财产权成本收益去产权化产权规则构造