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Development and identification of two novel wheat-rye 6R derivative lines with adult-plant resistance to powdery mildew and high-yielding potential

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The Crop Journal 2024年第1期12卷 308-313页

作者： Guohao Han Jing wang Hanwen Yan Tiantian Gu lijun Cao Shiyu Liu Xiuquan Li Yilin zhou Jieru Fan Zhipeng Shi Hong Liu Lihui Li Diaoguo An center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050021HebeiChina The National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China The State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China

Powdery mildew,caused by Blumeria graminis ***(Bgt),is a devastating disease that seriously threatens wheat yield and *** control this disease,host resistance is the most effective *** with the resistance genes from common wheat,alien resistance genes can better withstand infection of this highly variable *** of elite alien germplasm resources with powdery mildew resistance and other key breeding traits is an attractive strategy in wheat *** this study,three wheat-rye germplasm lines YT4-1,YT4-2,and YT4-3 were developed through hybridization between octoploid triticale and common wheat,out of which the lines YT4-1 and YT4-2 conferred adult-plant resistance(APR)to powdery mildew while the line YT4-3 was susceptible to powdery mildew during all of its growth *** genomic in situ hybridization,multi-color fluorescence in situ hybridization,multi-color GISH,and molecular marker analysis,YT4-1,YT4-2,and YT4-3 were shown to be cytogenetically stable wheat-rye 6R addition and T1RS.1BL translocation line,6RL ditelosomic addition and T1RS.1BL translocation line,and T1RS.1BL translocation line,*** with previously reported wheat-rye derivative lines carrying chromosome 6R,YT4-1 and YT4-2 showed stable APR without undesirable pleiotropic effects on agronomic ***,these novel wheat-rye 6R derivative lines are expected to be promising bridge resources in wheat disease breeding.

关键词： Powdery mildew Secale cereale Triticum aestivum Wheat-rye 6R derivatives Agronomic performance

Impact of inhaled corticosteroid use on elderly chronic pulmonary disease patients with community acquired pneumonia

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chinese Medical Journal 2024年第2期137卷 241-243页

作者： Xiudi Han Hong wang Liang chen Yimin wang Hui Li Fei zhou Xiqian Xing Chunxiao Zhang lijun Suo Jinxiang wang Guohua Yu Guangqiang wang Xuexin Yao Hongxia Yu Lei wang Meng Liu Chunxue Xue Bo Liu Xiaoli Zhu Yanli Li Ying Xiao Xiaojing Cui Lijuan Li Xuedong Liu Bin Cao Department of Pulmonary and Critical Care Medicine Qingdao Municipal HospitalQingdaoShandong 266011China Department of Nosocomial Infection Qingdao Municipal HospitalQingdaoShandong 266011China Department of Infectious Diseases Nanjing Lishui People’s HospitalNanjingJiangsu 211213China Department of Pulmonary and Critical Care Medicine National Clinical Research Center of Respiratory DiseasesCenter for Respiratory DiseasesChina-Japan Friendship HospitalBeijing 100020China Department of Respiratory Medicine Yan’an Hospital Affiliated to Kunming Medical UniversityKunmingYunnan 652199China Department of Respiratory Medicine Beijing Huimin HospitalBeijing 100054China Department of Pulmonary and Critical Care Medicine Zibo Municipal HospitalZiboShandong 255000China Department of Respiratory Medicine Beijing Luhe HospitalCapital Medical UniversityBeijing 101149China Department of Pulmonary and Critical Care Medicine Weifang No.2 People’s HospitalWeifangShandong 261599China Department of Respiratory Medicine Shandong University Affiliated Qilu Hospital(Qingdao)QingdaoShandong 266035China Department of Respiratory Medicine the 2nd Hospital of Beijing CorpsChinese Armed Police ForcesBeijing 100044China Department of Infectious Disease Qingdao University Medical College Affiliated Yantai Yuhuangding HospitalYantaiShandong 100191China Department of Respiratory Medicine Rizhao Chinese Medical Hospital Affiliated to Shandong Chinese Medical UniversityRizhaoShandong 276800China Department of Respiratory Medicine Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical UniversityBeijing 100010China Department of Occupational Medicine and Toxicology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China

To the Editor:With an aging global population,the incidences of community-acquired pneumonia(CAP)and chronic obstructive pulmonary disease(COPD)have signicantly increased.[1]Previous studies have conrmed that COPD and asthma are independently associated with the prevalence of *** use of inhaled corticosteroid(ICS),the cornerstone of treatment for asthma,COPD with frequent acute exacerbations,and asthma-COPD overlap(ACO)may induce changes in the local lung microbiome and abnormal lung immunity,ultimately,causing a signicantly increased risk of ***,in cases of pneumonia,the effect of the use of ICS on CAP mortality remains *** data from one study favored the prior use of ICS,which was associated with a signicantly lower short-term mortality rate,[2]other studies have identied no impact on *** date,data on the impact of the use of ICS on mortality,prehospitalization or during hospitalization,are scarce,particularly in the older ***,this multicenter,retrospective study explored the association between the use of ICS during hospitalization and short-term mortality in older patients with CAP and those with chronic pulmonary disease(CPD).

关键词： pneumonia patients immunity

Controlled assembly of copper phthalocyanine with 1-iodooctadecane

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chinese Science Bulletin 2003年第15期48卷 1519-1524页

作者： LEI Shengbin, wang chen, wan lijun & bai chunli center of molecular sciences, institute of chemistry, chinese academy of sciences, beijing 100080, china Correspondence should be addressed to bai chunli (e-mail: clbai@ ***) center of molecular sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

The binary assembly behavior of 1-iodoocta- decane with substituted phthalocyanine (Pc) is studied using the scanning tunneling microscopy (STM). By altering the substituted alkyl groups attached to the phthalocyanine ring, either uniform assembly or phase separation behavior can be observed. It is suggested that the strength of intermolecular interaction between phthalocyanine molecules is the determining factor for the assembly structure.

关键词：铜酞菁碘代十八烷扫描隧道电子显微镜化学结构

A Projection of Life Expectancy Based on the Global Burden of Disease Study 2019—china,1990-2030

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china CDC weekly 2023年第2期5卷 40-44页

作者： Jing Yang Ruhai bai lijun wang Xiaoqi Feng Yunning Liu Maigeng zhou National center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing MunicipalityChina School of Public Affairs Nanjing University of Science and TechnologyNanjing CityJiangsu ProvinceChina School of Population Health The University of New South WalesSydneyAustralia.

Life expectancy(LE)is an important indicator for the overall health of a population,usually refers to the total number of years a group of people at birth can expect to live,given existing age-specific mortality rates(1).Healthy china 2030,the national strategic health plan released in 2016,set a goal that by 2030,the average LE of chinese residents should reach 79 *** examine the success of the plan at its midterm stage,it is necessary to evaluate its achievements so far,and assess if the goal can be realized by 2030 in each provincial-level administrative division(PLAD)separately.

关键词： residents administrative strategic

STING and TLR9 agonists synergistically enhance the immunogenicity of SARS-CoV-2 subunit vaccine

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Nano Research 2023年第12期16卷 13322-13334页

作者： Yang Li Ziwei chen Xinyi Lu Jiufeng Sun Mengyu Guo Huige zhou Ru bai Yuliang Zhao Chunying chen Yaling wang CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China University of chinese academy of sciences Beijing 100049China The GBA National institute for Nanotechnology Innovation Guangzhou 510700China Guangdong Provincial institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhou 511430China Research Unit of Nanoscience and Technology Chinese Academy of Medical SciencesBeijing 100049China

Vaccines that are reliable and efficacious are essential in the fight against the COVID-19 *** this study,we designed a dual-adjuvant system with two pathogen-associated molecular patterns(PAMPs),MnOx and *** system can improve the retention of antigens at the injection site,facilitate pro-inflammatory cytokines secretion,further recruit and activate dendritic cells(DCs).As a result,antigens can be delivered to lymph nodes specifically,and adaptive immunity was *** immunized group showed an enhanced and broadened humoral and cellular immune response in systemic immunity and lung protection when combined with a tandem repeat-linked dimeric antigen version of the SARS-CoV-2 receptor binding domain(RBDdimer).Remarkably,even with a significant reduction in antigen dosage(three times lower)and a decrease in injection frequencies,our nanovaccine was able to produce the highest neutralizing antibody titers against various *** titers were four-fold higher for the wild-type strain and two-fold higher for both the Beta and Omicron variants in comparison with those elicited by the Alum adjuvant *** conclusion,our dual-adjuvant formulation presents a promising protein subunit-based candidate vaccine against SARS-CoV-2.

关键词： dual-adjuvant system synergistic immune activation antigen dosage reducing variants neutralizing

Enhanced nanocrystalline stability of BCC iron via copper segregation

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Progress in Natural Science:Materials International 2023年第2期33卷 185-192页

作者： Feiyang wang Linshuo Dong Hong-Hui Wu Penghui bai Shuize wang Guilin Wu Junheng Gao Jiaming Zhu Xiaoye zhou Xinping Mao beijing Advanced Innovation center for Materials Genome Engineering Institute for Carbon Neutrality University of Science and Technology Beijing institute of Materials Intelligent Technology Liaoning Academy of Materials 3. Institute of Steel Sustainable Technology Liaoning Academy of Materials School of Civil Engineering Shandong University Department of Materials Science and Engineering Shenzhen MSU-BIT University

Nanocrystalline alloys are known for their high density of grain boundaries(GBs), which results in low thermal stability and a tendency for coarsening. In this work, we investigated Fe–Cu alloys to explore the effects of Cu concentration on the thermal stability of nanocrystalline samples. Using hybrid molecular dynamics(MD) and Monte Carlo(MC) simulations, annealing treatments of nanocrystalline samples with varied Cu concentrations were conducted. The simulation results revealed that Cu atoms tended to accumulate at GBs. Subsequently, the model with Cu segregation was subjected to mechanical creep loading at various temperatures. Through the analysis of atomic structure evolution during creep deformation, it was found that Cu segregation efficiently stabilizes GBs and restricts their movement. The present findings highlight that the thermal stability of nanocrystalline Fe–Cu alloys can be effectively improved by introducing suitable Cu segregation at GBs.

关键词： Nanocrystalline alloys molecular dynamics simulations Grain boundary Thermal stability

Enhanced Hydrogen Embrittlement Resistance via Cr Segregation in Nanocrystalline Fe-Cr Alloys

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Acta Metallurgica Sinica(English Letters) 2023年第12期36卷 1925-1935页

作者： Linshuo Dong Feiyang wang Hong-Hui Wu Mengjie Gao Penghui bai Shuize wang Guilin Wu Junheng Gao Xiaoye zhou Xinping Mao beijing Advanced Innovation center for Materials Genome Engineering Innovation Research Institute for Carbon NeutralityUniversity of Science and Technology BeijingBeijing 100083China institute of Steel Sustainable Technology Liaoning Academy of MaterialsShenyang 110004China Department of Materials Science and Engineering Shenzhen MSU-BIT UniversityShenzhen 518172China

Hydrogen is a clean fuel with numerous sources,yet the hydrogen industry is plagued by hydrogen embrittlement(HE)issues during the storage,transportation,and usage of hydrogen *** can compromise material performance during service,leading to significant safety hazards and economic *** the current work,the influence of element Cr on the HE resistance of nanocrystalline Fe-Cr alloys under different hydrogen concentrations and strain rates was *** hybrid Monte Carlo(MC)and molecular dynamics(MD)simulations,it was found that Cr atoms were segregated at grain boundaries(GB)and inhibited the GB ***,Cr segregation improved the strength and plasticity of the nanocrystalline Fe-Cr alloys,especially the HE ***,the Cr segregation reduced the diffusion coefficient of hydrogen and inhibited hydrogen-induced *** work provided new insight into the development of iron-based alloys with high HE resistance in the future.

关键词： Hydrogen embrittlement molecular dynamics simulations Cr segregation Grain boundary Nanocrystalline materials

Impeded degradation of perovskite solar cells via the dual interfacial modification of siloxane

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Science china chemistry 2022年第11期65卷 2299-2306页

作者： Xiao Zhang Changsu Cao Yang bai cheng Zhu Huachao Zai Sai Ma Yihua chen Zhenhua Cui Congbo Shi chenyue wang chenxiao zhou Guizhou Yuan Ziyan Gao Jiawang Hong Jie Dou Hao wang Huanping zhou Hai Xiao Jun Li Qi chen beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic Systems School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Experimental center of Advanced Materials School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Department of chemistry and Key Laboratory of Organic Optoelectronics and molecular Engineering of Ministry of Education Tsinghua UniversityBeijing 100084China Department of chemistry Southern University of Science and TechnologyShenzhen 518055China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing 100871China Shanghai Synchrotron Radiation Facility(SSRF) Zhangjiang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China

It is challenging to improve the long-term stability of perovskite solar cells(PSCs) without sacrificing efficiency. The perovskite absorbers degrade from the film surface/interfaces, which follows entangled mechanisms that have not been fully revealed ***, we decouple and elaborate two distinctive pathways regarding film degradation based on ***, a dual interfacial modification strategy has been developed for improving the material’s intrinsic stability, thus leading to the film degrading in a more retardant pathway. The corresponding PSCs achieve a stable power output efficiency of 23.75%.More importantly, the unencapsulated PSCs devices retain over 93% of their initial PCE after the maximum power point(MPP)tracking under the continuous 1-sun illumination and show significantly improved stability after aged under the thermal treatment or stored in ambient atmosphere for over 1500 hours without obvious PCE decay. This work shows the importance of modulating the degradation pathway on stability improvement, and at the same time, proposes a strategy for designing perovskite-based optoelectronics with excellent performance and stability.

关键词： perovskite solar cells stability degradation kinetics

由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong Li Ruo-Yu Liu Ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Beijing 100049China TIANFU Cosmic Ray Research center ChengduChina institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of china Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster