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Jurassic sedimentary features and tectonic settings of southeastern China

Science China Earth Sciences 2009年第12期52卷 1969-1978页

作者： SHU LiangShu wang Yan sha JinGeng JIANG shaoYong yu JinHai wang YanBin State Key Laboratory for Mineral Deposits Research School of Earth Sciences and EngineeringNanjing UniversityNanjing 210093China LPS Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Liaohe Oilfield Company PetroChinaPanjin 124010China Beijing SHRIMP Center Chinese Academy of Geological SciencesBeijing 100037China

Two types of the Jurassic basins are distinguished in SE China based on their geodynamic features: the Late Triassic-Early Jurassic post-orogenic basins and the Middle Jurassic intra-continental extensional basins. The Lower Jurassic sequence shows a change from coarseto fine-grained accumulation, suggesting a gradually deepening depositional environment from river to shore-lake and to deep-water lake. In contrast, the Middle Jurassic accumulation was changed from claystone to conglomerate along the coastal provinces in SE China, indicative of an initial crustal uplift. The Wuyi Mountains have been a paleogeograghic separating zone since the Middle Jurassic. The Late Jurassic strata are absent in most areas of SE China. A large-scale bimodal intra-continental rift-type volcanism occurred during the Middle Jurassic along a 40-60 km wide and 200 km long area in western Fujian and southern Jiangxi provinces, which is most likely the strongest volcanism in SE China since the Cambrian. The SHRIMP zircon U-Pb analyses on the rhyolite from the Dongkeng basin in the southern Jiangxi area yield a concord U-Pb age of 160±0.5 Ma, providing an upper age limit for the bimodal volcanic eruption. The analyses of the basin features indicate a change of the depositional environment during the interval from Middle Triassic to Late Triassic from a shallow-sea to an intra-continent in SE China in response to the strong collision between the Yangtze and North China Blocks. Sedimentary structures record a southward direction of Early Jurassic paleo-currents, reflecting that their source areas were to the north side. We propose that the Wuyi region was uplifted as early as Middle Jurassic, followed by a wide E-W-trending extended depression and bimodal volcanism in the western foot of the Wuyi Mountains. Presumably the uplift of the Wuyi domain changed the Middle Jurassic paleo geographic outline and formed the transformational tectonic regime from compression to extension as a tectonic r

关键词： sedimentary features paleo-geographic framework tectonic transformation SHRIMP U-Pb dating Jurassic southeastern

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Nonlinear response analysis and experimental verification for thin-walled plates to thermal-acoustic loads

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Chinese Journal of Aeronautics 2017年第6期30卷 1919-1930页

作者： yundong sha Jian wang Liaoning Key Laboratory of Advanced Test Technology for Aeronautical Propulsion System Shenyang Aerospace University Shenyang 110136 China

For large deflection strongly nonlinear response problem of thin-walled structure to thermal-acoustic load, thermal-acoustic excitation test and corresponding simulation analysis for clamped metallic thin-walled plate have been implemented. Comparing calculated values with experimental values shows the consistency and verifies the effectiveness of calculation method and model for thin-walled plate subjected to thermal-acoustic load. Then this paper further completes dynamic response calculation for the cross reinforcement plate under different thermalacoustic load combinations. Based on the obtained time-domain displacement response, analyses about structure vibration forms are mainly focused on three typical motions of post-buckled plate,indicating that the relative strength between thermal load and acoustic load determines jump forms of plate. The Probability spectrum Density Functions（PDF） of displacement response were drawn and analyzed by employing statistical analysis method, and it clearly shows that the PDF of postbuckled plate exhibits bimodal phenomena. Then the Power Spectral Density（PSD） functions were used to analyze variations of response frequencies and corresponding peaks with the increase of temperatures, as well as how softening and hardening areas of the plate are determined. In the last section, this paper discusses the change laws of tensile stress and compressive stress in pre/post buckling areas, and gives the reasons for N glyph trend of the stress Root Mean Square（RMS）.

关键词： Buckling Experimental verification Nonlinear response Power spectral density Probability spectrum densitySnap-through Thermal-acoustic load Thin-walled structure

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Selective binding of bile salts by β-cyclodextrin derivatives with appended quinolyl arms

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Chinese Chemical Letters 2013年第6期24卷 442-446页

作者： sha-sha Zhai Yong Chen yu Liu Department of Chemistry State Key Laboratory of Elemento-Organic ChemistryNankai University

Two β-cyclodextrin derivatives bearing appended quinolyl and isoquinolyl arms,***-（6-quinolyl- 6-deoxy）-β-cyclodextrin（1） and mono-（6-isoquinolyl-6-deoxy）-β-cyclodextrin（2） were synthesized in satisfactory yields and fully *** original conformations and binding behaviors toward four bile salt guests,that is,sodium cholate（CA）,sodium deoxycholate（DCA）,sodium glycocholate （GCA）,and sodium taurocholate（TCA）,were investigated by means of fluorescence,circular dichroism and 2D NMR *** study of solution structures revealed that both quinolyl and isoquinolyl arms were located outside the cyclodextrin *** results obtained from the fluorescence titrations showed that the binding abilities of hosts 1 and 2 with selected bile salts varied in an order of DCA 〉 CA 〉 *** selective binding of hosts toward bile salt guests was discussed from the viewpoints of induced-fit and multiple binding.

关键词： Cyclodextrin derivatives Bile salts Molecular recognition

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Nomograms predicting long-term survival in patients with invasive intraductal papillary mucinous neoplasms of the pancreas: A population-based study

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World Journal of Gastroenterology 2020年第5期26卷 535-549页

作者： Jia-yuan Wu yu-Feng wang Huan Ma sha-sha Li Hui-Lai Miao Department of Clinical Research the Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001Guangdong ProvinceChina School of Public Health Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina Department of Hepatobiliary Surgery the Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001Guangdong ProvinceChina Department of Hepatobiliary Surgery the Second Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524003Guangdong ProvinceChina

BACKGROUND There are few effective tools to predict survival in patients with invasive intraductal papillary mucinous neoplasms of the *** To develop comprehensive nomograms to individually estimate the survival outcome of patients with invasive intraductal papillary mucinous neoplasms of the *** Data of 1219 patients with invasive intraductal papillary mucinous neoplasms after resection were extracted from the Surveillance,Epidemiology,and End Results database,and randomly divided into the training(n=853)and the validation(n=366)*** on the Cox regression model,nomograms were constructed to predict overall survival and cancer-specific survival for an individual *** performance of the nomograms was measured according to discrimination,calibration,and clinical ***,we compared the predictive accuracy of the nomograms with that of the traditional staging *** In the training cohort,age,marital status,histological type,T stage,N stage,M stage,and chemotherapy were selected to construct *** with the American Joint Committee on Cancer 7th staging system,the nomograms were generally more *** nomograms passed the calibration steps by showing high consistency between actual probability and nomogram *** net classification improvements and integrated discrimination improvements suggested that the predictive accuracy of the nomograms exceeded that of the American Joint Committee on Cancer staging *** respect to decision curve analyses,the nomograms exhibited more preferable net benefit gains than the staging system across a wide range of threshold *** The nomograms show improved predictive accuracy,discrimination capability,and clinical utility,which can be used as reliable tools for risk classification and treatment recommendations.

关键词： Invasive intraductal papillary mucinous neoplasm Pancreas Nomogram Overall survival Cancer-specific survival Surgical resection

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不同年龄及体重2型糖尿病患者肾小球滤过率影响因素分析

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河北医科大学学报 2020年第3期41卷 287-290,310页

作者：郭哲颜红梅付世新常薪霞王玉沙河北省眼科医院内科河北邢台054000 复旦大学附属中山医院内分泌科上海200032 河北省邢台市中医院疼痛科河北邢台054000

目的观察不同年龄及体重2型糖尿病患者肾小球滤过率(estimating glomerular filtration rate,eGFR)的变化情况,分析代谢参数与肾小球滤过率的相关性。方法收集糖尿病患者207例及非糖尿病者68例,应用改良MDRD公式计算eGFR,以年龄分组,多... 详细信息

目的观察不同年龄及体重2型糖尿病患者肾小球滤过率(estimating glomerular filtration rate,eGFR)的变化情况,分析代谢参数与肾小球滤过率的相关性。方法收集糖尿病患者207例及非糖尿病者68例,应用改良MDRD公式计算eGFR,以年龄分组,多重比较分析每组间eGFR差异情况并分析与其他代谢参数相关性,并进行线性回归分析;进一步以40~70岁年龄患者组,以不同体重指数(body mass index,BMI)分组,分析各组间差异情况。结果随着年龄的增长,BMI、天冬氨酸转氨酶(glutaminc oxalacetic transaminase,AST)、丙氨酸转氨酶(glutamic pyruvic transaminase,ALT)、尿酸(uric acid,UA)、eGFR均是下降的,各年龄组组间eGFR存在差异(P<0.001);Pearson相关性分析结果提示,eGFR与BMI、三酰甘油(triglyceride,TG)、ALT、AST、谷氨酰转肽酶(gamma-glutamyl transpeptidase,GGT)、UA呈正相关,与性别、同型半胱氨酸(homocysteine,HCY)、糖化血红蛋白(hemoglobin A 1c,HbA 1c)、25-羟维生素D(25-hydroxyvitamin-D,25(OH)D)呈负相关。线性回归分析结果提示,BMI、TG、ALT(P<0.001)与eGFR独立正相关;AST、GGT、UA、HbA 1c、HCY、25(OH)D(P<0.001)与其独立负相关。相近年龄患者以不同BMI分组,随着BMI增加,eGFR逐渐增高,组间多重比较显示肥胖组与体重正常组组间比较eGFR差异有统计学意义(P<0.001),严重肥胖组与其他各组间eGFR差异均有统计学意义(P<0.001)。结论随着年龄增长,2型糖尿病患者代谢水平及eGFR降低,AST、25(OH)D、UA、HCY为肾损伤的独立危险因素。年龄相近患者,肥胖患者eGFR水平高。

关键词：糖尿病,2型肥胖症肾小球滤过率

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The secondary periodic element ■ and its applications

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Science China Mathematics 2025年第1期 207-222页

作者： Jianguo Hong Xiangjun wang yu Zhang Science College Shijiazhuang University School of Mathematical Sciences Nankai University Center for Applied Mathematics Tianjin University

Let p≥7 be a *** prove that ■ survives to E∞in the Adams-Novikov spectral ***,using the Thom map Φ:■,we can see that h0h3also survives to E∞in the classical Adams spectral *** an application of these results,we ...

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Repeatability of Ophtha Top topography and comparison with IOL-Master and Lenstar LS900 in cataract patients

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1703-1709页

作者： sha-sha yu Hui Song Xin Tang Clinical College of Ophthalmology Tianjin Medical University Tianjin 300020 China Tianjin Eye Hospital Tianjin 300020 China Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin 300020 China Tianjin Eye Institute Tianjin 300020 China

AIM：To determine the repeatability of Ophtha Top topography and assess the consistency with intraocular lens（IOL）-Master and Lenstar LS900（Lenstar）in measuring corneal parameters among cataract ***：Totally 125 eyes were *** were successively measured with Ophtha Top,IOL-Master and Lenstar at least three *** flattest meridian power（Kf）,the steepest meridian power（Ks）,mean power（Km）,J0 and J45 were ***-class correlation coefficients（ICCs）,the coefficient of variance（COV）,within subject standard deviation（Sw）,and test-retest repeatability（2.77Sw）were adopted to determine the *** 95%limit of agreement（95%LOA）and Bland-Altman plots were used to assess ***：Repeatability of Ophtha Top topography for measuring corneal parameters showed the ICCs were all above 0.93,2.77Sw was lower than 0.31,and the COV of the Kf and Ks was lower than *** keratometric readings with Ophtha Top topography were flatter than with the IOLMaster and Lenstar devices,while the Pearson correlation coefficients were over *** J0 and J45 with Ophtha Top topography were smaller compared with Lenstar and IOL-Master,while was comparable between Lenstar and ***：Ophtha Top topography shows excellent repeatability for measuring corneal ***,differences between the Ophtha TOP topography and Lenstar,IOL-Master both in cornea curvature and the astigmatism should be noted clinically.

关键词： Repeatability of Ophtha Top topography and comparison with IOL-Master and Lenstar LS900 in cataract patients IOL LS

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In-situ High-Temperature XRD and FTIR for Calcite, Dolomite and Magnesite: Anharmonic Contribution to the Thermodynamic Properties

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Journal of Earth Science 2019年第5期30卷 964-976页

作者： Xiang wang Xiaoxiang Xu yu Ye Chao wang Dan Liu Xiaochao Shi sha wang Xi Zhu State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Wuhan 430074 China shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and Engineering Tongji University Shanghai 200092 China

In-situ powder X-ray diffraction(XRD) and Fourier transform infrared(FTIR) spectra were measured on the natural crystals of calcite(Ca0.996 Mg0.004 CO3), dolomite(Ca0.497 Mg0.454 Fe0.046 Mn0.003 CO3) and magnesite(Mg0.988 Ca0.010 Fe0.002 CO3), with a temperature up to 796 K. The thermal expansion coefficients were evaluated for these carbonate minerals, resulting in the values of 2.7×10^-5, 3.3×10^-5 and 3.5×10^-5 K^-1 for calcite, dolomite and magnesite, respectively. The magnitude of these coefficients is in the same order as those for the isothermal and elastic moduli of these carbonates(e.g., calcitedolomite>magnesite. The Debye model(harmonic approximation) would be valid for magnesite to simulating the thermodynamic properties and isotope fractionation β-factor at high P-T condition.

关键词： calcite dolomite magnesite high-temperature FTIR anharmonicity thermodynamics

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Acid-sensing ion channels: potential therapeutic targets for neurologic diseases

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Translational Neurodegeneration 2015年第1期4卷 68-75页

作者： sha Liu Xiao-yu Cheng Fen wang Chun-Feng Liu Department of Neurology the Second Affiliated Hospital of Soochow UniversitySoochow University1055 Sanxiang RoadSuzhou 215004China Institute of Neuroscience Soochow UniversitySuzhou 215123China Beijing Key Laboratory for Parkinson’s Disease Beijing 100053China

Maintaining the physiological pH of interstitial fluid is crucial for normal cellular *** disease states,tissue acidosis is a common pathologic change causing abnormal activation of acid-sensing ion channels(ASICs),which according to cumulative evidence,significantly contributes to inflammation,mitochondrial dysfunction,and other pathologic mechanisms(i.e.,pain,stroke,and psychiatric conditions).Thus,it has become increasingly clear that ASICs are critical in the progression of neurologic *** review is focused on the importance of ASICs as potential therapeutic targets in combating neurologic diseases.

关键词： Acid sensing ionic channels Neurologic diseases Pathophysiology Neurodegeneration

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Progress in Fluorene-based Wide-bandgap Steric Semiconductors

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Chinese Journal of Polymer Science 2017年第2期35卷 155-170页

作者： Meng-na yu Chang-jin Ou Bin Liu Dong-qing Lin yu-yu Liu Wei Xue Zong-qiong Lin Jin-yi Lin Yan Qian sha-sha wang Hong-tao Cao Lin-yi Bian 解令海黄维 Center for Molecular Systems and Organic Devices (CMSOD) Key Laboratory for Organic Electronics and Information Displays ＆ Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts ＆ Telecommunications Nanjing 210023 China Key Laboratory of Flexible Electronics (KLOFE) ＆ Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University (Nanjing Tech) Nanjing 211816 China

Molecular bulks are favorable for the thermal and morphological stability in organic wide-bandgap semiconducting polymers with potential applications in both information and energy electronics. In this review, we present our progress in the design of fluorene-based bulky semiconductors with a fractal four-element pattern. Firstly, we established one-pot methods to spirofluorenes, especially spiro[fluorene-9,9＇-xanthene] （SFX） serving as the next-generation spiro-based semiconductors. Secondly, we observed the supramolecular forces at the bulky groups and discovered the supramolecular steric hindrance （SSH） effect on polymorphisms, nanocrystals as well as device performance. Thus, a synergistically molecular attractor-repulsor theory （SMART） was proposed for the control of nanocrystal morphology, thin film phase and morphology. Thirdly, the third possible type of defects has been identified to generate green band （g-band） emission in wide- bandgap semiconductors by the introduction of molecular strain design of cyclofluorene. Finally, the first bulky polydiarylfluorene with highly crystalline and β conformation was achieved by an attractor-repulsor design of tadpole-shape monomer, which offered an effective platform to fabricate stable wide-bandgap semiconducting devices. All the discoveries offer the solid basis to break through bottlenecks of organic/polymer wide-bandgap semiconductors by the improvements of overall performances.

关键词： Organics Steric effect Attractor-repulsor Molecular defects Wide-bandgap

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