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High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： bokun Zhang Xiaoyun wang Shuai wang Yan Li Libo Chen Handong Jiao Zhijing yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (LiMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** LiMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable LiMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Semiconductor doping

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： yunfan Long Jiajia Liu yu wang Haidong Guo Guohong Cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

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低气压下CuBr激光的光谱结构

物理学报 2007年第10期56卷 5808-5812页

作者：陈立毛邦宁王煜博王丽敏潘佰良浙江大学物理系杭州310027

综合考虑能级精细结构和同位素分裂等因素,计算了铜原子511nm和578nm自发跃迁谱线的光谱结构.设计制作了可周期更换缓冲气体封闭运转的CuBr激光器,测量了低气压下以氖气为缓冲气体的CuBr激光器的511nm和578nm激光谱线在不同工作温度和... 详细信息

综合考虑能级精细结构和同位素分裂等因素,计算了铜原子511nm和578nm自发跃迁谱线的光谱结构.设计制作了可周期更换缓冲气体封闭运转的CuBr激光器,测量了低气压下以氖气为缓冲气体的CuBr激光器的511nm和578nm激光谱线在不同工作温度和激励电压时的光谱结构.结果表明铜原子511nm和578nm谱线的自发辐射光谱和激光光谱具有类似的多峰结构,但578nm激光光谱线形与工作温度和激励电压密切相关,对实验结果做了定性分析.

关键词： CuBr激光光谱结构工作温度激励电压

Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology Research 2025年第1期33卷 67-81页

作者： XIANG LI WENKE JIN LIFENG WU HUAN wang XIN XIE WEI HUANG bo LIU State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** contrast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC,aiming to uncover novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and CO-IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,uncovering its interactions with 39 newly identified ***,the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1

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中国土地财政中的地方政府行为与负效应研究

中国软科学 2013年第6期 1-11页

作者：娄成武王玉波东北大学文法学院辽宁沈阳110819

研究中国土地财政中的地方政府行为与负效应,对于土地财的兴利除弊、实现可持续的地方土地财税收益具有重要意义。阐述了土地财政的起源、涵义与性质,从社会经济发展阶段、分税的财政体制、国家土地制度及农地征用流转制度方面分析了地... 详细信息

研究中国土地财政中的地方政府行为与负效应,对于土地财的兴利除弊、实现可持续的地方土地财税收益具有重要意义。阐述了土地财政的起源、涵义与性质,从社会经济发展阶段、分税的财政体制、国家土地制度及农地征用流转制度方面分析了地方政府获取土地财政的行为策略选择,进一步论述了由此产生的被征地农民利益受损、地方政府土地违法行为、推动房价快速上涨并积累财政金融风险,以及形成届际不公平和不可持续的财政等负效应。论述了后土地财政时代的涵义与存在的困局,在此基础上,从转变地方政府角色、完善财政体制、推进土地房产税系与农地产权及征用制度改革、改变以土地财政为动力机制的城市化发展、约束地方政府获取财政收入风险性行为等方面,提出后土地财政时代转型的政策建议。

关键词：土地财政地方政府行为负效应转型

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土地财政构成要素区域差异及驱动因素研究

地理与地理信息科学 2018年第5期34卷 106-112页

作者：王玉波邹水平东北大学文法学院辽宁沈阳110169

以土地财政构成要素为着力点,选取2005-2014年全国31省(市)土地财政构成要素与驱动因素数据,采用SPSS 21.0中的系统聚类分析方法对其关系进行聚类,并根据结果采用灰色关联分析法分区域测算土地财政构成要素与驱动因素的关联度,结果表明... 详细信息

以土地财政构成要素为着力点,选取2005-2014年全国31省(市)土地财政构成要素与驱动因素数据,采用SPSS 21.0中的系统聚类分析方法对其关系进行聚类,并根据结果采用灰色关联分析法分区域测算土地财政构成要素与驱动因素的关联度,结果表明:1)影响土地财政构成要素区域差异的因素主要包括分税制、以GDP为标准的政绩考核体系、二三产业发展和土地违法等。2)全国范围内土地出让面积与土地财政规模、产业结构指标联系最为紧密,土地出让价格则受地区竞争程度影响最大。3)根据聚类结果,将北京、上海划入第Ⅰ区域,该区域土地出让价格与土地违法指标联系密切;江苏、浙江、山东、广东、天津、福建和辽宁划入第Ⅱ区域,中部、东北及海南划入第Ⅲ区域,Ⅱ、Ⅲ区域土地财政各构成要素主要受产业结构和城市扩张指标影响;西北五省、云南、贵州划入第Ⅳ区域,该区域地方政府财政压力影响以市场方式出让的土地面积和价格,土地违法对土地财政构成系统各要素影响最小。

关键词：土地财政构成要素驱动因素聚类分析灰色关联分析法

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin Fang Limin wang Haoqin Li Jiaxin Zhang Yang Ding Pan Pan Li bo Peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH2O2-activatable super-resolution imaging fluorogenic probe

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基于理想格的公钥加密方案快速实现技术研究

密码学报 2023年第4期10卷 852-861页

作者：王伯宇高海英信息工程大学郑州450001

在基于理想格和模格的公钥加密方案中,多项式环上的乘法运算是影响方案实现效率的重要模块,而该模块通常可通过数论变换(number theoretic transform,NTT)来快速实现.本文采用结合Karatsuba算法的带预处理的NTT(preprocess-then-NTT wit... 详细信息

在基于理想格和模格的公钥加密方案中,多项式环上的乘法运算是影响方案实现效率的重要模块,而该模块通常可通过数论变换(number theoretic transform,NTT)来快速实现.本文采用结合Karatsuba算法的带预处理的NTT(preprocess-then-NTT with Karatsuba,KNTT),提升格公钥加密方案的实现效率.在使用KNTT前,通过改进采样和密文打(解)包结果的存储方式来调整多项式环元素的数据结构,使之直接适用KNTT,从而省去KNTT算法中的预处理和组合环节.改进了KNTT中的NTT变换的实现方式,进一步提高格公钥加密方案的实现效率.KYBER是NIST在第三轮评选中决定标准化的格公钥密码算法,本文将上述改进技术应用于KYBER类加密方案,得到了KNTT-based KYBER算法,与***相比,密钥生成实现效率提高了5%–8%,加密实现效率提高了7%–10%,解密实现效率提高了9%–10%.

关键词：格公钥密码容错学习问题 KYBER类加密方案数论变换结合Karatsuba的带预处理的数论变换

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai Jian Hui Jia yu wang Chun Cheng Yang Qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries