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Journal of Environmental Sciences 2016年第3期28卷 138-145页

作者： Jing Tong youwei wang Yuanan Lu Institute of TCM & Natural Products School of Pharmaceutical SciencesWuhan University Department of Public Health Sciences University of Hawaii at Manoa Global Health Center School of Public HealthWuhan University

To extend the current understanding of the mercury-mediated cytotoxic effect,five neural cell lines established from different animal species were comparatively analyzed using three different endpoint bioassays：thiazolyl blue tetrazolium bromide,3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide assay（MTT）,neutral red uptake assay（NRU）,and Coomassie blue assay（CB）.Following a 24-hr exposure to selected concentrations of mercury chloride（HgCl_2） and methylmercury（Ⅱ） chloride（MeHgCl）,the cytotoxic effect on test cells was characterized by comparing their 50%inhibition concentration（IC_（50）） *** results indicated that both these forms of mercury were toxic to all the neural cells,but at very different *** IC_（50）values of MeHgCl among these cell lines ranged from 1.15±0.22 to 10.31 ± 0.70 μmol/L while the IC_（50） values for HgCl_2 were much higher,ranging from 6.44 ± 0.36 to 160.97±19.63 μmol/L,indicating the more toxic nature of *** IC_（50） ratio between HgCl_2and MeHgCl ranged from 1.75 to 96.0,which confirms that organic mercury is much more toxic to these neural cells than inorganic *** these cell lines,HGST-BR and TriG44 derived from marine sea turtles showed a significantly high tolerance to HgCl_2 as compared to the three mammalian neural *** these neural cells,SK-N-SH represented the most sensitive cells to both chemical forms of mercury.

关键词： In vitro cytotoxicity Neural cell lines HgCl_2 MeHgCl

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A Bionic Study on the Anti-erosion Mechanism of Laudakia stoliczkana:Experimental and Numerical Aspects

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Journal of Bionic Engineering 2019年第5期16卷 882-893页

作者： Ping Liang Youhong Sun Sihan Liu Tianwei Liang Yuhang Zhang youwei wang Luquan Ren Key Laboratory of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130022China Construction Engineering College Jilin UniversityChangchun 130000China School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130022China China FAW Group Corporation R&D Center Changchun 130000China

The scales of body surface of Laudakia stoliczkana have the morphology of convex hulls,which are arranged in groove structure in macroscopic *** body surface skin is mainly composed of the"soft"layer of keratin and the"hard"layer of the cuticle covering on the"soft"*** coupling effect of the scale morphology and skin's structure gives Laudakia stoliczkana the excellent ability to resist the sand erosion in desert *** by the convex surface morphology and the composite structure of the"soft"and"hard"layers of the skin of Laudakia stoliczkana^the coupling bionic samples are febricated and the erosion resistance performance is *** test results show that the coupling bionic samples have good erosion resistance perfbimance and the samples with spherical convex hull exhibit the best erosion resistance ***,based on the theory of stress wave propagation in solid the numerical simula tions of particles impacting to the coupling bionic samples and bionic layered structure are done respectively and the anti-erosion me chanism of the bionic layered structure is *** simulation results are consistent with the experimental results,which show that the coupling bionic samples can effectively reduce the amplitude of the incident stress wave,and thus can prevent the failure of samples.

关键词： coupling bionic anti-erosion sand blasting test stress wave bionic layered structure

Hydrocarbon Generation and Expulsion of the Upper Triassic T3x5Source Rocks in the Western Sichuan Depression: Assessment for Unconventional Natural Gas

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Acta Geologica Sinica(English Edition) 2015年第1期89卷 175-186页

作者： GUO Yingchun SONG Yan PANG Xiongqi wang youwei YANG Keming LI Boyuan State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum Institute of Unconventional Natural Gas China University of Petroleum Research Institute of Petroleum Exploration and Development PetroChina Southwest Branch Company China Petroleum and Chemical Corporation

Tight-sand gas in the Jurassic and shale gas within the fifth member of Xujiahe Formation （T3xs） in the Western Sichuan Basin （WSD） are currently regarded as the most prolific emerging unconventional gas plays in China. This study conducted a conventional evaluation of T3x5 source rocks in the WSD, and investigated their hydrocarbon generation and expulsion characteristics, including intensity, efficiency and amount. The results show that, the T3x5 source rocks are thick （generally 〉200 m）, and have a high total organic content （TOC）, ranging from 2.5 to 4.5 wt%. It is thus indivative of a great hydrocarbon generation potential when they underwent high thermal evolution （Ro〉1.2%） in the area. In addition, an improved method of hydrocarbon generation potential is applied, indicating that the source rocks reached a hydrocarbon expulsion threshold with vitrinite reflectance （Ro） reaching 1.06%. and that the comprehensive hydrocarbon expulsion efficiency is about 60%. The amount of hydrocarbon generation and expulsion from Tax5 source rocks is 3.14x10^10 t and 1.86x10^10 t, respectively, with a residual amount of 1.28x10^10t within them. Continuous-type tight-sand gas is predicted to have developed in the Jurassic in the Chengdu Sag of the WSD because of the good source-reservoir configuration; the Jurassic sandstone reservoirs are tight, and the gas expelled from the T3xs source rocks migrates for very short distances vertically and horizontally. The amount of gas accumulation in the Jurassic reservoirs derived from T3x5 source rocks is up to 9.3x10s t. Geological resources of shale gas are up to 1.05x10TM t. Small differences between the amounts calculated by the volumetric method and those obtained by hydrocarbon generation potential method may be due to other gas accumulations present within interbedded sands associated with gas shales.

关键词： source rocks evaluation hydrocarbon generation and expulsion tight-sand gas shale gas,resource assessment Upper Triassic Western Sichuan Depression

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Recent progress in theoretical and computational investigations of structural stability and activity of single-atom electrocatalysts

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Progress in Natural Science:Materials International 2019年第3期29卷 256-264页

作者： youwei wang Erhong Song Wujie Qiu Xiaolin Zhao Yao Zhou Jianjun Liu Wenqing Zhang State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences Department of Physics and Shenzhen Institute for Quantum Science & Technology Southern University of Science and Technology

This review has been made an attempt to seek some observed descriptors to comprehensively optimize structural stability and catalytic activity of single-atom catalysts. Electronic structure analysis can reveal the underlying mechanisms of atomic phy-chemical properties and local coordination structures on binding strength. The free electrons around Fermi level play an important role to determine the binding strength, which can be further influenced by electronegativity difference between single atom and nearby support atoms. This investigation can contribute to understanding the underlying mechanisms for the design of stable and active catalysts, and further provide a deep insight to the potential pathways in the research field of single-atom catalysts.

关键词： SAC Recent progress in theoretical and computational investigations of structural stability and activity of single-atom electrocatalysts

Functional analysis of zona pellucida domain protein Dusky in Tribolium castaneum

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Insect Science 2022年第2期29卷 388-398页

作者： Chengjun Li Liu Yang youwei wang Huanyu Du Jiangyan Zhang Yaoyao Lu Bin Li Keping Chen School of Life Sciences Jiangsu UniversityZhenjiangJiangsu Province212013 China Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life SciencesNanjing Normal UniversityNanjing210023 China

The zona pellucida domain protein Dusky(Dy)plays a vital role in wing morphogenesis in insects,but little information on its function has been *** this study,we found that dy regulated wing cell size,larval and pupal duration,and the metabolism of amino acid and 20-hydroxyecdysone in Tribolium *** RNA-seq,413 differentially expressed genes were identified between physiological buffer-injected and dy-double-stranded RNA-treated larvae,including 88 downregulated genes and 325 upregulated *** these genes,dy knockdown increased CYP18A1 expression to elevate the 26-hydroxylation of 20-hydroxyecdysone,which ultimately led to growth defects in wing *** of dy upregulated the transcription of genes encoding tyrosine aminotransferase,4-hydroxyphenylpyruvate dioxygenase,homogentisate 1,2-dioxygenase,and Pale to promote the catabolism of tyrosine and phenylalanine,which eventually reduced amino acid ***,dy knockdown upregulated 4E-BP expression,and 4E-BP silencing partially phenocopied dy RNA interference-mediated wing *** results suggest that Dy controls 20-hydroxyecdysone and amino acid metabolism to regulate wing morphogenesis in the insect.

关键词： Dusky 4E-BP Tribolium castaneum 20-hydroxyecdysone wing

Adsorption-energy-based activity descriptors for electrocatalysts in energy storage applications

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National Science Review 2018年第3期5卷 327-341页

作者： youwei wang Wujie Qiu Erhong Song Feng Gu Zhihui Zheng Xiaolin Zhao Yingqin Zhao Jianjun Liu Wenqing Zhang State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Materials Genome Institute Shanghai University

Energy storage technologies, such as fuel cells, ammonia production and lithium–air batteries, are important strategies for addressing the global challenge of energy crisis and environmental *** overpotential as a direct criterion, we illustrate in theory and experiment that the adsorption energies of charged species such as Li~++e~-and H~++e~-are a central parameter to describe catalytic activities related to electricity-in/electricity-out efficiencies. The essence of catalytic activity is revealed to relate with electronic coupling between catalysts and charged species. Based on adsorption energy, some activity descriptors such as d-band center, e-electron number and charge-transfer capacity are further defined by electronic properties of catalysts that directly affect interaction between catalysts and charged species. The present review is helpful for understanding the catalytic mechanisms of these electrocatalytic reactions and developing accurate catalytic descriptors, which can be employed to screen high-activity catalysts in future high-throughput calculations and experiments.

关键词： activity descriptors electrocatalysts adsorption energy energy storage applications overpotential

Synthesis and Biological Activities of Novel Methyl Xanthine Derivatives

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Chemical Research in Chinese Universities 2014年第1期30卷 98-102页

作者： CHEN youwei wang Baolei GUO Yanjun ZHOU Yunyun PAN Li XIONG Lixia YU Shujing LI Zhengming State Key Laboratory of Elemento-organic Chemistry Research Institute of Elemento-organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Nankai University Tianjin 300071 P. R. China

Caffeine is one of methyl xanthine compounds,which has the similar mode of action as ryanodine receptor *** order to find novel and efficient insecticide,structural modification of certain methyl xanthine compounds was made by introducing some common pesticidal active moieties into the structure of *** novel methyl xanthine compounds were synthesized and characterized by 1H nuclear magnetic resonance（1H NMR）,elemental analylsis or high-resolution mass spectrometry（HRMS）.According to the biological activity results,it was found that these new compounds show moderate activity towards Mythimna separata Walker and Culex pipiens *** example,compound 2d shows a lethality rate of 40％ at 200 mg/L towards Mythimna separata Walker,compounds 2i and 2f show 56.7％ and 53.3％ lethality rates at 2 mg/L towards Culex pipiens pallens,which are all better than *** addition,some compounds of them show moderate antifungal activity to some plant pathogenous fungi.

关键词： Caffeine Xanthine Insecticidal activity Antifungal activity

LARGE MAGNETIC ENTROPY CHANGE IN La0.67-xGdxCa0.33MnO3

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南京大学学报(自然科学) 1998年第4期 124-126页

作者： Huang He Guo Zaibing wang Dunhui Du youwei

Ｒｅｃｅｎｔｌｙ，ｍｏｒｅａｎｄｍｏｒｅｐｅｏｐｌｅｆｏｃｕｓｔｈｅｉｒａｔｅｎｔｉｏｎｏｎｔｈｅｍａｇｎｅｔｉｃｒｅｆｒｉｇｅｒａｔｉｏｎｂｅｃａｕｓｅｉｔｈａｓｌｏｔｓｏｆａｄｖａｎｔａｇｅｓｏｖｅｒｔｈｅｇａｓ... 详细信息

Ｒｅｃｅｎｔｌｙ，ｍｏｒｅａｎｄｍｏｒｅｐｅｏｐｌｅｆｏｃｕｓｔｈｅｉｒａｔｅｎｔｉｏｎｏｎｔｈｅｍａｇｎｅｔｉｃｒｅｆｒｉｇｅｒａｔｉｏｎｂｅｃａｕｓｅｉｔｈａｓｌｏｔｓｏｆａｄｖａｎｔａｇｅｓｏｖｅｒｔｈｅｇａｓｒｅｆｒｉｇｅｒａｔｉｏｎ．Ｉｎｔ...

关键词： refrigeration magnetic entropy perovskite

Carbon deficiency introduced plasticity of rock-salt-structured transition metal carbides

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Journal of Materials Science & Technology 2023年第33期164卷 205-214页

作者： Buhao Zhang youwei wang Jie Yin Yichen wang Hangfeng Zhang Tamás Csanádi Ján Dusza Michael J.Reece Nan Lin Xiao Yang Xuejian Liu Zhengren Huang Dongliang Jiang State Key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Faculty of Engineering University of NottinghamNottinghamNG7 2RDUnited Kingdom School of Engineering and Materials Science Queen Mary University of LondonMile End RoadLondon E1 4NSUK Institute of Materials Research Slovak Academy of SciencesWatsonova 4704353KošiceSlovak Republic College of Materials Science and Engineering Hunan UniversityChangsha410082China

High-hardness rock-salt structured transitional metal carbides(TMC)are attracting substantial interest as potential next-generation thermal protection ***,the intrinsic brittleness of TMC ceramics impedes their performance in aerodynamically harsh *** this work,a promising strategy is proposed to introduce plasticity in TaC–HfC solid solutions by manipulating carbon *** approach combines density-functional theory(DFT)with experiments and takes Pugh's ratio(k)as the *** of carbon atoms in TaC–HfC solid solutions results in the de-localizing of valence electrons,deviation of spatial modulus along different crystal plane directions,and leading to significant elastic *** carbon deficient Ta_(0.8)Hf_(0.2)C_(0.8) is predicted to be a‘softer phase’with reduced modulus and Pugh's ratio(k=0.58).A series of Ta1–xHfxCy(x=0.2 and 0.8,y=0.8,0.9,and 1.0)bulk ceramics are experimentally fabricated by an excessive metal alloying *** and hexagonal close-packed structured carbides are derived when the carbon deficiency y decreased to *** indentation modulus drops from 641.8±14.8 GPa for Ta_(0.8)Hf_(0.2)C_(1.0) to 555.8±9.9 GPa for *** specific stoichiometric composition of Ta_(0.8)Hf_(0.2)C_(0.8) is experimentally verified to possess both plasticity(k=0.41)and ultra-high nanohardness(41.3±1.3 GPa).

关键词： Brittle Plasticity Transitional metal carbides Pugh's ratio Carbon deficiency

A Novel Federated Learning with Bidirectional Adaptive Differential Privacy

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国际计算机前沿大会会议论文集 2023年第1期 329-337页

作者： Yang Li Jin Xu Jianming Zhu youwei wang School of Information Central University of Finance and EconomicsBeijing 100081China Engineering Research Center of State Financial Security Ministry of EducationCentral University of Finance and EconomicsBeijing 102206China

With the explosive growth of personal data in the era of big data,federated learning has broader application prospects,in order to solve the problem of data island and preserve user data privacy,a federated learning model based on differential privacy(DP)is *** share the parameters after adding noise to the central server for parameter aggregation by training local ***,there are two problems in this model:on the one hand,the data information in the process of broadcasting parameters by the central server is still compromised,with the risk of user privacy leakage;on the other hand,adding too much noise to parameters will reduce the quality of parameter aggregation and affect the model accuracy of federated learning ***,a novel federated learning approach with bidirectional adaptive differential privacy(FedBADP)is proposed,it can adaptively add noise to the gradients transmitted by participants and central server,and protects data security without affecting model *** addition,considering the performance limitations of the participants’hardware devices,this model samples their gradients to reduce communication overhead,and uses RMSprop to accelerate the convergence of the model on the participants and central server to improve the ac-curacy of the *** show that our novel model can not only obtain better results in accuracy,but also enhance user privacy preserving while reducing communication overhead.

关键词： bidirectional adaptive noise RMSprop gradient sampling differential privacy federated learning