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Changes of ghrelin following oral glucose tolerance test in obese children with insulin resistance

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World Journal of Gastroenterology 2008年第12期14卷 1919-1924页

作者： Xiu-Min wang you-jun Jiang Li Liang Li-Zhong Du Department of endocrinology The Children's Hospital of ZhejiangUniversity School of Medicine 57 Zhugan Xiang Hangzhou310003 Zhejiang Province China

AIM： To characterize changes in ghrelin levels in response to oral glucose tolerance test （OGTT） and to correlate changes in ghrelin levels with changes in insulin and glucose following OGTT in Chinese obese children of Tanner Ⅰ and Ⅱ stage with insulin resistance. METHODS： 22 obese children with insulin resistance state were divided into four groups according to their Tanner stage and gender： boys of Tanner Ⅰ （fir- Ⅰ ）, boys of Tanner Ⅱ（BT-Ⅱ ）, girls of Tanner Ⅰ （GT- Ⅰ ）, girls of Tanner Ⅱ （GT-Ⅱ）. Ghrelin, insulin and glucose were measured at 0, 30, 60 and 120 rain following OGTT. The control children with normal BMI were divided into control boys of Tanner Ⅰ （CBT- Ⅰ, n = 6）, control boys of Tanner Ⅱ （CBT-Ⅱ, n = 5）, control girls of Tanner Ⅰ （CGT- Ⅰ, n = 6）, control girls of Tanner Ⅱ （CGT-Ⅱ, n = 5）. Fasting serum ghrelin levels were analyzed. RESULTS： Ghrelin levels were lower in obese groups. Ghrelin levels of control group decreased in Tanner Ⅱ stage （CGT- Ⅰ vs CGT-Ⅱ t = -4.703, P = 0.001; CBT- Ⅰ vs CBT- Ⅱ t = -4.794, P = 0.001）. Basal ghrelin levels in fir-Ⅱ decreased more significantly than that in BT- Ⅰ group （t = 2.547, P = 0.029）. Ghrelin levels expressed a downward trend after OGTT among obese children. The decrease in ghrelin levels at 60 min with respect to basal values was 56.9% in BT- Ⅰ. Ghrelin concentrations at 0 min correlated directly with glucose level at 0 min in fir- Ⅰ （r = 0.898, P = 0.015）. There wasn＇t a significant correlation of ghrelin changes with glucose changes and insulin changes during OGTT in obese children with insulin resistance. CONCLUSION： In conclusion, in obese children with insulin resistance, ghrelin levels decreased with advancing pubertal stage. Ghrelin secretion suppression following OGTT was influenced by gender and pubertal stage. Baseline ghrelin levels and ghrelin suppression after OGTT did not significantly correlate with the degree of insulin resistance and insulin sensitivity.

关键词： Ghrelin Oral glucose tolerance test Insulinresistance Obese children

Double-layer probiotic encapsulation for enhanced bacteriotherapy against inflammatory bowel disease

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Nano Research 2024年第10期17卷 9103-9110页

作者： Yixin wang jun Liu Sichen Yuan Yawen you Quanyin Hu Pharmaceutical Sciences Division School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53705USA Carbone Cancer Center School of Medicine and Public HealthUniversity of Wisconsin-MadisonMadisonWI 53705USA Wisconsin Center for NanoBioSystems School of PharmacyUniversity of Wisconsin-MadisonMadisonWI 53705USA

Inflammatory bowel disease(IBD)is inflammatory intestinal disorders associated with dysregulated gut *** that leverages bacteria as therapeutics has shown tremendous promise in resolving gut dysbiosis and reducing inflammatory mediators to treat *** delivered probiotics,such as Escherichia coli Nissle 1917(EcN),can produce beneficial ingredients,competitively inhibit the proliferation of pathogens,and promote the restoration of gut microbiome ***,environmental stresses(such as gastric acids)in the gastrointestinal(GI)tract pose an enormous challenge to the probiotics following oral administration,leading to decreases in viability and activity of ***,the inferior mucoadhesive capability of probiotics results in low colonization efficacy,further compromising their therapeutic *** probiotics with functional biomaterials may protect them from elimination and prolong their retention in the GI ***,we developed a facile double-layer electrostatic assembly technique to encapsulate EcN bacteria in protective layers of mucoadhesive chitosan(CS)and immunomodulatory hyaluronic acid(HA)to generate *** biomaterials confer the coated EcN resistance to environmental assault and enhanced mucoadhesion in the GI *** probiotics equipped with the multifunctional shield can thus suppress inflammation and reshape the intestinal microenvironment to enhance therapeutic efficacy for the prevention and treatment of ***,this study presents a novel probiotic coating strategy to augment the outcome of bacteriotherapy to combat IBD.

关键词： probiotics biomaterial coating inflammatory bowel disease mucoadhesion oral administration

The historical to future linkage of Arctic amplification on extreme precipitation over the Northern Hemisphere using CMIP5 and CMIP6 models

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Advances in Climate Change Research 2024年第4期15卷 573-583页

作者： jun LIU Xiao-Fan wang Dong-you WU Xin wang Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China

Arctic warming played a dominant role in recent occurrences of extreme events over the Northern Hemisphere,but climate models cannot accurately simulate the *** a significant positive correlation(0.33-0.95)between extreme precipitation and Arctic amplification(AA)is found using observations and CMIP5/6 multi-model ***,CMIP6 models are superior to CMIP5 models in simulating the temporal evolution of extreme precipitation and *** to 14 optimal CMIP6 models,the maximum latitude of planetary waves and the strength of Northern Hemisphere annular mode(NAM)will increase with increasing AA,contributing to increased extreme precipitation over the Northern *** the Shared Socioeconomic Pathway SSP5-8.5,AA is expected to increase by 0.85℃ per decade while the maximum latitude of planetary waves will increase by 2.82°per ***,the amplitude of the NAM will increase by 0.21 hPa per decade,contributing to a rise in extreme precipitation of 1.17% per decade for R95pTOT and 0.86% per decade for R99pTOT by 2100.

关键词： Arctic amplification Extreme precipitation CMIP5 CMIP6 Model evaluation Planetary waves Northern hemisphere annular mode

Manipulating Crystal Growth and Secondary Phase PbI_(2)to Enable Efficient and Stable Perovskite Solar Cells with Natural Additives

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Nano-Micro Letters 2024年第9期16卷 432-448页

作者： Yirong wang Yaohui Cheng Chunchun Yin Jinming Zhang Jingxuan you Jizheng wang Jinfeng wang jun Zhang Institute of Chemistry Chinese Academy of Sciences(CAS)Beijing 100190People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Nanjing University Nanjing 210023People’s Republic of China Wuhan Textile University Wuhan 430200People’s Republic of China

In perovskite solar cells(PSCs),the inherent defects of perovskite film and the random distribution of excess lead iodide(PbI_(2))prevent the improvement of efficiency and ***,natural cellulose is used as the raw material to design a series of cellulose derivatives for perovskite crystallization *** cationic cellulose derivative C-Im-CN with cyano-imidazolium(Im-CN)cation and chloride anion prominently promotes the crystallization process,grain growth,and directional orientation of ***,excess PbI_(2)is transferred to the surface of perovskite grains or formed plate-like crystallites in local *** effects result in suppressing defect formation,decreasing grain boundaries,enhancing carrier extraction,inhibiting non-radiative recombination,and dramatically prolonging carrier ***,the PSCs exhibit a high power conversion efficiency of 24.71%.Moreover,C-Im-CN has multiple interaction sites and polymer skeleton,so the unencapsulated PSCs maintain above 91.3%of their initial efficiencies after 3000 h of continuous operation in a conventional air atmosphere and have good stability under high humidity *** utilization of biopolymers with excellent structure-designability to manage the perovskite opens a state-of-the-art avenue for manufacturing and improving PSCs.

关键词： Perovskite Solar cells Defect passivation Biomass additives Crystal orientation

Characterization of geological uncertainties from limited boreholes using copula-based coupled Markov chains for underground construction

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Underground Space 2024年第3期16卷 94-105页

作者： Fan wang Heng Li Gang Li Zheng-jun you Elton J.Chen National Center of Technology Innovation for Digital Construction Huazhong University of Science and TechnologyWuhan 430074China Department of Civil and Hydraulic Engineering Huazhong University of Science and TechnologyWuhan 430074China Department of Building and Real Estate The Hong Kong Polytechnic UniversityKowloon 999077Hong KongChina Shanghai Tunnel Engineering Co. Ltd.Shanghai 200032China Wuhan Metro Group Co.Ltd. Wuhan 430070China

This paper proposes an efficient method for quantifying the stratigraphic uncertainties and modeling the geological formations based on *** Markov chains are used to describe the soil transitions along different directions,and the transition probability matrices(TPMs)of the Markov chains are analytically expressed by *** copula expression is efficient since it can represent a large TPM by a few unknown *** to the analytical expression of the TPMs,the likelihood function of the Markov chain model is given in an explicit *** estimation of the TPMs is then re-casted as a multi-objective constrained optimization problem that aims to maximize the likelihoods of two independent Markov chains subject to a set of parameter *** the method which determines the TPMs by counting the number of transitions between soil types,the proposed method is more statistically ***,a random path sampling method is presented to avoid the directional effect problem in *** soil type at a location is inferred from its nearest known neighbors along the cardinal directions.A general form of the conditional probability,based on Pickard’s theorem and Bayes rule,is presented for the soil type *** proposed stratigraphic characterization and simulation method is applied to real borehole data collected from a construction site in Wuhan,*** is illustrated that the proposed method is accurate in prediction and does not show an inclination during simulation.

关键词： Geological stratigraphy Markov chain Transition probability matrix Statistical method Copula

On the Correlation between Radio Properties and Black Hole Mass of Quasars

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Chinese Journal of Astronomy and Astrophysics 2003年第3期3卷 212-224页

作者： Xue-Guang Zhang, Ting-Gui wang and you-jun LuCenter for Astrophysics, and Department of Astronomy and Applied Physics, University of Science and Technology of China, Hefei 230026 zxg@*** Center for Astrophysics and Department of Astronomy and Applied Physics University of Science and Technology of China Hefei 230026

The question whether the radio properties of quasars are related to the massof the central black hole or the accretion rate is important for our understanding of the formationof relativistic jets, but no consensus has been reached from statistical analyses. Using two largequasar samples, one radio-selected, one optical-selected, we re-examined these relations and findthat previous differences between radio- and optical- selected samples can be ascribed, at leastpartly, to the effect of the narrow line component. All previous claimed correlations are muchweaker, if exist at all.

关键词： galaxies: active galaxies: nuclei quasars black hole

改性硅溶胶对路用泡沫混凝土力学性能的影响及应用研究

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化学工程师 2024年第7期38卷 103-106页

作者：余茂林沈海玉罗盛王友军孙旭兵中国人民解放军陆军勤务学院重庆401331 96784部队河南洛阳471000

采用硅烷偶联剂KH560作为硅溶胶改性剂,研究了改性硅溶胶及未改性硅溶胶掺入质量对泡沫混凝土7d、28d抗折强度、抗压强度、导热系数及过度路桥段载荷沉降值的影响。实验结果表明,KH560可以显著降低硅溶胶的团聚程度,降低纳米硅溶胶的平... 详细信息

采用硅烷偶联剂KH560作为硅溶胶改性剂,研究了改性硅溶胶及未改性硅溶胶掺入质量对泡沫混凝土7d、28d抗折强度、抗压强度、导热系数及过度路桥段载荷沉降值的影响。实验结果表明,KH560可以显著降低硅溶胶的团聚程度,降低纳米硅溶胶的平均粒径,提升纳米溶胶的表面活性。当泡沫混凝土中加入质量分数为3%的改性硅溶胶时,泡沫混凝土力学性能及保温隔热性能达到最优,此时泡沫混凝土28d龄期抗折强度、抗压强度分别为13.7、57.9MPa,28d龄期导热系数为0.24W·(m·K)^(-1),同时在过度路桥段具有实际使用价值。

关键词： KH560 硅溶胶泡沫混凝土力学性能导热系数硅烷偶联剂

Research progress on cottonseed meal as a protein source in pig nutrition:An updated review

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Animal Nutrition 2024年第3期18卷 220-233页

作者： An Tao Jiahao wang Bin Luo Bowen Liu Zirui wang Xingping Chen Tiande Zou jun Chen Jinming you Jiangxi Province Key Laboratory of Animal Nutrition Jiangxi Agricultural UniversityNanchang 330045China Jiangxi Province Key Innovation Center of Integration in Production and Education for High-Quality and Safe Livestock and Poultry Jiangxi Agricultural UniversityNanchang 330045China

At a global level,the supply of protein sources is insufficient to support the current magnitude of pig ***,given the exorbitant expense of conventional protein feed options like soybean meal and fish meal,it becomes imperative to promptly explore alternative sources of protein feed for the sustainable advancement of the pig *** meal,a by-product from the extraction of cottonseed oil,exhibits significant potential as a protein source for pig feed owing to its high protein content,high yield,low cost,well-balanced amino acid composition,and sufficient ***,cottonseed meal possesses several anti-nutritional factors,especially gossypol,which adversely affect growth and reproductive performance,resulting in the limited utilization of cottonseed meal in pig *** maximize the benefits of cottonseed meal and promote its application in pig production,it is imperative to acquire comprehensive knowledge regarding its nutritional value and current *** this review,we initially presented a summary of the nutritional values of cottonseed meal,primary anti-nutritional factors,and effective approaches for improving its utilization as a protein source ***,we comprehensively summarized the latest research progress of cottonseed meal application in pig nutrition over the past *** outcome of this review serves as a theoretical foundation and practical guidance for the research and application of cottonseed meal in pig nutrition and promotes the reduction of soybean meal utilization in the pig industry.

关键词： Cottonseed meal Nutritional value Protein source Pig nutrition

Eco-friendly fractionation of natural straws:sustainable ultralong room-temperature phosphorescence and super anti-ultraviolet materials

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Science China Chemistry 2024年第7期67卷 2373-2381页

作者： Zhenghao Xia Jingxuan you Haojie An Yirong wang Jinming Zhang Chunchun Yin Yaohui Cheng Kunfeng Jin jun Zhang CAS Key Laboratory of Engineering Plastics Institute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China HongDa Research Institute Co. Ltd.Beijing 100176China Key National Laboratory of Solid State Microstructures Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China

We demonstrate a new green solvent consisting of ionic liquid and polyol to achieve a selective fractionation of lignin from *** lignin from corn straw is rich in syringyl unit and phenolic hydroxyl group,resulting in excellent room-temperature phosphorescence(RTP)performance,antioxidation property and long-term *** film,fiber,aerogel and coatings with an ultralong RTP lifetime of 0.654 s are *** lignin from corn straw completely blocks UV light of290–400 nm at an extremely low usage due to many p-coumarate *** the content is as low as 1.54 mg/g,which is two orders of magnitude lower than the previous reports,the corresponding sunscreen cream has a super-high sun protection factor(SPF)of *** importantly,the lignin self-assembles into nanospheres of 250–350 nm,preventing penetration into the *** easily-available,abundant,low-cost,safe and natural lignin provides an innovative avenue for sustainable optical function materials.

关键词： lignin phosphorescence anti-ultraviolet biomass ionic liquids