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Neiguan(PC6) acupoint stimulation for preventing chemotherapy-induced nausea and vomiting: a cost-effective supplement in guideline-inconsistent chemotherapy-induced nausea and vomiting prophylaxis subgroup

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Journal of Traditional Chinese Medicine 2024年第3期44卷 581-585页

作者： YU Wenxi TANG Lina LI Hongtao wang yonggang SHEN Zan Department of Oncology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

OBJECTIVE: To assess the efficacy and safety of Neiguan(PC6) acupoint acustimulation in preventing chemotherapy-induced nausea and vomiting(CINV),especially for patients with guideline-inconsistent CINV prophylaxis(GICP) due to personal reasons METHODS: From January 2021 to December 2021, 373 patients suffered from solid malignancy were recruited according to the inclusion criteria. Complete response(no emesis and no rescue medication use) rate during the overall phase(0-120 h of each chemo-cycle) was the primary assessment of CINV control. The Functional Living Index-Emesis(FLIE) questionnaire was investigated among these patients as a secondary 'quality of life' objective to assess the impact of CINV on patients' daily life by recording score of nausea and vomiting. RESULTS: With acustimulation of Neiguan(PC6) acupuncture point through a portable, noninvasive and user-friendly device, in terms of complete response rate and scores in nausea/vomiting by FLIE questionnaire, patients achieve a better outcome in highly emetogenic chemotherapy(HEC) induced CINV, especially GICP subgroup. Meanwhile, analysis also demonstrated this tendency existed in other patients with HEC/GCCP(guideline consistent CINV prophylaxis) and moderate emetogenic chemotherapy, although the difference was not significant. CONCLUSION: Considering advantages of Neiguan(PC6) acustimulation such as noninvasive, covered by medical insurance and few side effects, we believe it would be an ideal auxiliary tool in CINV control, especially in patients who receive highly emetogenic chemoprotocol and are reluctant to GCCP for economic reasons.

关键词： acupuncture acustimulation chemotherapy-induced nausea and vomiting tumor

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Study on Dynamic Mechanical Behavior of Al-Mg-Si Alloy

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Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 454-462页

作者：陶小旺 LIU Jibo LIU Xianbin CHEN Jianbin wang yonggang 汪小锋 Key Laboratory of Impact and Safety Engineering Ministry of EducationNingbo UniversityNingbo 315211China Ningbo Zhanci New Material Co. Ltd.Ningbo 315338China

The dynamic mechanical behavior of Al-Mg-Si alloy was investigated under different strain rates by mechanical property and microstructure characterization,constitutive behavior analysis and numerical simulation in the present study.As the strain rate increases,the yield strength,ultimate tensile strength and elongation increase first,then remain almost constant,and finally increase.The alloy always exhibits a typical ductile fracture mode,not depending on the strain rate.However,as the strain rate increases,the number of dimples gradually increases.Tensile deformation can refine grains,however,the grain structure is slightly affected by the strain rate.An optimized Johnson-Cook constitutive equation was used to describe the mechanical behavior and obtained by fitting the true stress-strain curves.The parameter C was described by a function related to the strain rate.The fitting true stress-strain curves by the JC model agree very well with the experimental true stress-strain curves.The true stress-strain curves calculated by the finite element numerical simulation agree well with the experimental true stress-strain curves.

关键词： Al-Mg-Si alloy strain rate mechanical property microstructure Johnson-Cook model finite element simulation

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Differential metabolite analysis of the pharmacodynamic differences between different ratios of Dahuang(Radix Et Rhizoma Rhei Palmati)-Taoren(Semen Persicae) herb pair

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Journal of Traditional Chinese Medicine 2024年第3期44卷 515-523页

作者： wang Xiang HUANG Jianping wang Yupeng wang Qilong JING Yajiang ZHANG Gang PENG Liang GAO Jing wang Hongyan YAN yonggang Department of Key Laboratory of "Qin Pharmaceutical" Research and Development Shaanxi University of Traditional Chinese Medicine Department of Yupeng Shaanxi Haitian Pharmaceutical Co. Ltd. Department of Acupuncture and Tuina Shaanxi University of Traditional Chinese Medicine

OBJECTIVE: To explore the material basis of the difference of efficacy of Dahuang(Radix Et Rhizoma Rhei Palmati)-Taoren(Semen Persicae)(DT) drugs with different proportions. METHODS: Samples of different ratios of Dahuang(Radix et Rhizoma Rhei Palnati, DH) to Taoren(Semen Persicae, TR)(Group A 1∶1, B 2∶3, C 3∶2) were analyzed based on gas chromatography time-of-flight mass spectrometry untargeted metabolomics technique. RESULTS: A total of 240 primary metabolites were detected. Forty-one differential metabolites involved nine differential metabolic pathways, of which four were closely related to the efficacy of DT in the treatment of heat and blood stasis syndrome. These pathways included the biosynthesis of amino acid(phenylalanine tyrosine and tryptophan), flavonoids, unsaturated fatty acids, and the glycolysis/glycogenesis pathway. CONCLUSION: There are significant differences in the efficacy of different ratios of DT drugs, and their optimal ratio for the treatment of heat and blood stasis syndrome should be 1∶1.

关键词： Dahuang () Taoren () differential metabolites kernel drug pairs metabolic networks and pathways metabolomics

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Ribonucleotide reductase subunit M1 blocks glucose catabolism via phosphorylation of pyruvate kinase M2 in human esophageal squamous cell cancer

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Genes & Diseases 2024年第3期11卷 69-71页

作者： Jian Yang Lingxiao wang Hui Sun Zhenxiang Zhao Yanchuan Ma Zhen Hu Liqin Zhai yonggang wang Translational Medicine Research Center Shanxi Medical UniversityTaiyuanShanxi030001China Department of Cell Biology and Genetics Shanxi Medical UniversityTaiyuanShanxi 030001China Key Laboratory of Cellular Physiology of the Ministry of Education Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Colorectal Surgery The Fifth Clinical Medical College of Shanxi Medical UniversityTaiyuanShanxi 030012China Science&Technology Information and Strategy Research Center of Shanxi TaiyuanShanxi 030006China Department of Pathology Shanxi Provincial People's HospitalTaiyuanShanxi 030012China Department of Anatomy College of Basic MedicineShanxi Medical UniversityTaiyuanShanxi 030001China

Esophageal squamous cell cancer(EScC)is one of the malignant tumors with high morbidity and mortality all over the world.^(1) In recent years,combined chemotherapy has gradually been the effective treatment method for EscC patients.Therefore,it is imperative to explore potential therapeutic targets for the treatment of EsCC.We previously reported a high-frequency amplification of pyrimidine metabolic pathway-related genes in EsCC tissues.

关键词： squamous esophageal cancer

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Rbm8a regulates neurogenesis and reduces Alzheimer's disease-associated pathology in the dentate gyrus of 5×FAD mice

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Neural Regeneration Research 2024年第4期19卷 863-871页

作者： Chenlu Zhu Xiao Ren Chen Liu Yawei Liu yonggang wang Department of Neurology Lanzhou University Second Hospital Department of Neurology The First Affiliated Hospital of Nanchang University Department of Neurology Xiaogan City Central Hospital Health Service Department of the Guard Bureau of the General Office of the Central Committee of the Communist Party of China Headache Center Department of NeurologyBeijing Tiantan HospitalCapital Medical University

Alzheimer’s disease is a prevalent and debilitating neurodegenerative condition that profoundly affects a patient’s daily functioning with progressive cognitive decline,which can be partly attributed to impaired hippocampal neurogenesis.Neurogenesis in the hippocampal dentate gyrus is likely to persist throughout life but declines with aging,especially in Alzheimer’s disease.Recent evidence indicated that RNA-binding protein 8A(Rbm8a)promotes the proliferation of neural progenitor cells,with lower expression levels observed in Alzheimer’s disease patients compared with healthy people.This study investigated the hypothesis that Rbm8a overexpression may enhance neurogenesis by promoting the proliferation of neural progenitor cells to improve memory impairment in Alzheimer’s disease.Therefore,Rbm8a overexpression was induced in the dentate gyrus of 5×FAD mice to validate this hypothesis.Elevated Rbm8a levels in the dentate gyrus triggered neurogenesis and abated pathological phenotypes(such as plaque formation,gliosis reaction,and dystrophic neurites),leading to ameliorated memory performance in 5×FAD mice.RNA sequencing data further substantiated these findings,showing the enrichment of differentially expressed genes involved in biological processes including neurogenesis,cell proliferation,and amyloid protein formation.In conclusion,overexpressing Rbm8a in the dentate gyrus of 5×FAD mouse brains improved cognitive function by ameliorating amyloid-beta-associated pathological phenotypes and enhancing neurogenesis.

关键词： Adora2a Alzheimer’s disease astrocyte cAMP signaling pathway dentate gyrus dystrophic neurites microglia neurogenesis plaque Rbm8a

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Machine learning will revolutionize perovskite solar cells

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The Innovation 2024年第3期5卷 13-14页

作者： Ziming Chen Shuang Pan Jing wang yonggang Min Yihuang Chen Qifan Xue State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSchool of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035China School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006China

With the emergence of ChatGPT and its rapid iteration speed,artificial intelligence(AI)has undoubtedly become the driving force behind a new wave of technological revolution.After more than half a century of development,AI has become akin to the steam engine of the Industrial Revolution,propelling humanity into the era of intelligence.The global industrial chain has also recognized that AI technology will spearhead a new wave of industrial transformation and development.Machine learning(ML),driven by data,abstracts real-life problems into mathematical problems and solves them using computers.It is currently the mainstream method for addressing many AI problems.Perovskite solar cells(PSCs)are currently the focus of researchers around the world due to their high efficiency,low cost,and simple manufacturing process.They are considered the most promising third-generation solar cell for commercialization.In 2011,the United States proposed the Materials Genome Initiative(MGI).The main idea is to utilize the“trinity”approach of computing,data,and experiments to transform the conventional“trial and error”model of materials research and development,which relies heavily on experience and experimentation,in order to enhance the quality,speed of discovery,development,production,and application of new materials.Driven by the MGI,research on the combination of ML with great application potential and rapidly developing PSC(ML&PSC)emerged(Figure 1).

关键词： utilize Figure doubt

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Atomization characteristics of pyrolysis oil derived from waste tires

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Waste Disposal and Sustainable Energy 2024年第1期6卷 39-52页

作者： Hong Feng Zhitong Yin Qin Hong Yiming Hu Lintao Liu Jun wang Qunxing Huang yonggang Zhou ZJMI Environmental Energy Co. LtdHangzhou310003China Tongxiang Taiaisi Environmental Protection Energy Co. Ltd.Jiaxing314500China State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou310027China Key Laboratory of Clean Energy and Carbon Neutrality of Zhejiang Province Jiaxing Research InstituteZhejiang UniversityJiaxing314031China

The atomization characteristics play a key role in the highly efficient combustion of pyrolysis oil derived from waste tires.In this study,the fuel properties of tire pyrolysis oil(TPO)were initially studied,and then a high-speed camera and a phase Doppler particle analyzer were employed to characterize the atomization feature of TPO.The influence of pressure and nozzle orifice diameter on atomization characteristics such as spray angle,droplet velocity,and droplet size distribution was investigated.The results showed that TPO had a high calorific value of about 43.6 MJ/kg and a low viscosity of 3.84×10^(–6)m^(2)/s at 40℃,which made it have the potential to be used as an alternative fuel.Higher pressure expanded the spray angle and extended the spray in both the axial and radial directions.With increasing pressure,spray angle and droplet velocity raised,and the increase in crushing effect of air reduced the Sauter mean diameter(SMD)of the droplets.To obtain proper atomization quality for combustion,the pressure is expected to be higher than 1.25 MPa.With increasing nozzle orifice diameter,droplet velocity increased,and the SMD of the droplets increased as well due to weakened crushing effect of the orifice.Therefore,the pressure must be increased to maintain the atomization quality when using a nozzle with a larger orifice.Due to the lower viscosity,the velocity and particle size distribution of TPO droplets after atomization were smaller than those of diesel droplets.The extremely small carbon black contained in TPO also contributed to the breaking of droplets and played a certain role in the size reduction of the oil droplets,but it may cause the risk of nozzle blockage.In summary,TPO showed great atomization characteristics for alternative fuel applications.

关键词： Pyrolysis oil Atomization characteristics Spray angle Droplet velocity Droplet size distribution

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Apically guiding electron/mass transfer reaction induced by Ag/FeNx Mott-Schottky effect within a hollow star reactor toward high performance zinc-air batteries

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Journal of Energy Chemistry 2024年第8期95卷 106-116页

作者： Kaixiang Shi Kaixin wang Tong Li Junhao Li Jie Ren Xu Li yonggang Min Zhouguang Lu Wei Tan Quanbing Liu Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center(Rongjiang Laboratory) Guangdong University of Technology Guangzhou Key Laboratory of Clean Transportation Energy Chemistry Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Key Laboratory of Electrochemical Energy Storage and Energy Conversion of Hainan Province School of Chemistry and Chemical Engineering Hainan Normal University School of Materials and Energy Guangdong University of Technology Department of Materials Science and Engineering Southern University of Science and Technology

The disparity in the transfer of carriers（electrons/mass） during the reaction in zinc-air batteries（ZABs）results in sluggish kinetics of the oxygen reduction reaction（ORR） and oxygen evolution reaction（OER）,along with elevated overpotentials,thereby imposing additional constraints on its utilization.Therefore,the pre-design and target-development of inexpensive,high-performance,and long-term stable bifunctional catalysts are urgently needed.In this work,an apically guiding dual-functional electrocatalyst（Ag-FeNx-N-C） was prepared,in which a hierarchical porous nitrogen-doped carbon with three-dimensional（3D） hollow star-shaped structure is used as a substrate and high-conductivity Ag nanoparticles are coupled with iron nitride（FeNx） nanoparticles.Theoretical calculations indicate that the Mott-Schottky heterojunction as an inherent electric field comes from the two-phase bound of Ag and FeNx,of which electron accumulation in the FeNxphase region and electron depletion in the Ag phase region promote orientated-guiding charge migration.The effective modulation of local electronic structures felicitously reforms the d-band electron-group distribution,and intellectually tunes the masstransfer reaction energy barriers for both ORR/OER.Additionally,the hollow star-s haped hierarchical porous structure provides an apical region for fast mass transfer.Experimental results show that the halfwave potential for ORR is 0.914 V,and the overpotential for OER is only 327 mV at 10 mA cm-2.A rechargeable ZAB with Ag-FeNx-N-C as the air cathode demonstrates long-term cycling performance exceeding 1500 cycles（500 h）,with a power density of 180 mW cm-2.Moreover,when employing AgFeNx-N-C as the air cathode,flexible ZABs demonstrate a notable open-circuit voltage of 1.42 V and achieve a maximum power density of 65.6 mW cm-2.Ag-FeNx-N-C shows guiding electron/mass transfer route and apical reaction microenvironment for the electrocatalyst architecture in the exploration prospects of ZABs.

关键词： Apically guiding effect Bifunctional catalysis Hollow star structure Mott-Schottky effect Zinc-air batteries

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Targeted regeneration and upcycling of spent graphite by defect‐driven tin nucleation

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Carbon Energy 2024年第4期6卷 91-103页

作者： Zhiheng Cheng Zhiling Luo Hao Zhang Wuxing Zhang wang Gao Yang Zhang Long Qie yonggang Yao Yunhui Huang Kun Kelvin Fu State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhanChina Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationDepartment of Materials Science and EngineeringJilin UniversityChangchunChina Electronic Materials Research Laboratory(Key Lab of Education Ministry) School of Electronic and Information Engineeringand Instrumental Analysis CenterXi'an Jiaotong UniversityXi'anChina Department of Mechanical Engineering University of DelawareNewarkUSA

The recycling of spent batteries has become increasingly important owing to their wide applications,abundant raw material supply,and sustainable development.Compared with the degraded cathode,spent anode graphite often has a relatively intact structure with few defects after long cycling.Yet,most spent graphite is simply burned or discarded due to its limited value and inferior performance on using conventional recycling methods that are complex,have low efficiency,and fail in performance restoration.Herein,we propose a fast,efficient,and“intelligent”strategy to regenerate and upcycle spent graphite based on defect‐driven targeted remediation.Using Sn as a nanoscale healant,we used rapid heating(~50 ms)to enable dynamic Sn droplets to automatically nucleate around the surface defects on the graphite upon cooling owing to strong binding to the defects(~5.84 eV/atom),thus simultaneously achieving Sn dispersion and graphite remediation.As a result,the regenerated graphite showed enhanced capacity and cycle stability(458.9 mAh g^(−1) at 0.2 A g^(−1) after 100 cycles),superior to those of commercial graphite.Benefiting from the self‐adaption of Sn dispersion,spent graphite with different degrees of defects can be regenerated to similar structures and performance.EverBatt analysis indicates that targeted regeneration and upcycling have significantly lower energy consumption(~99%reduction)and near‐zero CO2 emission,and yield much higher profit than hydrometallurgy,which opens a new avenue for direct upcycling of spend graphite in an efficient,green,and profitable manner for sustainable battery manufacture.

关键词： battery recycling spent graphite targeted regeneration upcycling graphite

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Combined effects of climate and land-use changes on the alpha and beta functional diversities of terrestrial mammals in China

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Science China Life Sciences 2024年

作者： Chao Zhang Yumei Li Wei wang Zexuan Gao Hanqing Liu yonggang Nie Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences College of Life Sciences Hebei University University of Chinese Academy of Sciences

Climate and land-use changes are predicted to impact biodiversity,threatening ecosystem services and functions.However,their combined effects on the functional diversity of mammals at the regional scale remain unclear,especially at the beta level.Here,we use projected climate and land-use changes in China to investigate their potential effects on the alpha and beta functional diversities of terrestrial mammals under low-and high-emission scenarios.In the current projection,we showed strong positive spatial correlations between functional richness and species richness.Functional evenness (FEve),functional specialization (FSpe),and functional originality (FOri)decreased with species richness,and functional divergence (FDiv) increased first and then plateaued.Functional beta diversity was dominated by its nestedness component,in contrast to the taxonomic facet.Potential changes in species richness are more strongly influenced by land-use change under the low-emission scenario,while under the high-emission scenario,they are more strongly influenced by climate change.Changes in functional richness (FRic) were inconsistent with those in species richness,with a magnitude of decreases greater than predicted from species richness.Moreover,mammal assemblages showed potential functional differentiation (FD) across the country,and the trends exceeded those towards taxonomic differentiation (TD).Our findings help us understand the processes underlying biodiversity responses to global changes on multiple facets and provide new insight for conservation plans.

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