Ribonucleotide reductase subunit M1 blocks glucose catabolism via phosphorylation of pyruvate kinase M2 in human esophageal squamous cell cancer

作     者：Jian Yang Lingxiao Wang Hui Sun Zhenxiang Zhao Yanchuan Ma Zhen Hu Liqin Zhai Yonggang Wang Jian Yang;Lingxiao Wang;Hui Sun;Zhenxiang Zhao;Yanchuan Ma;Zhen Hu;Liqin Zhai;Yonggang Wang

作者机构：Translational Medicine Research CenterShanxi Medical UniversityTaiyuanShanxi030001China Department of Cell Biology and GeneticsShanxi Medical UniversityTaiyuanShanxi 030001China Key Laboratory of Cellular Physiology of the Ministry of EducationShanxi Medical UniversityTaiyuanShanxi 030001China Department of Colorectal SurgeryThe Fifth Clinical Medical College of Shanxi Medical UniversityTaiyuanShanxi 030012China Science&Technology Information and Strategy Research Center of ShanxiTaiyuanShanxi 030006China Department of PathologyShanxi Provincial People's HospitalTaiyuanShanxi 030012China Department of AnatomyCollege of Basic MedicineShanxi Medical UniversityTaiyuanShanxi 030001China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2024年第11卷第3期

页      面：69-71页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.82103175) the Natural Science Foundation of Shanxi Province,China(No.201901D111432,20210302123316,202103021224379) 

主　　题：squamous esophageal cancer 

摘      要：Esophageal squamous cell cancer(EScC)is one of the malignant tumors with high morbidity and mortality all over the world.^(1) In recent years,combined chemotherapy has gradually been the effective treatment method for EscC ***,it is imperative to explore potential therapeutic targets for the treatment of *** previously reported a high-frequency amplification of pyrimidine metabolic pathway-related genes in EsCC tissues.