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Bioactive sesquineolignans from the twigs of Litsea cubeba

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Chinese Journal of Natural Medicines 2021年第10期19卷 796-800页

作者： XIA Huan XIA Gui-yang wang ling-yan wang Min wang Ya-Nan LIN Peng-Cheng LIN Sheng Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China College of Pharmaceutical Sciences Qinghai University for NationalitiesXining 810000China

In a continuing search for biological natural products with structure diversity from traditional Chinese herbs,five new sesquineolignans(1−5)were isolated from an ethyl acetate extract of the twigs of Litsea *** structures were elucidated based on MS,1D and 2D NMR spectroscopic data,as well as experimental electronic circular dichroism(ECD)*** 1−5 showed moderate inhibitory effects against LPS-induced NO production in RAW264.7 macrophages,with IC50 values of 16.2,20.2,22.1,15.1,and 16.6μmol·L^(−1),respectively.

关键词： Litsea cubeba Sesquineolignans NO production inhibitory activity

Synthesis of Coumarin-functionalized Calix[4]arene and Selective Recognition for L-Tryptophan

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Chinese Chemical Letters 2006年第5期17卷 575-577页

作者： Jian Quan LU Li ZHANG Ting Quan SUN Gui Xiang wang ling yan WU Hubei Key Laboratory of Bioanalytical Technique Hubei Normal University Huangshi 435002

5,11,17,23-Tetra-tert-butyl-25, 27-bis（7＇-methoxycoumarin-3＇-methyloxy）-26, 28-dihydroxycalix[4]arene was synthesized and characterized. The derivative could recognize L-tryptophan with a 1：1 complexing ratio and an apparent equilibrium constant of 111 L mol^-1 in DMF acetonitrile as solvent by UV-visible and fluorescent spectrophotometry.

关键词： Calixarene synthesis recognition L-tryptophan.

Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase

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Chinese Journal of Natural Medicines 2020年第1期18卷 75-80页

作者： XIA Gui-yang wang ling-yan ZHANG Jing-Fang WU Yu-Zhuo GE Guang-Bo wang Ya-Nan LIN Peng-Cheng LIN Sheng State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 1Q0050China Institute of Interdisciplinaty Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China College of Pharmaceutical Sciences Qinghai University for NationalitiesXining 810000China

Purpurolides D–F(1–3),three new polyoxygenated bergamotanes bearing a 6/4/5/5 tetracyclic ring system,were isolated from the endophytic fungus Penicillium purpurogenum IMM *** structures were unambiguously elucidated based on extensive spectroscopic data analyses,13 C NMR chemical shifts calculations coupled with the DP4+probability method,and the calculated and experimental electronic circular dichroism(ECD)*** 1–3 showed significant inhibitory activity against pancreatic lipase(PL).The result highlights that the presence of 3-hydroxylated decanoic acid moiety at C-14 is important for increasing the inhibition potency against PL.

关键词： Penicillium purpurogenum Sesquiterpene lactones Pancreatic lipase inhibitors

Comparative results of corneal curvature measurements with three different keratometers after radial keratotomy

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Chinese Medical Journal 2011年第24期124卷 4260-4263页

作者： ZHAO Lu ZHANG Li wang yan-ling wang Wei yan yan Department of Ophthalmology Beijing Friendship HospitalCapital Medical University Beijing 100050 China Hankou Aier Eye Hostital Wuhan Hubei 430000 China School of Biological Engineering Capital Medical UniversityBeiiing100069 China

Background Corneal curvatures measured by conventional instruments after refractive surgeries were greater than the real values. This study on the instruments and methods for measuring corneal curvature was carried out with the aim of determining an accurate, simple and effective method to evaluate corneal refractive power after radial keratotomy （RK）. Methods A retrospective study was carried out on 52 eyes of 42 patients with a history of RK. The postoperative measurements after RK were performed with a manual keratometer （Rodenstock, Munchen-Hamburg, Germany）, a corneal topographer （Tomey TMS-1） and an automated IOLMaster keratometer （Carl Zeiss GmbH, USA）. The results obtained from analyzing clinical histories （clinical history method, CHM） were compared to the postoperative measurements with a two-way analysis of variance. Adjusted keratometry was used to correct the corneal central refractive power （K） values of the three keratometers. The CHM results were also compared to the corrected K values obtained with the three keratometers using the same statistical method. Results The smallest mean value was found for the CHM （（36.61±2.23） diopters）. The K values obtained with the CHM were very different from the results obtained with the three different instruments. The corrected K values obtained with the IOLMaster were the closest to the K values from the CHM. Conclusions It was shown that K values from measurements with the three instruments were higher. When the power of the intraocular lens of the patients after RK was calculated, the errors of the K values measured with the instruments should be taken into consideration.

关键词： radial keratotomy corneal curvature keratometer corneal topography

Relationship between community type of wetland plants and site elevation on sandbars of the East Dongting Lake,China

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Forestry Studies in China 2009年第1期11卷 44-48页

作者： ZHENG Jing-ming wang ling-yan LI Su-yan ZHOU Jin-xing SUN Qi-xiang Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry University Beijing 100083 E R. China Key Laboratory for Forest Tree Breeding of State Forestry Administration Chinese Academy of Forestry Beijing 100091 P. R. China

Plant communities on sandbars were important, and restoration of degraded wetland were significant to biological conservation in the East Dongting Lake region. In this study, typical wetland community types on sandbars and their site elevation were surveyed to explore relationship between community distribution and site elevation. Results show that eight major communities in this region were wetland communities dominated by Juncus effusus, Carex brevicuspis, Polygonum hydropiper, Salix triandra, Oenanthe Javanica, Phalaris arundinacea, Miscanthus sacchariflorus and Phragmites communis respectively. These communities had obvious constructive species and companion species, while site elevation could affect community composition and their species diversity. On sandbars in the East Dongting Lake, vegetation was largely composed of hygrophytes companied with a few mesophytes. The higher the site elevation was, the nearer the site was to the water, and the lower community diversity became. Except soil humidity and site elevation, growth period of plants after inundation could also affect species richness in the communities.

关键词： wetland restoration sandbar elevation the East Dongting Lake

Bioactive neolignans and lignans from the roots of Paeonia lactiflora

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Chinese Journal of Natural Medicines 2022年第3期20卷 210-214页

作者： XIA Huan ZHANG Jing-Fang wang ling-yan XIA Gui-yang wang Ya-Nan WU Yu-Zhuo LIN Peng-Cheng XIONG Liang LIN Sheng Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China College of Pharmaceutical Sciences Qinghai University for NationalitiesXining 810000China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China

Two new neolignans and one new lignan(1-3)were obtained from the roots of Paeonia *** structures were unambiguously elucidated based on extensive spectroscopic analysis,single-crystal X-ray crystallography,and the calculated and experimental electronic circular dichroism(ECD)*** 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase *** 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1(hCES2Al)with an IC_(50) value of 7.28±0.94 μmol·L^(-1).

关键词： Paeonia lactiflora Neolignan Lignan Human carboxylesterase 2A1

Modification of High Performances of Polymer Cement Concrete

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Journal of Wuhan University of Technology(Materials Science) 2003年第1期18卷 61-64页

作者：刘军 ShenyangArchitecturalandCivilEngineeringUniversity

The workability,mechanical and physical properties are investigated,based on the requirements of the high properties of polymer cement concrete (PCC).The research results reveal that PCC is greatly improved and strengthened by adding appropriate *** polymer/cement=0-0.15,its porosity decreases greatly due to the improved pore *** weak area at interface is *** workability,mechanical and physical properties are obviously enhanced with the proportion of polymer and *** the same time the properties are much improved under the adequate curing conditions and admixture (0-10%).

关键词： polymer cement concrete high property

Improved circulation in ocular ischemic syndrome after carotid artery stenting

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Chinese Medical Journal 2011年第21期124卷 3598-3600页

作者： wang yan-ling ZHAO Lu LI Ming-ming Department of Ophthalmology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

Ocular ischemic syndrome is a chronic ischemic eye disease including a series of ischemic ocular and brain syndromes caused by carotid artery occlusion or stenosis. Because of the different degrees of ischemia, clinical manifestations of ocular ischemic syndrome are diverse, and it is difficult to diagnose in the initial stage. The main strategy to treat ocular ischemic syndrome is elimination of carotid stenosis. We presented a patient who recovered dramatically after carotid artery stenting. The pre-stenting arm-retinal circulation time of the patient＇s left eye was prolonged, and a large amount of microaneurysm appeared at the posterior polar and mid-peripheral aspects of the left retina. The post-stenting arm-retinal circulation time of the left eve decreased to 16.3 seconds, and the microaneurvsm almost disappeared.

关键词： ocular ischemic syndrome retinal microaneurysm carotid artery stenosis stent

Collapsin Response Mediator Protein-2-induced Retinal Ischemic Injury in a Novel Mice Model of Ocular Ischemia Syndrome

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Chinese Medical Journal 2017年第11期130卷 1342-1351页

作者： Yu wang Xiao-Lei wang Guo-Li Xie Hong-yang Li yan-ling wang Department of Ophthalmology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

Background： Collapsin response mediator protein-2 （CRMP2） has been shown to be involved in ischemia/hypoxia （IH） injury. We determined whether CRMP2 modulates ischemic injury in the retinal of Ocular ischemic syndrome （OIS）. This study was to explore the molecular mechanisms underlying O1S in a novel mice model. Methods： Experiments were performed oil adult male C57/BL6 mice that received bilateral internal carotid arteries ligation for 1,2, or 4 weeks. The mice received injection of calpeptin group before occlusion for 4 weeks or not. The expression of CRMP2 in the retinal was exalnined by western blotting （WB） analysis and immunohistochemical analysis （IHC）. The effects of ischemic injury on retinal were evaluated by fundus examination, fundus fluorescein angiography, electroretinogram, cell cotinting of retinal ganglion cell （RGC）, and measurement of the thickness of the retina. Results： The veins dilated after chronic ischemia. In the electroretinography, the amplitudes of a- and b-waves kept diminishing in an ischemia time-dependent manner. Moreover, the tail vein-retinal circulation time prolonged in the l- and 2-week group. In comparison, thickness of the retina decreased gradually with the ischemia time elapsed. WB analysis showed the CRMP2 and p-CRMP2 levels decreased in the 2- and 4-week groups. The results of IHC analysis were compatible with our results of WB. The loss of RGCs, decrease of the total reaction time and reduction of CRMP2 was alleviated by intravitreal injection of calpeptin. Conclusions： These results revealed that bilateral ligation of the internal carotid artery causes retinal ischemia in mice. Moreover, CRMP2 might play a pivotal role during the ischemic injury in the retina and inhibit the cleavage of CRM P2 can ameliorate the IH injury.

关键词： Calpeptin Collapsin Response Mediator Protein 2 Ischemia Injury Ocular Ischemic Syndrome Phosphorylation