Bioactive sesquineolignans from the twigs of Litsea cubeba

作     者：XIA Huan XIA Gui-Yang WANG Ling-Yan WANG Min WANG Ya-Nan LIN Peng-Cheng LIN Sheng XIA Huan;XIA Gui-Yang;WANG Ling-Yan;WANG Min;WANG Ya-Nan;LIN Peng-Cheng;LIN Sheng

作者机构：Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingDongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China State Key Laboratory of Bioactive Substance and Function of Natural MedicinesInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China College of Pharmaceutical SciencesQinghai University for NationalitiesXining 810000China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2021年第19卷第10期

页      面：796-800页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.81903489 and 81522050) the Science and Technology Program of Qinghai(No.2018-ZJ-739) the Innovation Platform for the Development and Construction of Special Project of Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province(No.2017-ZJ-Y19) the Fundamental Research Funds for the Central Universities(No.3332019080) 

主　　题：Litsea cubeba Sesquineolignans NO production inhibitory activity 

摘      要：In a continuing search for biological natural products with structure diversity from traditional Chinese herbs,five new sesquineolignans(1−5)were isolated from an ethyl acetate extract of the twigs of Litsea *** structures were elucidated based on MS,1D and 2D NMR spectroscopic data,as well as experimental electronic circular dichroism(ECD)*** 1−5 showed moderate inhibitory effects against LPS-induced NO production in RAW264.7 macrophages,with IC50 values of 16.2,20.2,22.1,15.1,and 16.6μmol·L^(−1),respectively.