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Downregulation of MUC1 Inhibits Proliferation and Promotes Apoptosis by Inactivating NF-κB Signaling Pathway in Human Nasopharyngeal Carcinoma

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生物化学与生物物理进展 2024年第9期51卷 2182-2193页

作者： WU Shou-Wu LIN Shao-Kun NIAN Zhong-Zhu wang xin-wen LIN Wei-Nian ZHUANG Li-Ming WU Zhi-Sheng HUANG Zhi-Wei wang A-Min GAO Ni-Li CHEN Jia-wen YUAN wen-Ting LU Kai-Xian LIAO Jun Department of Otolaryngology Quanzhou First HospitalQuanzhou 362001China Department of Otolaryngology Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362001China Department of Ultrasound Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362001China Department of Orthopaedics Dongguan City People’s HospitalDongguan 523016China

Objective To investigate the effect of mucin 1(MUC1)on the proliferation and apoptosis of nasopharyngeal carcinoma(NPC)and its regulatory *** The 60 NPC and paired para-cancer normal tissues were collected from October 2020 to July 2021 in Quanzhou First *** expression of MUC1 was measured by real-time quantitative PCR(qPCR)in the patients with *** 5-8F and HNE1 cells were transfected with siRNA control(si-control)or siRNA targeting MUC1(si-MUC1).Cell proliferation was analyzed by cell counting kit-8 and colony formation assay,and apoptosis was analyzed by flow cytometry analysis in the 5-8F and HNE1 *** qPCR and ELISA were executed to analyze the levels of TNF-αand *** blot was performed to measure the expression of MUC1,NFкB and apoptosis-related proteins(Bax and Bcl-2).Results The expression of MUC1 was up-regulated in the NPC tissues,and NPC patients with the high MUC1 expression were inclined to EBV infection,growth and metastasis of *** of MUC1 restrained malignant features,including the proliferation and apoptosis,downregulated the expression of p-IкB、p-P65 and Bcl-2 and upregulated the expression of Bax in the NPC *** Downregulation of MUC1 restrained biological characteristics of malignancy,including cell proliferation and apoptosis,by inactivating NF-κB signaling pathway in NPC.

关键词： mucin 1 nasopharyngeal carcinoma NF-κB signaling pathway proliferation apoptosis

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方解石热释光定年技术的发展历史与展望

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地震地质 2024年第3期46卷 699-722页

作者：秦可心胡贵明刘静沈续文高云鹏王文鑫温欣语蒋帅宇天津大学地球系统科学学院表层地球系统科学研究院天津300072 中国地震局地质研究所地震动力学国家重点实验室北京100029

矿物晶体中累积的释光信号与其暴露在辐射环境中的时间相关,可用于测定沉积物年代。近年来,依托石英和长石2种矿物释光信号的测年方法日臻成熟,但这2种矿物的释光信号过早饱和,限制了其测年上限(通常<300ka)。前人研究表明,方解石亦有... 详细信息

矿物晶体中累积的释光信号与其暴露在辐射环境中的时间相关,可用于测定沉积物年代。近年来,依托石英和长石2种矿物释光信号的测年方法日臻成熟,但这2种矿物的释光信号过早饱和,限制了其测年上限(通常<300ka)。前人研究表明,方解石亦有可能成为热释光测年材料,因为其热释光信号对剂量响应的灵敏度高,且特征饱和剂量约可达3000~5000Gy,有望将释光测年范围扩展至第四纪尺度。特别地,这一技术的发展也将拓展目前仅限于剥露速率极高地区的释光低温热年代学的应用范围,使其更好地贡献于地貌演化和构造活动的研究。文中对方解石热释光的基本原理和测年流程进行了简要概括,总结了方解石热释光测年应用及动力学参数的研究成果。此外,利用方解石热释光技术对虎跳峡段的基岩样品进行了测试,结果表明,ITL-235℃释光信号可用于该地区剥露历史的恢复工作。同时,文中基于上述内容讨论了方解石热释光技术的应用潜力和待解决问题,以期为该技术在构造地貌领域的应用提供帮助。

关键词：方解石热释光低温热年代学虎跳峡

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低温熔融盐体系电沉积制备铝锡合金

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Journal of Central South University 2024年第3期31卷 783-795页

作者：阚洪敏王文鑫孔令明吴江 School of Mechanical Engineering Shenyang UniversityShenyang 110044China Key Laboratory of Research and Application of Multiple Hard Films of Liaoning Province Shenyang UniversityShenyang 110044China Key Laboratory of Advanced Materials Technology of Liaoning Province Shenyang UniversityShenyang 110044China

以AlCl_(3)-NaCl-KCl低温熔融盐体系作为电解质,无水SnCl_(2)作为原料,对电沉积制备Al-Sn合金进行研究。通过扫描电子显微镜(SEM)、能谱(EDS)和X射线衍射仪(XRD)分析合金产物的形貌和成分组成;通过极化曲线法和摩擦磨损实验对合金产物... 详细信息

以AlCl_(3)-NaCl-KCl低温熔融盐体系作为电解质,无水SnCl_(2)作为原料,对电沉积制备Al-Sn合金进行研究。通过扫描电子显微镜(SEM)、能谱(EDS)和X射线衍射仪(XRD)分析合金产物的形貌和成分组成;通过极化曲线法和摩擦磨损实验对合金产物的耐蚀性和耐磨减摩性进行检测分析;通过维氏硬度计和涂层附着力自动划痕仪对合金产物的硬度与膜基结合力进行表征。结果表明:当SnCl_(2)添加量为0.04~0.08 g时可制备出锡含量为10%~18%的中锡铝合金,最佳沉积温度为160~200℃、沉积时间为40~50 min、电流密度为40~50 mA/cm^(2);随镀层中锡含量的提高,其耐蚀性逐渐变差,而耐摩擦磨损性能先提高后降低,并在SnCl_(2)添加量为0.06 g,即镀层中锡的含量为14 wt%时有最佳摩擦磨损性能;沉积温度对合金镀层的硬度及结合力有很大影响,随沉积温度的升高,合金镀层的膜基结合力和硬度均呈现先提高后降低的趋势,当沉积温度为200℃时,其结合力和硬度最佳。

关键词：铝锡合金低温熔融盐体系电沉积法耐蚀性耐磨减摩性

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非编码RNA在病毒性心肌炎中的研究现状

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中国临床药理学杂志 2024年第14期40卷 2143-2147页

作者：何小龙胡鑫鑫王翻宁王文鑫周国磊移康尤涛甘肃中医药大学第一临床医学院甘肃兰州730000 先天性心脏病诊疗甘肃省国际科技合作基地甘肃兰州730000 兰州大学第一临床医学院甘肃兰州730000 甘肃省人民医院心血管外科甘肃兰州730000

病毒性心肌炎(VMC)是扩张型心肌病的主要原因,可导致心力衰竭和心源性猝死。随着高通量测序技术的发展,非编码RNA(ncRNA)在VMC的发生发展中具有重要作用。ncRNA通过调节病毒复制、免疫细胞功能、心肌细胞死亡、心肌间质纤维化等病理过... 详细信息

病毒性心肌炎(VMC)是扩张型心肌病的主要原因,可导致心力衰竭和心源性猝死。随着高通量测序技术的发展,非编码RNA(ncRNA)在VMC的发生发展中具有重要作用。ncRNA通过调节病毒复制、免疫细胞功能、心肌细胞死亡、心肌间质纤维化等病理过程促进VMC的发生发展。本文就ncRNA在VMC中的研究进展做一综述,为VMC的发病机制及诊疗提供新的思路。

关键词：非编码RNA 病毒性心肌炎柯萨奇病毒

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Teleportation of an Arbitrary Two-Particle State via a Single Cluster-Class State

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Communications in Theoretical Physics 2009年第8期52卷 209-213页

作者： wang xin-wen Department of Physics Hunan University of Science and Engineering Yongzhou 425100 China Department of Physics and Applied Optics Beijing Area Major Laboratory Beijing Normal University Beijing 100875China

Teleportation of an arbitrary two-qubit state with a single partially entangled state,a four-qubit linearcluster-class state,is *** case is more practical than previous ones using maximally entangled states as thequantum *** order to realize teleportation,we first construct a cluster-basis of 16 orthonormal cluster *** show that quantum teleportation can be successfully implemented with a certain probability if the receiver can adoptappropriate unitary transformations after receiving the sender's cluster-basis measurement *** addition,animportant conclusion can be obtained that a four-qubit maximally entangled state (cluster state) can be extracted froma single copy of the cluster-class state with the same probability as the teleportation in principle.

关键词： probabilistic teleportation cluster-class state cluster-basis measurement unitary transformation

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Quantum Teleportation via Hybrid Entangled States

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Communications in Theoretical Physics 2007年第3X期48卷 441-444页

作者： XIONG wen-Yuan wang xin-wen Department of Electronic Engineering and Physics Hunan University of Science and Engineering Yongzhou 425100China

In this paper, we study quantum teleportation of atomic states via a hybrid entangled state （HES） involving an atom and a cavity field. And we investigate how to implement controlled phase （CP） gates between atomic internal states and coherent states of cavity field. We also discuss the methods of distinguishing coherent states [±α〉 in a cavity. Finally, a brief discussion about the feasibility of this scheme in experiment is presented.

关键词： hybrid entangled states quantum teleportation controlled phase gates discrimination of cavityfield coherent states

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Preparation of a New Type of Multiqubit Entangled States in Cavity QED

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Communications in Theoretical Physics 2008年第9期50卷 738-740页

作者： XIONG wen-Yuan wang xin-wen XIA Li-xin Department of Electronic Engineering and Physics Hunan University of Science and Engineering Yongzhou 425100 China Department of Physics Beijing Normal University Beijing 100875 China Department of Physics Tsinghua University Beijing 100084 China

Recently Yang,Chu,and Han [***.A 70 (2004) 022329] presented a new type of multipartiteentangled states for implementing efficient many-party controlled teleportation of multiqubit quantum *** propose a simple scheme for preparing such a type of multi-atom entangled states in cavity quantum electrodynamics(QED).The scheme involves atom-cavity interaction with large detuning,and is immune to the cavity decay and thethermal field *** practical analyses show its availability with the present technology.

关键词： new type of entangledsates cavity QED controlled quantum communication

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A Feasible Scheme for Teleportation of Multi-atom Cat-like States in Thermal Cavities

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Communications in Theoretical Physics 2006年第4期45卷 625-629页

作者： wang xin-wen LIU Xiang Department of Physics Hunan Normal University Changsha 410081 China Department of Physics Hunan University of Science and Engineering Yongzhou 425006 China

An experimentally feasible scheme for implementing teleportation of multi-atom cat-like states in cavity QED is proposed. In the scheme the atoms interact simultaneously with a highly detuned cavity mode and are driven by a strong classical field, and the atomic state evolution is independent of cavity field state. Thus the scheme is insensitive to both the cavity decay and the thermal field, which is of importance from the experimental point of view. All the orthogonal and complete multi-atom GHZ states can be exactly distinguished only by one step, so our scheme can also be used for other purposes such as dense coding using multi-atom GHZ states as quantum channels.

关键词： teleportation multi-atom cat-like state multi-atom GHZ multi-atom GHZ discrimination

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Scheme for Teleportation of a Multipartite Quantum State by Using a Single Entangled Pair as Quantum Channel

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Communications in Theoretical Physics 2007年第2期47卷 257-260页

作者： wang xin-wen wang Zhi-Yong XIA Li-xin Department of Physics Hunan University of Science and Engineering Yongzhou 425100 China Department of Physics Hengyang Normal University Hengyang 421008 China

We present a theoretical scheme for perfect teleportation of an unknown multipartite two-level state by a single EPR （Einstein-Podolsky-Rosen） pair, and then generalize it to multilevel, i.e., an N-quNit state can be teleported by a single quNit entangled pair, with additional local unitary operations. The feature of the scheme is that teleporting a multipartite state with a reduced amount of entanglement costs less classical bits.

关键词： EPR pair quNit entangled pair N-qubit cat-like state N-quNit cat-like state teleportation

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The effects of intraspecific competition and light transmission within the canopy on wheat yield in a wide-precision planting pattern

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Journal of Integrative Agriculture 2020年第6期19卷 1577-1585页

作者： LIU xin wang wen-xin LIN Xiang GU Shu-bo wang Dong College of Agronomy Shandong Agricultural University/State Key Laboratory of Crop BiologyMinistry of Science and Technology/Key Laboratory of Crop Ecophysiology and Farming SystemMinistry of AgricultureTai'an 271018P.R.China

The wide-precision planting pattern has become widely used in the North China Plain as a practice for increasing wheat ***,the effects of tilled ng developme nt and light tran smissi on within can opy on wheat yield un der differe nt sowi ng widths have not bee n clearly ***,a two-year experime nt was con ducted,in cludi ng four different seeding widths(6 cm,W6;8 cm,W8;10 cm,W10;12 cm,W12)and the traditional planting pattern with seeding width of 4 cm(W4).The results indicated mainly positive effects by the reduced intraspecific competition,specifically all three yield components of W6 and W8 were higher than those for *** configurations with more than 10-cm seeding width were mainly affected by the negative effect of a relative homogeneous canopy,leading to the weakened light transmission,leaf senescence,and reduced grain number per ***,the yields of W6 and W8 were significantly higher than that of W4,whereas the yield in W12 was lower(though not significantly)than *** wheat production,therefore,the appropriate seeding width of 6-8 cm is recommended for farmers,whereas the too wide seeding width,with more than 10 cm,should be avoided.

关键词： light tra nsmissi on seedi ng width tillers nu mber win ter wheat yield comp orients

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