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A Case Series of Olfactory Dysfunction in Imported COVID-19 Patients:A 12-Month Follow-Up Study

Biomedical and Environmental Sciences 2022年第5期35卷 402-411页

作者： wang Ni YANG Ming Bo YANG Pu Ye CHEN Ren Bo HUANG Fei SHI Nan Nan MA Yan ZHANG Yan XU You LIU Si hong LU Heng Yi FU Qing Qing FAN Yi Pin KAN hong Min wang xiao hong GUO Ya Ling National Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Hepatology Department of TCM Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Department of Integrated Chinese and Western Medicine Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Infection Xi’an NO.8 HospitalXi’an 710061ShaanxiChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China

Objective The scientific community knows little about the long-term influence of coronavirus disease2019(COVID-19) on olfactory dysfunction(OD). With the COVID-19 pandemic ongoing worldwide, the risk of imported cases remains high. In China, it is necessary to understand OD in imported cases.Methods A prospective follow-up design was adopted. A total of 11 self-reported patients with COVID-19 and OD from Xi’an No. 8 Hospital were followed between August 19, 2021, and December 12, 2021.Demographics, clinical characteristics, laboratory and radiological findings, and treatment outcomes were analyzed at admission. We surveyed the patients via telephone for recurrence and sequelae at the1-, 6-, and 12-month follow-up.Results Eleven patients with OD were enrolled;of these, 54.5%(6/11) had hyposmia and 45.5%(5/11)had anosmia. 63.6%(7/11) reported OD before or on the day of admission as their initial symptom;of these, 42.9%(3/7) described OD as the only symptom. All patients in the study received combined treatment with traditional Chinese medicine and Western medicine, and 72.7%(8/11) had partially or fully recovered at discharge. In terms of OD recovery at the 12-month follow-up, 45.5%(5/11) reported at least one sequela, 81.8%(9/11) had recovered completely, 18.2%(2/11) had recovered partially, and there were no recurrent cases.Conclusions Our data revealed that OD frequently presented as the initial or even the only symptom among imported cases. Most OD improvements occurred in the first 2 weeks after onset, and patients with COVID-19 and OD had favorable treatment outcomes during long-term follow-up. A better understanding of the pathogenesis and appropriate treatment of OD is needed to guide clinicians in the care of these patients.

关键词： COVID-19 Olfactory Imported cases Hyposmia Anosmia Follow-up

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Local Invariants for a Class of Tripartite Quantum Mixed States

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Communications in Theoretical Physics 2006年第2期45卷 262-266页

作者： wang xiao-hong Department of Mathematics Capital Normal University Beijing 100037 China

我们在本地单一的转变下面学习分成三部分的混合状态的等价。为在 C~K 直接 X C~MdirectX C~N 合成系统的分成三部分的量状态的一个类的非局部的性质被调查，在为这些状态的本地单一的转变下面的 invariants 的一个完全的集合被介绍。... 详细信息

我们在本地单一的转变下面学习分成三部分的混合状态的等价。为在 C~K 直接 X C~MdirectX C~N 合成系统的分成三部分的量状态的一个类的非局部的性质被调查，在为这些状态的本地单一的转变下面的 invariants 的一个完全的集合被介绍。如果并且仅当，二个这些状态是局部地相等的，这被显示出所有这些 invariants 有一样的价值。

关键词：局部不变量三重量子态局部整体转化三重混合态

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High mobility group box 1 protein： possible pathogenic link to atrial fibrillation

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Chinese Medical Journal 2012年第13期125卷 2346-2348页

作者： HU xiao-rong wang xiao-hong LIU Hua-fen ZHOU Wen-jie JIANG hong Department of Cardiology Renmin Hospital of Wuhan UniversityCardiovascular Research Institute of Wuhan UniversityWuhanHubei 430060China

Atrial fibrillation （AF） is the most common sustained dysrhythmia in clinical practice. The bulk of evidence suggests that inflammatory processes, oxidative stress and matrix metalloproteinase are associated with development of AF. However, these agents may be involved in high mobility group box 1 protein （HMGB1）. We hypothesized that HMGB1 may be a possible pathogenic link to AF. A growing body of evidence supports these hypotheses. First, the level of serum HMGB1 is significantly increased in patients with AF including paroxysmal and persistent AF. Second, HMGB1 has been identified as a new pro-inflammatory cytokine in cardiovascular diseases, along with tumor necrosis factor （TNF）-a, interleukin （IL）-6, and C-reactive protein, and there is cross-talk between HMGB1 and inflammatory cytokines. Third, oxidative stress is involved in the release of the pro-inflammatory cytokine, HMGB1, indicating there is cross-talk between oxidative stress and inflammation, and oxidative stress may reinforce the effect of inflammation on the pathogenesis of AF and inflammation may play a more important role in the pathogenesis of AF. Fourth, HMGB1 can promote matrix metalloproteinase-9 upregulation and activation. Fifth, HMGB1 receptors （receptor for advanced glycation end products, Toll-like receptor-2,4） may mediate the atrial structural remodeling or be up-regulated in patients with non-valvular AF. These results suggest that HMGB1 may participate in the pathogenesis of AF and provide a potential target for pharmacoloclical interruption of AF.

关键词： atrial fibrillation high mobility group box l protein inflammation oxidative stress matrix metalloproteinase

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气相爆轰合成碳纳米材料的研究进展

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爆破 2024年第2期41卷 160-169页

作者：陈端花李晓杰闫鸿浩王小红王宇新大连理工大学工程力学系大连116024 大连理工大学工业装备结构分析优化与CAE软件全国重点实验室大连116024

气相爆轰合成是一种新型的碳纳米材料制备方法,相对于其他碳纳米材料制备方法而言具有反应速度快、产物种类多、产量大、纯度高、操作简单和经济性高等优点,有利于促进碳纳米材料的工业化生产。为深入阐明气相爆轰法合成碳纳米材料的研... 详细信息

气相爆轰合成是一种新型的碳纳米材料制备方法,相对于其他碳纳米材料制备方法而言具有反应速度快、产物种类多、产量大、纯度高、操作简单和经济性高等优点,有利于促进碳纳米材料的工业化生产。为深入阐明气相爆轰法合成碳纳米材料的研究与发展状况,介绍了气相爆轰法合成所需仪器设备、实验流程、理论计算以及产物的表征方法等,整理归纳了气相爆轰法合成碳包覆纳米金属粒子、碳纳米球、碳纳米管、碳点和碳纳米胶囊等技术与方法,分析了合成产物的形貌、结构及性能特征,展望了气相爆轰下各种新型碳纳米材料的应用潜力与技术发展趋势,以期为合理设计、针对性优化、规模化合成纳米材料奠定理论基础。研究表明:爆轰合成应结合宏观的爆轰理论和微细观的粒子生长。当前借助爆轰波发动机与爆轰胞格结构研究热点,使宏观爆轰胞格与纳米材料微观合成过程构成联系是重点研究方向。然而,在研究爆轰合成粒子的生长机理时,聚集在微细尺度上的纳米粒子生长仍然也是一种跨尺度问题,有必要引入分子动力学和格子波尔兹曼计算方法加以解决。

关键词：气相爆轰合成碳纳米材料冲击波碳包覆纳米金属碳纳米胶囊

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Classification of Bipartite and Tripartite Qutrit Entanglement Under SLOCC

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Communications in Theoretical Physics 2008年第9期50卷 651-654页

作者： YANG Xin-Gang wang Zhi-Xi wang xiao-hong FEI Shao-Ming College of Mathematical Sciences Capital Normal University Beijing 100037 China Max-Planck-Institute for Mathematics in the Sciences 04103 Leipzig Germany

We classify biqutrit and triqutrit pure states under stochastic local operations and classical communication.By investigating the right singular vector spaces of the coefficient matrices of the states,we obtain explic... 详细信息

关键词：通信技术技术性能缠结物理

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Most common SLC25A13 mutation in 400 Chinese infants with intrahepatic cholestasis

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World Journal of Gastroenterology 2010年第18期16卷 2278-2282页

作者： Fu, Hai-Yan Zhang, Shao-Ren Yu, Hui wang, xiao-hong Zhu, Qi-Rong wang, Jian-She Fudan Univ Childrens Hosp Ctr Pediat Liver Dis Shanghai 201102 Peoples R China Fudan Univ Shanghai Med Coll Dept Pediat Shanghai 201102 Peoples R China

AIM:To establish the real time fluorescence polymerase chain reaction(RT-PCR) with dual labeled probes for fast detection of SLC25A13 gene mutation 851del4.METHODS:Four hundred infants(< 1 year of age) with unexplained intrahepatic cholestasis from 18 provinces or municipalities in China were enrolled in this study for detecting their SLC25A13 gene mutation 851del4.Suitable primers and fluorescence-labeled probes for detecting SLC25A13 gene mutation 841del4 were designed.Normal and mutant sequences were detected by PCR with two fluorescence-labeled probes.After a single RT-PCR,results were obtained by analyzing the take-off curves.Twenty-four positive and 14 negative samples were retested by direct sequencing.RESULTS:Eight homozygous and 30 heterozygous mutations were detected in 46 mutant alleles with a 851del4 mutation rate of 5.8%(46/800).Twenty-six and 20 mutant alleles were observed respectively,in 474 and 242 alleles from the intermediate and southern areas of China.No mutant allele was detected in 84 alleles from northern China.Twenty-four positive samples including 4 homozygous and 20 heterozygous mutations,and 14 negative samples were retested by direct sequencing,which confirmed that the accuracy of RTPCR was 100%.CONCLUSION:RT-PCR can detect the mutation 851del4 in infants with intrahepatic cholestasis with an accuracy of 100%.

关键词： 851del4 mutation Neonatal intrahepatic cholestasis Real-time fluorescent polymerase chain reaction SLC25A13 gene

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Biotic and abiotic stress-responsive genes are stimulated to resist drought stress in purple wheat

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Journal of Integrative Agriculture 2020年第1期19卷 33-50页

作者： LI xiao-lan LÜXiang wang xiao-hong PENG Qin ZHANG Ming-sheng REN Ming-jian School of Life Sciences Guizhou University/State Engineering Technology Institute for Karst Desertification Control/Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous RegionMinistry of EducationGuiyang 550025P.R.China School of Agriculture Guizhou University/Guizhou Sub-Center of National Wheat Improvement CenterGuiyang 550025P.R.China Special Key Laboratory of Microbial Resources and Drug Development from Higher Education Institution of Guizhou Province/Research Center for Medicine and Biology Zunyi Medical UniversityZunyi 563006P.R.China

Triticum aestivum L. cv. Guizi 1(GZ1) is a drought-tolerant local purple wheat cultivar. It is not clear how purple wheat resists drought stress, but it could be related to anthocyanin biosynthesis. In this study, transcriptome data from droughttreated samples and controls were compared. Drought slightly reduced the anthocyanin, protein and starch contents of GZ1 grains and significantly reduced the grain weight. Under drought stress, 16 682 transcripts were reduced, 27 766 differentially expressed genes(DEGs) were identified, and 379 DEGs, including DREBs, were related to defense response. The defense-response genes included response to water deprivation, reactive oxygen, bacteria, fungi, etc. Most of the structural and regulatory genes in anthocyanin biosynthesis were downregulated, with only Ta DFR, Ta OMT, Ta5,3GT, and Ta MYB-4 B1 being upregulated. Ta CHS, Ta F3H, TaCHI, Ta4CL, and TaF3’H are involved in responses to UV, hormones, and stimulus. Ta CHS-2D1, Ta DFR-2D2, Ta DFR-7D, TaOMT-5A, Ta5,3 GT-1B1, Ta5,3GT-3A, and Ta5,3GT-7B1 connect anthocyanin biosynthesis with other pathways, and their interacting proteins are involved in primary metabolism, genetic regulation, growth and development, and defense responses. There is further speculation about the defense-responsive network in purple wheat. The results indicated that biotic and abiotic stress-responsive genes were stimulated to resist drought stress in purple wheat GZ1, and anthocyanin biosynthesis also participated in the drought defense response through several structural genes.

关键词： transcriptome purple wheat drought anthocyanin differentially expressed genes defense response stress

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基于光谱反射率的低照度图像增强方法研究

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光谱学与光谱分析 2024年第3期44卷 610-616页

作者：麻祥才曹前白春燕王晓红张大伟上海理工大学光电信息与计算机工程学院上海200093 上海出版印刷高等专科学校印刷包装工程系上海200093 上海理工大学出版印刷与艺术设计学院上海200093

低照度图像增强技术是机器视觉研究热点之一,Retinex理论模型假设图像是反射分量与光照分量乘积,通过去除或校正光照分量并结合物体的反射特性来恢复图像,被广泛应用在传统算法和深度学习增强模型中。光谱反射率是颜色的指纹,多光谱图... 详细信息

低照度图像增强技术是机器视觉研究热点之一,Retinex理论模型假设图像是反射分量与光照分量乘积,通过去除或校正光照分量并结合物体的反射特性来恢复图像,被广泛应用在传统算法和深度学习增强模型中。光谱反射率是颜色的指纹,多光谱图像比普通图像的信息量更为丰富。色度学理论和Retinex理论都认为图像的颜色特性取决于反射系数,但光谱反射率是基于仪器测量获得真实的数据,而图像反射分量是基于图像分解假设的数据,目前文献没有从光谱角度对低照度图像增强进行研究。受Retinex理论启发结合深度学习非线性拟合能力,用颜色的光谱反射率代替RetinexNet网络中的图像反射分量,用CIE标准光源的光谱功率分布代替网络中的图像照明分量,提出了一种基于光谱反射率的低照度图像增强方法。首先对图像数据库中正常光照图像进行光谱重建,构建低照度图像与正常光照的多光谱图像数据集。然后训练将低照度图像转换成多光谱图像的深度学习网络模型。任意低照度图像通过网络模型得到多光谱图像,多光谱图像根据色度学理论得到CIEXYZ三刺激值,再通过标准颜色空间转换到RGB颜色空间中显示。该方法在公开LOL数据集上进行训练与测试,结果表明在图像噪声抑制和颜色恢复方面都优于常用方法,证明该方法对低照度图像增强的优越性和有效性。

关键词：光谱反射率低照度图像增强 Retinex理论深度学习

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Heteropolytungstates Containing Organotin and Cobalt or Zinc Atom

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Chemical Research in Chinese Universities 1999年第4期15卷 317-321页

作者： wang xiao-hong FANG Xi-kui LIU Jing-fu Department of Chemistry Northeast Normal UniversityChangchun 130024P.R.China

Organotin substituted heteropolytungstates with cobalt or zinc atom as the central atom, \{K 6H[XW 11 O 39 (RSn)]\}· n H 2O(X=Zn, Co; R=CH 3OOCCH 2CH 2, CH 2OOCCH(CH 3)CH 2, NCCH 2CH 2) were prepared and characterized by elemental analysis, IR, UV Vis spectroscopy, ESR, NMR spectroscopy and electrochemical study. The results show that these anions possess Keggin like structures.

关键词： Organotin Transition metal Heteropolyanion

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Clinicopathologic and prognostic implications of progranulin in breast carcinoma

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Chinese Medical Journal 2011年第13期124卷 2045-2050页

作者： LI Li-qin HUANG Hui-lian PING Jin-liang wang xiao-hong Zhong Jing DAI Li-cheng Huzhou Key Laboratory of Molecular Medicine Affiliated Central Hospital of Huzhou Teachers College Huzhou Zhejiang 313000 China Department of Pathology Affiliated Central Hospital of Huzhou Teachers College Huzhou Zhejiang 313000 China Department of Breast Surgery Affiliated Central Hospital of Huzhou Teachers College Huzhou Zhejiang 313000 China

Background Progranulin is a newly discovered 88-kDa glycoprotein originally purified from the highly tumorigenic mouse teratoma-derived cell line PC. Its expression is closely correlated with the development and metastasis of several cancers. However, no immunohistochemical evidence currently exists to correlate progranulin expression with clinicopathologic features in breast carcinoma biopsies, and the role of progranulin as a new marker of metastatic risk and prognosis in breast cancer has not yet been studied. The aim of this study was to investigate the clinicopathologic and prognostic implications of progranulin expression in breast carcinoma and its correlation with tumor angiogenesis. Methods Progranulin expression was determined immunohistochemically in 183 surgical specimens from patients with breast cancer and 20 tissue samples from breast fibroadenomas. The tumor angiogenesis-related biomarker, vascular endothelial growth factor was assayed and microvessel density was assessed by counting vascular endothelial cells in tumor tissues labeled with endoglin antibody. The relationship between progranulin expression and the clinicopathologic data were analyzed. Results Progranulin proteins were overexpressed in breast cancer. The level of progranulin expression was significantly correlated with tumor size （P=0.004）, lymph node metastasis （P 〈0.001） and TNM staging （P 〈0.001）. High progranulin expression was associated with higher tumor angiogenesis, reflected by increased vascular endothelial growth factor expression （P〈0.001） and higher microvessel density （P=0.002）. Conclusion Progranulin may be a valuable marker for assessing the metastasis and prognosis of breast cancer, and could provide the basis for new combination regimens with antiangiogenic activity.

关键词： breast carcinoma progranulin endoglin angiogenesis immunohistochemistry

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